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| Product | Description | |
|---|---|---|
| 5-Dodecyldihydro-2(3H)-Furanone | 5-Dodecyldihydro-2(3H)-Furanone, a chemically synthesized organic compound, exhibits remarkable antibacterial, antifungal, and antiviral activities. This exceptionally versatile compound has been the subject of in-depth research for its potential therapeutic application in combating drug-resistant bacterial infections and mitigating biofilm formation in diverse microbial communities, imparting outstanding promise for numerous industrial and healthcare applications. Group: Pharmaceutical. CAS No. 730-46-1. Pack Sizes: 250 mg. Product ID: B4059-133916. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| AMG 925 | AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. AMG 925 inhibited AML xenograft tumor growth by 96% to 99% without significant body weight loss. The antitumor activity of AMG 925 correlated with the inhibition of STAT5 and RB phosphorylation, the pharmacodynamic markers for inhibition of FLT3 and CDK4, respectively. In addition, AMG 925 was also found to inhibit FLT3 mutants (e.g., D835Y) that are resistant to the current FLT3 inhibitors (e.g., AC220 and sorafenib). AMG 925, which combines inhibition of two kinases essential for proliferation and survival of FLT3-mutated AML cells, may improve and prolong clinical responses. Group: Pharmaceutical. CAS No. 1401033-86-0. Pack Sizes: 25 mg. Product ID: B2693-463215. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ammonium Aluminium Sulphate | . Ammonium aluminium sulfate, commonly known as ammonium alum, has diverse applications primarily in water purification, baking as a leavening agent, and as a mordant in textile dyeing processes. Additionally, it finds use in cosmetics, papermaking, and fire retardant applications due to its astringent, strengthening, and fire-resistant properties. Group: Ammoniums \ potassium ammonium sulphate. CAS No. 7784-26-1. Pack Sizes: 100g, 500g, 1kg, 6kg, 25kgs. |  |
| Baloxavir | Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Group: Pharmaceutical. CAS No. 1985605-59-1. Pack Sizes: 50 mg. Product ID: B2692-008721. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Baloxavir-[d4] | Baloxavir-[d4] is an isotope compound of Baloxavir. Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Group: Pharmaceutical. CAS No. 2415027-80-2. Pack Sizes: 2 mg. Product ID: BLP-003387. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Baloxavir marboxil | Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Group: Pharmaceutical. CAS No. 1985606-14-1. Pack Sizes: 50 mg. Product ID: B2692-291710. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bedaquiline fumarate | Bedaquiline fumarate is an anti-tuberculosis drug which selectively inhibits the mycobacterial energy metabolism and found to be effective against all states of Mycobacterium tuberculosis. It possesses a unique mechanism of action that disrupts the activity of the mycobacterial adenosine triphosphate synthase. It has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis, however, its side effect profile limits its use against MDR-TB when no other effective regimen can be provided. Uses: Antitubercular agents. Group: Pharmaceutical. CAS No. 845533-86-0. Pack Sizes: 200 mg. Product ID: B0084-463644. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Difloxacin Impurities | Difloxacin Impurities are crucial in pharmaceutical research for ensuring the purity, stability, and efficacy of the antibiotic difloxacin, primarily used to treat bacterial infections. These impurities provide insights into the compound's degradation pathways and safety profile, essential for maintaining therapeutic consistency and effectiveness in combating resistant bacterial strains. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ethyl (4-((2-(Methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. CAS No. 2206827-12-3. Pack Sizes: 100 mg. Product ID: B2694-479756. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Icaritin | Icaritin is unable to promote proliferation, migration and tube-like structure formation by human umbilical vein endothelial cells (HUVECs) in vitro. Icaritin potently inhibited proliferation of K562 cells (IC50 was 8 μM) and primary CML cells (IC50 was 13.4 μM for CML-CP and 18 μM for CML-BC), induced CML cells apoptosis and promoted the erythroid differentiation of K562 cells with time-dependent manner. Furthermore, Icaritin was able to suppress the growth of primary CD34+ leukemia cells (CML) and Imatinib-resistant cells, and to induce apoptosis. Icaritin strongly inhibited the growth of breast cancer MDA-MB-453 and MCF7 cells. At concentrations of 2-3 μM, icaritin induced cell cycle arrest at the G(2)/M phase accompanied by a down-regulation of the expression levels of the G(2)/M regulatory proteins such as cyclinB, cdc2 and cdc25C. Icaritin at concentrations of 4-5 μM, however, induced apoptotic cell death characterized by the accumulation of the annexin V- and propidium iodide-positive cells, cleavage of poly ADP-ribose polymerase (PARP) and down-regulation of the Bcl-2 expression. In mouse leukemia model, Icaritin could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells as effective as Imatinib without suppression of bone marrow. Icaritin could up-regulate phospho-JNK or phospho-C-Jun and down-regulate phospho-ERK, phospho-P-38, Jak-2, phospho-Stat3 and phospho-Akt expression with dose- or ti | London |
| K-7174 dihydrochloride | K-7174, one of proteasome inhibitory homopiperazine derivatives, exhibits a therapeutic effect, which is stronger when administered orally than intravenously, without obvious side effects in a murine myeloma model. Moreover, K-7174 kills bortezomib-resistant myeloma cells carrying a β5-subunit mutation in vivo and primary cells from a patient resistant to bortezomib. Group: Pharmaceutical. CAS No. 191089-60-8. Pack Sizes: 100 mg. Product ID: B2693-463577. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| KW-2449 | KW-2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Recent research showed that HDACIs increase KW-2449 lethality in Bcr/Abl(+) cells in association with inhibition of Bcr/Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW-2449 with HDACIs warrants attention in IM-resistant Bcr/Abl(+) leukemias. Group: Pharmaceutical. CAS No. 1000669-72-6. Pack Sizes: 100 mg. Product ID: B0084-286439. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Qingyangshengenin 3-O-α-L-cymaropyranosyl-(1?4)-β-D-oleandropyranosyl-(1?4)-β-D-cymaropyranosyl-(1?4)-β-D-cymaropyranoside | Derived from the root of Cynanchum otophyllum Schneid, Qingyangshengenin 3-O-α-L-cymaropyranosyl-(1→4)-β-D-oleandropyranosyl- (1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside stands as an intriguing natural compound with potential anti-tumor activity. This promising molecule is traditionally used in Chinese medicine and may be particularly effective in the treatment of hepatocellular carcinoma, a lethal form of cancer that is notoriously resistant to conventional therapies. Its active constituents exhibit a remarkably complex structure that is worthy of further study, as the implications for cancer treatment may be significant. Group: Pharmaceutical. CAS No. 1808159-02-5. Pack Sizes: 1 mg. Product ID: NP6148. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib related compound 10 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. CAS No. 1012058-78-4. Pack Sizes: 10 mg. Product ID: B1630-479761. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib Related Compound 15 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. CAS No. 284670-98-0. Pack Sizes: 250 mg. Product ID: B2694-479766. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib related compound 2 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. CAS No. 18585-06-3. Pack Sizes: 2 g. Product ID: B2694-233982. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sunitinib malate | Sunitinib (marketed as Sutent by Pfizer, and previously known as SU11248) is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib was the first cancer drug simultaneously approved for two different indications. Uses: Angiogenesis inhibitors. Group: Pharmaceutical. CAS No. 341031-54-7. Pack Sizes: 1 g. Product ID: NP3249. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Taurolidine Impurities | Taurolidine Impurities serve a crucial role in the development and optimization of antimicrobial treatments, primarily targeting infections related to resistant bacteria and inflammation, such as peritonitis and surgical site infections. Their analysis enhances drug purity and efficacy, facilitating advancements in therapeutic applications and safety evaluations in clinical settings. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tobramycin Impurities | Tobramycin impurities are crucial in the biomedical industry for developing and optimizing Tobramycin-based therapies. They serve as reference standards, ensuring quality control in the synthesis of Tobramycin, an aminoglycoside antibiotic used primarily to treat severe bacterial infections like Pseudomonas aeruginosa in cystic fibrosis and other resistant infections. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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