nilotinib Suppliers UK

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Product
Nilotinib Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM. It is under investigation as a possible treatment for chronic myelogenous leukemia (CML). Group: Pharmaceutical. Alternative Names: Tasigna; AMN107; AMN 107; AMN-107; BW 33A, 51W89. CAS No. 641571-10-0. Pack Sizes: 10 g. Product ID: B0084-074229. Molecular formula: C28H22F3N7O. Mole weight: 529.52. Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Nilotinib EP Impurity H An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 40 nM. Group: Pharmaceutical. Alternative Names: Nilotinib Regio Isomer; 4-Methyl-N-(3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide. CAS No. 641571-15-5. Pack Sizes: 10 mg. Product ID: B1370-242094. Molecular formula: C28H22F3N7O. Mole weight: 529.53. Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Nilotinib monohydrochloride monohydrate Nilotinib monohydrochloride monohydrate is an orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. It binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells. It also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor (PDGF-R) and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors (GISTs). Uses: Tyrosine kinase inhibitors. Group: Pharmaceutical. Alternative Names: AMN-107; AMN 107; AMN107; Tasigna. CAS No. 923288-90-8. Pack Sizes: 100 mg. Product ID: B0084-182383. Molecular formula: C28H25ClF3N7O2. Mole weight: 583.99. Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 36 nM. Group: Pharmaceutical. Alternative Names: 641571-16-6; 3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine3-(5-methylimidazol-1-yl)-5-(trifluoromethyl)aniline3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)anilinestarbld0029650. CAS No. 641571-16-6. Pack Sizes: 10 mg. Product ID: B1416-478156. Molecular formula: C11H10F3N3. Mole weight: 241.217. Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Radotinib Radotinib, also known as IY-5511, is an orally available, hydrochloride salt form of radotinib, a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome-positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. This agent has shown potent efficacy in CML cells that are resistant to the first-generation standard tyrosine kinase inhibitors, such as imatinib, nilotinib and dasatinib. PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. Alternative Names: IY-5511; IY 5511; IY5511; 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyrazin-2-ylpyrimidin-2-yl)amino]benzamide. CAS No. 926037-48-1. Pack Sizes: 50 mg. Product ID: B0084-465339. Molecular formula: C27H21F3N8O. Mole weight: 530.515. Custom synthesis is available. Send your inquiries for more inf BOC Sciences
London

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