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| Product | Description | |
|---|---|---|
| 1-Methylpiperazine | 1kg Pack Size. Group: Building Blocks, Organics, Piperazines. Formula: C5H12N2. CAS No. 109-01-3. Prepack ID : 56338967-1kg. Molecular Weight : 100.16. |  |
| 2-Methylpiperazine | 100g Pack Size. Group: Building Blocks, Organics, Piperazines. Formula: C5H12N2. CAS No. 109-07-9. Prepack ID : 29441587-100g. Molecular Weight : 100.16. | |
| 2-Methylpiperazine | 2-Methylpiperazine Uses: Pharmaceutical Research and Development. Group: Intermediates. CAS No. 109-07-9. Pack Sizes: Enquire for MOQ. Categories: Nordmann UK Fine Chemicals suppliers (Formerly Melrob-Eurolabs). |  UK / EU / USA / Japan |
| N-Methylpiperazine | N-Methylpiperazine Uses: Pharmaceutical Research and Development. Group: Intermediates. CAS No. 109-01-3. Pack Sizes: Enquire for MOQ. Categories: NORDMANN innovative sourcing and supply. | UK / EU / USA / Japan |
| Imatinib Guanidine Impurity | An impurity of Imatinib, a tyrosine kinase receptor inhibitor used for cancer therapy. Group: Pharmaceutical. Alternative Names: N-(3-Guanidino-4-methylphenyl)-4-(methylpiperazine-1-yl-methyl)benzamide; N-[3-[(Aminoiminomethyl)amino]-4-methylphenyl]-4-[(4-methyl-1-piperazinyl)methyl]benzamide; N-[2-Methyl-5-[[4-[(4-methylpiperazin-1-yl)methyl]benzoyl]amino]phenyl]guanidine. CAS No. 581076-65-5. Pack Sizes: 100 mg. Product ID: B2694-257315. Molecular formula: C21H28N6O. Mole weight: 380.5. Custom synthesis is available. Send your inquiries for more information. |  London |
| LB-100 | LB-100 is a water-soluble protein phosphatase 2A (PP2A) inhibitor (IC50 = 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells) that enhanced the effects of sorafenib in HCC cells only during hypoxic environments. Group: Pharmaceutical. Alternative Names: (1S,4R)-2-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-3-carboxylic acid; LB 100; LB100. CAS No. 1632032-53-1. Pack Sizes: 100 mg. Product ID: B1370-474642. Molecular formula: C13H20N2O4. Mole weight: 268.31. Custom synthesis is available. Send your inquiries for more information. | London |
| Levofloxacin N-oxide | An impurity of Levofloxacin, which is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Group: Pharmaceutical. Alternative Names: (S)-4-(6-carboxy-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-10-yl)-1-methylpiperazine 1-oxide. CAS No. 117678-38-3. Pack Sizes: 50 mg. Product ID: B0185-473746. Molecular formula: C18H20FN3O5. Mole weight: 377.38. Custom synthesis is available. Send your inquiries for more information. | London |
| Marbofloxacin EP Impurity F | An impurity of Marbofloxacin, which exhibits high bactericidal activity against a broad spectrum of aerobic Gram-negative and some Gram-positive bacteria, as well as Mycoplasma spp. Group: Pharmaceutical. Alternative Names: Marbofloxacin N-oxide; 4-[6-Carboxy-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[3,2,1-ij][4,1,2]benzoxadiazin-10-yl]-1-methylpiperazine 1-oxide. CAS No. 194023-72-8. Pack Sizes: 10 mg. Product ID: B1370-181987. Molecular formula: C17H19FN4O5. Mole weight: 378.36. Custom synthesis is available. Send your inquiries for more information. | London |
| MKC-3946 | MKC-3946 is a potent inhibitor of inositol-requiring enzyme 1α (IRE1α). It inhibits XBP1 mRNA splicing and exhibits cytotoxicity against AML cells. MKC-3946 leads to modest growth inhibition in MM cells but has no effect on normal mononuclear cells in vitro. Group: Pharmaceutical. Alternative Names: MKC-3946; MKC 3946; MKC3946; 2-hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde. CAS No. 1093119-54-0. Pack Sizes: 300 mg. Product ID: B0084-054003. Molecular formula: C21H20N2O3S. Mole weight: 380.462. Custom synthesis is available. Send your inquiries for more information. | London |
