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| Product | Description | |
|---|---|---|
| 1kg Deep Blue Pro Pool Multi Stain Remover | Deep Blue Pro Multi-Stain Remover Granules are used for the removal of coloured metal stains on swimming pool surfaces. The product contains a special blend of three organic acids and has been specifically developed to remove coloured stains (copper, iron and manganese) from swimming pool surfaces. Product may be sprinkled directly over the stained areas or evenly distributed around the pool. It is important to follow the instructions on the packaging when applying to coloured marble or printed vinyl liners. It can be used on concrete, fibreglass or vinyl liner pools. Use as an all over treatment for stain removal or as a spot treatment. 1kg will treat up to 15,000 gallons. For the removal of coloured metal stains on swimming pool surfaces Multi-stain remover contains a special blend of three organic acids The product has been specifically developed to remove coloured stains (copper, iron and manganese) from swimming pool surfaces Use 1kg of granules per 50,000 litres (11000 gallons) o . Uses: Swimming pools, hot tubs. Maintenance. Grades: A+. Product ID: 5060220113381. MPN: DBPRCH098S. Brand: Deep Blue Pro. Categories: Pool Chemicals. |  Lincolnshire, Wiltshire, Online |
| 1kg Deep Blue Pro Pool Multi Stain Remover - Box of 6 | Deep Blue Pro Multi-Stain Remover Granules are used for the removal of coloured metal stains on swimming pool surfaces. The product contains a special blend of three organic acids and has been specifically developed to remove coloured stains (copper, iron and manganese) from swimming pool surfaces. Product may be sprinkled directly over the stained areas or evenly distributed around the pool. It is important to follow the instructions on the packaging when applying to coloured marble or printed vinyl liners. It can be used on concrete, fibreglass or vinyl liner pools. Use as an all over treatment for stain removal or as a spot treatment. 1kg will treat up to 15,000 gallons. For the removal of coloured metal stains on swimming pool surfaces Multi-stain remover contains a special blend of three organic acids The product has been specifically developed to remove coloured stains (copper, iron and manganese) from swimming pool surfaces Use 1kg of granules per 50,000 litres (11000 gallons) o . Uses: Swimming pools, hot tubs. Maintenance. Grades: A+. Product ID: 5060220113374. MPN: DBPRCH098. Brand: Deep Blue Pro. Categories: Pool Chemicals. | Lincolnshire, Wiltshire, Online |
| 1 Litre Deep Blue Pro Pool Leak Sealer | Leak Sealer - 1 litre - For minor leaks in swimming pools and spas. This leak sealer remains the professionals ; favourite. Its special formula can seal small holes/leaks in hot tub & swimming pool pipework & swimming pool 'liners'. It CANNOT be guaranteed to fix 'every leak' but it is remarkable nevertheless and if you call out a repair company they will more than probably try this product first anyway! Save a fortune and do it yourself. This bottle will treat up to 60,000 litres of water. Directions for Use 1) Turn pool pump off. Remove any automatic pool cleaner from the pool. 2) Set the filter on By-pass or re-circulate setting. If neither of these settings are available then remove the filter grids or cartridges from the filter prior to commencing treatment. 3) Leak Sealer should be added to the pool at the rate of 1 litre per 60,000 litres of pool water. There are two methods of application depending on the location of the leak. A) Leak in pool walls or floor - add the leak . Uses: Swimming pools, hot tubs. Maintenance. Grades: A+. Product ID: 5060220113237. MPN: DBPRCH102S. Brand: Deep Blue Pro. Categories: Pool Chemicals. | Lincolnshire, Wiltshire, Online |
| 1 Litre Deep Blue Pro Pool Leak Sealer - Box of 6 | Leak Sealer - 1 litre - For minor leaks in swimming pools and spas. This leak sealer remains the professionals ; favourite. Its special formula can seal small holes/leaks in hot tub & swimming pool pipework & swimming pool 'liners'. It CANNOT be guaranteed to fix 'every leak' but it is remarkable nevertheless and if you call out a repair company they will more than probably try this product first anyway! Save a fortune and do it yourself. This bottle will treat up to 60,000 litres of water. Directions for Use 1) Turn pool pump off. Remove any automatic pool cleaner from the pool. 2) Set the filter on By-pass or re-circulate setting. If neither of these settings are available then remove the filter grids or cartridges from the filter prior to commencing treatment. 3) Leak Sealer should be added to the pool at the rate of 1 litre per 60,000 litres of pool water. There are two methods of application depending on the location of the leak. A) Leak in pool walls or floor - add the leak . Uses: Swimming pools, hot tubs. Maintenance. Grades: A+. Product ID: 5060220113220. MPN: DBPRCH102. Brand: Deep Blue Pro. Categories: Pool Chemicals. | Lincolnshire, Wiltshire, Online |
