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| Product | Description | |
|---|---|---|
| Lipid 5 | Lipid 5 is a cationic amino lipid. LNPs incorporating Lipid 5 (from Sabnis et al.) demonstrated potent delivery of mRNA in primates but also were rapidly cleared from the body resulting in low toxicity. Group: Pharmaceutical. Alternative Names: Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate. CAS No. 2089251-33-0. Pack Sizes: 100 mg. Product ID: B1370-376226. Molecular formula: C44H87NO5. Mole weight: 710.18. Custom synthesis is available. Send your inquiries for more information. |  London |
| Lipid ALC-0159 | ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid), specifically, it is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). Group: Pharmaceutical. Alternative Names: 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide; ALC-0159; mPEG-N,N-Ditetradecylacetamide. CAS No. 1849616-42-7. Pack Sizes: 500 mg. Product ID: B2699-051402. Custom synthesis is available. Send your inquiries for more information. | London |
| Lipid ALC-0315 | ALC-0315 can be used to form lipid nanoparticle (LNP, non-viral gene delivery system). Group: Pharmaceutical. Alternative Names: ALC-0315; ((4-Hydroxybutyl)azanediyl)bis(hexane-6,1-diyl) bis(2-hexyldecanoate). CAS No. 2036272-55-4. Pack Sizes: 250 mg. Product ID: B2699-358155. Molecular formula: C48H95NO5. Mole weight: 766.27. Custom synthesis is available. Send your inquiries for more information. | London |
| 08:0 PA (sodium salt) | 08:0 PA (sodium salt) is a phosphatidic acid derivative utilized for investigative endeavors within the biomedical realm. Its properties lend themselves to potential therapeutic interventions in the realm of neurodegenerative pathologies and oncological conditions, while concurrently serving as a tool for delving into the intricacies of lipid homeostasis and signal transduction cascades. Group: Pharmaceutical. Alternative Names: Dioctanoyl phosphatidic acid sodium salt; 1,2-dioctanoyl-sn-glycero-3-phosphate (sodium salt); PA(8:0/8:0) (sodium salt); Sodium 1,2-dioctanoyl-SN-glycero-3-phosphate. CAS No. 321883-54-9. Pack Sizes: 10 mg. Product ID: B1370-363690. Molecular formula: C19H36NaO8P. Mole weight: 446.45. Custom synthesis is available. Send your inquiries for more information. | London |
| 1,18-Octadecanediol | 1,18-Octadecanediol is a natural lipid found in the herb of Spartium japonicum. Group: Pharmaceutical. Alternative Names: Octadecane-1,18-diol. CAS No. 3155-43-9. Pack Sizes: 2 g. Product ID: NP4333. Molecular formula: C18H38O2. Mole weight: 286.5. Custom synthesis is available. Send your inquiries for more information. | London |
| 1,2-dioleoyl-3-trimethylammonium-propane (methyl sulfate salt) | 1,2-dioleoyl-3-trimethylammonium-propane (methyl sulfate salt) is a liposome formulation for cationic lipid DOTAP. DOTAP can be used for the efficiency of DNA transfection, including yeast artificial chromosomes (YAC) transfection to eukaryotic cells used in transient or stable gene expression, and also suitable for efficient will other negatively charged molecules, such as RNA, oligonucleotides, and glutamic acid, the ribosome protein (RNP) complex, and protein, transferred to the study sample of mammalian cells. Group: Pharmaceutical. Alternative Names: DOTAP Transfection Reagent; DOTAP-MS; N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium methyl sulfate; DOTAP methosulfate; 18:1 TAP (DOTAP, MS Salt); n-(2,3-dioleoyloxy-1-propyl) trimethylammonium methyl sulfate. CAS No. 144189-73-1. Pack Sizes: 500 mg. Product ID: BAT-006359. Molecular formula: C43H83NO8S. Mole weight: 774.19. Custom synthesis is available. Send your inquiries for more information. | London |
| 1,2-dioleoyl-sn-glycero-3-succinate | 1,2-Dioleoyl-sn-glycero-3-succinate, a lipid-based molecule of interest, displays significant promise as a potent player in drug delivery systems for the treatment of cancer and other diseases. In virtue of its amphipathic character, it establishes stable nanostructures that can be used for the targeted transportation and delivery of therapeutic agents. Beyond this, its applicability extends to the development of vaccines and gene therapy strategies. Group: Pharmaceutical. Alternative Names: Succinic acid 1-[(2R)-2,3-bis(oleoyloxy)propyl] ester; 18:1 DGS, 1,2-dioleoyl-sn-glycero-3-succinate, chloroform. CAS No. 127640-49-7. Pack Sizes: 1 g. Product ID: B4059-358159. Molecular formula: C43H76O8. Mole weight: 721.06. Custom synthesis is available. Send your inquiries for more information. | London |
| 1,2-Distearoyl-sn-glycero-3-phospho-L-serine sodium salt | 1,2-Distearoyl-sn-glycero-3-phospho-L-serine sodium salt, an imperative lipidic component, finds application in developing liposomes deployed for efficacious drug delivery. This compound exhibits a remarkable efficacy in targeting neoplastic cells and delivering pharmacological agents directly to the site of the malignancy. Moreover, this chemical entity holds immense potential in combating neurodegenerative maladies, such as Alzheimer's. Group: Pharmaceutical. Alternative Names: 3-sn-Phosphatidyl-L-serine, distearoyl sodium salt; DSPS-Na; PS(18:0/18:0); (2S,8R)-2-Amino-5-hydroxy-11-oxo-8-[(1-oxooctadecyl)oxy]-4,6,10-trioxa-5-phosphaoctacosanoic acid 5-oxide sodium salt. CAS No. 321595-13-5. Pack Sizes: 25 mg. Product ID: B4059-188606. Molecular formula: C42H81NNaO10P. Mole weight: 814.05. Custom synthesis is available. Send your inquiries for more information. | London |
| 13-Oxo-9E,11E-octadecadienoic acid | 13-Oxo-9E,11E-octadecadienoic acid is a lipid that is isolated from the leaves of Artemisia argyi. Group: Pharmaceutical. CAS No. 29623-29-8. Pack Sizes: 5 mg. Product ID: B0005-053960. Molecular formula: C18H30O3. Mole weight: 294.43. Custom synthesis is available. Send your inquiries for more information. | London |
| 1-Stearoyl-sn-glycero-3-phosphocholine | 1-Stearoyl-2-hydroxy-sn-glycero-3-PC is a saturated 18:0 lysophosphatidylcholine found in plasma and oxidized LD. Uses: 1-stearoyl-sn-glycero-3-phosphocholine can be used in lipid metabolism studies. Group: Pharmaceutical. Alternative Names: 1-Stearoyl-2-hydroxy-sn-glycero-3-PC; C18:0-PC; Lyso-PC; 1-Octadecanoyl-2-hydroxy-sn-glycero-3-phosphatidylcholine; PC(18:0/0:0); 1-Stearoyl-2-hydroxy-sn-glycero-3-Phosphocholine. CAS No. 19420-57-6. Pack Sizes: 100 mg. Product ID: BAT-006370. Molecular formula: C26H54NO7P. Mole weight: 523.68. Custom synthesis is available. Send your inquiries for more information. | London |