| X-396 | X-396 is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK is not expressed in healthy adult human tissue but ALK dysregulation and gene rearrangements are associated with a series of tumors; ALK mutations are associated with acquired resistance to small molecule tyrosine kinase inhibitors. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: X-376; (R)-6-Amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-(4-methylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide; 3-Pyridazinecarboxamide, 6-amino-5-((1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-((4-methyl-1-piperazinyl)carbonyl)phenyl)-; 6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-{4-[(4-methyl-1-piperazinyl)carbonyl]phenyl}-3-pyridazinecarboxamide. CAS No. 1365267-27-1. Pack Sizes: 25 mg. Product ID: B2693-462239. Molecular formula: C25H25Cl2FN6O3. Mole weight: 547.41. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride | 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride: Within the biomedical sector, this compound finds application in addressing select psychiatric and neurological ailments. Furthermore, it plays a pivotal role in the creation of innovative pharmaceuticals aimed at modulating distinct receptors within the brain's central nervous system. Group: Pharmaceutical. Alternative Names: 106261-49-8; 4-[(4-methylpiperazin-1-yl)methyl]benzoic Acid Dihydrochloride4-((4-methylpiperazin-1-yl)methyl)benzoic acid dihydrochloride4-[(4-Methyl-1-piperazinyl)methyl]benzoic Acid Dihydrochloride; UNII-DJ6E7RG2D9. CAS No. 106261-49-8. Pack Sizes: 1mg;1g;10g. Product ID: NP3479. Molecular formula: C13H18N2O2·2(HCL). Mole weight: 316.23. Custom synthesis is available. Send your inquiries for more information. | London |
| A1B1 hydrochloride | A1B1 hydrochloride is a potent and orally-available chemokine CCR1 antagonist. Group: Pharmaceutical. Alternative Names: N-[5-chloro-2-[(E)-3-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-3-oxoprop-1-enyl]phenyl]acetamide hydrochloride. Pack Sizes: 1mg;1g;10g. Molecular formula: C23H25ClFN3O2.HCl. Mole weight: 466.38. Custom synthesis is available. Send your inquiries for more information. | London |
| AV-412 | AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Group: Pharmaceutical. Alternative Names: AV 412; AV412; N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide. CAS No. 451492-95-8. Pack Sizes: 20 mg. Product ID: B0084-324573. Molecular formula: C27H28ClFN6O. Mole weight: 507.01. Custom synthesis is available. Send your inquiries for more information. | London |
| Benzamide, N-[4-methyl-3-[[4-(6-methyl-3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]- | This product is a kinase inhibitor used in the treatment of certain types of cancer, including non-small cell lung cancer and pancreatic cancer. It works by inhibiting specific enzymes involved in cell growth and proliferation, ultimately leading to tumor regression. Group: Pharmaceutical. Alternative Names: N-[4-methyl-3-[[4-(6-methylpyridin-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide; CHEMBL1079113; 1032314-85-4; SCHEMBL11939618; BDBM50313640; ZINC49018631. CAS No. 1032314-85-4. Pack Sizes: 10 mg. Product ID: B2699-456548. Molecular formula: C30H33N7O. Mole weight: 507.63. Custom synthesis is available. Send your inquiries for more information. | London |
| BVT 2733 | BVT 2733 is a non-steroidal small molecule as a selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC = 96 ± 14 nM). Group: Pharmaceutical. Alternative Names: BVT-2733; BVT 2733; BVT2733; 3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide; Piperazine, 1-((2-(((3-chloro-2-methylphenyl)sulfonyl)amino)-4-thiazolyl)acetyl)-4-methyl-. CAS No. 376640-41-4. Pack Sizes: 25 mg. Product ID: B0084-474151. Molecular formula: C17H21ClN4O3S2. Mole weight: 428.95. Custom synthesis is available. Send your inquiries for more information. | London |
