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| Product | Description | |
|---|---|---|
| 3'-Cholesterol CPG | 3'-Cholesterol CPG 1000 is a highly sought-after phosphoramidite building block, coveted by experts in the field for its impressive versatility and usefulness. Boasting numerous applications within the biomedical industry, its primary function is in the synthesis of oligonucleotides with cholesterol conjugates. Scientists and researchers alike utilize this remarkable product in their study of lipoprotein metabolism, and its effectiveness in the treatment of hypercholesterolemia-associated diseases such as atherosclerosis cannot be overstated. Group: Pharmaceutical. Pack Sizes: 1 g. Product ID: B1370-362784. Custom synthesis is available. Send your inquiries for more information. |  London |
| Berberine hydrochloride | Berberine hydrochloride is an isoqinoline alkaloid and acts as a COX-2 inhibitor that exhibits chemopreventive activity against colon tumor formation. Study in humans and hamsters shows that berberine reduces total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides. It also inhibits c-Jun and suppresses inflammation and cancers. Nutritional supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: Berberine chloride; Natural Yellow 18; Benzodioxide; Berberinium chloride. CAS No. 633-65-8. Pack Sizes: 250 g. Product ID: B0084-073975. Molecular formula: C20H18ClNO4. Mole weight: 371.817. Custom synthesis is available. Send your inquiries for more information. | London |
| Blumeatin | Blumeatin is found in tea and is extracted from the herbs of Blumea balsamifera. It can enhance adipocyte differentiation by increasing triglyceride levels in 3T3L1 cells. It also can increase the accumulation of lipid droplets and induce upregulation of the expression of the adipocyte-specific genes GLUT4 and aP2. It inhibits the increase of liver triglyceride and serum alanine aminotransferase, and increases serum beta-lipoprotein, liver glycogen and triglyceride content in CCl4-intoxicated rats, thus shorten the pentobarbital sleeping time in CCl4-intoxicated mice. It shows free radical scavenging activity, xanthine oxidase (XO) inhibitory activity and antioxidant properties. It can protect liver against injury induced by CCl4 and TAA. Group: Pharmaceutical. Alternative Names: 5,3',5'-Trihydroxy-7-methoxyflavanone; 2-(3,5-Dihydroxyphenyl)-5-hydroxy-7-methoxy-3,4-dihydro-2H-1-benzopyran-4-one. CAS No. 118024-26-3. Pack Sizes: 10 mg. Product ID: B1370-267733. Molecular formula: C16H14O6. Mole weight: 302.28. Custom synthesis is available. Send your inquiries for more information. | London |
| Choline Fenofibrate | Choline fenofibrate is a hydrophilic formulation of fenofibric acid that acts primarily by activating peroxisome proliferator-activated receptor alpha (PPARα). This nuclear receptor modulates the transcription of genes involved in lipid metabolism. Once activated, PPARα increases the expression of lipoprotein lipase (LPL), which hydrolyzes triglycerides in lipoproteins, thereby reducing plasma triglyceride levels. It also decreases the production of apolipoprotein C-III (ApoC-III), an inhibitor of LPL, further promoting triglyceride breakdown. Additionally, choline fenofibrate stimulates the synthesis of high-density lipoprotein cholesterol (HDL-C) by upregulating the expression of apolipoprotein A-I (ApoA-I) and apolipoprotein A-II (ApoA-II). This multifaceted mechanism helps in managing mixed dyslipidemia by lowering triglycerides and increasing HDL-C levels. Group: Pharmaceutical. Alternative Names: Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate (1:1); Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid (1:1); ABT 335; FNFC; Trilipix. CAS No. 856676-23-8. Pack Sizes: 5 g. Product ID: B0084-259938. Molecular formula: C22H28ClNO5. Mole weight: 421.91. Custom synthesis is available. Send your inquiries for more information. | London |
| Colesevelam hydrochloride | Colesevelam is a bile acid sequestrant that helps reduce elevated low-density lipoprotein cholesterol (LDL-C) in patients with primary hyperlipidemia, and also improve blood glucose balance in adults with type 2 diabetes mellitus. Group: Pharmaceutical. Alternative Names: CholestaGel; GT 31-104; GT 31-104HB; Welchol. CAS No. 182815-44-7. Pack Sizes: 500 mg. Product ID: B0046-086232. Molecular formula: (C13H27N)n.(C12H27ClN2)n.(C3H7N)n.(C3H5ClO)n.xHCl. Custom synthesis is available. Send your inquiries for more information. | London |
| Darapladib | Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Group: Pharmaceutical. Alternative Names: SB-480848; SB 480848; SB480848; Darapladib. CAS No. 356057-34-6. Pack Sizes: 10 mg. Product ID: B0084-111850. Molecular formula: C36H38F4N4O2S. Mole weight: 666.77. Custom synthesis is available. Send your inquiries for more information. | London |
| Dextrothyroxine sodium | Dextrothyroxine is an antihyperlipidemic. It stimulates the formation of low-density lipoprotein (LDL) and increases the catabolism of LDL thereby leading to increased excretion of cholesterol and bile acids via the biliary route. Group: Pharmaceutical. Alternative Names: D-Thyroxine sodium salt; dynothel; Debetrol; 3:5:3':5'-tetraiodo-d-thyroninesodium; biotirmone; choloxin; dethyrona; detyroxin; dextroid; dextrothyroxinesodium; dextroxin. CAS No. 137-53-1. Pack Sizes: 100 mg. Product ID: B2692-068737. Molecular formula: C15H10I4NNaO4. Mole weight: 798.86. Custom synthesis is available. Send your inquiries for more information. | London |