| 3-Amino-2,2,4,4-tetramethylcyclobutanol phosphate | 3-Amino-2,2,4,4-tetramethylcyclobutanol phosphate, a critical biochemical substance, plays an instrumental role in synthesizing phospholipids and mitigating lipid metabolic disorders. Additionally, this compound holds noteworthy potential towards developing drug candidates for conditions such as hyperlipidemia and atherosclerosis. Group: Pharmaceutical. Alternative Names: RP 1541 phosphate. CAS No. 1338812-52-4. Pack Sizes: 100 mg. Product ID: B0001-008682. Molecular formula: C8H20NO5P. Mole weight: 241.22. Custom synthesis is available. Send your inquiries for more information. | London |
| (3S,5S)-Atorvastatin Acetonide tert-Butyl Ester | (3S,5S)-Atorvastatin Acetonide tert-Butyl Ester is a pharmaceutical compound employed in managing hyperlipidemia and cardiovascular disorders. It is a modified form of atorvastatin, acting as a potent HMG-CoA reductase inhibitor to mitigate cholesterol biosynthesis within hepatic cells. This medication plays a pivotal role in ameliorating lipid profiles and averting atherosclerosis progression. Uses: An intermediate for the preparation of (3s,5s)-atorvastatin. Group: Pharmaceutical. Alternative Names: (4S,6S)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester. CAS No. 472967-95-6. Pack Sizes: 25 mg. Product ID: B2692-117415. Molecular formula: C40H47FN2O5. Mole weight: 654.81. Custom synthesis is available. Send your inquiries for more information. | London |
| 5-(4-Chlorobenzylidene)-2,4-thiazolidinedione | 5-(4-Chlorobenzylidene)-2,4-thiazolidinedione, a well-researched organic compound, exhibits remarkable promise in treating diabetes mellitus type 2 owing to its ability to function as an agonist for peroxisome proliferator-activated receptor gamma (PPAR-γ). PPAR-γ is implicated in the modulation of glucose and lipid metabolism. Beyond its anti-diabetic attributes, this compound has been the subject of inquiry for its potential anti-cancer properties. The chemical's therapeutic significance is evidenced by the numerous investigations conducted on its biological activity. Group: Pharmaceutical. Alternative Names: 5-(4-Chloro-benzylidene)-thiazolidine-2,4-dione; 2,4-Thiazolidinedione, 5-[(4-chlorophenyl)methylene]-. CAS No. 24138-83-8. Pack Sizes: 50 mg. Product ID: B0001-284763. Molecular formula: C10H6ClNO2S. Mole weight: 239.673. Custom synthesis is available. Send your inquiries for more information. | London |
| A2-Iso5-2DC18 | A2-Iso5-2DC18 is a top-performing lipid for mRNA delivery in bone marrow-derived dendritic cells (BMDCs), BMDMs and HeLa cells. Group: Pharmaceutical. Alternative Names: ethyl 5,5-di((z)-heptadec-8-en-1-yl)-1-(3-(pyrrolidin-1-yl)propyl)-2,5-dihydro-1h-imidazole-2-carboxylate. Pack Sizes: 1mg;1g;10g. Molecular formula: C47H87N3O2. Mole weight: 726.21. Custom synthesis is available. Send your inquiries for more information. | London |
| ABC294640 | ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. Group: Pharmaceutical. Alternative Names: ABC-294640; ABC294640; ABC 294640; Opaganib; 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide. CAS No. 915385-81-8. Pack Sizes: 1mg;1g;10g. Product ID: 915385-81-8. Molecular formula: C23H25ClN2O. Mole weight: 380.9104. Custom synthesis is available. Send your inquiries for more information. | London |
| ABTL-0812 | ABTL-0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR), rictor-mTOR and dihydrofolate reductase with potential antineoplastic activity. It binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells upon oral administration. It was developed by Ability Pharmaceuticals and is in phase I/II clinical trials for the treatment of solid tumors. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015. Uses: Abtl-0812 has potential antineoplastic activity. it is used for the treatment of solid tumors. Group: Pharmaceutical. Alternative Names: ABTL0812; ABTL 0812; ABTL-0812; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoate. CAS No. 57818-44-7. Pack Sizes: 1mg;1g;10g. Product ID: 57818-44-7. Molecular formula: C18H31O3. Mole weight: 294.93. Custom synthesis is available. Send your inquiries for more information. | London |
| Acetylcorynoline | Acetylcorynoline, which can be extracted from the tubers of Corydalis ambigua, inhibits the maturing of bone marrow-derived dendritic cells in mice. However, it is only cytotoxic in amounts of greater than 20 μM. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. Acetylcorynoline significantly decreases dopaminergic neuron degeneration induced by 6-hydroxydopamine in BZ555 strain; prevents α-synuclein aggregation; recovers lipid content in OW13 strain; restores food-sensing behavior, and dopamine levels; and prolongs life-span in 6-hydroxydopamine-treated N2 strain, thus showing its potential as a possible antiparkinsonian drug. Acetylcorynoline may exert its effects by decreasing egl-1 expression to suppress apoptosis pathways and by increasing rpn5 expression to enhance the activity of proteasomes. Uses: Antifungal/anti-inflammatory. Group: Pharmaceutical. Alternative Names: (5bR,6S,12bR)-5b,6,7,12b,13,14-Hexahydro-5b,13-dimethyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol 6-acetate; Corynoline acetate; O-Acetylcorynoline; [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol,5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-, 6-acetate, (5bR,6S,12bR)-. CAS No. 18797-80-3. Pack Sizes: 10 mg. Product ID: B2703-464490. Molecular formula: C23H23NO6. Mole weight: 409.43. Custom synthesis is available. Send your inqui | London |
| AP1903 | AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. Group: Pharmaceutical. Alternative Names: AP1903; AP 1903; AP-1903; Rimiducid. CAS No. 195514-63-7. Pack Sizes: 50 mg. Product ID: B1370-462662. Molecular formula: C78H98N4O20. Mole weight: 1411.63. Custom synthesis is available. Send your inquiries for more information. | London |
| Astaxanthin | Astaxanthin is a carotenoid pigment found mostly in animal organisms, but also occurring in plants. It is thought to be the precursor of astacin. It is a potent lipid-soluble antioxidant. It has broad application prospects in health products, medicine, cosmetics, food additives and aquaculture. Astaxanthin is a natural antioxidant with the strongest antioxidant and anti-aging ability in nature, and its antioxidant capacity is much higher than VE and β-carotene. It significantly enhances mitochondrial activity required for cell recombination and effectively protects the skin from UVA, UVB and blue light damage. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: Ovoester; Astaxanthine; (3S,3'S)-Astaxanthin; All-trans-Astaxanthin; 3,3'-Dihydroxy-β,β-carotene-4,4'-dione; 3,3'-Dhydroxy-4,4'-diketo-β-carotene; trans-Astaxanthin; (3S,3'S)-all-trans-Astaxanthin; (6S,6'S)-3,3'-((1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl)bis(6-hydroxy-2,4,4-trimethylcyclohex-2-enone). CAS No. 472-61-7. Pack Sizes: 10 g. Product ID: BBF-05817. Molecular formula: C40H52O4. Mole weight: 596.84. Custom synthesis is available. Send your inquiries for more information. | London |