| Caderofloxacin | Cadrofloxacin is a novel fluoroquinolone antibacterial. It is effective against aerobic/anaerobic Gram-positive and Gram-negative bacteria. Group: Pharmaceutical. Alternative Names: (S)-1-Cyclopropyl-8-(difluoromethoxy)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Caderofloxacin; CS-940. CAS No. 153808-85-6. Pack Sizes: 1mg;1g;10g. Product ID: 153808-85-6. Molecular formula: C19H20F3N3O4. Mole weight: 411.38. Custom synthesis is available. Send your inquiries for more information. | London |
| Difloxacin Hydrochloride | A fluoroquinolone antibiotic commonly used in veterinary medicine. It is an inhibitor of Topo II. Group: Pharmaceutical. Alternative Names: 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid hydrochloride; Difloxacin HCl. CAS No. 91296-86-5. Pack Sizes: 1mg;1g;10g. Product ID: BBF-04642. Molecular formula: C21H19F2N3O3.HCl. Mole weight: 435.85. Custom synthesis is available. Send your inquiries for more information. | London |
| DU717 | DU717, an amphoteric compound, is an antihypertensive compound. Group: Pharmaceutical. Alternative Names: 7-chloro-3-(4-methylpiperazin-1-yl)-4H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide; DU 717; DU-717; DU717. CAS No. 59943-31-6. Pack Sizes: 1mg;1g;10g. Product ID: 59943-31-6. Molecular formula: C12H15ClN4O2S. Mole weight: 314.79. Custom synthesis is available. Send your inquiries for more information. | London |
| E260 | E260 is a Fer/FerT kinase inhibitor with Kd of 0.85 uM, which selectively evokes metabolic stress and necrotic death in cancer cells. Group: Pharmaceutical. Alternative Names: E260; E 260; E-260; 2-[4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl]-6-(4-propan-2-ylphenyl)imidazo[2,1-b][1,3,4]thiadiazole. CAS No. 1241537-79-0. Pack Sizes: 5 mg. Product ID: B0084-284773. Molecular formula: C24H34N6S. Mole weight: 438.638. Custom synthesis is available. Send your inquiries for more information. | London |
| Entrectinib | Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Phase 2. Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: RXDX101; RXDX 101; RXDX-101; NMS E628; NMS-E628; Entrectinib; N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide. CAS No. 1108743-60-7. Pack Sizes: 250 mg. Product ID: B0084-470812. Molecular formula: C31H34F2N6O2. Mole weight: 560.64. Custom synthesis is available. Send your inquiries for more information. | London |
| Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate | An impurity of Dovitinib, a potent VEGFR inhibitor exhibiting antitumor activity. Group: Pharmaceutical. Alternative Names: ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate. CAS No. 402948-37-2. Pack Sizes: 500 mg. Product ID: B2694-108985. Molecular formula: C16H22N4O2. Mole weight: 302.37. Custom synthesis is available. Send your inquiries for more information. | London |
| Gilteritinib | Gilteritinib, also known as (ASP2215, is a potent FLT3/AXL inhibitor, which showed potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations. In invitro, among the 78 tyrosine kinases tested, ASP2215 inhibited FLT3, LTK, ALK, and AXL kinases by over 50% at 1 nM with an IC50 value of 0.29 nM for FLT3, approximately 800-fold more potent than for c-KIT, the inhibition of which is linked to a potential risk of myelosuppression. ASP2215 inhibited the growth of MV4-11 cells, which harbor FLT3-ITD, with an IC50 value of 0.92 nM, accompanied with inhibition of pFLT3, pAKT, pSTAT5, pERK, and pS6. ASP2215 decreased tumor burden in bone marrow and prolonged the survival of mice intravenously transplanted with MV4-11 cells. ASP2215 may have potential use in treating AML. Group: Pharmaceutical. Alternative Names: ASP2215; ASP-2215; ASP 2215; Xospata; Gilteritinibum; 6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide; 6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide. CAS No. 1254053-43-4. Pack Sizes: 100 mg. Product ID: B0084-462531. Molecular formula: C29H44N8O3. Mole weight: 552.71. Custom synthesis is available. Send your inquiries for more information. | London |
