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| Product | Description | |
|---|---|---|
| Protein Kinase Inhibitors 1 | Protein Kinase Inhibitors 1 is a HIPK2 inhibitor with IC50 of 74 nM and Kd of 9.5 nM. Group: Pharmaceutical. Alternative Names: 2,4-Thiazolidinedione, 5-[[1,2-dihydro-2-oxo-6'-(1-piperazinyl)[3,3'-bipyridin]-5-yl]methylene]-; 5-((2-oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione; 5-[[1,2-Dihydro-2-oxo-6'-(1-piperazinyl)[3,3'-bipyridin]-5-yl]methylene]-2,4-thiazolidinedione. CAS No. 1365986-44-2. Pack Sizes: 20 mg. Product ID: B0084-284772. Molecular formula: C18H17N5O3S. Mole weight: 383.43. Custom synthesis is available. Send your inquiries for more information. |  London |
| 1,2-Dioleoyl-sn-glycerol | 1,2-Dioleoyl-sn-glycerol is an analog of the protein kinase C-activating second messenger DAG. Group: Pharmaceutical. Alternative Names: Sn-1,2-Diolein; DG(18:1(9Z)/18:1(9Z)/0:0); 1,2-di-(9Z-octadecenoyl)-sn-glycerol; (S)-glyceryl 1,2-dioleate; DG(18:1/18:1/0:0). CAS No. 24529-88-2. Pack Sizes: 100 mg. Product ID: B0084-203872. Molecular formula: C39H72O5. Mole weight: 620.98. Custom synthesis is available. Send your inquiries for more information. | London |
| 1,4-Bis(4-nitrophenyl)piperazine | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Group: Pharmaceutical. Alternative Names: 1,4-Bis(4-nitrophenyl)piperazine; 16264-05-4; Piperazine, 1,4-bis(4-nitrophenyl)-EINECS 240-371-8UNII-P6TE7B2EYY. CAS No. 16264-05-4. Pack Sizes: 100 mg. Product ID: B1476-166965. Molecular formula: C16H16N4O4. Mole weight: 328.328. Custom synthesis is available. Send your inquiries for more information. | London |
| 17-DMAG hydrochloride | 17-DMAG hydrochloride (Alvespimycin hydrochloride) is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Group: Pharmaceutical. Alternative Names: 17-DMAG HCl; Alvespimycin HCl; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride; 17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride; 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin Hydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride. CAS No. 467214-21-7. Pack Sizes: 100 mg. Product ID: BBF-05796. Molecular formula: C32H48N4O8.HCl. Mole weight: 653.21. Custom synthesis is available. Send your inquiries for more information. | London |
| 1-NA-PP1 | 1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. Group: Pharmaceutical. Alternative Names: 1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-Naphthyl PP1. CAS No. 221243-82-9. Pack Sizes: 25 mg. Product ID: B2693-102805. Molecular formula: C19H19N5. Mole weight: 317.39. Custom synthesis is available. Send your inquiries for more information. | London |
| ((1R,3R)-3-Amino-cyclopentyl)-carbamic Acid tert-Butyl Ester | ((1R,3R)-3-Amino-cyclopentyl)-carbamic Acid tert-Butyl Ester is used in the preparation of quinoline-3-carboxoamides as H-PGDS inhibitors as well as novel triazolo-pyrrolopyridines as Janus kinase 1 inhibitors. Group: Pharmaceutical. Alternative Names: tert-Butyl ((1R,3R)-3-aminocyclopentyl)carbamate; tert-butyl n-[(1r,3r)-3-aminocyclopentyl]carbamate; tert-Butyl rac-[(1R,3R)-3-aminocyclopentyl] carbamate; tert-Butyl ((1R,3R)-rel-3-aminocyclopentyl)carbamate; tert-Butyl N-[trans-3-aminocyclopentyl]carbamate; tert-Butyl [trans-3-aminocyclopentyl]carbamate. CAS No. 1009075-44-8. Pack Sizes: 1 g. Product ID: BB074488. Molecular formula: C10H20N2O2. Mole weight: 200.28. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-((3-Iodo-1H-indazol-6-yl)thio)-N-methylbenzamide | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Group: Pharmaceutical. Alternative Names: Benzamide, 2-[(3-iodo-1H-indazol-6-yl)thio]-N-methyl-. CAS No. 885126-34-1. Pack Sizes: 100 mg. Product ID: B2694-467100. Molecular formula: C15H12IN3OS. Mole weight: 409.25. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Aminoadenosine-5'-Triphosphate 100mM Sodium Solution | 2-Aminoadenosine-5'-Triphosphate, a versatile compound, finds extensive applications in enzymology and biotechnology as a substrate for kinases, ATPases, and nucleotide pyrophosphatases. Additionally, it is noteworthy for its ability to stimulate bone resorption activity in separated osteoclasts, therefore facilitating the study of bone metabolism and related diseases like osteoporosis and osteopenia. Group: Pharmaceutical. Alternative Names: 2-Amino-adenosine-5'-triphosphate; 2-NH2-ATP; 2-Amino-ATP; 2,6-Diaminopurine-ribose-5'-Triphosphate; DAP-rTP; 2-Aminoadenosine 5'-(tetrahydrogen triphosphate); 9H-Purine, 2,6-diamino-9-β-D-ribofuranosyl-, 5'-(tetrahydrogen triphosphate); 9H-Purine, 2,6-diamino-9-β-D-ribofuranosyl-, 5'-triphosphate; 2,6-Diaminopurine ribonucleoside triphosphate; 2,6-Diaminopurine riboside 5'-triphosphate; 2,6-Diaminopurine riboside triphosphate; 2,6-Diaminopurineribosyl-5'-triphosphate. CAS No. 18549-34-3. Pack Sizes: 1 mL. Product ID: B1370-362752. Molecular formula: C10H17N6O13P3. Mole weight: 522.2. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide | 2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide, is a precursor in the synthesis of Dasatinib, a protein tyrosine kinase inhibitor, and also for 2-Amino-thiazole-5-carboxylic Acid Phenylamide Derivatives, used as potent and selective anti-tumor drugs. Group: Pharmaceutical. Alternative Names: 2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide. CAS No. 302964-24-5. Pack Sizes: 1mg;1g;10g. Product ID: NP3528. Molecular formula: C11H10ClN3OS. Mole weight: 267.73. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-butoxy-7-[[4-(1-pyrrolidinylmethyl)phenyl]methyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine | 2-butoxy-7-[[4-(1-pyrrolidinylmethyl)phenyl]methyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine, a medicinal molecule known for its kinase-inhibiting properties, has been identified as a potential candidate for cancer therapy due to its unique ability to induce apoptosis and inhibit the proliferation of malignant cells. With promising applications in the treatment of leukemia and lung cancer, this small-molecule inhibitor has the potential to address critical unmet clinical needs in cancer management. Its effectiveness and suitability as a therapeutic intervention call for further investigation in the field of oncology. Group: Pharmaceutical. Alternative Names: 5H-Pyrrolo[3,2-d]pyrimidin-4-amine, 2-butoxy-7-[[4-(1-pyrrolidinylmethyl)phenyl]methyl]-. CAS No. 1878111-20-6. Pack Sizes: 5 mg. Product ID: B0001-008679. Molecular formula: C22H29N5O. Mole weight: 379.51. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol | 2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinemethanol is one of Pitavastatin intermediates. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Uses: Pitavastatin intermediate. Group: Pharmaceutical. Alternative Names: 2-Cyclopropyl-4-(4'-fluorophenyl)Quinolyl-3-methanol; Pitavastatin Impurity 31. CAS No. 121660-11-5. Pack Sizes: 1mg;1g;10g. Product ID: NP3461. Molecular formula: C19H16FNO. Mole weight: 293.33. Custom synthesis is available. Send your inquiries for more information. | London |
| 2'-Deoxycytidine 3'-monophosphate ammonium salt | 2'-Deoxycytidine 3'-monophosphate ammonium salt is a nucleotide-like compound that is extensively employed in scientific research, especially in the disciplines of DNA sequencing and synthesis. Furthermore, it serves as an essential ingredient for various phosphatases and kinases. With its unique properties, it has the potential to combat a variety of viral infections and cancers, thus opening up new avenues for therapeutic interventions. Group: Pharmaceutical. Alternative Names: 2'-Deoxycytidine-3'-monophosphate tetraammonium salt; (2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl dihydrogen phosphate, ammonia salt; 2'-Deoxy-3'-cytidylic acid ammoniate (1:1); 2'-Desoxycytidine 3'-(dihydrogen phosphate) ammonium salt (1:1). CAS No. 102783-50-6. Pack Sizes: 20 mg. Product ID: B2001-297040. Molecular formula: C9H17N4O7P. Mole weight: 324.23. Custom synthesis is available. Send your inquiries for more information. | London |
