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| Product | Description | |
|---|---|---|
| ACBC | ACBC has been found to be a NMDA receptor partial agonist and could probably affect the signal transmission in the CNS. Group: Pharmaceutical. Alternative Names: 1-Aminocyclobutane-1-carboxylic acid. CAS No. 22264-50-2. Pack Sizes: 1mg;1g;10g. Product ID: 22264-50-2. Molecular formula: C5H9NO2. Mole weight: 115.13. Custom synthesis is available. Send your inquiries for more information. |  London |
| Agmatine sulfate salt | Agmatine sulfate, the sulfate preparation of Agmatine, is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. Agmatine displaces clonidine at α2-adrenergic and at imidazoline receptors and produces blockade of the NMDA-receptor associated cation channels. Nutritional supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: Agmatine sulfate; 1-(4-Aminobutyl)guanidine sulfate; 1-Amino-4-guanidinobutane sulfate salt; Guanidine, (4-aminobutyl)-, sulfate (1:1). CAS No. 2482-00-0. Pack Sizes: 1 kg. Product ID: BAT-008149. Molecular formula: C5H16N4O4S. Mole weight: 228.27. Custom synthesis is available. Send your inquiries for more information. | London |
| Apimostinel | Apimostinel is a selective partial agonist of an allosteric site of the glycine site of the NMDA receptor complex under investigation by Naurex. Its mechanism of action and effects are similar to those of rapastinel. But Apimostinel is 100-fold more potent by weight and, unlike rapastinel (which must be administered via intravenous injection), is orally-active. Phase II clinical trials for the treatment of Major depressive disorder is on-going. Uses: Major depressive disorder. Group: Pharmaceutical. Alternative Names: NRX-1074; NRX 1074; NRX1074; AGN-241660; AGN241660; AGN 241660. Apimostinel;(2R)-1-[(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-2-benzylpyrrolidine-2-carboxamide. CAS No. 1421866-48-9. Pack Sizes: 5 mg. Product ID: B2693-475419. Molecular formula: C25H37N5O6. Mole weight: 503.6. Custom synthesis is available. Send your inquiries for more information. | London |
| Caroverine | Caroverine is a muscle-relaxing drug, also can be used for the treatment of cerebrovascular diseases and tinnitus. It acts as a nonselective NMDA and AMPA glutamate receptor antagonist. Group: Pharmaceutical. Alternative Names: 1-[2-(diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]quinoxalin-2-one. CAS No. 23465-76-1. Pack Sizes: 1mg;1g;10g. Product ID: 23465-76-1. Molecular formula: C22H27N3O2. Mole weight: 365.477. Custom synthesis is available. Send your inquiries for more information. | London |
| Caroverine hydrochloride | Caroverine is a muscle-relaxing drug, also can be used for the treatment of cerebrovascular diseases and tinnitus. It acts as a nonselective NMDA and AMPA glutamate receptor antagonist. Group: Pharmaceutical. Alternative Names: Spadon; 1-[2-(diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]quinoxalin-2-one hydrochloride. CAS No. 55750-05-5. Pack Sizes: 1mg;1g;10g. Product ID: 55750-05-5. Molecular formula: C22H28ClN3O2. Mole weight: 401.935. Custom synthesis is available. Send your inquiries for more information. | London |
| CNQX | CNQX, also known as FG9065, is a potent and competitive AMPA/kainate receptor antagonist and also an antagonist at glycine modulatory site on NMDA receptor complex. Uses: Excitatory amino acid antagonists. Group: Pharmaceutical. Alternative Names: FG 9065; FG-9065; FG9065; 6-Cyano-2,3-dihydroxy-7-nitroquinoxaline; 1,4-dihydro-2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile. CAS No. 115066-14-3. Pack Sizes: 125 mg. Product ID: B1370-161226. Molecular formula: C9H4N4O4. Mole weight: 232.15. Custom synthesis is available. Send your inquiries for more information. | London |