| HG-9-91-01 | HG-9-91-01,a small molecule inhibitor that targets specificly salt-inducible kinase (SIKs) IC50: SIK1=0.92 nM; SIK2=6.6 nM; SIK3=9.6 nM. Group: Pharmaceutical. Alternative Names: 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]ureaHG-9-91-01; HG-9-91-01; HG 9-91-01; HG9-91-01; HG99101; HG-99101; HG 99101;GTPL8049SCHEMBL15271960BDBM192712CS-1749HG-9-91-01 (1)1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[4-(4-methylpiper. CAS No. 1456858-58-4. Pack Sizes: 5 mg. Product ID: B0084-474589. Molecular formula: C32H37N7O3. Mole weight: 567.68. Custom synthesis is available. Send your inquiries for more information. | London |
| Imatinib | Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with an IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. Imatinib is an oral chemotherapy agent used to treat cancers. Specifically, it is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+), certain types of gastrointestinal stromal tumors (GIST), hypereosinophilic syndrome (HES), chronic eosinophilic leukemia (CEL), systemic mastocytosis, and myelodysplastic syndrome. Group: Pharmaceutical. Alternative Names: CGP057148B; STI571; Gleevec; Glivec; N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide; 4-[(4-Methyl-1-piperazinyl)methyl]-N-(4-methyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}phenyl)benzamide. CAS No. 152459-95-5. Pack Sizes: 10 g. Product ID: BBF-05855. Molecular formula: C29H31N7O. Mole weight: 493.6. Custom synthesis is available. Send your inquiries for more information. | London |
| Imatinib-[d4] | Imatinib-[d4] is an isotopically labelled analogue of Imatinib. Imatinib is an inhibitor of multiple tyrosine kinases. It is a COVID-19-related research product. Group: Pharmaceutical. Alternative Names: N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide-2,3,5,6-d4; Imatinib D4. CAS No. 1134803-16-9. Pack Sizes: 5 mg. Product ID: BLP-005865. Molecular formula: C29H27D4N7O. Mole weight: 497.64. Custom synthesis is available. Send your inquiries for more information. | London |
| Imatinib EP Impurity D | An impurity of Imatinib, a tyrosine kinase inhibitor used as a chemotherapy drug for the treatment of leukemia and other kinds of cancer. Group: Pharmaceutical. Alternative Names: Des(methylpiperazinyl) Imatinib Dimer Piperazinium Chloride; 1-Methyl-1,4-bis[4-[(4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl)carbamoyl]benzyl]piperazin-1-ium chloride. CAS No. 1821122-73-9. Pack Sizes: 100 mg. Product ID: B2694-473167. Molecular formula: C53H51ClN12O2. Mole weight: 923.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Imatinib Impurity E | an impurity of Imatinib (Gleevec). Group: Pharmaceutical. Alternative Names: Des(methylpiperazinyl-N-methyl) Imatinib Dimer Impurity; 4,4'-(piperazine-1,4-diylbis(methylene))bis(N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide). CAS No. 1365802-18-1. Pack Sizes: 10 mg. Product ID: B2694-473163. Molecular formula: C52H48N12O2. Mole weight: 873.04. Custom synthesis is available. Send your inquiries for more information. | London |
| Imatinib Impurity M | An impurity of Imatinib, a tyrosine kinase inhibitor used as a chemotherapy drug for the treatment of leukemia and other kinds of cancer. Group: Pharmaceutical. Alternative Names: 1,4-Bis(4-carboxybenzyl)-1-methylpiperazin-1-ium (Imatinib Impurity); 1,4-BIS(4-CARBOXYBENZYL)-1-METHYLPIPERAZIN-1-IUM; Imatinib Impurity M; SCHEMBL14646970; CS-0255288; F83280. CAS No. 1407229-73-5. Pack Sizes: 25 mg. Product ID: B2694-104820. Molecular formula: C21H25N2O4+. Mole weight: 369.44. Custom synthesis is available. Send your inquiries for more information. | London |
