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| Product | Description | |
|---|---|---|
| Balanol Impurities | Balanol Impurities, integral to pharmaceutical R&D, are paramount for elucidating enzyme inhibitor characteristics. These secondary compounds illuminate kinase modulation, essential for innovating oncology and metabolic disorder therapies. Their meticulous analysis enhances drug formulation refinement, ensuring robust pharmacological efficacy, and advancing therapeutic precision. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| D-Glucose-6-phosphate dipotassium salt trihydrate | D-Glucose-6-phosphate dipotassium salt trihydrate is a pivotal compound extensively employed in the biomedical research and pharmaceutical industry, unveiling noteworthy potential in investigating intricate metabolic disorders and glucose metabolism. This paramount product seamlessly acts as a substrate for a diverse array of enzymes, facilitating the meticulous identification and characterization of pertinent pathways germane to therapeutic drug development of afflictions such as diabetes and glycogen storage diseases. Group: Pharmaceutical. CAS No. 207727-36-4. Pack Sizes: 250 mg. Product ID: B2705-101654. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ethyl b-D-thioglucopyranoside | Ethyl b-D-thioglucopyranoside is a valuable chemical compound acting as an inhibitor for enzymes involved in carbohydrate metabolism. Additionally, it is employed in the synthesis of biologically active molecules, specifically designed to study diseases related to carbohydrate metabolism, such as diabetes and metabolic disorders. Group: Pharmaceutical. CAS No. 7473-36-1. Pack Sizes: 5 g. Product ID: B2705-097910. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| LDCA | LDCA is a dual-hit metabolic modulator and inhibits LDH-A enzyme activity to stimulate apoptosis in the malignant population. LDCA can be used for the research of oncogenic progression. Group: Pharmaceutical. CAS No. 349106-80-5. Pack Sizes: 25 mg. Product ID: B1370-257402. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| NADPH Impurities | NADPH Impurities, integral to biomedical scrutiny, assess the purity and stability of NADPH-dependent entities, crucial for enzyme and drug formulation analyses. Their role is paramount in pioneering treatments for cancer and neurodegenerative diseases, offering profound insights into pharmacodynamics and metabolic pathways, thereby propelling therapeutic innovation. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PseudoUridine 5'-monophosphate Sodium salt | A metabolic process has been acknowledged for pseudoUridine, and it involves the pseudoUridine phosphorylation to generate pseudoUridine 5?-monophosphate (ΨMP) catalyzed by the enzyme pseudoUridine kinase and thereafter the C-C glycosidic bond cleavage to give uracil and ribose 5-phosphate which mediated by the pseudoUridine 5?-monophosphate glycosidase. Group: Pharmaceutical. Pack Sizes: 100 mg. Product ID: B1370-285301. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (S)-5'-(S)-(3-amino-3-carboxypropyl)-5'-thioadenosine | (S)-5'-(S)-(3-amino-3-carboxypropyl)-5'-thioadenosine, an important compound, is frequently utilized in scientific endeavors towards the development of medications for the treatment of diverse ailments, encompassing cancer and autoimmune diseases. Typically employed as a substrate for enzymes participating in the purine metabolic pathway, this substance exhibits notably high perplexity, owing to its intricate chemical composition. In addition, it boasts considerable burstiness, with some instances of relatively lucid nomenclature alongside more elaborative descriptions of its molecular properties. Uses: A novel biomarker for predicting susceptibility of a subject to a mental or neurodegenerative disorder. Group: Pharmaceutical. CAS No. 979-92-0. Pack Sizes: 100 mg. Product ID: B0001-080350. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Succinylacetone | Succinylacetone is an inhibitor of δ-aminolevulinic acid dehydratase that inhibits heme biosynthesis. It is used as a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. Uses: Enzyme inhibitors. Group: Pharmaceutical. CAS No. 51568-18-4. Pack Sizes: 250 mg. Product ID: B0084-015144. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Zofenopril Calcium Salt | Zofenopril Calcium is an antioxidant and acts as an angiotensin-converting enzyme (ACE) inhibitor. lt is also an inhibitor of PEPT2, the predominant peptide transporter in kidney and choroid plexus. lt is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat. lt promotes the regeneration of peripheral nerve injuries in rat models. lt increases SR calcium cycling and stimulates active calcium uptake into the SR. It was developed by the Bristol Myers Squibb Company. Uses: Zofenopril calcium promotes the regeneration of peripheral nerve injuries in rat models. lt increases sr calcium cycling and stimulates active calcium uptake into the sr. Group: Pharmaceutical. CAS No. 81938-43-4. Pack Sizes: 25 mg. Product ID: B0084-077909. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2,3,4,6-Tetra-O-acetyl-a-D-glucopyranosyl fluoride | 2,3,4,6-Tetra-O-acetyl-a-D-glucopyranosyl fluoride, a glycosyl fluoride, serves as a significant donor substrate for synthesizing complex carbohydrates. Employing this compound enzymatically generates various α-linked glycoconjugates for experimental and pharmacological purposes. Additionally, its application extends to investigations regarding the enzymatic mechanisms implicated in the metabolism of the carbohydrate. Group: Pharmaceutical. CAS No. 3934-29-0. Pack Sizes: 5 g. Product ID: B1370-371910. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Chloro-4-nitrophenyl b-D-glucopyranoside | 2-Chloro-4-nitrophenyl b-D-glucopyranoside is a biomedical product used for studying intracellular glucoside transport and enzyme activity. It can serve as a substrate for β-glucosidases, aiding research on drug metabolism and disease mechanisms. This compound's properties can be explored on the websites mentioned to further understand its applications in biomedicine. Group: Pharmaceutical. CAS No. 120221-14-9. Pack Sizes: 500 mg. Product ID: B2705-306449. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Octyl itaconate | 4-Octyl itaconate is a prodrug form of itaconate, an endogenous cellular metabolite produced via decarboxylation of cis-aconitate by the enzyme encoded by IRG1. It activates Nrf2. It inhibits LPS-induced increases in IL-1β mRNA, HIF-1α and IL-10 in macrophages. It decreases cytokine production in response to LPS in mice and prolongs survival. Group: Pharmaceutical. CAS No. 3133-16-2. Pack Sizes: 100 mg. Product ID: B0001-007866. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5'-O-DMT-N2-isobutyrylguanosine | 5'-O-DMT-N2-isobutyrylguanosine is a biomedicine product commonly used in the field of nucleic acid research. This compound is a modified form of guanosine and is often utilized as a substrate to study various enzymatic reactions related to DNA and RNA synthesis. It plays a crucial role in investigating the functions of guanine derivatives, offering insights into potential therapeutic approaches for diseases involving nucleic acid metabolism. Group: Pharmaceutical. CAS No. 81246-83-5. Pack Sizes: 25 g. Product ID: B1370-340277. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Methylchrysene | 6-Methylchrysene, a polycyclic aromatic hydrocarbon, has been postulated as a potential carcinogen and may increase the likelihood of developing lung and skin cancer. Due to its carcinogenic properties, this compound is commonly employed in research to investigate the health risks posed by PAH and examine measures to mitigate such threats. Further studies indicate that catabolism of 6-Methylchrysene by enzymes CYP1A1 and CYP1B1 produces deleterious metabolites, implying that these enzymes could possibly contribute to the development of specific cancers. The intricate relationship between 6-Methylchrysene and cancer has encouraged extensive research to comprehend the mechanisms by which it adversely affects human health. Group: Pharmaceutical. CAS No. 1705-85-7. Pack Sizes: 10 mg. Product ID: B0001-085628. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC-PEG-COOH, MW 1k-10k | AC-PEG-COOH has two different activated terminal groups, an acrylate and a carboxylic acid. Heterobifunctionalized PEG derivatives are used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0644. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC-PEG-NH-Boc, MW 1k-10k | AC-PEG-NH-Boc has two different activated terminal groups, an acrylate and a Boc protected amine. Heterobifunctionalized PEG derivatives are used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0654. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC-PEG-OH, MW 1k-10k | AC-PEG-OH with two different activated terminal groups, an acrylate and a hydroxyl, is used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0659. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC-PEG-SCM, MW 1k-10k | AC-PEG-SCM with two different activated terminal groups, an Acrylate and an activated NHS ester, is used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0664. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC-PEG-Silane, MW 1k-10k | AC-PEG-Silane with two different activated terminal groups, an acrylate and a silane group, is used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0669. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Alectinib | Alectinib, marketed as Alecensa, is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). Alectinib has a low potential for interactions. While it is metabolised by the liver enzyme CYP3A4, and blockers of this enzyme accordingly increase its concentrations in the body, they also decrease concentrations of the active metabolite M4, resulting in only a small overall effect. Conversely, CYP3A4 inducers decrease alectinib concentrations and increase M4 concentrations. Interactions via other CYP enzymes and transporter proteins cannot be excluded but are unlikely to be of clinical significance. Group: Pharmaceutical. CAS No. 1256580-46-7. Pack Sizes: 200 mg. Product ID: B0084-454466. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Arabinitol Impurities | Arabinitol Impurities, present in biomedical research, aid in the detection and analysis of various metabolic disorders, such as those caused by fungi or yeasts. These compounds are valuable in understanding enzymatic pathways and assessing the purity of arabinitol-based medications, ultimately contributing to the development of targeted therapeutic interventions. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Captopril disulfide | A metabolite of Captopril, an orally active angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension and congestive heart failure. Group: Pharmaceutical. CAS No. 64806-05-9. Pack Sizes: 100 mg. Product ID: B1370-468095. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CAY10499 | Monoglyceride lipase (MGL) plays an important role in the metabolism of the lipid transmitter 2-arachidonoylglycerol (2-AG). CAY10499 is a potent and selective monoglyceride lipase (MGL) inhibitor exhibiting an IC50 of 90 nM for the recombinant enzyme. It is also a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC50s = 4.2, 46, 106.7, and 79.8 mM, respectively). Group: Pharmaceutical. CAS No. 359714-55-9. Pack Sizes: 100 mg. Product ID: B1370-292092. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CB-839 | CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). ( ). Group: Pharmaceutical. CAS No. 1439399-58-2. Pack Sizes: 20 mg. Product ID: B0084-462472. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cilastatin Ammonium Salt | Cilastatin Ammonium Salt is the ammonium salt of Cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Group: Pharmaceutical. CAS No. 877674-82-3. Pack Sizes: 500 mg. Product ID: B2693-468925. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cilastatin sodium | Cilastatin sodium is the sodium salt of cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Group: Pharmaceutical. CAS No. 81129-83-1. Pack Sizes: 1 g. Product ID: B0084-077802. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| D-Fructose 1-phosphate disodium salt | D-Fructose 1-phosphate disodium salt is a crucial component used in the biomedical industry playing a vital role in the research of metabolic disorders and genetic diseases associated with defects in fructose metabolism. This product acts as a substrate for the enzymatic reaction leading to the conversion of fructose-1-phosphate to fructose-6-phosphate, facilitating normal fructose metabolism. Group: Pharmaceutical. CAS No. 71662-09-4. Pack Sizes: 5 mg. Product ID: B1370-149824. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Fosinoprilat | Fosinoprilat is a metabolite of Fosinopril. Fosfenopril is a potent angiotensin converting enzyme (ACE) inhibitor. Group: Pharmaceutical. CAS No. 95399-71-6. Pack Sizes: 50 mg. Product ID: B1370-301422. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Guanosine 5'-diphosphate disodium salt | Guanosine 5'-diphosphate disodium salt is an imperative biomolecule esteemed in the biomedical sector, exhibiting noteworthy involvement in cellular signaling and serves as a substrate for diverse nucleic acid metabolism-encompassing enzymes. Its significance is exemplified through extensive employment in research and manufacturing, enabling comprehensive exploration of G-protein coupled receptors, protein synthesis and drug discovery-related signaling pathways, as well as disease research. Group: Pharmaceutical. CAS No. 7415-69-2. Pack Sizes: 10 g. Product ID: B2001-013437. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Kaempferitrin | Kaempferitrin isolated from the root of Kaempferia galangal L. It stimulates glucose-metabolizing enzymes and promotes glucose homeostasis. Uses: Cytotoxic and antitumor effects; antidepressant-like effect; immunostimulatory effects. Group: Pharmaceutical. CAS No. 482-38-2. Pack Sizes: 20 mg. Product ID: NP1860. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Lanreotide | Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the 06 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits 06-alkyl-guanine transferase, an enzyme involved with DNA repair. Group: Pharmaceutical. CAS No. 108736-35-2. Pack Sizes: 25 mg. Product ID: BAT-010202. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Leucovorin Calcium | leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Group: Pharmaceutical. CAS No. 1492-18-8. Pack Sizes: 5 g. Product ID: B2693-301409. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Methyl b-D-glucuronide sodium salt | Methyl b-D-glucuronide sodium salt is a chemical compound used in the biomedical industry for its role in drug metabolism studies. It is commonly employed as a substrate to evaluate glucuronidation reactions mediated by glucuronosyltransferase enzymes. This product aids in understanding drug metabolism and its implications in treating various diseases by facilitating the study of drug elimination pathways. Group: Pharmaceutical. CAS No. 134253-42-2. Pack Sizes: 5 g. Product ID: B2705-209389. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Naringin | Naringin inhibits hepatic P-glycoprotein (P-gp) and some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions. Naringin can be used as an edible additive, mainly for gum, refreshing drinks, etc. It is a plant polyphenol that can inhibit tyrosinase, block melanin synthesis, reduce skin pigment intensity, absorb UV, prevent photoaging, reduce sun damage and age spot formation, and whiten and lighten spots. It also has the anti-glycation and antibacterial effect, can effectively improve skin tone and skin texture, prevent the generation of age spots, remove red bloodlines, and improve skin blood microcirculation. Uses: Antioxidant, anticancer, anti-atherogenic. Group: Pharmaceutical. CAS No. 10236-47-2. Pack Sizes: 250 g. Product ID: NP1904. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-Desmethyl Imatinib-[d8] | N-Desmethyl Imatinib-[d8] is a deuterated metabolite of gleevec, a tyrosine kinase inhibitor specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). Group: Pharmaceutical. CAS No. 1185103-28-9. Pack Sizes: 5 mg. Product ID: BLP-009648. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| OXi-4503 | OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated levels in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production. CA1 binds to tubulin at the same site as colchicine but with higher affinity. Group: Pharmaceutical. CAS No. 288847-35-8. Pack Sizes: 100 mg. Product ID: B0084-353235. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Oxypeucedaninhydrate | Oxypeucedanin hydrate usually can be found in the roots of Angelica dahurica. It exhibited carbohydrate metabolizing enzymes inhibitory effect. Uses: Antimutagenic / antioxidant / antimicrobial. Group: Pharmaceutical. CAS No. 2643-85-8. Pack Sizes: 20 mg. Product ID: B2703-464765. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PFK15 | PFK15 is a potent and selective inhibitor of 6-phosphofructo-2-kinase (PFKFB3) with IC50 of 207 nM. Overexpression of the PFKFB3 enzyme leads to high glycolytic metabolism, which is required for cancer cells to survive in the harsh tumor microenvironment. Group: Pharmaceutical. CAS No. 4382-63-2. Pack Sizes: 250 mg. Product ID: B2693-463353. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Protoporphyrin IX | Created by the enzyme protoporphyrinogen oxidase, protoporphyrin IX is an important precursor to biologically essential prosthetic groups. Uses: Metabolism of porphyrin. Group: Pharmaceutical. CAS No. 553-12-8. Pack Sizes: 2 g. Product ID: B2693-071431. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ramipril | Ramipril is a second generation angiotensin-converting enzyme (ACE) inhibitor that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. It is used in treatment of congestive heart failure, hypertension and heart attacks. It is also useful in preventing renal and retinal complications in diabetes. It was developed by Pfizer and has been listed. Uses: Ramipril is used in treatment of congestive heart failure, hypertension and heart attacks. it is also useful in preventing renal and retinal complications in diabetes. Group: Pharmaceutical. CAS No. 87333-19-5. Pack Sizes: 10 g. Product ID: B0084-140017. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Resorufin Impurities | Resorufin Impurities are critical intermediates in drug metabolism studies and diagnostics. They are primarily utilized to investigate enzymatic activity in various cancers and liver diseases, offering potential insights for creating highly effective therapeutic agents. Additionally, their role extends to oxidative stress research, contributing to the understanding of diverse pathologies. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Resveratrol | Resveratrol is a phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity), mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity), and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose-and time-dependent manner. Resveratrol is a natural compound used in cosmetic materials. It is widely used in anti-aging and wrinkle removal, whitening and whitening spots, antibacterial and anti-inflammatory, oil control and acne, anti-allergy and analgesia, scar repair, hair care and other products, and it is compatible with lotion cream formula, gel formula and water formula. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 501-36-0. Pack Sizes: 20 g. Product ID: BBF-03781. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ruboxistaurin HCl | Ruboxistaurin, also called as LY 333531, initially developed for the treatment of diabetic retinopathy, inhibits isolated enzymes PKCβI and PKCβII with a half-maximal inhibitory constant of 4.5 and 5.9 nM, respectively. The half-life of ruboxistaurin, which can be orally administered, is approximately 9h and that of its metabolite 16h, therefore allowing once-daily dosing. Based on data from clinicalTrials.gov, Children's Hospital Medical Center, Cincinnati plan a phase I/II trial of the effect of ruboxistaurin for its safety, tolerability, and effectiveness in treating adult patients with heart failure on June 9, 2016. Uses: Enzyme inhibitors. Group: Pharmaceutical. CAS No. 169939-93-9. Pack Sizes: 10 mg. Product ID: B0084-263880. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SENECIONINE | Senecionine is a pyrrolizidine alkaloid isolated from Senecio scandens. Study shows that senecionine exhibits activity against hepatic drug metabolizing enzymes in rat cells. Group: Pharmaceutical. CAS No. 130-01-8. Pack Sizes: 10 mg. Product ID: NP0017. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Seneciphylline | Seneciphylline, a natural pyrrolizidine alkaloid isolated from the herbs of Senecio scandens, may cause reduction of cytochrome P-450 and related monooxygenase activities. Seneciphylline is a pyrrolizidine alkaloid with the potential to affect hepatic drug metabolizing enzymes in rat cells. In vitro, seneciphylline has no effection on hepatic drug metabolizing enzymes, but has seneciphyllineslight activity of reducing aminopyrine demethylase. Group: Pharmaceutical. CAS No. 480-81-9. Pack Sizes: 10 mg. Product ID: NP0002. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sulforaphane | Sulforaphaneis a naturally-occurring phytochemical belonging to the class of isothiocyanates. As the aglycone metabolite of glucosinolate glucoraphanin (sulforaphane glucosinolate), sulforaphane acts as an antioxidant and potent stimulator of endogenous detoxifying enzymes. This agent displays anticarcinogenic properties due to its ability to induce phase II detoxification enzymes, such as glutathione S-transferase and quinone reductase, thereby providing protection against certain carcinogens and toxic, reactive oxygen species. Broccoli sprouts contain large amounts of sulforaphane, which is also found in other cruciferous vegetables including cabbage and kale. Uses: Anti-inflammatory/antitumor. Group: Pharmaceutical. CAS No. 4478-93-7. Pack Sizes: 1 g. Product ID: NP4355. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Teriflunomide | Teriflunomide, the active metabolite of leflunomide, is an immunomodulatory drug inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase. It inhibits rapidly dividing cells, including activated T cells, and tyrosine kinase enzymes. Uses: Anti-inflammatory agents, non-steroidal. Group: Pharmaceutical. CAS No. 163451-81-8. Pack Sizes: 1 g. Product ID: NP3105. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| UDP-D-glucose disodium salt | UDP-D-glucose disodium salt is a phosphorylated uridine derivative used in nucleotide sugars metabolism as a substrate for the enzyme glucosyltransferases. It is used in the treatment of chronic alcoholism and in characterization of limonoid glucosyltransferase. Group: Pharmaceutical. CAS No. 28053-08-9. Pack Sizes: 1 g. Product ID: B1370-368748. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| UDP-D-glucuronide trisodium salt | UDP-D-glucuronide trisodium salt is a crucial compound used for drug metabolism studies. It acts as a donor molecule for the glucuronyl transferase enzyme, which helps in the biotransformation and detoxification of a wide range of drugs and endogenous compounds. This trisodium salt form facilitates stability and solubility, making it suitable for drug discovery and pharmacokinetic studies. Group: Pharmaceutical. CAS No. 63700-19-6. Pack Sizes: 250 mg. Product ID: B2706-146244. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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