| Atorvastatin USP Related Compound A | Atorvastatin USP Related Compound A is an impurity in the synthesis of Atorvastatin, which is a competitive HMG-CoA reductase inhibitor. Atorvastatin is a lipid-lowering medication of the statin class. Atorvastatin suppresses the production of cholesterol and prevents some cardiovascular diseases. Group: Pharmaceutical. Alternative Names: Calcium (3R,5R)-7-[2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate (1:2); Atorvastatin Desfluoro impurity; (3R,5R)-7-[3-(phenylcarbamoyl)-2-isopropyl-4,5-diphenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoicacid, calcium salt; USP Atorvastatin Related Compound A; Defluoro Atorvastatin Calcium Salt; Atorvastatin Related Compound A; Calcium (3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate; 1H-Pyrrole-1-heptanoic acid, β,δ-dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-, calcium salt (2:1), (βR,δR)-; Calcium (βR,δR)-β,δ-dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoate (1:2). CAS No. 433289-83-9. Pack Sizes: 100 mg. Product ID: B0190-168852. Molecular formula: C66H70CaN4O10. Mole weight: 1119.38. Custom synthesis is available. Send your inquiries for more information. | London |
| AtuFECT01 | AtuFect01 is part of the lipid system AtuPLEX and shows more effective siRNA binding activity and delivery to vascular endothelial cells. Group: Pharmaceutical. Alternative Names: β-Alaninamide, L-arginyl-2-amino-N-hexadecyl-N-(9Z)-9-octadecenyl-, trihydrochloride, (2S)-; β-Alaninamide, L-arginyl-2-amino-N-hexadecyl-N-(9Z)-9-octadecen-1-yl-, hydrochloride (1:3), (2S)-; (S)-2-amino-N-((S)-2-amino-3-(hexadecyl((Z)-octadec-9-en-1-yl)amino)-3-oxopropyl)-5-guanidinopentanamide trihydrochloride. CAS No. 869094-19-9. Pack Sizes: 10 mg. Product ID: BRP-02120. Molecular formula: C43H87N7O2.3HCl. Mole weight: 843.58. Custom synthesis is available. Send your inquiries for more information. | London |
| Avicularin | Avicularin, a natural plant flavonoid isolated from the herbs of Polygonum aviculare, exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. By decreasing C/EBPα-activated GLUT4-mediated glucose uptake in adipocytes and potently inhibiting fatty acid synthase, avicularin can inhibit the accumulation of the intracellular lipids. Uses: Anti-inflammatory. Group: Pharmaceutical. Alternative Names: Fenicularin; Quercetin 3-alpha-L-arabinofuranoside; Avicularoside. CAS No. 572-30-5. Pack Sizes: 10 mg. Product ID: NP1949. Molecular formula: C20H18O11. Mole weight: 434.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Beauveriolide I | Beauveriolide I is produced by the strain of Beauveria sp. FO-6979. The effect of I and III can inhibit the formation of Lipid droplet. 10μmol/L can reduce the number and size of the cytolipid droplet in the macrophage but it is not cytotoxic to the macrophages. Group: Pharmaceutical. Alternative Names: CHEMBL516093; SCHEMBL15474166. CAS No. 154491-55-1. Pack Sizes: 1mg;1g;10g. Product ID: BBF-00273. Molecular formula: C27H41N3O5. Mole weight: 487.63. Custom synthesis is available. Send your inquiries for more information. | London |
| Beauveriolide III | Beauveriolide III is produced by the strain of Beauveria sp. FO-6979. The effect of I and III can inhibit the formation of Lipid droplet. 10μmol/L can reduce the number and size of the cytolipid droplet in the macrophage but it is not cytotoxic to the macrophages. Group: Pharmaceutical. Alternative Names: CHEMBL409855; SCHEMBL16174055. CAS No. 221111-70-2. Pack Sizes: 1mg;1g;10g. Product ID: BBF-00274. Molecular formula: C27H41N3O5. Mole weight: 487.63. Custom synthesis is available. Send your inquiries for more information. | London |
| Benfotiamine | Benfotiamine is an amphiphilic S-acyl thiamine derivative used as a lipid soluble alternative source of bioavailable thiamine. Benfotiamine is being investigated in a variety of therapeutic applications. Uses: Adjuvants, immunologic. Group: Pharmaceutical. Alternative Names: Benzenecarbothioic acid, S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester; Benzoylthiamine monophosphate; Berdi; Betivina; Bietamine; Biotamin; Milgamma; Nitanevril; S-Benzoylthiamine O-monophosphate; Tabiomyl; Vitanevril; BTMP; Benzenecarbothioic acid, S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester; Benzoic acid, thio-, S-ester with N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide dihydrogen phosphate (ester); Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)-, S-benzoate O-(dihydrogen phosphate); 8088CB; Benfothiamine; Benzoylthiamine O-monophosphate; N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide S-benzoate O-phosphate; Neurostop; S-Benzoylthiamine monophosphate. CAS No. 22457-89-2. Pack Sizes: 500 g. Product ID: B1370-063311. Molecular formula: C19H23N4O6PS. Mole weight: 466.45. Custom synthesis is available. Send your inquiries for more information. | London |
| β-Cyclodextrin, methyl ethers | β-Cyclodextrin, methyl ethers has been used to improve the water solubility of various compounds and extract cholesterol from lipid membranes. Group: Pharmaceutical. Alternative Names: b-Cyclodextrin methyl ethers; Methyl-b-cyclodextrin. CAS No. 128446-36-6. Pack Sizes: 100 g. Product ID: B1999-056768. Custom synthesis is available. Send your inquiries for more information. | London |
| Blumeatin | Blumeatin is found in tea and is extracted from the herbs of Blumea balsamifera. It can enhance adipocyte differentiation by increasing triglyceride levels in 3T3L1 cells. It also can increase the accumulation of lipid droplets and induce upregulation of the expression of the adipocyte-specific genes GLUT4 and aP2. It inhibits the increase of liver triglyceride and serum alanine aminotransferase, and increases serum beta-lipoprotein, liver glycogen and triglyceride content in CCl4-intoxicated rats, thus shorten the pentobarbital sleeping time in CCl4-intoxicated mice. It shows free radical scavenging activity, xanthine oxidase (XO) inhibitory activity and antioxidant properties. It can protect liver against injury induced by CCl4 and TAA. Group: Pharmaceutical. Alternative Names: 5,3',5'-Trihydroxy-7-methoxyflavanone; 2-(3,5-Dihydroxyphenyl)-5-hydroxy-7-methoxy-3,4-dihydro-2H-1-benzopyran-4-one. CAS No. 118024-26-3. Pack Sizes: 10 mg. Product ID: B1370-267733. Molecular formula: C16H14O6. Mole weight: 302.28. Custom synthesis is available. Send your inquiries for more information. | London |
| C12-200 | C12-200 is almost a macromolecule. It contains multiple tertiary amines, the pKa of which should also be close to but no greater than 7. Ionizable lipids in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. Group: Pharmaceutical. Alternative Names: 1,1'-((2-(4-(2-((2-(Bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol). CAS No. 1220890-25-4. Pack Sizes: 1 g. Product ID: B1370-358162. Molecular formula: C70H145N5O5. Mole weight: 1136.93. Custom synthesis is available. Send your inquiries for more information. | London |
