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| Product | Description | |
|---|---|---|
| 5-Hydroxy-3',4',7-trimethoxyflavone | 7,3',4'-Tri-O-methylluteolin is a natural flavonoid found in the herbs of Callicarpa bodinieri Levl, it shows prominent inhibitory activity against soybean lipoxygenase. Group: Pharmaceutical. Alternative Names: 5-Hydroxy-3',4',7-trimethoxyflavone. CAS No. 29080-58-8. Pack Sizes: 10 mg. Product ID: NP1805. Molecular formula: C18H16O6. Mole weight: 328.3. Custom synthesis is available. Send your inquiries for more information. |  London |
| 6-Shogaol | 6-Shogaol is a pungent constituent of ginger similar in chemical structure to gingerol. It has anti-inflammatory properties. lt was reported to have antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. lt effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-κB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis. lt inhibits the growth of human cancer cells and induces apoptosis in COLO 205 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). Uses: 6-shogaol exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. it has a very strong antitussive (anti-cough) effect. Group: Pharmaceutical. Alternative Names: 1-(3-Methoxy-4-hydroxyphenyl)-4-decene-3-one; 1-(4-Hydroxy-3-methoxyphenyl)-4-decen-3-one. CAS No. 555-66-8. Pack Sizes: 50 mg. Product ID: NP5193. Molecular formula: C17H24O3. Mole weight: 276.37. Custom synthesis is available. Send your inquiries for more information. | London |
| Caffeic acid | Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound. It is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LOX). Uses: Antioxidant activity; antineoplastic activity; anti-hiv activity; hepatotropic activity; choleretic activity. Group: Pharmaceutical. Alternative Names: 3-(3,4-Dihydroxyphenyl)-2-propenoic Acid; 3,4-Dihydroxycinnamic Acid; 3,4-Dihydroxybenzeneacrylic Acid; 4-(2-Carboxyethenyl)-1,2-dihydroxybenzene; NSC 57197; NSC 623438; 3-(3,4-Dihydroxy-phenyl)-acrylic acid. CAS No. 331-39-5. Pack Sizes: 1 kg. Product ID: NP5450. Molecular formula: C9H8O4. Mole weight: 180.16. Custom synthesis is available. Send your inquiries for more information. | London |
| Cardanol monoene | Cardanol monoene is also known as anacardic acid (C15:1). It inhibits the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 with an IC50 of 6.8 mM. Cardanol monoene is also a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 56 μM in vitro. It halts the cell cycle at the S phase and inhibits proliferation dose- and time-dependently in M14 melanoma cells (IC50s = 23.15 and 12.30 μM after 24 and 48 hours of treatment, respectively). A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation. Group: Pharmaceutical. Alternative Names: Cardanol C15:1; 6[8'(Z)-pentadecenyl]salicylic acid. CAS No. 501-26-8. Pack Sizes: 5 mg. Product ID: B2693-292204. Molecular formula: C21H34O. Mole weight: 302.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Chebulagic acid | Chebulagic acid is a polyphenol and tannin that has been found in T. chebula and has diverse biological activities. It is an inhibitor of COX-1, COX-2, and 5-lipoxygenase (5-LO; IC50s = 15, 0.92, and 2.1 μM, respectively) as well as α-glucosidase and 15-LO (IC50s = 0.05 and 24.9 μM, respectively). Chebulagic acid inhibit the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. And it can also inhibit the production of NO, prostaglandin E2 (PGE2), and reactive oxygen species (ROS), and nuclear translocation of NF-κB in RAW 264.7 macrophages in a concentration-dependent manner. Chebulagic acid also show a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Uses: Topoisomerase i inhibitors. Group: Pharmaceutical. Alternative Names: β-D-glucopyranose; Cyclic 3,6-[(1R)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1-(3,4,5-trihydroxybenzoate); Cyclic 2→2:4→1-ester with (2S)-2-[(3S,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid. CAS No. 23094-71-5. Pack Sizes: 50 mg. Product ID: B1370-300064. Molecular formula: C41H30O27. Mole weight: 954.66. Custom synthesis is available. Send your inquiries for more information. | London |
| Edaravone | Edaravone is a novel potent free radical scavenger that reduces reactive oxygen species, inhibites apoptosis, and blocks nonenzymatic peroxidation and lipoxygenase activity. Group: Pharmaceutical. Alternative Names: Edaravone; MCI-186; MCI 186; MCI186; Radicut; Arone. CAS No. 89-25-8. Pack Sizes: 1mg;1g;10g. Product ID: NP3392. Molecular formula: C10H10N2O. Mole weight: 174.2. Custom synthesis is available. Send your inquiries for more information. | London |