| Dansyl sarcosine piperidinium salt | Dansyl sarcosine piperidinium salt, a chemical compound utilized in biochemical research, holds a pivotal position in the study of NMDA receptors. Owing to its proficiency in fluorescence detection of glutamate or glycine binding sites on these receptors, it may have the potential to augment the therapeutic treatment of prevalent neurological disorders such as Alzheimer's and Parkinson's. Its multifaceted uses offer researchers the versatility to investigate a host of biological phenomena related to the aforementioned conditions. Group: Pharmaceutical. Alternative Names: Dansylsarcosine piperidinium salt; Piperidin-1-ium 2-(5-(dimethylamino)-N-methylnaphthalene-1-sulfonamido)acetate. CAS No. 72517-44-3. Pack Sizes: 100 mg. Product ID: B0001-111116. Molecular formula: C20H29N3O4S. Mole weight: 407.53. Custom synthesis is available. Send your inquiries for more information. | London |
| Dizocilpine | Dizocilpine is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM. Group: Pharmaceutical. Alternative Names: MK-801; MK 801; MK801; (5S)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene. CAS No. 77086-21-6. Pack Sizes: 100 mg. Product ID: B0084-133490. Molecular formula: C16H15N. Mole weight: 221.303. Custom synthesis is available. Send your inquiries for more information. | London |
| Eliprodil | Eliprodil, a NR2B-NMDA receptor antagonist, was found to have neuroprotective activity in study of ischemia. Uses: Eliprodil is a nr2b-nmda receptor antagonist that was found to have neuroprotective activity in study of ischemia. Group: Pharmaceutical. Alternative Names: -(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, SL-82,0715; SL82,0715; SL 82,0715; SL-820715; SL820715; SL 820715; Eliprodil. CAS No. 119431-25-3. Pack Sizes: 50 mg. Product ID: B0084-359860. Molecular formula: C20H23ClFNO. Mole weight: 347.85. Custom synthesis is available. Send your inquiries for more information. | London |
| Glycine, N-(1-iminopentyl)- | N-(1-iminopentyl)glycine, a neurotransmitter analog, has demonstrated agonist activity at both the NMDA and glycine receptors, highlighting its unique properties. Promising clinical results in animal models of stroke have suggested its potential as a critical agent in the treatment of cerebral ischemia and its associated symptoms. The complexity of its action, coupled with its potential therapeutic value, make this compound an essential prospect for further investigation and development. Group: Pharmaceutical. Alternative Names: 2-(1-aminopentylideneamino)acetic Acid; N-(1-Iminopentyl)-Glycine; Pentanimidoylamino-acetic acid. CAS No. 193140-43-1. Pack Sizes: 50 mg. Product ID: B2699-172634. Molecular formula: C7H14N2O2. Mole weight: 158.2. Custom synthesis is available. Send your inquiries for more information. | London |
| Huperzine A | (-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: N/A. CAS No. 102518-79-6. Pack Sizes: 100 mg. Product ID: NP0543. Molecular formula: C15H18N2O. Mole weight: 242.32. Custom synthesis is available. Send your inquiries for more information. | London |
| Ibotenic acid | Ibotenic acid is a neuroexcitatory amino acid originally isolated from amanita species. It is used as a non-selective NMDA and metabotropic glutamate receptor agonist. It is a neurotoxin and is often used to induce brain lesions in animals. It has been used to perform surgery in adult male zebra finches to study reversing reinforcement-induced vocal changes. Group: Pharmaceutical. Alternative Names: (+/-)-Ibotenic acid; DL-Ibotenic acid. CAS No. 2552-55-8. Pack Sizes: 25 mg. Product ID: B1370-060612. Molecular formula: C5H6N2O4. Mole weight: 158.11. Custom synthesis is available. Send your inquiries for more information. | London |
| Ifenprodil Tartrate | Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM. Uses: Adrenergic alpha-antagonists. Group: Pharmaceutical. Alternative Names: Ifenprodil (tartrate). CAS No. 23210-58-4. Pack Sizes: 1 g. Product ID: B2693-367328. Molecular formula: 2(C21H27NO2).C4H6O6. Mole weight: 800.98. Custom synthesis is available. Send your inquiries for more information. | London |