| C16 Ceramide | C16 ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling. It has also been found to activate NF-κB and PKCζ3. Uses: A predominant, rather hydrophobic natural ceramide. activates a cytosolic serine/threonine protein phosphatase in t9 cells; induces egf receptor phosphorylation in a-431 cells; stimulates ceramide-activated protein kinase. Group: Pharmaceutical. Alternative Names: C16 Ceramide (d18:1/16:0); N-(hexadecanoyl)-sphing-4-enine; N-Palmitoylsphingosine. CAS No. 24696-26-2. Pack Sizes: 100 mg. Product ID: B1370-059982. Molecular formula: C34H67NO3. Mole weight: 537.9. Custom synthesis is available. Send your inquiries for more information. | London |
| Capsular polysaccharide | Bacterial polysaccharides are classified into two different types: capsular polysaccharides (K-antigens) (CPS) and exopolysaccharides (EPS). CPS are defined as polymers linked to the cell surface via covalent bond to phospholipid or lipid A molecules, while EPS appear to be released on the cell surface with no attachment to the cell and they are often sloughed off to form slime. Capsular polysaccharides (CPSs) fortify the cell boundaries of many commensal and pathogenic bacteria. Capsular polysaccharide (CPS) or K-antigen that is located on the bacterial surface armors bacteria from host immune response. Group: Pharmaceutical. Alternative Names: CPS. Pack Sizes: 10 mg. Product ID: B1370-099033. Custom synthesis is available. Send your inquiries for more information. | London |
| (-)-Catechin gallate | (-)-Catechin gallate, a minor polyphenolic constituent in green tea, is used to study its cytotoxicity. It enhances Fe(2+)-induced, lipid peroxidation. It also inhibits aromatase activity, an enzyme that converts androgens to estrogen and is thought to play a role in the etiology of breast cancer. Uses: (-)-catechin gallate has been found to be probably effective in restraining tyrosine phosphorylation caused by vegf and have potential activity in the study of breast cancer. Group: Pharmaceutical. Alternative Names: (-)-CG; (-)-Catechin gallate; (2S,3R)-2-(3,4-Dihydroxyphenyl)-3-(3,4,5-trihydroxybenzoyloxy)-3,4-dihydro-2H-1-benzopyran-5,7-diol; 3,4,5-Trihydroxybenzoic acid [[(2S)-2β-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran]-3α-yl] ester. CAS No. 130405-40-2. Pack Sizes: 25 mg. Product ID: B2703-464825. Molecular formula: C22H18O10. Mole weight: 442.37. Custom synthesis is available. Send your inquiries for more information. | London |
| CAY10499 | Monoglyceride lipase (MGL) plays an important role in the metabolism of the lipid transmitter 2-arachidonoylglycerol (2-AG). CAY10499 is a potent and selective monoglyceride lipase (MGL) inhibitor exhibiting an IC50 of 90 nM for the recombinant enzyme. It is also a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC50s = 4.2, 46, 106.7, and 79.8 mM, respectively). Group: Pharmaceutical. Alternative Names: CAY-10499; CAY 10499; Magl-IN-5. CAS No. 359714-55-9. Pack Sizes: 100 mg. Product ID: B1370-292092. Molecular formula: C18H17N3O5. Mole weight: 355.34. Custom synthesis is available. Send your inquiries for more information. | London |
| Cepharanthine | Cepharanthine (CEP) is a biscoclaurine alkaloid isolated from Stephania cepharantha. It has anticancer, antiinflammatory, antiallergic, immunomo- dulatory, and many other interesting biological activities. Cepharanthine has been widely used in Japan for more than 40 years to treat a wide variety of acute and chronic diseases. CEP inhibits tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppresses cytokine production. It has also been shown to scavenge free radicals and to have a protective effect against some of the responses mediated by pro-inflammatory cytokines such as TNF-α, interleukin (IL)-1β and IL6. CEP has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported. Uses: Anti-tumor/anti-inflammatory. Group: Pharmaceutical. Alternative Names: Cepharanthin; NSC-623442; 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan; (+)-Cepharanthine; O-Methylcepharanoline; Cepharantin; [14aS-(14aR*,26aS*)]-2,3,13,14,14a,15,26,26a-Octahydro-22,30-dimethoxy-1,14-dimethyl-1H-4,6:16,19-dietheno-21,25-metheno-12H- | London |
| Ceramide NP | Ceramide NP is a ceramide 3 lipid with aggregation behavior. Ceramide NP has multiple physiological functions like a penetration enhancer and co-emulsifier, playing an important role in barrier function stability. Group: Pharmaceutical. Alternative Names: Ceramide 3B; Ceramide 3; Ceramide IIIB; N-octadecanoylphytosphingosine. CAS No. 178436-06-1. Pack Sizes: 5 g. Product ID: B1370-099098. Molecular formula: C36H71NO4. Mole weight: 581.95. Custom synthesis is available. Send your inquiries for more information. | London |
| CHIR-090 | CHIR-090 is a very potent and tight-binding inhibitor of LpxC, which is a zinc-dependent amidase and present in almost all Gram-negative bacteria, and is a promising target for the development of novel antibiotic substances against multigrug-resistant Gram-negative bacteria. Its Ki value is 4.0 nM. It displays two-step time-dependent inhibition and kills a wide range of Gram-negative pathogens as effectively as ciprofloxacin or tobramycin. It has a different selectivity with the reported LpxC inhibitor L-161. It has excellent antibiotic activity against Pseudomonas aeruginosa and Escherichia coli by inhibiting LpxC orthologs at low nM concentrations. It is an excellent lead for the further development of new antibiotics targeting the lipid A pathway. Uses: Chir-090 displays two-step time-dependent inhibition and kills a wide range of gram-negative pathogens as effectively as ciprofloxacin or tobramycin. it has excellent antibiotic activity against pseudomonas aeruginosa and escherichia coli by inhibiting lpxc orthologs at low nm concentrations. Group: Pharmaceutical. Alternative Names: CHIR-090; CHIR 090; CHIR090. N-[(1S,2R)-2-Hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[[4-(4-morpholinylmethyl)phenyl]ethynyl]benzamide. CAS No. 728865-23-4. Pack Sizes: 300 mg. Product ID: B0084-474822. Molecular formula: C24H27N3O5. Mole weight: 437.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Cholesteryl Hydroxystearate | Cholesteryl Hydroxystearate, a prominent lipid-based compound in biomedical research, possesses a strong potential for treating atherosclerosis and other cardio related conditions. It plays a crucial role in maintaining cholesterol level homoeostasis, which further contributes to its therapeutic potential. A promising candidate for hypercholesterolemia treatment, Cholesteryl Hydroxystearate could have a significant impact on future drug development. Group: Pharmaceutical. Alternative Names: Salacos HS; Estemol CHS; Cholesterol 12-hydroxystearate. CAS No. 40445-72-5. Pack Sizes: 10 g. Product ID: B0001-021780. Molecular formula: C45H80O3. Mole weight: 669.132. Custom synthesis is available. Send your inquiries for more information. | London |
