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| Product | Description | |
|---|---|---|
| MMP-2/MMP-9 Inhibitor I | MMP-2/MMP-9 inhibitor I is a potent inhibitor of matrix metalloproteinase MMP-2/MMP-9 with IC50 values of 310 and 240 nM, respectively. It blocks MMP-2/MMP-9-dependent invasion, tumor growth, and metastasis in both cell culture and mouse tumor models. Group: Pharmaceutical. Alternative Names: Gelatinase A; N-([1,1'-biphenyl]-4-ylsulfonyl)-D-phenylalanine. CAS No. 193807-58-8. Pack Sizes: 100 mg. Product ID: B1370-291169. Molecular formula: C21H19NO4S. Mole weight: 381.44. Custom synthesis is available. Send your inquiries for more information. |  London |
| 6-Shogaol | 6-Shogaol is a pungent constituent of ginger similar in chemical structure to gingerol. It has anti-inflammatory properties. lt was reported to have antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. lt effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-κB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis. lt inhibits the growth of human cancer cells and induces apoptosis in COLO 205 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). Uses: 6-shogaol exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. it has a very strong antitussive (anti-cough) effect. Group: Pharmaceutical. Alternative Names: 1-(3-Methoxy-4-hydroxyphenyl)-4-decene-3-one; 1-(4-Hydroxy-3-methoxyphenyl)-4-decen-3-one. CAS No. 555-66-8. Pack Sizes: 50 mg. Product ID: NP5193. Molecular formula: C17H24O3. Mole weight: 276.37. Custom synthesis is available. Send your inquiries for more information. | London |
| JNJ 0966 | JNJ 0966 is a selective inhibitor of MMP-9 (IC50 = 440 nM) with no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity. JNJ 0966 was indicated to alleviate the pain of experimental autoimmune encephalomyelitis in a mouse model. Group: Pharmaceutical. Alternative Names: JNJ-0966; JNJ0966; N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide. CAS No. 315705-75-0. Pack Sizes: 1 g. Product ID: B2693-291173. Molecular formula: C16H16N4O2S2. Mole weight: 360.45. Custom synthesis is available. Send your inquiries for more information. | London |
| SB-3CT | SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. SB-3CT is a 2-[(arylsulfonyl)methyl]thiirane that achieves potent inhibition, by a thiirane-opening mechanism, of the MMP2 and MMP9 zinc metalloproteases. SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury in rat. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. Besides, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. Group: Pharmaceutical. Alternative Names: MMP-2/MMP-9 Inhibitor IV; 2-((4-phenoxyphenylsulfonyl)methyl)thiirane; SB-3CT; SB3CT; SB3-CT; IN1250; IN 1250; IN-1250. CAS No. 292605-14-2. Pack Sizes: 20 mg. Product ID: B0084-369142. Molecular formula: C15H14O3S2. Mole weight: 306.394. Custom synthesis is available. Send your inquiries for more information. | London |
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