| Isorhynchophylline | Rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and anticonvulsant activity of the Uncaira species plant extracts. Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, the present results suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia. Group: Pharmaceutical. Alternative Names: methyl (E)-2-((3S,6'R,7'S,8a'S)-6'-ethyl-2-oxo-2',3',6',7',8',8a'-hexahydro-5'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate; Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'R,7'S,8'aS)-; 7-Isorhyncophylline; Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E,20α)-; (+)-Isorhynchophylline; Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, [1'S-[1'α,6'α,7'β(E),8'aα]]-. CAS No. 6859-1-4. Pack Sizes: 50 mg. Product ID: NP0065. Molecular formula: C22H28N2O4. Mole weight: 384.47. Custom synthesis is available. Send your inquiries for more information | London |
| Memantine | Memantine, also called Namenda, a N-methyl D-aspartate (NMDA) antagonist prescribed to treat symptoms of moderate to severe Alzheimer's, blocks the toxic effects associated with excess glutamate and regulates glutamate activation. Group: Pharmaceutical. Alternative Names: 3,5-Dimethyltricyclo[3.3.1.13,7]decan-1-amine; AlzantinD 145; DMAA; DRG 0267; Ebixa; Acid salts MeMantine; 1,3-Dimethylaminoadamantane; 1-Amino-3,5-dimethyladamantane; Memantina; Memantinum; Namenda; Memantin; 3,5-Dimethyl-1-adamantylamine; Memantina; 1,3-Dimethyl-5-adamantanamine; CHEMBL807; UNII-W8O17SJF3T; 3,5-Dimethyl-1-aminoadamantan. CAS No. 19982-08-2. Pack Sizes: 5 g. Product ID: B2693-086852. Molecular formula: C12H21N. Mole weight: 179.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Memantine hydrochloride | Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA receptors.It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively. Uses: Antiparkinson agents. Group: Pharmaceutical. Alternative Names: 3,5-Dimethyltricyclo[3.3.1.13,7]decan-1-amine Hydrochloride; 3,5-Dimethyl-1- adamantanamine; 1-Amino-3,5-dimethyladamantane Hydrochloride; Akatinol; Axura; Ebix; Ebixia; Ebixza; NSC 102290; Namenda; SUN Y7017; Tocris. CAS No. 41100-52-1. Pack Sizes: 25 g. Product ID: NP3138. Molecular formula: C12H21N.HCl. Mole weight: 215.76. Custom synthesis is available. Send your inquiries for more information. | London |
| Octahydro-1H-1,4,7-triazonine Trihydrochloride | Octahydro-1H-1,4,7-triazonine Trihydrochloride, a chemical compound utilized in drug discovery, exhibits neuroprotective properties. It is regarded as a potent NMDA receptor antagonist, and preclinical evaluations suggest its potential for treating afflictions such as epilepsy and Alzheimer's disease. The compound's effectiveness in targeting these and other neurological disorders has piqued the interest of scientists with promising results. Group: Pharmaceutical. Alternative Names: 1,4,7-Triazacyclononane Trihydrochloride; 1H-1,4,7-Triazonine, octahydro-, trihydrochloride. CAS No. 58966-93-1. Pack Sizes: 2.5 g. Product ID: B2699-153380. Molecular formula: C6H18Cl3N3. Mole weight: 238.59. Custom synthesis is available. Send your inquiries for more information. | London |
| Radiprodil | Radiprodil is an orally active and selective NMDA NR2B antagonist as a potential therapeutic agent in treatment of neuropathic pain and possibly other chronic pain conditions, blocking pain signaling without interacting with other NMDA receptor subtypes thus potentially improving therapeutic index and side effect profile. Uses: Nmda nr2b antagonist. Group: Pharmaceutical. Alternative Names: RGH-896; RGH896; RGH 896; 2-(4-((4-Fluorophenyl)methyl)piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)acetamide. CAS No. 496054-87-6. Pack Sizes: 100 mg. Product ID: B1370-475760. Molecular formula: C21H20FN3O4. Mole weight: 397.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Rapastinel | Rapastinel, a brain penetrable tetrapeptide, could be a partial agonist of NMDA receptor. It was already finished the Phase II trial for acting as an antidepressant agent. It was just planed a phase III trial for Major depressive disorder. Uses: Rapastinel is a brain penetrable tetrapeptide and could be a partial agonist of nmda receptor. Group: Pharmaceutical. Alternative Names: GLYX-13; GLYX 13; GLYX13; BV-102; BV102; BV 102; TPPT-amide; Rapastinel; UNII-6A1X56B95E; GLYX-13 trifluoroacetate; TPPT-amide trifluoroacetate. CAS No. 117928-94-6. Pack Sizes: 5 mg. Product ID: BAT-010744. Molecular formula: C18H31N5O6. Mole weight: 413.47. Custom synthesis is available. Send your inquiries for more information. | London |