| Choline Fenofibrate | Choline fenofibrate is a hydrophilic formulation of fenofibric acid that acts primarily by activating peroxisome proliferator-activated receptor alpha (PPARα). This nuclear receptor modulates the transcription of genes involved in lipid metabolism. Once activated, PPARα increases the expression of lipoprotein lipase (LPL), which hydrolyzes triglycerides in lipoproteins, thereby reducing plasma triglyceride levels. It also decreases the production of apolipoprotein C-III (ApoC-III), an inhibitor of LPL, further promoting triglyceride breakdown. Additionally, choline fenofibrate stimulates the synthesis of high-density lipoprotein cholesterol (HDL-C) by upregulating the expression of apolipoprotein A-I (ApoA-I) and apolipoprotein A-II (ApoA-II). This multifaceted mechanism helps in managing mixed dyslipidemia by lowering triglycerides and increasing HDL-C levels. Group: Pharmaceutical. Alternative Names: Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate (1:1); Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid (1:1); ABT 335; FNFC; Trilipix. CAS No. 856676-23-8. Pack Sizes: 5 g. Product ID: B0084-259938. Molecular formula: C22H28ClNO5. Mole weight: 421.91. Custom synthesis is available. Send your inquiries for more information. | London |
| CMX 001 | CMX 001 is an antiviral inhibitor, working against BK polymavirus replication in primary human urothelial cells.An alkoxyalkyl ester prodrug containing the synthetic, acyclic nucleoside monophosphate analog cidofovir linked, through its phosphonate group, to a lipid, 3-hexadecyloxy-1-propanol, with antiviral activity against double-stranded DNA viruses. Uses: Broad spectrum antiviral drug. Group: Pharmaceutical. Alternative Names: CMX 001; CMX-001; CMX001; HDP-CDV; HDPCDV; Brincidofovir; [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic acid. CAS No. 444805-28-1. Pack Sizes: 50 mg. Product ID: B0084-459195. Molecular formula: C27H52N3O7P. Mole weight: 561.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Coenzyme Q9 | Coenzyme Q9 is a co-enzyme that is lipid solumbe compononet of cell membranes. It is useful in electron and proton transport of liposome systems. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis. Group: Pharmaceutical. Alternative Names: 2,5-cyclohexadiene-1,4-dione, 2,3-dimethoxy-5-methyl-6-((2E,6E,10E,14E,18E,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaen-1-yl)-; coenzyme Q9; CoQ9; ubiquinone 9; ubiquinone 9, (Z,Z,Z,Z,Z,E,E,E)-isomer; ubiquinone Q-9; ubiquinone-9. CAS No. 303-97-9. Pack Sizes: 50 mg. Product ID: B2699-305013. Molecular formula: C54H82O4. Mole weight: 795.23. Custom synthesis is available. Send your inquiries for more information. | London |
| Curcumin | Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). Curcumin is a natural phenolic antioxidant extracted from the rhizome of turmeric, curcuma, mustard, curry, turmeric and so on. It is a rare pigment with diketone in the plant kingdom. It is a commonly used seasoning and food coloring and is non-toxic. It has the pharmacological effects of making the uterus produce paroxysmal contractions, reducing blood cholesterol, anti-gallbladder, anti-infection, antiviral, antibacterial, antioxidant (stronger than α-tocopherol), anticoagulation, lowering blood lipids and anti-atherosclerosis. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; Natural Yellow 3; Curcuma; Curcumin I; Curcumine; Diferuloylmethane; Haidr; Halad; Haldar; Ukon; Turmeric Yellow; NSC32982. CAS No. 458-37-7. Pack Sizes: 1 kg. Product ID: NP5248. Molecular formula: C21H20O6. Mole weight: 368.38. Custom synthesis is available. Send your inquiries for more information. | London |
| Cynarin | Cynarin, phenolic compound, is an antichoke agent with a variety of biological activities including antioxidant, antihistamic and antiviral activities. Cynarin is used in weight loss and lipid-lowering formulas, liver protection and anti-alcoholic drugs, etc. Group: Pharmaceutical. Alternative Names: Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-; (1R,3R,4S,5R)-1,3-Bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxycyclohexanecarboxylic acid; Cinnamic acid, 3,4-dihydroxy-, 1-carboxy-4,5-dihydroxy-1,3-cyclohexylene ester; Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-; Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-4,5-dihydroxy-, [1R-(1α,3α,4α,5β)]-; Cynarine; 1,3-Dicaffeoylquinic acid; 1,5-Dicaffeoylquinic acid; Cinarin; Cinarine. CAS No. 30964-13-7. Pack Sizes: 25 mg. Product ID: B2703-007275. Molecular formula: C25H24O12. Mole weight: 516.45. Custom synthesis is available. Send your inquiries for more information. | London |
| CZ415 | CZ415 is a highly selective potent mTOR inhibitor with little activity on other lipid and protein kinases with efficacy in a collagen induced arthritis model and exhibits excellent cell permeability. In the issue, Bergamini et al., who has identified CZ415, confirmed with its extraordinary selectivity, drug-like properties and proven efficacy in vivo, CZ415 represents an ideal molecule for the pharmacological investigation of mTOR pathophysiological role in vivo. Assessed in dose response format from HEK293T cells after treatment with CZ415: 1. inhibition of S6RP (downstream of mTORC1) phosphorylation in HEK293T: IC50 = 14.5 nM; 2. inhibition of Akt (mTORC2 substrate) phosphorylation in HEK293T: IC50 = 14.8 nM; 3. inhibition of IFNγ release in stimulated human whole blood: IC50 = 226 nM. Group: Pharmaceutical. Alternative Names: CZ415; CZ-415; CZ 415; (S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea. CAS No. 1429639-50-8. Pack Sizes: 5 mg. Product ID: B0084-474821. Molecular formula: C22H29N5O4S. Mole weight: 459.57. Custom synthesis is available. Send your inquiries for more information. | London |
| Deoxyandrographolide | Deoxyandrographolide is a natural compound extracted from the herbs of Andrographis paniculata (Burm. f.) Nees. It could potently inhibit the growth of liver (HepG2 and SK-Hep1) and bile duct (HuCCA-1 and RMCCA-1) cancer cells. It controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. It was capable of preventing the development of fatty liver through AMPK-mediated regulation of lipid metabolism. It reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microM. It reduced PAF-induced calcium flux in the presence of extracellular calcium. It mediated activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism. Uses: Deoxyandrographolide could potently inhibit the growth of liver (hepg2 and sk-hep1) and bile duct (hucca-1 and rmcca-1) cancer cells. it controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. it reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microm. it reduced p. Group: Pharmaceutical. Alternative Names: 4-[2-[(4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-2,5,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalen-1-yl]ethyl]-2H-furan-5-one;2 | London |
