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| Product | Description | |
|---|---|---|
| Netupitant | Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. On 10/10 2014 FDA approved netupitant for the treatment of nausea and vomiting in patients undergoing cancer chemotherapy. Group: Pharmaceutical. CAS No. 290297-26-6. Pack Sizes: 50 mg. Product ID: B2693-465324. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Netupitant Impurities | Netupitant Impurities are crucial in the development and quality control of netupitant-based formulations, primarily used for preventing chemotherapy-induced nausea and vomiting. These impurities facilitate the assessment of drug purity and stability, ensuring the safety and efficacy of netupitant in clinical settings. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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