| (R)-(+)-HA-966 | (R)-(+)-HA-966 is a cell-permeable antagonist/partial agonist at the glycine site of the NMDA receptor. Group: Pharmaceutical. Alternative Names: R(+)-HA-966; 1-Hydroxy-3-amino-pyrrolidine-2-one, (R)-; Tocris-0281; (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one. CAS No. 123931-04-4. Pack Sizes: 100 mg. Product ID: B1370-047738. Molecular formula: C4H8N2O2. Mole weight: 116.12. Custom synthesis is available. Send your inquiries for more information. | London |
| SA-4503 dihydrochloride | SA-4503 is a potent sigma receptor agonist. SA-4503 may have effects on depressive symptoms such as agitation, loss of interest, and impaired cognition, which are mediated by NMDA receptors. SA 4503 attenuates cocaine-induced hyperactivity and enhances methamphetamine substitution for a cocaine discriminative stimulus. Group: Pharmaceutical. Alternative Names: SA 4503 dihydrochloride; 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride; SA4503 (dihydrochloride); Cutamesine dihydrochloride. CAS No. 165377-44-6. Pack Sizes: 100 mg. Product ID: B0084-169082. Molecular formula: C23H34Cl2N2O2. Mole weight: 441.437. Custom synthesis is available. Send your inquiries for more information. | London |
| Sarcosine | Sarcosine is an endogenous GlyT1 inhibitor. Sarcosine displays antipsychotic activity and has the potential to treat schizophrenia. Sarcosine has been shown to potentiate the action of glycine on the NMDA glycine binding site. Uses: Sarcosine, also known as n-methylglycine, is a naturally occurring amino acid derivative that has shown promise in various areas including drug discovery and development. in recent years, there has been growing interest in exploring the pharmacological properties of sarcosine and its derivatives due to their diverse biological activities. sarcosine is a basic derivative of amino acids that is ess. Group: Pharmaceutical. Alternative Names: N-Methylglycine; Sarcosinic acid; Methylglycine; Glycine, N-methyl-. CAS No. 107-97-1. Pack Sizes: 1 kg. Product ID: BAT-008139. Molecular formula: C3H7NO2. Mole weight: 89.09. Custom synthesis is available. Send your inquiries for more information. | London |
| Sevoflurane | Sevoflurane is an ether inhalation anaesthetic agent primarily used for the induction and maintenance of general anesthesia. It has been shown to enhance inhibitory postsynaptic channel activity (GABA and glycine), and inhibit excitatory synaptic channel activity (NMDA, nicotinic acetylcholine, serotonin, and glutamate) in the central nervous system. Group: Pharmaceutical. Alternative Names: Sevofluran; Ultane; 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane; Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl ester; Fluoromethyl 1,1,1,3,3,3-Hexafluoro-2-propyl ester. CAS No. 28523-86-6. Pack Sizes: 1mg;1g;10g. Product ID: 28523-86-6. Molecular formula: C4H3F7O. Mole weight: 200.1. Custom synthesis is available. Send your inquiries for more information. | London |
| Trofinetide | Trofinetide is a NMDA antagonist under the development of Neuren Pharmaceuticals. It is an analogue of the neuropeptide (1-3) IGF-1, which is a simple tripeptide with sequence Gly-Pro-Glu formed by enzymatic cleavage of the growth factor IGF-1 within the brain. Phase II clinical trials against Fragile X syndrome and Rett syndrome are on-going. Uses: Brain injuries; fragile x syndrome; rett syndrome. Group: Pharmaceutical. Alternative Names: NNZ-2566; NNZ 2566; NNZ2566; Trofinetide; ((S)-1-glycyl-2-methylpyrrolidine-2-carbonyl)-L-glutamic acid. CAS No. 853400-76-7. Pack Sizes: 250 mg. Product ID: B1370-215136. Molecular formula: C13H21N3O6. Mole weight: 315.32. Custom synthesis is available. Send your inquiries for more information. | London |
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