| Dimethylmethoxy chromanol | Dimethylmethoxy chromanol can professionally scavenge free radicals, has a double scavenging effect on RNS and RCS, and effectively clears singlet oxygen activity, reduces lipid peroxidation in human cells, resists photooxidation, protects DNA, improves cell vitality and reduces oxidative stress. It is particularly suitable for use in anti-aging, anti-premature aging products. Group: Pharmaceutical. Alternative Names: 3,4-Dihydro-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-ol; 3,4-Dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran; CR 6; Lipochroman; Lipochroman 6. CAS No. 83923-51-7. Pack Sizes: 10 g. Product ID: B1370-137145. Molecular formula: C12H16O3. Mole weight: 208.25. Custom synthesis is available. Send your inquiries for more information. | London |
| DLinDMA | DLinDMA, an ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. Group: Pharmaceutical. Alternative Names: 1,2-dilinoleyloxy-n,n-dimethyl-3-aminopropane; N,N-dimethyl-2,3-bis[(9Z,12Z)-octadeca-9,12-dienoxy]propan-1-amine; N,N-Dimethyl-2,3-bis(((9Z,12Z)-octadeca-9,12-dien-1-yl)oxy)propan-1-amine. CAS No. 871258-12-7. Pack Sizes: 100 mg. Product ID: B4059-051365. Molecular formula: C41H77NO2. Mole weight: 616.05. Custom synthesis is available. Send your inquiries for more information. | London |
| DLin-KC2-DMA | DLin-KC2-DMA is a cationic/ionizable lipid for siRNA delivery. DLin-KC2-DMA was formulated and characterized in SNALP and demonstrated to have in vivo activity at siRNA doses as low as 0.01 mg/kg in rodents and 0.1 mg/kg in nonhuman primates. Group: Pharmaceutical. Alternative Names: 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane; N,N-Dimethyl-2,2-di-(9Z,12Z)-9,12-octadecadien-1-yl-1,3-dioxolane-4-ethanamine; 2,2-Dilinoleyl-4-(2-dimethylaminoethyl)-1,3-dioxolane; 2-[2,2-Di-(9Z,12Z)-octadeca-9,12-dienyl-1,3-dioxolan-4-yl]-N,N-dimethylethanamine; DLin-K-XTC2-DMA; Dlin-KC2-DMA; D-Lin-KC2-DMA; XTC; XTC (synthetic lipid). CAS No. 1190197-97-7. Pack Sizes: 10 mg. Product ID: B4059-291966. Molecular formula: C43H79NO2. Mole weight: 642.09. Custom synthesis is available. Send your inquiries for more information. | London |
| D-Lin-MC3-DMA | D-Lin-MC3-DMA is the most potent cationic lipid that has been synthesized for lipid nanoparticles (LNPs) to deliver the siRNA. D-Lin-MC3-DMA is useful for design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. LNP systems containing D-Lin-MC3-DMA can be highly effective, non-toxic pDNA delivery systems for gene expression both in vitro and in vivo. Group: Pharmaceutical. Alternative Names: DLin-MC3-DMA; Butanoic acid, 4-(dimethylamino)-, (10Z,13Z)-1-(9Z,12Z)-9,12-octadecadien-1-yl-10,13-nonadecadien-1-yl ester; RV 28; RV-28; O-(Z,Z,Z,Z-heptatriaconta-6,9,26,29-tetraen-19-yl)-4-(N,N-dimethylamino)butanoate; (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate; MC 3; RV28. CAS No. 1224606-06-7. Pack Sizes: 25 mg. Product ID: B4059-291965. Molecular formula: C43H79NO2. Mole weight: 642.09. Custom synthesis is available. Send your inquiries for more information. | London |
| DLin-MC4-DMA | DLin-MC4-DMA is a cationic lipid which can be used for delivery of nucleic acids. Group: Pharmaceutical. Alternative Names: DLin-M-C4-DMA; (10Z,13Z)-1-(9Z,12Z)-9,12-Octadecadien-1-yl-10,13-nonadecadien-1-yl 5-(dimethylamino)pentanoate. CAS No. 1226909-66-5. Pack Sizes: 50 mg. Product ID: B1370-427866. Molecular formula: C44H81NO2. Mole weight: 656.12. Custom synthesis is available. Send your inquiries for more information. | London |
| DOP-DEDA | DOP-DEDA is a charge-reversible lipid derivative for lipid nanoparticles (LNPs), which are used as delivery systems employed in the field of nucleic acid drugs. Group: Pharmaceutical. Alternative Names: 2-[(2-Aminoethyl)amino]ethyl (R)-2,3-Bis(oleoyloxy)propyl Hydrogen Phosphate. CAS No. 2247753-10-0. Pack Sizes: 1 g. Product ID: B1370-358143. Molecular formula: C43H83N2O8P. Mole weight: 787.12. Custom synthesis is available. Send your inquiries for more information. | London |
| DOPE-PEG-FA ammonium salt | DOPE-PEG-FA is a heterobifunctional PEGylation reagent with an unsaturated DOPE phospholipid and a folic acid. It can be used in targeted drug delivery with the lipid bilayer. Group: Pharmaceutical. Alternative Names: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol)-Folic acid ammonium salt. Pack Sizes: 10 mg. Product ID: B1370-383268. Custom synthesis is available. Send your inquiries for more information. | London |
| DOTMA | DOTMA is one of the first cationic lipid used for gene transfection. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome. Group: Pharmaceutical. Alternative Names: 1,2-Di-O-Octadecenyl-3-Trimethylammonium Propane; Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride; N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium. CAS No. 104872-42-6. Pack Sizes: 50 mg. Product ID: BAT-006262. Molecular formula: C42H84ClNO2. Mole weight: 670.57. Custom synthesis is available. Send your inquiries for more information. | London |
| DPhPC | DPhPC (1,2-Diphytanoyl-sn-glycero-3-PC) is a phospholipid containing the tetramethylated long-chain (16:0) diphytanic acid at the sn-1 and sn-2 positions, which has been used in the creation of lipid bilayer membranes. Group: Pharmaceutical. Alternative Names: Diphytanoyl Phosphatidylcholine; 1,2-Diphytanoyl-sn-glycero-3-PC; 1,2-diphytanoylphosphatidylcholine; 1,2-di-(3,7,11,15-tetramethylhexadecanoyl)-sn-glycero-3-phosphocholine. CAS No. 207131-40-6. Pack Sizes: 500 mg. Product ID: BAT-006268. Molecular formula: C48H96NO8P. Mole weight: 846.27. Custom synthesis is available. Send your inquiries for more information. | London |
| DPPE-mPEG | DPPE-mPEG is a phospholipid containing a polyether unit. It can be used for PEG-biochemical conjugation, and be utilized in micelles, liposomes, and other lipid-based drug carriers. Group: Pharmaceutical. Alternative Names: N-(Carbamoyl-methoxypolyethylene glycol)-1,2-dipalmitoyl-cephalin; N-(Carbonyl-methoxypolyethylenglycol)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine, Carbonyl-methoxypolyethylenglycol labeled; Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxohexadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphaheptacos-1-yl]-ω-methoxy-. CAS No. 205494-72-0. Pack Sizes: 100 mg. Product ID: B4059-254018. Molecular formula: (C2H4O)nC39H76NO10P. Mole weight: 794. Custom synthesis is available. Send your inquiries for more information. | London |
