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| Product | Description | |
|---|---|---|
| Coronarin B | Coronarin B, also called 3H-1,2-Dioxepin-5-carboxaldehyde, 7-(decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl)-4,7-dihydro-3-hydroxy-, is a natural diterpenoid isolated from the rhizomes of Hedychium coronarium. Coronarin B has cytotoxic and antiplasmodial activities. Uses: Anti-plasmodial. Group: Pharmaceutical. CAS No. 119188-38-4. Pack Sizes: 1 mg. Product ID: NP1316. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| GlyH-101 | N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a glycine hydrazide that has recently been shown to block CFTR channels. However, its effects on cardiomyocytes are unknown. Studies have demonstrated that GlyH-101 blocks cardiac I Cl.PKA channels in a similar fashion to that reported for recombinant CFTR. Group: Pharmaceutical. CAS No. 328541-79-3. Pack Sizes: 25 mg. Product ID: B0084-430555. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Purmorphamine | Purmorphamine, under the IUPAC name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine, is a cell-permeable 6,9-trisubstituted purine which directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ).So it has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. In vitro: An activator of the hedgehog (Hh) signaling pathway by directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ). In vivo: Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats. Uses: Directly binds and activates smoothened (in hek293t cell:ic50= ~ 1.5 μm ); an activator of the hedgehog (hh) signaling pathway; an inducer of osteoblast differentiation (ec50= 1 μm). Group: Pharmaceutical. CAS No. 483367-10-8. Pack Sizes: 100 mg. Product ID: B0084-211514. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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