| Evacetrapib | Evacetrapib (LY2484595) is a drug that inhibits cholesterylester transfer protein, which transfers and thereby increases high-density lipoprotein and lowers low-density lipoprotein. Group: Pharmaceutical. Alternative Names: LY2484595; LY 2484595; LY-2484595. CAS No. 1186486-62-3. Pack Sizes: 10 mg. Product ID: B0084-457317. Molecular formula: C31H36F6N6O2. Mole weight: 638.659. Custom synthesis is available. Send your inquiries for more information. | London |
| FSL-1 TFA salt | FSL-1 is a TLR2/6 peptide agonist (also a putative TLR10 ligand) that activates NF-κB. FSL-1 induces the expression of some pro-inflammatory cytokines such as IL-8, IL-1β, CCL20 and TNF-α in vitro. Group: Pharmaceutical. Alternative Names: FSL 1 TFA salt; FSL1 TFA salt; L-Phenylalanine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-, 2,2,2-trifluoroacetic acid; S-[2,3-Bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine 2,2,2-trifluoroacetic acid; FSL-1 lipoprotein, synthetic TFA salt; Fibroblast-stimulating lipopeptide-1 TFA salt; Pam2-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-OH TFA. Pack Sizes: 5 mg. Product ID: B1370-425891. Molecular formula: C86H141F3N14O20S. Mole weight: 1780.18. Custom synthesis is available. Send your inquiries for more information. | London |
| Lathosterol | Lathosterol is an intermediate in the biosynthesis of cholesterol. Lathosterol in serum is carried on lipoproteins and is indicative of the rate of cholesterol synthesis. It acts as a marker of synthesis of cholesterol and is not affected by dietary consumption of cholesterol. Group: Pharmaceutical. Alternative Names: 5alpha-Cholest-7-en-3beta-ol; Cholest-7-en-3-ol; 7-Cholesten-3-beta-ol. CAS No. 80-99-9. Pack Sizes: 1 g. Product ID: B1370-033919. Molecular formula: C27H46O. Mole weight: 386.65. Custom synthesis is available. Send your inquiries for more information. | London |
| Obicetrapib | Obicetrapib is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors can increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may help reduce the risk of cardiovascular disease. Group: Pharmaceutical. Alternative Names: 1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl][5-(3-carboxypropoxy)-2-pyrimidinyl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, 1-ethyl ester, (2R,4S)-; 1-Ethyl (2R,4S)-4-[[[3,5-bis(trifluoromethyl)phenyl]methyl][5-(3-carboxypropoxy)-2-pyrimidinyl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-1(2H)-quinolinecarboxylate; (2R,4S)-4-[[3,5-Bis(trifluoromethyl)benzyl][5-(3-carboxypropoxy)pyrimidin-2-yl]amino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester; AMG-899; AMG 899; AMG899; TA-8995; TA8995; TA 8995; DEZ-001; DEZ 001; DEZ001; Obicetrapib (free base). CAS No. 866399-87-3. Pack Sizes: 25 mg. Product ID: B1370-447410. Molecular formula: C32H31F9N4O5. Mole weight: 722.6. Custom synthesis is available. Send your inquiries for more information. | London |
| Pitavastatin Impurity 8 | An impurity of Pitavastatin which lowers both total cholesterol and low density lipoprotein cholesterol in animals and humans. Group: Pharmaceutical. Alternative Names: 3,5-Dideoxy-2,4-O-(1-methylethylidene)-D-erythro-hexuronic Acid 1,1-Dimethylethyl Ester. CAS No. 1044518-75-3. Pack Sizes: 25 mg. Product ID: B2694-478922. Molecular formula: C13H22O5. Mole weight: 258.32. Custom synthesis is available. Send your inquiries for more information. | London |
| Rilapladib | Rilapladib is the third genomics-derived small molecule drug as a lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor which is an enzyme associated with the formation of atherosclerotic plaques. Uses: 1-alkyl-2-acetylglycerophosphocholine esterase inhibitors. Group: Pharmaceutical. Alternative Names: GSK 659032; GSK659032; GSK-659032; SB-659032; SB659032; SB 659032; GTPL7376; GTPL-7376; GTPL 7376; D05728. CAS No. 412950-08-4. Pack Sizes: 50 mg. Product ID: B1370-068407. Molecular formula: C40H38F5N3O3S. Mole weight: 735.81. Custom synthesis is available. Send your inquiries for more information. | London |
| Silybin A | Silymarin, isolated from the herb of Silybum marianum (L.) Gaertn, is an antioxidant or free radical scavenger. Silymarin and Prunella vulgaris improve antioxidant status in blood and liver, and positively affect plasma lipoprotein profile in an experimental model of dietary induced hypertriglyceridemia. Both in vitro and animal research suggest that Silymarin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silymarin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells. Silymarin treatment in type II diabetic patients for 4 months has a beneficial effect on improving the glycemic profile. Treatment with silymarin may reduce the lipoperoxidation of cell membranes and insulin resistance, significantly decreasing endogenous insulin overproduction and the need for exogenous insulin administration. Silybin is a natural compound also can be used in cosmetics material. Uses: Protective agents. Group: Pharmaceutical. Alternative Names: Silybin; 4H-1-Benzopyran-4-one, 2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-; (2R,3R)-2-[(2R,3R)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodio | London |
| T0901317 | T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice. Group: Pharmaceutical. Alternative Names: T 0901317; T-0901317; TO-901317; TO901317; N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide; T-1317. CAS No. 293754-55-9. Pack Sizes: 300 mg. Product ID: B0084-369166. Molecular formula: C17H12F9NO3S. Mole weight: 481.33. Custom synthesis is available. Send your inquiries for more information. | London |
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