| ARV-825 | ARV-825 is a BRD4 inhibitor based on PROTAC technology. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4. In post-myeloproliferative neoplasm secondary (s) AML cell lines, treatment with ARV-825 induces apoptosis and inhibits cell proliferation. Group: Pharmaceutical. CAS No. 1818885-28-7. Pack Sizes: 100 mg. Product ID: B1370-474664. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| AS 1842856 | AS 1842856 is a potent and selective inhibitor of Forkhead box protein O1 transcription factor (FoxO1; IC50 = 33 nM). AS 1842856 reduces glucose production in dose manner via the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. AS 1842856 is promisingly to be a therapy of type 2 diabetes mellitus and obesity. Uses: Potential treatment of type 2 diabetes mellitus and obesity. Group: Pharmaceutical. CAS No. 836620-48-5. Pack Sizes: 200 mg. Product ID: B1370-054875. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BAY-1895344 | BAY-1895344 is a selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor that inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). BAY-1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas, and it is undergoing a phase I clinical trial of safety and tolerability for cancer patients. Uses: A selective atr (ataxia-telangiectasia and rad3 related protein) inhibitor used for the treatment of advanced solid tumors and lymphomas. Group: Pharmaceutical. CAS No. 1876467-74-1. Pack Sizes: 10 mg. Product ID: B0084-484682. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Chrysophanol | Chrysophanic acid (Chrysophanol) is a natural anthraquinone with anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 μm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. Chrysophanol is a natural compound found in the roots and rhizomes of Rheum palmatum L. It can be used in cosmetics material. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 481-74-3. Pack Sizes: 1 g. Product ID: NP0901. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cirsimaritin | Cirsimaritin is purified from the herbs of Microtea debilis. Cirsimaritin has the potential use in patients with congestive heart failure that can mitigate cardiac remodeling and left ventricular dysfunction through augmenting myocardial autophagy and decreasing matrix metalloproteinase-2&9 activities. Cirsimaritin inhibits the growth of tumor cells and induces mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), and it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt. Cirsimaritin shows moderate anti-proliferative activity against COLO-205 cells with IC 50 values of 13.1uM. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner; support the putative application of cirsimaritin in ultraviolet photoprotection and hair coloration treatments. Group: Pharmaceutical. CAS No. 6601-62-3. Pack Sizes: 5 mg. Product ID: NP2021. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Defluoro Linezolid | Defluoro Linezolid is an impurity of Linezolid, which is an antibiotic used for the treatment of infections caused by Gram-positive bacteria. Group: Pharmaceutical. CAS No. 556801-15-1. Pack Sizes: 100 mg. Product ID: B2694-472430. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Dovitinib | Dovitinib (TKI258) potently inhibited FLT3, c-KIT, FGFR, VEGFR1/2/3, PDGFRß and CSF-1R with IC50 values of 1, 2, 5, 10, 8, 27, 36 nM respectively. Dovitinib selectively blocked the growth of wild-type (WT) or activated mutant FGFR3-transformed B9 cells and human myeloma cell lines. Dovitinib was an effective treatment in a xenograft mouse model of FGFR3 multiple myeloma. Group: Pharmaceutical. CAS No. 405169-16-6. Pack Sizes: 50 mg. Product ID: B2693-091881. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ganoderiol F | Lansiumarin C is a natural coumarin found in the branches of Clausena lansium. and found to induce senescence of cancer cell lines, it induces growth arrest of cancer cell lines HepG2, Huh7 and K562; activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 were found in early stages of Ganoderiol F treatment and were presumed to cause cell-cycle arrest and trigger premature senescence of HepG2 cells; suggests that the growth-arrest and senescence induction capability on cancer cells suggest anticancer potential of Ganoderiol F. It could be developed further as both anti-HIV and antimalaria.In Compared to plasmepsin I, ganoderiol-F is higher towards HIV-1 protease. Uses: Anti-inflammatory; anti-hiv. Group: Pharmaceutical. CAS No. 114567-47-4. Pack Sizes: 1 mg. Product ID: NP6829. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ML241 | ML241 is a selective p97 ATPase inhibitor and IC50 value is 100 nM. It can inhibit degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the treatment of cancer. Uses: Anticancer. Group: Pharmaceutical. CAS No. 1346528-06-0. Pack Sizes: 100 mg. Product ID: B0084-475332. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mubritinib | Mubritinib, also known as TAK-165, is a protein kinase inhibitor which was under development by Takeda for the treatment of cancer. It completed phase I clinical trials (may be discontinued since 2008). Mubritinib(TAK 165) is a potent EGFR, HER2 and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 μM, respectively. Mubritinib(TAK 165) also inhibits p33cdk2 and p33cdk5. Mubritinib(TAK 165) displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Mubritinib(TAK 165) exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo. Group: Pharmaceutical. CAS No. 366017-09-6. Pack Sizes: 50 mg. Product ID: B0084-067201. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (R)-Linezolid | (R)-Linezolid is an enatiomeric impurity of Linezolid, an antibiotic used for the treatment of infections caused by Gram-positive bacteria. Group: Pharmaceutical. CAS No. 872992-20-6. Pack Sizes: 1 g. Product ID: B1370-472432. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SCH772984 | SCH772984 is a potent and selective ERK inhibitor with potential anticancer activity. SCH722984 showed activity against BRAF mutant, NRAS mutant and wild-type melanoma. Combining vemurafenib and SCH722984 in BRAF mutant melanoma was synergistic in a majority of cell lines and significantly delayed the onset of acquired resistance in long term in vitro assays. Therefore, SCH772984 may be clinically applicable as a treatment for non-BRAF mutant melanoma or in BRAF-mutant melanoma with innate or acquired resistance, alone or in combination with BRAF inhibitors. Group: Pharmaceutical. CAS No. 942183-80-4. Pack Sizes: 25 mg. Product ID: B2693-429803. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| TAS-102 | TAS-102 is a combination drug composed of the cytotoxic pyrimidine analog Trifluridine (5-trifluoro-2'-deoxythymidine or TFT) and a thymidine phosphorylase inhibitor (TPI) tipiracil hydrochloride, in a molar ratio of 1.0:0.5 (TFT:TPI). TAS-102 is used as a third- or fourth-line treatment of metastatic colorectal cancer. Group: Pharmaceutical. CAS No. 733030-01-8. Pack Sizes: 50 mg. Product ID: B0046-462799. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| TAS4464 | TAS4464 is a potent and selective NEDD8 activating enzyme (NAE) inhibitor with IC50 of 0.955 nM. It selectively inhibits NAE relative to the other E1s UAE and SAE. TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylated IkBa in human cancer cell lines. Group: Pharmaceutical. CAS No. 1848959-10-3. Pack Sizes: 5 mg. Product ID: B2693-010141. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Temozolomide Acid | Temozolomide acid is an active metabolite of temozolomide(T017775) with anticancer activity in vitro. Temozolomide is an alkylating agent used as a treatment of some brain cancer, a second-line treatment for astrocytoma and a first-line treatment for glioblastoma multiforme.In Apr 2016, Stanford University and Merck suspended enrolment in a phase II trial for Acute myeloid leukaemia (Combination therapy, Newly diagnosed, Second-line therapy or greater) in USA. In 14 Jul 2016, Medivation planed a phase II trial for Endometrial cancer in USA (NCT02836028) After two days, M.D. Anderson Cancer Center completed a phase II trial in Malignant melanoma (Late-stage disease, Neoadjuvant therapy, Monotherapy, Combination therapy) in USA. Uses: As an antitumor agent. Group: Pharmaceutical. CAS No. 113942-30-6. Pack Sizes: 1 g. Product ID: B2694-161090. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Theaflavin | Theaflavin is an antioxidant polyphenol which is formed from the condensation of flavan-3-ols in tea leaves during the enzymatic oxidation (fermentation) of black?tea. It can inhibit HIV-1 replication with multiple mechanisms of action, and tumor necrosis factor-alpha mediated Interleukin-8 gene expression. It exhibits differential inhibitory effects on cancer cell lines and has the potential to be used individually for functional food applications and for therapy targeting specific cancer treatment. Nutritional supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 4670-5-7. Pack Sizes: 20 mg. Product ID: B0005-464630. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| UNC-0638 | UNC0638 is an inhibitor of G9a and GLP with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 treatment of a variety of cell lines resulted in lower global H3K9me2 levels, equivalent to levels observed for small hairpin RNA knockdown of G9a and GLP with the functional potency of UNC0638 being well separated from its toxicity. UNC0638 markedly reduced the clonogenicity of MCF7 cells, reduced the abundance of H3K9me2 marks at promoters of known G9a-regulated endogenous genes and disproportionately affected several genomic loci encoding microRNAs. Group: Pharmaceutical. CAS No. 1255580-76-7. Pack Sizes: 25 mg. Product ID: B2693-456088. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| venetoclax | Venetoclax is a small-molecule inhibitor that has high selectivity for Bcl-2 (Ki < 0.01 nM in cell-free assays) over Mcl-1. It suppresses anti-apoptotic Bcl-2, a protein commonly overexpressed in cancer cells, to induce programmed death of CLL cells. Venetoclax is used as a second-line treatment of chronic lymphocytic leukemia (CLL). Uses: The treatment of chronic lymphocytic leukemia (cll). Group: Pharmaceutical. CAS No. 1257044-40-8. Pack Sizes: 500 mg. Product ID: B0084-462638. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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