| Levofloxacin hydrochloride | Levofloxacin Hydrochloride is potent fluoroquinolone antibiotic utilized in the treatment of a wide range of bacterial infections, including pneumonia, chronic bronchitis, sinusitis, and skin infections. By targeting bacterial DNA gyrase, it effectively hinders DNA replication and transcription processes, thereby exerting its antimicrobial effects. Group: Pharmaceutical. Alternative Names: Levofloxacin hydrochloride;177325-13-2;Weilisu;Levofloxacin (hydrochloride);HTN0D03VRZ;(S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrochloride (1:1), (3S)-;(2S)-7-fluoro-2-methyl-6-(4-me. CAS No. 177325-13-2. Pack Sizes: 1mg;1g;10g. Product ID: 177325-13-2. Molecular formula: C18H21ClFN3O4. Mole weight: 397.83. Custom synthesis is available. Send your inquiries for more information. | London |
| MK-1775 | MK-1775, also known as AZD-1775, is a WEE1 inhibitor and a small-molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. Unlike normal cells, most p53-deficient or mutated human cancers lack the G1 checkpoint as p53 is the key regulator of the G1 checkpoint and these cells rely on the G2 checkpoint for DNA repair to damaged cells. Annulment of the G2 checkpoint may therefore make p53-deficient tumor cells more vulnerable to antineoplastic agents and enhance their cytotoxic effect. Group: Pharmaceutical. Alternative Names: MK-1775; MK1775; MK 1775; AZD1775; AZD-1775; AZD 1775; adavosertib. 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one. CAS No. 955365-80-7. Pack Sizes: 300 mg. Product ID: B0084-157422. Molecular formula: C27H32N8O2. Mole weight: 500.607. Custom synthesis is available. Send your inquiries for more information. | London |
| Naquotinib | Naquotinib is an irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity with IC50 of 8-33 nM toward EGFR mutants. Group: Pharmaceutical. Alternative Names: ASP 8273; ASP8273; ASP-8273; (R)-5-((1-acryloylpyrrolidin-3-yl)oxy)-6-ethyl-3-((4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazine-2-carboxamide. CAS No. 1448232-80-1. Pack Sizes: 5 mg. Product ID: B0084-475727. Molecular formula: C30H42N8O3. Mole weight: 562.719. Custom synthesis is available. Send your inquiries for more information. | London |
| Nintedanib Ethanesulfonate (Intedanib Ethanesulfonate) | Nintedanib esylate is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β. Uses: The treatment of idiopathic pulmonary fibrosis. Group: Pharmaceutical. Alternative Names: Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylidene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate ethanesulfonate; BIBF1120; BIBF 1120 BIBF-1120; Nintedanib esylate Nintedanib ethanesulfonate salt; Intedanib; Brand name OFEV Vargatef. CAS No. 656247-18-6. Pack Sizes: 500 mg. Product ID: B0084-434827. Molecular formula: C33H39N5O7S. Mole weight: 649.76. Custom synthesis is available. Send your inquiries for more information. | London |
| Nintedanib Impurity 6 (Intedanib Impurity 6) | BIBF 1202 is the major in-vivo metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR. It is a related compound of Intedanib, which is an indolinone derivative that inhibits angiokinase and an antitumor agent. It is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (VEGF) signaling pathway thus inhibition of tumor angiogenesis. Uses: Bibf 1202 is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (vegf) signaling pathway thus inhibition of tumor angiogenesis. Group: Pharmaceutical. Alternative Names: BIBF-1202; BIBF 1202; BIBF1202. (3Z)-2,3-Dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid;(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1 -yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic acid;Nintedanib Impurity 5. CAS No. 894783-71-2. Pack Sizes: 50 mg. Product ID: B0084-474893. Molecular formula: C30H31N5O4. Mole weight: 525.6. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Methyl-2-(4-methyl-1-piperazinyl)-N-(4-nitrophenyl)acetamide | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Group: Pharmaceutical. Alternative Names: N-methyl-2-(4-methyl-1-piperazinyl)-N-(4-nitrophenyl)acetamide; N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide. CAS No. 1139453-98-7. Pack Sizes: 100 mg. Product ID: B1421-258623. Molecular formula: C14H20N4O3. Mole weight: 292.33. Custom synthesis is available. Send your inquiries for more information. | London |
