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| Product | Description | |
|---|---|---|
| 2,2-dimethyldodecanoic Acid | 2,2-Dimethyldodecanoic acid, an intriguing biochemical, has emerged as a promising therapeutic candidate for the treatment of neurological disorders and diabetes. As a modulator of the mitochondrial membrane, this compound has garnered attention for its ability to enhance insulin sensitivity and glucose tolerance in experimental subjects, showcasing its therapeutic potential in metabolic disorders. Furthermore, preclinical investigations have yielded encouraging results, highlighting its potential to serve as a potent anxiolytic and antidepressant agent, rendering it a prime target for future research. Group: Pharmaceutical. CAS No. 2874-73-9. Pack Sizes: 10 g. Product ID: B1370-204330. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 4,4'-DIHYDROXY-2-METHOXYCHALCONE | Echinatin is extracted from the root of Glycyrrhiza glabra L. It inhibits DNP-ATPase activity while stimulating range latent ATPase activity in the low concentration. It disturbs the mitochondrial energy transfer reactions and membrane permeability. It was demonstrated to inhibit the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells. Group: Pharmaceutical. CAS No. 34221-41-5. Pack Sizes: 10 mg. Product ID: NP0936. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Hydroxyisoleucine | 4-Hydroxyisoleucine, which comes from the seeds of Trigonella foenum-graecum L, could inhibit palmitate-induced, ROS-associated inflammation and restored insulin sensitivity through regulating IRS-1 function. It acts to improve insulin resistance by promoting mitochondrial biogenesis in high fructose diet fed STZ induced diabetic rats. Besides, 4-Hydroxyisoleucine could remarkably improve high glucose-induced IR in 3T3-L1 adipocytes. Meanwhile, 4-HIL could inhibit the secretion of TNF-alpha. Group: Pharmaceutical. CAS No. 781658-23-9. Pack Sizes: 100 mg. Product ID: B0005-347850. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Shogaol | 6-Shogaol is a pungent constituent of ginger similar in chemical structure to gingerol. It has anti-inflammatory properties. lt was reported to have antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. lt effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-κB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis. lt inhibits the growth of human cancer cells and induces apoptosis in COLO 205 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). Uses: 6-shogaol exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. it has a very strong antitussive (anti-cough) effect. Group: Pharmaceutical. CAS No. 555-66-8. Pack Sizes: 50 mg. Product ID: NP5193. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Alsterpaullone | Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Group: Pharmaceutical. CAS No. 237430-03-4. Pack Sizes: 50 mg. Product ID: B2693-103248. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Annonacin | Annonacin is a natural lipophilic mitochondrial complex I inhibitor found in the herbs of Annona glabra. Annonacin has cytotoxicity and may have anti-cancer activity. Uses: Anti-cancer. Group: Pharmaceutical. CAS No. 111035-65-5. Pack Sizes: 5 mg. Product ID: NP4409. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Astaxanthin | Astaxanthin is a carotenoid pigment found mostly in animal organisms, but also occurring in plants. It is thought to be the precursor of astacin. It is a potent lipid-soluble antioxidant. It has broad application prospects in health products, medicine, cosmetics, food additives and aquaculture. Astaxanthin is a natural antioxidant with the strongest antioxidant and anti-aging ability in nature, and its antioxidant capacity is much higher than VE and β-carotene. It significantly enhances mitochondrial activity required for cell recombination and effectively protects the skin from UVA, UVB and blue light damage. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 472-61-7. Pack Sizes: 10 g. Product ID: BBF-05817. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atpenin A5 | Atpenin A5 is an inhibitor of SDHB, SDHC and SDHD. It is an antifungal antibiotic produced by Penicillium sp. and an ubiquinone-binding site inhibitor of succinate dehydrogenase with IC50s of 12 nM for nematode and IC50s of 3.7 nM for mammalian mitochondria. Atpenin A5 is the most effective inhibitor against complex II from all the atpenins and has been shown to protect against cardiac-reperfusion injury in rat studies through the stimulation of mitochondrial KATP channels. Group: Pharmaceutical. CAS No. 119509-24-9. Pack Sizes: 50 mg. Product ID: BBF-04652. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atractyloside potassium salt | Atractyloside potassium salt is the potassium salt of atractyloside, which inhibits oxidative phosphorylation by blocking the transfer of adenosine nucleotides through the mitochondrial membrane. Uses: Inhibitor of the adenine nucleotide translocator (ant). Group: Pharmaceutical. CAS No. 102130-43-8. Pack Sizes: 20 mg. Product ID: B0005-158965. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Azoxystrobin | Azoxystrobin is a systemic fungicide commonly used in agriculture. It is used as an active agent protecting plants and fruit/vegetables from fungal diseases. It inhibits mitochondrial respiration by blocking electron transfer between cytochromes b and c1. Group: Pharmaceutical. CAS No. 131860-33-8. Pack Sizes: 5 g. Product ID: B0084-467187. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BAM 15 | BAM 15 is a novel mitochondrial protonophore uncoupler that uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). BAM 15 cannot depolarize the plasma membrane, and protects mice from acute renal ischemic-reperfusion injury. BAM 15 has the potential to treat obesity, Parkinson's disease, and aging. Group: Pharmaceutical. CAS No. 210302-17-3. Pack Sizes: 100 mg. Product ID: B1370-119162. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Benzoylhypacoitine | Benzoylhypacoitine is extracted from the roots of Aconitum carmichaeli Debx. It might be the principal active components which affect mitochondrial growth by Fuzi and its processed products. Uses: Might be the principal active components which affect mitochondrial growth by fuzi and its processed products. Group: Pharmaceutical. CAS No. 63238-66-4. Pack Sizes: 20 mg. Product ID: B0005-464498. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Betulinic acid | Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Betulinic acid is a natural compound found in the herbs of Ziziphus jujuba. It can be used in cosmetics material. Uses: Anti-melanogenic/antitumor/anti-hiv. Group: Pharmaceutical. CAS No. 472-15-1. Pack Sizes: 10 g. Product ID: NP6980. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Birinapant | Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. CAS No. 1260251-31-7. Pack Sizes: 100 mg. Product ID: B0084-462223. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bruceine D | Bruceine D is extracted from the barks of Ailanthus altissima. It is an inhibitor of hepatocellular carcinoma growth and inhibits the growth of three pancreatic cancer cell lines, which acts by targeting β-catenin/jagged1 pathways. It also induces cytotoxicity in Capan-2 cells by inducing cellular apoptosis involving the mitochondrial pathway. It may be used as a lead compound for new viricides, or a natural viricide. Group: Pharmaceutical. CAS No. 21499-66-1. Pack Sizes: 10 mg. Product ID: NP1540. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Butin | Butin is a natural flavonoid found in the seeds of Cassia tora. Butin has activity of antioxidant, which can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction. Uses: Antioxidant. Group: Pharmaceutical. CAS No. 492-14-8. Pack Sizes: 10 mg. Product ID: NP2469. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Carboxyatractyloside | Carboxyatractyloside is a highly selective inhibitor of cytosolic side-specific mitochondrial ADP/ATP carrier. Group: Pharmaceutical. CAS No. 77228-71-8. Pack Sizes: 20 mg. Product ID: B0005-379637. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CB-839 | CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). ( ). Group: Pharmaceutical. CAS No. 1439399-58-2. Pack Sizes: 20 mg. Product ID: B0084-462472. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cirsimaritin | Cirsimaritin is purified from the herbs of Microtea debilis. Cirsimaritin has the potential use in patients with congestive heart failure that can mitigate cardiac remodeling and left ventricular dysfunction through augmenting myocardial autophagy and decreasing matrix metalloproteinase-2&9 activities. Cirsimaritin inhibits the growth of tumor cells and induces mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), and it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt. Cirsimaritin shows moderate anti-proliferative activity against COLO-205 cells with IC 50 values of 13.1uM. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner; support the putative application of cirsimaritin in ultraviolet photoprotection and hair coloration treatments. Group: Pharmaceutical. CAS No. 6601-62-3. Pack Sizes: 5 mg. Product ID: NP2021. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cyanidin 3-O-arabinoside chloride | Cyanidin 3-O-arabinoside chloride, a flavonoid compound found in Erica sp. and Vaccinium sp., has antioxidant activity and reduces the peroxynitrite-induced suppression of mitochondrial respiration, DNA damage, PARS activation, and vascular dysfunction in HUVECs. Group: Pharmaceutical. CAS No. 111613-04-8. Pack Sizes: 5 mg. Product ID: B1370-061662. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Elesclomol | Elesclomol is a HSP-90 Inhibitor, and is a small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. Elesclomol induces oxidative stress, creating high levels of reactive oxygen species (ROS), such as hydrogen peroxide, in both cancer cells and normal cells. Because tumor cells have elevated levels of ROS compared to normal cells, the increase in oxidative stress beyond baseline levels elevates ROS beyond sustainable levels, exhausting tumor cell antioxidant capacity, which may result in the induction of the mitochondrial apoptosis pathway. Normal cells are spared because the increase in the level of oxidative stress induced by this agent is below the threshold at which apoptosis is induced. Elesclomol is currently developed by Synta Pharmaceuticals Corp. Group: Pharmaceutical. CAS No. 488832-69-5. Pack Sizes: 25 mg. Product ID: B0084-212109. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Erastin | Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces non-apoptotic tumor cell death by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. Reversal of tubulin-VDAC interaction by erastin antagonizes Warburg metabolism and restores oxidative mitochondrial metabolism. Group: Pharmaceutical. CAS No. 571203-78-6. Pack Sizes: 100 mg. Product ID: B0084-300990. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GDC-0152 | GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Smac, the endogenous IAP antagonist, relies on its N-terminal four amino-acid motif for binding to IAPs. Group: Pharmaceutical. CAS No. 873652-48-3. Pack Sizes: 50 mg. Product ID: B2693-462525. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ginsenoside F2 | Ginsenoside F2 is extracted from the root of Panax ginseng C. A. Mey. It was assessed for its antiproliferative activity against breast cancer stem cells (CSCs). It induced apoptosis in breast CSCs by activating the intrinsic apoptotic pathway and mitochondrial dysfunction. It decreased the expression of TGF-β2 and SCAP proteins. Group: Pharmaceutical. CAS No. 62025-49-4. Pack Sizes: 20 mg. Product ID: NP6994. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ginsenoside Rf | Ginsenoside Rf, extracted from the traditional Chinese herb ginseng, is a novel natural anticancer products known for its favorable safety and efficacy profiles. It inhibits Ca2+ channels in mammalian sensory neurons through a mechanism requiring G-proteins, whereas a variety of other ginsenosides were relatively ineffective. It might be useful in itself or as a template for designing additional modulators of neuronal Ca2+ channels. It induces G2/M phase cell cycle arrest and apoptosis in human osteosarcoma MG-63 cells through the mitochondrial pathway. Uses: Anti-arthritic agent. Group: Pharmaceutical. CAS No. 52286-58-5. Pack Sizes: 20 mg. Product ID: B0005-465147. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Griffipavixanthone | Griffipavixanthone is a natural xanthone found in the fruits of Garcinia oblongifolia Champ, it inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, with IC50 values of 3.03 ± 0.21 μM at 48h, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production; which demonstrates that the potential application of griffipavixanthone as an anti-non-small cell lung cancer agent. Uses: Anti-non-small cancer. Group: Pharmaceutical. CAS No. 219649-95-3. Pack Sizes: 1 mg. Product ID: NP7252. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| IACS-010759 | IACS-010759 is an orally bioavailable inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targeting complex I of the electron transport chain (NADH ubiquinone oxidoreductase). Study showed that IACS-010759 induced AMPK activation leading to mTOR suppression which resulted in cell growth inhibition in AML cells. Group: Pharmaceutical. CAS No. 1570496-34-2. Pack Sizes: 10 mg. Product ID: B2693-291404. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Imisopasem manganese | Imisopasem manganese is a manganese-based non-peptidyl mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with potential antioxidant and chemo/radioprotective activities. Upon administration, imisopasem manganese mimics the activity of MnSOD and scavenges reactive oxygen species (ROS), such as superoxide anion, which prevents oxygen free radical damage to macromolecules such as DNA. Group: Pharmaceutical. CAS No. 218791-21-0. Pack Sizes: 10 mg. Product ID: B0084-102510. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| L-Carnitine | L-carnitine is a constituent striated muscle and liver, and also a cofactor involved in fatty acid metabolism for transporting fatty acids through the inner mitochondrial membrane. It also acts as an inhibitor of HDAC. Nutritional supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 541-15-1. Pack Sizes: 50 g. Product ID: BAT-008091. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| LCL-161 | LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9, which play essential roles in apoptosis (programmed cell death), necrosis and inflammation. Group: Pharmaceutical. CAS No. 1005342-46-0. Pack Sizes: 25 mg. Product ID: B0084-462558. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MOTS-C | MOTS-C is a peptide hormone encoded in the mitochondrial genome. It regulates metabolic homeostasis and enhances physical performance. Group: Pharmaceutical. CAS No. 1627580-64-6. Pack Sizes: 100 mg. Product ID: BAT-006155. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-Acetylcysteine Amide | N-Acetylcysteine amide is a blood brain barrier permeant and cell membranes thiol antioxidant with anti-inflamatory activity via regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. It readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. It may be used in research and exploration for the treatment of radiation exposure, neurodegeneration and other oxidation-mediated disorders. It is also used for the treatment of acquired immune deficiency syndrome and HIV infection. It is also used as an authentic imaging probe for accurate tracing of cells viability from beginning to end to distinguish apoptotic and necrotic cells. It improves neuronal mitochondrial bioenergetics, reduces tissue damage and enhances behavioral recovery in rats following traumatic brain injury. It is a neuroprotective agent. Group: Pharmaceutical. CAS No. 38520-57-9. Pack Sizes: 1 g. Product ID: BAT-008155. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Narcissin | Narcissoside is extracted from the bulbus of Narcissus tazettaL. var. chinensis Roem. It could be responsible for stronger protection against mitochondrial induced oxidative stress with synergism of rutin in B.flavum flavonoid. Group: Pharmaceutical. CAS No. 604-80-8. Pack Sizes: 20 mg. Product ID: NP1932. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Nicotinamide riboside | Nicotinamide riboside is a form of pyridine nucleoside with a nicotinamide. It is a precursor to NAD+ and a source of vitamin B3. Nicotinamide riboside increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells. It also activates SIRT1 and SIRT3 in vitro. Group: Pharmaceutical. CAS No. 1341-23-7. Pack Sizes: 5 g. Product ID: B0001-394639. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Oxyresveratrol | Oxyresveratrol is isolated from the herbs of Dracaena angustifolia. Because toxicity to glia could be beneficial by inhibiting reactive gliosis, Oxyresveratro is useful to trauma models. Oxyresveratrol can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction, which may be associated with activation of Nrf2. Group: Pharmaceutical. CAS No. 29700-22-9. Pack Sizes: 1 g. Product ID: NP5366. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pinostrobin | Pinostrobin, which can be extracted from the herbs of Cajanus cajan, may be responsible for the anti-hemorrhagic and analgesic activity (peripheral analgesic activity) of Renealmia alpinia. It leads to depolarisation of the cell potential of endothelial cells. Pinostrobin was able to exert a neuroprotective effect against Aβ(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis. Besides, Pinostrobin (50mg/kg/dose) possesses definite therapeutical effect in the development of lesion score. Uses: Anti-hemorrhagic/analgesic. Group: Pharmaceutical. CAS No. 480-37-5. Pack Sizes: 10 mg. Product ID: NP1825. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Plitidepsin | Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin shows potent anticancer activity against a large variety of cultured human cancer cells, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth. Group: Pharmaceutical. CAS No. 137219-37-5. Pack Sizes: 1 mg. Product ID: BAT-010093. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Propionyl-L-Carnitine HCl | The hydrochloride salt form of L-Propionylcarnitine which has been found to be related to mitochondrial metabolism so that could be used in the treatment deterioration of renal function and sorts of other diseases. Uses: The hydrochloride salt form of l-propionylcarnitine which has been found to be related to mitochondrial metabolism so that could be used in the treatment deterioration of renal function and sorts of other diseases. Group: Pharmaceutical. CAS No. 119793-66-7. Pack Sizes: 250 mg. Product ID: B0084-055506. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SCIADOPITYSIN | Sciadopitysin comes from the leaves of Ginkgo biloba L. Sciadopitysin may prevent the development of diabetic osteopathy and exert its therapeutic effects via upregulation of mitochondrial biogenesis. Uses: Anti-alzheimer's disease. Group: Pharmaceutical. CAS No. 521-34-6. Pack Sizes: 25 mg. Product ID: NP1808. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Thiabendazole-[d4] | Labelled Thiabendazole. Thiabendazole inhibits the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property. Group: Pharmaceutical. CAS No. 1190007-20-5. Pack Sizes: 5 mg. Product ID: BLP-004619. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Verbenalin | Cornin has protective potential against cerebral ischemia injury and its protective effects may be due to amelioration of cerebral mitochondrial function and its antioxidant property. Group: Pharmaceutical. CAS No. 548-37-8. Pack Sizes: 50 mg. Product ID: NP3882. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ZLN005 | Selective transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). ZLN005 selectively stimulated the expression of PGC-1α and downstream genes in skeletal muscle cells, and led to changes in glucose uptake, and fatty acid oxidation in L6 myotubes in a AMPK dependent manner. Since ZLN 005 did not increase the expression of the PGC-1α gene in rat primary hepatocytes, it is hypothesized that expression of PGC-1α was regulated in a cell type-specific manner. ZLN005 exerts promising therapeutic effects for treating type 2 diabetes, as PGC-1α is a powerful transcriptional coregulator of GLUT4 and mitochondrial genes, a crucial player in the field of glucose uptake in skeletal muscle. Group: Pharmaceutical. CAS No. 49671-76-3. Pack Sizes: 100 mg. Product ID: B2693-463461. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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