| [(2S,6R)-6-{N4-Benzoylcydin-1-yl}-4-tritylmorpholin-2-yl]methyl dimethyl-phosphoramidochloridate | This product is a potent inhibitor of Abl kinases and was developed for the treatment of chronic myeloid leukemia (CML). It works by blocking the activity of the Bcr-Abl fusion protein, which drives the growth of CML cells. Clinical trials have shown promising results, with high rates of complete remission and durable responses in patients with CML who were resistant or intolerant to previous treatments. Group: Pharmaceutical. Alternative Names: PMO-BzC; Morpholino C subunit; Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester; [(2S,6R)-6-[4-(Benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate; N4-Bz protected C PMO Monomer. CAS No. 956139-21-2. Pack Sizes: 1 g. Product ID: B2706-339313. Molecular formula: C37H37ClN5O5P. Mole weight: 698.15. Custom synthesis is available. Send your inquiries for more information. | London |
| 3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile | One of the impurities of Tofacitinib, which is a Janus kinase inhibitor and could be used against rheumatoid arthritis. Group: Pharmaceutical. Alternative Names: N-Methyl-N-(3R,4R)-1-cyanoacetyl-4-methylpiperidin-3-yl-2-chloro-7-deazapurine-6-amine; Tofacitinib Impurity 21. CAS No. 1616761-00-2. Pack Sizes: 25 mg. Product ID: B1370-379650. Molecular formula: C16H19ClN6O. Mole weight: 346.81. Custom synthesis is available. Send your inquiries for more information. | London |
| 3-((3R,4R)-4-methyl-3-(methylamino)piperidin-1-yl)-3-oxopropanenitrile hydrochloride | An impurity of Tofacitinib, a Janus kinase inhibitor that could be used against rheumatoid arthritis. Group: Pharmaceutical. CAS No. 1640971-87-4. Pack Sizes: 5 mg. Product ID: B2694-063174. Molecular formula: C10H18ClN3O. Mole weight: 231.72. Custom synthesis is available. Send your inquiries for more information. | London |
| 3-Ketosphingosine | 3-Ketosphingosine is a biomarker for Niemann-Pick disease type A and B, as well as for sphingosine kinase-associated inflammatory disorders. It is also used as a research tool for studying the metabolism and signaling pathways of sphingolipids in various biological processes. Group: Pharmaceutical. Alternative Names: 3-Keto Sphingosine; Ketosphingosine. CAS No. 19767-16-9. Pack Sizes: 10 mg. Product ID: B1370-154089. Molecular formula: C18H35NO2. Mole weight: 297.48. Custom synthesis is available. Send your inquiries for more information. | London |
| 3-Methyladenine | 3-Methyladenine is an autophagy inhibitor that protects cerebellar granule cells (CGCs) from apoptosis following serum/potassium deprivation. 3-Methyladenine inhibits phosphoinositide 3-kinase (PI3K) activity, which plays a key role in autophagy process. Group: Pharmaceutical. Alternative Names: NSC 66389; NSC-66389; NSC66389; 6-Amino-3-methylpurine; 3-MA; 3H-Purin-6-amine, 3-methyl-; 3-Methyl Adenine; 3-Methyl-6-aminopurine; N3-Methyladenine. CAS No. 5142-23-4. Pack Sizes: 250 mg. Product ID: B0084-070159. Molecular formula: C6H7N5. Mole weight: 149.15. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide | [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide is an intermediate of Sorafenib, which is a kinase inhibitor drug used for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), FLT3-ITD positive AML and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: 4-(4-Aminophenoxy)-N-methylpicolinamide; 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]aniline; 4-[(4-aminomethyl)phenoxy]-2-pyridine carbonic acid methylamide; Sorafenib Imp -1; Sorafenib Related Compound 23. CAS No. 284462-37-9. Pack Sizes: 1mg;1g;10g. Product ID: NP2695. Molecular formula: C13H13N3O2. Mole weight: 243.26. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Chloro-5H-pyrrolo[3,2-d]pyrimidin-2-amine | 4-Chloro-5H-pyrrolo[3,2-d]pyrimidin-2-amine is a highly potent and selective protein kinase CK1ε inhibitor. Evidence suggests that this compound exhibits strong neuroprotective and anti-tumor activity, and holds great promise as a potential treatment for Alzheimer's disease and select cancers. Its unique chemical structure and mechanism of action make it an exciting candidate for further preclinical and clinical development. Group: Pharmaceutical. Alternative Names: 4-Chloro-5H-pyrrolo[3,2-d]pyrimidin-2-ylamine; 5H-Pyrrolo[3,2-d]pyrimidin-2-amine, 4-chloro-. CAS No. 943736-58-1. Pack Sizes: 10 g. Product ID: B2699-100946. Molecular formula: C6H5ClN4. Mole weight: 168.58. Custom synthesis is available. Send your inquiries for more information. | London |
| 5,7-Dihydrox -4'-methoxyisoflavone | Biochanin A, an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM. Uses: Anti-tumorigenesis, anti-oxidation, and anti-inflammatory. Group: Pharmaceutical. Alternative Names: Biochanin; Pratensol; olmelin; 4'-methyl Genistein; 4-methylGenistein; 5,7-dihydroxy-4'-Methoxyisoflavone; NSC 123538; NSC-123538; NSC123538. CAS No. 491-80-5. Pack Sizes: 5 g. Product ID: NP1827. Molecular formula: C16H12O5. Mole weight: 284.26. Custom synthesis is available. Send your inquiries for more information. | London |
| 5'-Amino-5'-deoxyadenosine | It is an adenosine kinase inhibitor. Group: Pharmaceutical. Alternative Names: 5'-Amino-5'-deoxy-D-adenosine; 5'-NH2-Ado; (2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(aminomethyl)tetrahydrofuran-3,4-diol; NSC 238990; 5'-Deoxy-5'-aminoadenosine. CAS No. 14365-44-7. Pack Sizes: 10 mg. Product ID: B1370-049796. Molecular formula: C10H14N6O3. Mole weight: 266.26. Custom synthesis is available. Send your inquiries for more information. | London |
| 5-bromo-4-chloro-N-cyclopentylpyrimidin-2-amine | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Group: Pharmaceutical. Alternative Names: 5-Bromo-4-chloro-N-cyclopentylpyrimidin-2-amine; 1823404-28-9; CS-0011349; D87404; 5-?Bromo-?4-?chloro-?N-?cyclopentylpyrimidin?-?2-?amine. CAS No. 1823404-28-9. Pack Sizes: 100 mg. Product ID: B1476-284923. Molecular formula: C9H11BrClN3. Mole weight: 276.56. Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Bromo-8-cyclopentyl-2-[[5-(4-Boc-1-piperazinyl)-2-pyridyl]amino]-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Group: Pharmaceutical. Alternative Names: 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-2-pyrido[2,3-d]pyrimidinyl)amino]-3-pyridinyl]-1-piperazinecarboxylic acid tert-butyl ester; tert-butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazine-1-carboxylate. CAS No. 571188-82-4. Pack Sizes: 100 mg. Product ID: B1476-282703. Molecular formula: C27H34BrN7O3. Mole weight: 584.51. Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Desacetyl-6-Bromo Palbociclib | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Group: Pharmaceutical. Alternative Names: 6-Bromo-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one; Pyrido-[2,3-d]-pyrimidin-7-one 41. CAS No. 851067-56-6. Pack Sizes: 100 mg. Product ID: B1476-283285. Molecular formula: C22H26BrN7O. Mole weight: 484.402. Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Desacetyl-6-Bromo Palbociclib Hydrochloride | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Group: Pharmaceutical. Alternative Names: 6-bromo-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride. CAS No. 850918-83-1. Pack Sizes: 100 mg. Product ID: B1476-284929. Molecular formula: C22H27ClBrN7O. Mole weight: 520.86. Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Desacetyl Palbociclib | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Group: Pharmaceutical. Alternative Names: Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]-; Pyrido-[2,3-d]-pyrimidin-7-one 38. CAS No. 571190-22-2. Pack Sizes: 100 mg. Product ID: B1476-478511. Molecular formula: C22H27N7O. Mole weight: 405.506. Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Desacetyl Palbociclib Hydrochloride | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Group: Pharmaceutical. Alternative Names: 8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride. CAS No. 571189-66-7. Pack Sizes: 100 mg. Product ID: B1476-284928. Molecular formula: C22H28ClN7O. Mole weight: 441.96. Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Gingerol | 6-gingerol is the active constituent of fresh ginger. It is bioactive compound found in ginger (Zingiber officinale) with antioxidant activity, which functions as an anti-inflammatory and antitumor agent. It has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin. lt may reduce nausea caused by motion sickness or pregnancy and may also relieve migraine. lt has been investigated for its effect on cancerous tumors in the bowel, breast tissue, ovaries, the pancreas, among other tissues, with positive results. Uses: Anti-inflammatory, antitumor and antioxidant activity. Group: Pharmaceutical. Alternative Names: (S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone;(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl)decan-3-one;3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-. CAS No. 23513-14-6. Pack Sizes: 25 mg. Product ID: NP5162. Molecular formula: C17H26O4. Mole weight: 294.39. Custom synthesis is available. Send your inquiries for more information. | London |
| 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile | 9-Ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, a promising therapeutic agent for the treatment of select neoplastic disorders, functions as a highly proficient suppressor of pathogenic kinase enzymes that exhibit heightened expression levels in malignant neoplastic cells. This mechanism of action, whereby key cellular signaling pathways are disrupted, culminates in the prevention of tumor growth and impairs the metastatic process. Group: Pharmaceutical. CAS No. 1256584-80-1. Pack Sizes: 100 mg. Product ID: B2699-281515. Molecular formula: C21H17IN2O. Mole weight: 440.28. Custom synthesis is available. Send your inquiries for more information. | London |
| A 1070722 | A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β) with 50-fold selectivity over other protein kinases such as CDK. It decreases phosphorylation of microtubule-associated protein Tau in vitro. A 1070722 exhibits neuroprotective activity thus is identified as a therapeutic drug candidate for neurodegenerative and psychiatric disorders. Uses: Potential treatment of neurodegenerative disorders. Group: Pharmaceutical. Alternative Names: A 1070722; A1070722; A-1070722; 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea. CAS No. 1384424-80-9. Pack Sizes: 1mg;1g;10g. Product ID: 1384424-80-9. Molecular formula: C17H13F3N4O2. Mole weight: 362.31. Custom synthesis is available. Send your inquiries for more information. | London |
| A12B4C3 | A12B4C3 is a potent and selective inhibitor of polynucleotide kinase/phosphatase (PNKP) (IC50 = 60 nM), a DNA repair enzyme. A12B4C3 is inactive to calcineurin, protein PP-1 or APTX. Group: Pharmaceutical. Alternative Names: A12B4C3; A-12-B-4-C-3; A 12 B 4 C 3; A12 B4 C3; A12-B4-C3; 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione. CAS No. 1005129-80-5. Pack Sizes: 1mg;1g;10g. Product ID: 1005129-80-5. Molecular formula: C30H38N4O5. Mole weight: 534.65. Custom synthesis is available. Send your inquiries for more information. | London |
