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| Product | Description | |
|---|---|---|
| 6-Gingerol | 6-gingerol is the active constituent of fresh ginger. It is bioactive compound found in ginger (Zingiber officinale) with antioxidant activity, which functions as an anti-inflammatory and antitumor agent. It has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin. lt may reduce nausea caused by motion sickness or pregnancy and may also relieve migraine. lt has been investigated for its effect on cancerous tumors in the bowel, breast tissue, ovaries, the pancreas, among other tissues, with positive results. Uses: Anti-inflammatory, antitumor and antioxidant activity. Group: Pharmaceutical. CAS No. 23513-14-6. Pack Sizes: 25 mg. Product ID: NP5162. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| CVT-313 | A cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 μM for Cdk2/A and Cdk2/E; 4.2 μM for Cdk1/B; 215 μM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 = ~1.25-20 μM) in vitro and prevent neointima formation in vivo. Group: Pharmaceutical. CAS No. 199986-75-9. Pack Sizes: 50 mg. Product ID: B0084-196573. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GDC-0994 | GDC-0994, also known as RG7842, is an orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 1453848-26-4. Pack Sizes: 50 mg. Product ID: B2693-462528. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GNE-3511 | GNE-3511 has been found to be a DLK, MAP3K12 kinase inhibitor that could probably exhibit protection action of primary neurons. IC50: 0.107 uM (DLK). Group: Pharmaceutical. CAS No. 1496581-76-0. Pack Sizes: 50 mg. Product ID: B0084-475829. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Losmapimod | Losmapimod is a promising new agent against cardiovascular diseases. This drug works by inhibiting p38 MAP kinases, which play an important role in the development of atherosclerosis and heart failure caused by ischemic conditions. Losmapimod did not cause an improvement in exercise tolerance or lung function, despite being well-tolerated in this COPD population. The p38 MAPK inhibitor losmapimod (GW856553) attenuates the pro-inflammatory response in humans by reducing PIC production. Group: Pharmaceutical. CAS No. 585543-15-3. Pack Sizes: 25 mg. Product ID: B0084-094991. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Nardosinone | Nardosinone, coming from the roots of Nardostachys jatamansi DC, enhances staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying both the MAP kinase-dependent and -independent signaling pathways of dbcAMP and staurosporine. It could protect against the neuronal injury exposed to OGD, which may be relevant to the promotion of PKA and ERK signaling pathway. Uses: Antidepressant/sedative. Group: Pharmaceutical. CAS No. 23720-80-1. Pack Sizes: 50 mg. Product ID: NP5946. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Neochinulin A | Neoechinulin A is isolated from Aspergillus chevalieri. It may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits. Uses: Antioxidant; anti-inflammatory; antioxidant/anti-nitration. Group: Pharmaceutical. CAS No. 51551-29-2. Pack Sizes: 1 mg. Product ID: NP0376. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PD0325901 | PD-0325901 is a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. Uses: Reprogramming, self-renewal. Group: Pharmaceutical. CAS No. 391210-10-9. Pack Sizes: 100 mg. Product ID: B0084-091588. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PD98059 | PD98059 is a potent, selective and cell-permeant inhibitor of MAP kinase kinase. It enhances human embryonic stem cell self-renewal. Group: Pharmaceutical. CAS No. 167869-21-8. Pack Sizes: 250 mg. Product ID: B2693-286170. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Perifosine | Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine. Group: Pharmaceutical. CAS No. 157716-52-4. Pack Sizes: 500 mg. Product ID: B0084-084985. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pexmetinib | Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. It has potential antineoplastic, anti-inflammatory, and antiangiogenic activities. It inhibits other kinases including vascular endothelial growth factor receptor (VEGFR2) and Src tyrosine kinases. Group: Pharmaceutical. CAS No. 945614-12-0. Pack Sizes: 50 mg. Product ID: B2693-470949. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sauchinone | Sauchinone, coming from the herbs of Saururus chinensis(Lour.) Baill, is a useful adjunctive treatment for bacterial infection. Sauchinone inhibited oxidative stress, as assessed by stainings of 4-hydroxynonenal and nitrotyrosine: these events may have a role in its inhibitory effects on HSCs activation. Sauchinone attenuated CCl4-induced liver fibrosis and TGF-β1-induced HSCs activation, which might be, at least in part, mediated by suppressing autophagy and oxidative stress in HSCs. Sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK signaling via upregulation of oxidative defense enzymes. Uses: Anti-inflammatory/antibacterial. Group: Pharmaceutical. CAS No. 177931-17-8. Pack Sizes: 10 mg. Product ID: B2703-464575. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Selumetinib | Selumetinib, also known as AZD6244, is an orally bioavailable small molecule with potential antineoplastic activity. Selumetinib inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, and so may inhibit cellular proliferation in MEK-overexpressing tumor cells. MEK 1 and 2 are dual-specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various tumor cell types, and are drivers of diverse cellular activities, including cellular proliferation. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. CAS No. 606143-52-6. Pack Sizes: 5 g. Product ID: B0084-095434. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SIS3 HCl | SIS3 is a potent and specific inhibitor of Smad3 via inhibiting the effects of TGF-β1. SIS3 inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation with no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. It inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts. Group: Pharmaceutical. CAS No. 521984-48-5. Pack Sizes: 20 mg. Product ID: B0084-121733. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SKF-86002 | SKF-86002 is a p38 MAP kinase inhibitor, the IC50 is 0.1 - 1 μM. It potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes, the IC50 is1 μM. It also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO). In vitro: SKF-86002 inhibited prostaglandin H2 synthase activity, the IC50 is 120 mM as well as prostanoid production by rat basophilic leukemia cells, the IC50 is mM and its sonicate ( the IC50 is 100 mM and human monocytes (the IC50 is 1 mM. It inhibited the generation of dihydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid by a high speed supernatant fraction of RBL-1 cells (the IC50 is 10 mM). It blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP. Uses: Skf-86002 could potently inhibit lps-induced il-1 and tnf-α production in human monocytes. it acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. Group: Pharmaceutical. CAS No. 72873-74-6. Pack Sizes: 300 mg. Product ID: B0084-195907. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SU 3327 | SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM) with selectivity over p38 MAPK and Akt. SU 3327 inhibits the interaction between JNK and JIP (IC50 = 239 nM). Group: Pharmaceutical. CAS No. 40045-50-9. Pack Sizes: 100 mg. Product ID: B2693-129660. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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