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| Product | Description | |
|---|---|---|
| Ansamitocin P 3' | Ansamitocin P 3' is an isomer of Ansamitocin P-3, a potent anti-tumor maytansinoid antibiotic found in Actinosynnema pretiosum, a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. Uses: Adcs cytotoxin. Group: Pharmaceutical. CAS No. 66547-09-9. Pack Sizes: 25 mg. Product ID: BBF-04267. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| DM1-SMe | DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). Group: Pharmaceutical. CAS No. 138148-68-2. Pack Sizes: 25 mg. Product ID: BADC-00020. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Trastuzumab emtansine | Trastuzumab emtansine is an antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surface surfaces. Upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers. Group: Pharmaceutical. CAS No. 1018448-65-1. Pack Sizes: 5 mg. Product ID: BADC-00023. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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