| DSPC | DSPC (1,2-Distearoyl-sn-glycero-3-phosphocholine) is a phosphatidylcholine, which is a phospholipid. It is a natural component of cell membranes and can be used to prepare lipid nanoparticles for mRNA vaccines. It forms part of the delivery system of Moderna and Pfizer COVID-19 vaccines. DSPC is used to produce non-pyrogenic liposomes capable of caging molecules. Group: Pharmaceutical. Alternative Names: 18:0 PC; Distearoylphosphatidylcholine; 1,2-Bis(stearoyl)-sn-g1,2-Bis(stearoyl)-sn-glycero-3-phosphocholinelycero-3-phosphocholine; 1,2-Distearoyl-sn-glycero-3-phosphocholine; 1,2-Dioctadecanoyl-sn-glycero-3-phosphocholine; (R)-2,3-Bis(stearoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate; Di-stearoyl-phosphatidylcholine; NSC 725285; 1,2-DSPC. CAS No. 816-94-4. Pack Sizes: 10 g. Product ID: B2697-191720. Molecular formula: C44H88NO8P. Mole weight: 790.15. Custom synthesis is available. Send your inquiries for more information. | London |
| DSPE-mPEG | DSPE-mPEG is a phospholipid containing a polyether unit. It can be used for PEG-biochemical conjugation, and be utilized in micelles, liposomes, and other lipid-based drug carriers. It is used to study the stability, biodistribution and toxicity of lung-specific liposome anti-tuberculosis drugs. Group: Pharmaceutical. Alternative Names: Poly(oxy-1,2-ethanediyl), α-[6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-; 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)]; N-(Carbonyl-methoxypolyethylenglycol)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine, Carbonyl-methoxypolyethylenglycol labeled; N-(Carbamoyl-methoxy peg)-1,2-distearoyl-cephalin; Poly(oxy-1,2-ethanediyl), alpha-((9R)-6-hydroxy-6-oxido-1,12-dioxo-9-((1-oxooctadecyl)oxy)-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl)-omega-methoxy-; α-[6-Hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-Poly(oxy-1,2-ethanediyl). CAS No. 147867-65-0. Pack Sizes: 1 g. Product ID: BAT-006378. Molecular formula: (C2H4O)nC43H84NO10P. Mole weight: 872.1. Custom synthesis is available. Send your inquiries for more information. | London |
| DSPE-PEG | MPEG2000-DSPE Sodium Salt can be used for the preparation of stabilized nucleic acid-lipid particllipid particles (SNALPs), which represent some of the earliest and best functional siRNA-ABC nanoparticles described. Group: Pharmaceutical. Alternative Names: Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-, sodium salt (1:1); Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-, monosodium salt; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-mPEG-2000, sodium salt; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol) monosodium salt; DSPE-PEG 2000; DSPE-PEG 5000; MPEG 2000 DSPE; MPEG-2000 DSPE; MPEG-DSPE 5000; N-(Carbonyl-methoxypolyethylene glycol 2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt; N-(Carbonyl-methoxypolyethylene glycol)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt; Sunbright DSPE 020CN. CAS No. 247925-28-6. Pack Sizes: 1 g. Product ID: B1370-291962. Molecular formula: (C2H4O)nC43H83NO10P.Na. Custom synthesis is available. Send your inquiries for more information. | London |
| DSPE-PEG(2000)-Amine Ammonium | DSPE-PEG(2000)-Amine Ammonium is a functionalized polyethylene glycol (PEG) conjugated lipid. Uses: Dspe-peg(2000) amine is used to prepare amine-functionalized vesicles and liposomes. Group: Pharmaceutical. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (ammonium salt). CAS No. 474922-26-4. Pack Sizes: 100 mg. Product ID: B4059-286481. Molecular formula: C132H266N3O54P. Mole weight: 2790.52. Custom synthesis is available. Send your inquiries for more information. | London |
| DSPE-PEG Azide (ammonium salt) | DSPE-PEG azide is a functionalized polyethylene glycol (PEG) lipid, used to prepare conjugated polymer nanoparticles. Group: Pharmaceutical. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-azido(polyethylene glycol)-5000] (ammonium salt). CAS No. 1938081-40-3. Pack Sizes: 100 mg. Product ID: B1370-286473. Molecular formula: C268H536N5O122P (average MW due to polydispersity of PEG). Mole weight: 5812.12. Custom synthesis is available. Send your inquiries for more information. | London |
| Eriocitrin | Eriocitrin is a powerful antioxidative flavonoid in lemon with lipid-lowering effects in a rat model of high-fat diet. It might play an important role in the control of the change in glutathione redox status in rat liver during exercise. These findings showed that Eriocitrin was effective in the prevention of oxidative damages caused by acute exercise-induced oxidative stress. Eriocitrin was suggested to be metabolized by intestinal bacteria, and then eriodictyol and 3,4-dihydroxyhydrocinnamic of its metabolite were absorbed. Following administration of Eriocitrin, plasma exhibited an elevated resistance effect to lipid peroxidation. Eriocitrin metabolites functioning as antioxidant agents are discussed. Uses: Antioxidant. Group: Pharmaceutical. Alternative Names: (S)-3',4',5,7-TETRAHYDROXYFLAVANONE-7-[6-O-(ALPHA-L-RHAMNOPYRANOSYL)-BETA-D-GLUCOPYRANOSIDE]; ERIOCITRIN; ERIODICTYL-7-RUTINOSIDE; ERIODICTYOL-7-O-RUTINOSIDE; ERIODICTYOL-7-RUTINOSIDE; (S)-7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5-hydroxy-4H-benzopyran-4-one; (s)-3',4',5,7-tetrahydroxyflavanone-7-[6-o-(α-l-rhamnopyranosyl)-β-d-glucopy. CAS No. 13463-28-0. Pack Sizes: 25 mg. Product ID: B2703-465065. Molecular formula: C27H32O15. Mole weight: 596.53. Custom synthesis is available. Send your inquiries for more information. | London |
| Ezetimibe Phenoxy Glucuronide-[d4] | Ezetimibe Phenoxy Glucuronide-[d4] is the labelled analogue of Ezetimibe Phenoxy Glucuronide, which is a metabolite of Ezetimibe. Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Group: Pharmaceutical. Alternative Names: Ezetimibe D4 Phenoxy Glucuronide. CAS No. 1426174-41-5. Pack Sizes: 10 mg. Product ID: BLP-005427. Molecular formula: C30H25D4F2NO9. Mole weight: 589.57. Custom synthesis is available. Send your inquiries for more information. | London |
| Fenofibric acid | Fenofibric acid is a lipid regulating agent available as delayed release capsules for oral administration. Group: Pharmaceutical. Alternative Names: Fenofibrate Impurity B; 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid; Procetofenic acid; 2-[4'-(p-Chlorobenzoyl)phenoxy]-2-methylpropionic acid; 2-[p-(p-Chlorobenzoyl)phenoxy]-2-methylpropionic acid; FNF acid; LF 153; LF 178 acid; NSC 281318; α-1081; Fenofibrate EP Impurity B; USP Fenofibrate Related Compound B; Fenofibrate USP Related Compound B; Fenofibrate Related Compound B. CAS No. 42017-89-0. Pack Sizes: 100 g. Product ID: NP3513. Molecular formula: C17H15ClO4. Mole weight: 318.75. Custom synthesis is available. Send your inquiries for more information. | London |