| OICR 9429 | OICR-9429 can inhibit the interaction of WDR5 with peptide regions of MLL and histone 3 as a chemical probe. It can reduce viability of acute myeloid leukemia cells and can also disrupt MLL1-RbBP5 interaction. Group: Pharmaceutical. Alternative Names: OICR-9429; OICR 9429; OICR9429. N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide. CAS No. 1801787-56-3. Pack Sizes: 100 mg. Product ID: B1370-054002. Molecular formula: C29H32F3N5O3. Mole weight: 555.59. Custom synthesis is available. Send your inquiries for more information. | London |
| Olanzapine Lactam Impurity | Olanzapine Lactam Impurity is an impurity of Olanzapine, which is an antipsychotic medication indicated for the treatment of schizophrenia, bipolar disorder, etc. Group: Pharmaceutical. Alternative Names: (Z)-Olanzapine Ketolactam; (3Z)-4-(4-methylpiperazin-1-yl)-3-(2-oxopropylidene)-2,3-dihydro-1H-1,5-benzodiazepin-2-one; (Z)-4-(4-methylpiperazin-1-yl)-3-(2-oxopropylidene)-1,3-dihydro-2H-benzo[b][1,4]diazepin-2-one. CAS No. 1017241-34-7. Pack Sizes: 10 mg. Product ID: B1370-377610. Molecular formula: C17H20N4O2. Mole weight: 312.37. Custom synthesis is available. Send your inquiries for more information. | London |
| Olanzapine Thiolactam Impurity | An impurity of Olanzapine, whcih is an antipsychotic indicated for the treatment of schizophrenia and bipolar disorder. Group: Pharmaceutical. Alternative Names: (Z)-1-(4-(4-methylpiperazin-1-yl)-2-thioxo-1,2-dihydro-3H-benzo[b][1,4]diazepin-3-ylidene)propan-2-one; 1-[(3Z)-4-(4-methylpiperazin-1-yl)-2-sulfanylidene-2,3-dihydro-1H-1,5-benzodiazepin-3-ylidene]propan-2-one. CAS No. 1017241-36-9. Pack Sizes: 10 mg. Product ID: B1370-291738. Molecular formula: C17H20N4OS. Mole weight: 328.43. Custom synthesis is available. Send your inquiries for more information. | London |
| Olmutinib | Olmutinib, also called as HM61713 and BI-1482694, is an orally available, mutant-selective third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) that is being developed for treatment of advanced and metastatic EGFR mutation-positive non-small cell lung cancer (NSCLC). In May 2016, olmutinib received its first global approval in South Korea for the treatment of EGFR T790M mutation-positive lung cancer. Olmutinib is also a potent small molecule inhibitor of Bruton's tyrosine kinase (BTK). Group: Pharmaceutical. Alternative Names: N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide; HM61713; HM 61713; HM-61713; BI 1482694; BI-1482694; BI1482694; Olmutinib. CAS No. 1353550-13-6. Pack Sizes: 200 mg. Product ID: B0084-470842. Molecular formula: C26H26N6O2S. Mole weight: 486.18. Custom synthesis is available. Send your inquiries for more information. | London |
| Pefloxacin-[d5] | Pefloxacin-[d5] is the labelled analogue of Pefloxacin, which is a quinolone antibiotic used to treat bacterial infections. Group: Pharmaceutical. Alternative Names: Pefloxacin-D5; 1-Ethyl-D5-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Pefloxacine-d5; Pefloxacino-d5; Pefloxacinum-d5; PFLX-d5. CAS No. 1228182-51-1. Pack Sizes: 10 mg. Product ID: BLP-011740. Molecular formula: C17H15D5FN3O3. Mole weight: 338.39. Custom synthesis is available. Send your inquiries for more information. | London |
| Pirenzepine hydrochloride | Pirenzepine hydrochloride is an antiulcerative that acts via suppressing gastric secretion. Pirenzepine is a selective muscarinic M1 receptor antagonist. Uses: M1 muscarinic receptor selective antagonist. Group: Pharmaceutical. Alternative Names: Pirenzepine dihydrochloride; Pirenzepine HCl; Bisvanil; 11-[2-(4-methylpiperazin-1-yl)acetyl]-5-H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride. CAS No. 29868-97-1. Pack Sizes: 5 g. Product ID: B0046-463922. Molecular formula: C19H23Cl2N5O2. Mole weight: 424.33. Custom synthesis is available. Send your inquiries for more information. | London |