| Edaravone Trimer | Edaravone Trimer is an impurity of Edaravone. Edaravone is a novel potent free radical scavenger that reduces reactive oxygen species, inhibits apoptosis, and blocks nonenzymatic peroxidation and lipoxygenase activity. Group: Pharmaceutical. Alternative Names: 5,?5',?5''-trimethyl-2,?2',?2''-triphenyl-[4,?4':4',?4''-Ter-4H-pyrazole]?-3,?3',?3''(2H,?2'H,?2''H)?-trione; 4,4-bis(3-methyl-5-oxo-1-phenyl(2-pyrazolin-4-yl))-3-methyl-1-phenyl-2-pyrazol in-5-one; 2-Phenyl-5-methyl-4,4-bis(2-phenyl-3-oxo-5-methyl-3,4-dihydro-2H-pyrazole-4-yl)-3,4-dihydro-2H-pyrazole-3-one. CAS No. 68195-63-1. Pack Sizes: 50 mg. Product ID: B1370-105475. Molecular formula: C30H26N6O3. Mole weight: 518.58. Custom synthesis is available. Send your inquiries for more information. | London |
| Oridonin | Oridonin, a diterpenoid purified from Rabdosia rubescens, is an antitumor agent. It also acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2. Uses: Lipoxygenase-inhibiting. Group: Pharmaceutical. Alternative Names: Rubescenin A; Oridonine; lasidonin; (14R)-7-alpha,20-Epoxy-1-alpha,6-beta,7,14-tetrahydroxykaur-16-en-15-one. CAS No. 28957-04-2. Pack Sizes: 10 g. Product ID: NP1543. Molecular formula: C20H28O6. Mole weight: 364.43. Custom synthesis is available. Send your inquiries for more information. | London |
| Procyanidin C1 | Procyanidin C1 is extracted from the fruits of Vitis vinifera L. It is a B type proanthocyanidin and found in grape. It belongs to a polyphenol flavonoid epicatechin trimer. It can decrease cytokine production of mast cells and Fc epsilon RI-mediated degranulation in vitro dose-dependently. It inhibits ROS generation in stimulated mast cells and the tyrosine phosphorylation of Syk and linker for activation of T cells. It may be used for the treatment of cardiovascular diseases and may be useful as a lead compound to develop inhibitors of cancer metastasis and other diseases related to EMT. It has HIV-related, antioxidant and anti-inflammatory effects. It also inhibits the activity of 15-lipoxygenase and α-glucosidase. It could scavenge 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radicals. Group: Pharmaceutical. Alternative Names: Procyanidol C1; (2R,2'R,2''R,3R,3'R,3''R,4R,4'S)-2,2',2''-tris(3,4-dihydroxyphenyl)-3,3',3'',4,4',4''-hexahydro-[4,8':4',8''-ter-2H-1-benzopyran]-3,3',3'',5,5',5'',7,7',7''-nonol; Proanthocyanidin C1; Cinnamtannin A1; [Epicatechin-(4beta->8)]2-epicatechin. CAS No. 37064-30-5. Pack Sizes: 10 mg. Product ID: NP1983. Molecular formula: C45H38O18. Mole weight: 866.77. Custom synthesis is available. Send your inquiries for more information. | London |
| SKF-86002 | SKF-86002 is a p38 MAP kinase inhibitor, the IC50 is 0.1 - 1 μM. It potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes, the IC50 is1 μM. It also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO). In vitro: SKF-86002 inhibited prostaglandin H2 synthase activity, the IC50 is 120 mM as well as prostanoid production by rat basophilic leukemia cells, the IC50 is mM and its sonicate ( the IC50 is 100 mM and human monocytes (the IC50 is 1 mM. It inhibited the generation of dihydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid by a high speed supernatant fraction of RBL-1 cells (the IC50 is 10 mM). It blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP. Uses: Skf-86002 could potently inhibit lps-induced il-1 and tnf-α production in human monocytes. it acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. Group: Pharmaceutical. Alternative Names: SKF-86002; SKF 86002; SKF86002. 6-(4-fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole; 4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene. CAS No. 72873-74-6. Pack Sizes: 300 mg. Product ID: B0084-195907. Molecular formula: C16H12FN3S. Mole weight: 297.36. Custom synthesis is available. Send your inquiries for more information. | London |
| Trachelosiaside | Trachelosiaside is isolated from the leaves of Trachelospermum lucidum (D. Don) Schum. Trachelosiaside shows moderate activity against lipoxygenase. Group: Pharmaceutical. Alternative Names: Matairesinol 5-C-glucoside. CAS No. 106647-12-5. Pack Sizes: 1 mg. Product ID: NP4131. Molecular formula: C26H32O11. Mole weight: 520.52. Custom synthesis is available. Send your inquiries for more information. | London |
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