| Fingolimod | Fingolimod, a derivative of the fungal metabolite myriocin, is an antagonist of S1P (IC50 of 0.033 nM) which is an extracellular lipid mediator. Fingolimod has been used as an immunomodulating drug to treat multiple sclerosis (MS). Group: Pharmaceutical. Alternative Names: FTY 720; FTY-720; FTY720; 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol. CAS No. 162359-55-9. Pack Sizes: 50 mg. Product ID: NP3693. Molecular formula: C19H33NO2. Mole weight: 307.47. Custom synthesis is available. Send your inquiries for more information. | London |
| FIPI | FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. It rapidly blocks in vivo PA production with subnanomolar potency. It has good pharmacokinetic parameters in rats. It did not significantly inhibit p38 or ERK phosphorylation in bone marrow-derived macrophages stimulated with lipopolysaccharide. It prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. Group: Pharmaceutical. Alternative Names: 5-Fluoro-2-Indolyl des-Chlorohalopemide; N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide; 5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide. CAS No. 939055-18-2. Pack Sizes: 100 mg. Product ID: B2693-438324. Molecular formula: C23H24FN5O2. Mole weight: 421.47. Custom synthesis is available. Send your inquiries for more information. | London |
| Gemcabene | Gemcabene is an orally available lipid-lowering small molecule designed to target known lipid metabolic pathways, as an adjunctive therapy to reduce LDL-C, hsCRP and triglycerides (TGs). Currentl, Gemcabene is under Phase-II clinical trials in Hypertriglyceridaemia in USA. Group: Pharmaceutical. Alternative Names: 6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid; gemcabene; 6,6'-oxybis(2,2-dimethylhexanoic acid); PD72953; PD 72953; PD-72953. CAS No. 183293-82-5. Pack Sizes: 100 mg. Product ID: B0084-244917. Molecular formula: C16H30O5. Mole weight: 302.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Geranylgeraniol | An intermediate in the lipidation of proteins, which plays a great importance for a variety of biological processes such as cell signalling. Group: Pharmaceutical. Alternative Names: Tetraprenol; Geranyl geraniol; (E,E,E)-Geranylgeraniol; trans-Geranylgeraniol; 3,7,11,15-tetramethylhexadeca-2E,6E,10E,14-tetraen-1-ol. CAS No. 24034-73-9. Pack Sizes: 5 g. Product ID: B2692-059518. Molecular formula: C20H34O. Mole weight: 290.48. Custom synthesis is available. Send your inquiries for more information. | London |
| GGTI-2418 | GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. GGTase I catalyzes the lipid posttranslational modification which is required for the function of Rho GTPases (frequently found aberrantly activated in human cancer). GGTase I inhibitors block Rho function in cancer cells and induce a G1 phase cell cycle arrest by a mechanism involving induction of the CDK inhibitors p21waf and p27kip, CDK2 and CDK4 inhibition and hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation of PI3K/Akt. Group: Pharmaceutical. Alternative Names: GGTI 2418; GGTI-2418; GGTI 2418. CAS No. 501010-06-6. Pack Sizes: 2.5 mg. Product ID: B0084-462530. Molecular formula: C23H31N5O4. Mole weight: 441.532. Custom synthesis is available. Send your inquiries for more information. | London |
| (±)-Hexanoylcarnitine chloride | (±)-Hexanoylcarnitine chloride is an intermediate in lipid metabolism and a homolog of acetylcarnitine chloride. Group: Pharmaceutical. Alternative Names: DL-Caproylcarnitine chloride; 3-Carboxy-2-(hexanoyloxy)-N,N,N-trimethylpropan-1-aminium chloride. CAS No. 6920-35-0. Pack Sizes: 1mg;1g;10g. Product ID: 6920-35-0. Molecular formula: C13H26ClNO4. Mole weight: 295.81. Custom synthesis is available. Send your inquiries for more information. | London |
| Idebenone | Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant. Idebenone is a smart promoting drug, which is mainly used in the treatment of many degenerative diseases of the central nervous system related to oxidative compressions, such as Parkinson's disease, Alzheimer's disease, multi-infarct dementia, cerebral anemia and cerebral failure, and is also used in the treatment of Friedreich's ataxia. It can also be used in cosmetic formulations to clear free radicals, inhibit lipid peroxidation, inhibit inflammation, inhibit DNA damage, photoprotection, reduce pigmentation, and other cosmetic effects. Group: Pharmaceutical. Alternative Names: CV 2619; CV-2619; CV2619; Catena; Raxone; Sovrima; 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione; 2,3-Dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone; 2,3-Dimethoxy-6-(10-hydroxydecyl)-5-methyl-1,4-benzoquinone; 2-(10-Hydroxy-decyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone; Avan; Daruma; Hydroxydecyl ubiquinone; Mnesis. CAS No. 58186-27-9. Pack Sizes: 10 g. Product ID: NP3168. Molecular formula: C19H30O5. Mole weight: 338.44. Custom synthesis is available. Send your inquiries for more information. | London |
| Imetelstat | Imetelstat is a telomerase inhibitor, also a synthetic lipid-conjugated, 13-mer oligonucleotide N3' P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the template region of telomerase RNA (hTR), imetelstat acts as a competitive enzyme inhibitor that binds and blocks the active site of the enzyme (a "telomerase template antagonist"), a mechanism of action which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase activity through telomerase mRNA binding. Inhibition of telomerase activity in tumor cells by imetelstat results in telomere shortening, which leads to cell cycle arrest or apoptosis. Group: Pharmaceutical. Alternative Names: Rytelo; GRN163L. CAS No. 868169-64-6. Pack Sizes: 1 mg. Product ID: B1370-462541. Custom synthesis is available. Send your inquiries for more information. | London |
| KRN7000 | KRN7000 is a synthetic analog of α-galactosylceramide and the marine natural product agelasphin. It is a specific ligand for human and mouse NKT cells and remains the best studied ligand of the lipid-binding MHC class I-like protein CD1d. It protects against LPS-induced shock and displays potent antitumor activity in various in vivo models. Group: Pharmaceutical. Alternative Names: a-Gal-Cer; N-[(1S,2S,3R)-1-[(a-D-Galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]hexacosanamide. CAS No. 158021-47-7. Pack Sizes: 1 mg. Product ID: B1370-001131. Molecular formula: C50H99NO9. Mole weight: 858.32. Custom synthesis is available. Send your inquiries for more information. | London |
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