| Ponatinib | Ponatinib is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively. Group: Pharmaceutical. Alternative Names: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide; AP24534; AP-24534; AP 24534; Ponatinib Brand name: Iclusig. CAS No. 943319-70-8. Pack Sizes: 300 mg. Product ID: B0084-272000. Molecular formula: C29H27F3N6O. Mole weight: 532.56. Custom synthesis is available. Send your inquiries for more information. | London |
| Ponatinib hydrochloride | Ponatinib hydrochloride is an oral drug for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). It is a multi-targeted tyrosine-kinase inhibitor. It has potential antiangiogenic and antineoplastic activities. It inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. It inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3). It was developed by Ariad Pharm and has been listed. Uses: Ponatinib hydrochloride is an oral drug for the treatment of chronic myeloid leukemia (cml) and philadelphia chromosome-positive (ph+) acute lymphoblastic leukemia (all). it has potential antiangiogenic and antineoplastic activities. Group: Pharmaceutical. Alternative Names: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride; AP24534; AP-24534; AP 24534; Ponatinib HCl; Ponatinib hydrochloride trade name Iclusig. CAS No. 1114544-31-8. Pack Sizes: 300 mg. Product ID: B0084-475072. Molecular formula: C29H28ClF3N6O. Mole weight: 569.03. Custom synthesis is available. Send your inquiries for more information. | London |
| tert-Butyl 2-Amino-4-(4-methyl-1-piperazinyl)benzoate | tert-Butyl 2-Amino-4-(4-methyl-1-piperazinyl)benzoate. Group: Pharmaceutical. Alternative Names: 2-amino-4-(4-methyl-1-piperazinyl)benzoic acid tert-butyl ester; tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate. CAS No. 1034975-35-3. Pack Sizes: 10 g. Product ID: BB001157. Molecular formula: C16H25N3O2. Mole weight: 291.39. Custom synthesis is available. Send your inquiries for more information. | London |
| thiethylperazine | Thiethylperazine is a dopamine receptor antagonist It is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects. It is useful in the treatment of nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. Uses: Antiemetic. Group: Pharmaceutical. Alternative Names: Torecan; Tietilperazina; Thiethylperazinum; Norzine; 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine; 3-Ethylmercapto-10-(1'-methylpiperazinyl-4'-propyl)phenothiazine. CAS No. 1420-55-9. Pack Sizes: 50 mg. Product ID: B1370-058545. Molecular formula: C22H29N3S2. Mole weight: 399.62. Custom synthesis is available. Send your inquiries for more information. | London |
| UNC-2025 hydrochloride | UNC-2025 hydrochloride is the hydrochloride salt of UNC-2025, which is the Mer/FLT3 dual inhibitor. Group: Pharmaceutical. Alternative Names: UNC-2025 hydrochloride; UNC 2025 hydrochloride; UNC2025 hydrochloride; (1r,4r)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol hydrochloride. CAS No. 2070015-17-5. Pack Sizes: 300 mg. Product ID: B0084-053987. Molecular formula: C28H41ClN6O. Mole weight: 513.12. Custom synthesis is available. Send your inquiries for more information. | London |
| WZ-4002 | WZ-4002 is an EGFR phosphorylation inhibitor with selectivity for EGFR T790M. It has a framework of pyrimidine compound which is different from other EGFR inhibitors. WZ-4002 exhibits anti-tumor activity. Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: WZ4002; N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide; WZ 4002. CAS No. 1213269-23-8. Pack Sizes: 50 mg. Product ID: B0084-286777. Molecular formula: C25H27ClN6O3. Mole weight: 494.98. Custom synthesis is available. Send your inquiries for more information. | London |
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