| A 419259 | A-419259 is a potent inhibitor of Src family kinases. IC50 values for src, lck, blk, csk, fyn and lyn range between 15 and 50 nM. Group: Pharmaceutical. Alternative Names: A419259; A-419259; RK 20449; RK20449; RK-20449. CAS No. 364042-47-7. Pack Sizes: 1mg;1g;10g. Product ID: 364042-47-7. Molecular formula: C29H34N6O. Mole weight: 482.62. Custom synthesis is available. Send your inquiries for more information. | London |
| A 419259 trihydrochloride | Potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo. Group: Pharmaceutical. Alternative Names: A419259 trihydrochloride; A-419259 trihydrochloride; RK 20449 trihydrochloride; RK20449 trihydrochloride; RK-20449 trihydrochloride. CAS No. 1435934-25-0. Pack Sizes: 1mg;1g;10g. Product ID: 1435934-25-0. Molecular formula: C29H37Cl3N6O. Mole weight: 592. Custom synthesis is available. Send your inquiries for more information. | London |
| A-443654 | A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines. It inhibits Akt-dependent signal transduction in cells and in vivo in a dose-responsive manner. Group: Pharmaceutical. Alternative Names: A443564; A-443564; A 443564. CAS No. 552325-16-3. Pack Sizes: 1mg;1g;10g. Product ID: 552325-16-3. Molecular formula: C24H23N5O. Mole weight: 397.47. Custom synthesis is available. Send your inquiries for more information. | London |
| A 484954 | A 484954 is a eukaryotic elongation factor-2 (eEF-2) kinase inhibitor (IC50 = 0.28 μM in enzymatic assay). A 484954 reduces eEF-2 phosphorylation with little effect on cancer cell growth. Group: Pharmaceutical. Alternative Names: A-484954; A 484954; A484954; 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide. CAS No. 142557-61-7. Pack Sizes: 1mg;1g;10g. Product ID: 142557-61-7. Molecular formula: C13H15N5O3. Mole weight: 289.29. Custom synthesis is available. Send your inquiries for more information. | London |
| A-770041 | A-770041 is an selective and orally bioavailable pyrazolo[3,4-d]pyrimidine exhibiting selectivity for Lck compared with previously reported compounds. It is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling. It is currently in the preclinical developlent stage and no clinical data are available. Group: Pharmaceutical. Alternative Names: A-770041; A 770041; A770041. CAS No. 869748-10-7. Pack Sizes: 1mg;1g;10g. Product ID: 869748-10-7. Molecular formula: C34H39N9O3. Mole weight: 621.73. Custom synthesis is available. Send your inquiries for more information. | London |
| A-77-01 | A-77-01 is an inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5( IC50 =25nM). Uses: Potent alk5 inhibitor. Group: Pharmaceutical. Alternative Names: A77-01; A 77-01; A-77-01. 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-quinoline;4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quinoline. CAS No. 607737-87-1. Pack Sizes: 1mg;1g;10g. Product ID: 607737-87-1. Molecular formula: C18H14N4. Mole weight: 286.34. Custom synthesis is available. Send your inquiries for more information. | London |
| A-83-01 | A 83-01 is an inhibitor of TGF-β type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively). It blocks the phosphorylation of SMAD2/3 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Group: Pharmaceutical. Alternative Names: A8301; A 8301; A-8301. CAS No. 909910-43-6. Pack Sizes: 50 mg. Product ID: B0084-155117. Molecular formula: C25H19N5S. Mole weight: 421.52. Custom synthesis is available. Send your inquiries for more information. | London |
| A-92 | A-92 inhibits the stress response of general control nonderepressible 2 kinase (GCN2 or EIF2AK4) (IC50 value of <0.3 μM). It is potentially used as a chemotherapeutic drug for the treatment of cancer. Uses: Potential chemotherapeutic drug. Group: Pharmaceutical. Alternative Names: A-92; A 92; A92. CAS No. 1448693-69-3. Pack Sizes: 1mg;1g;10g. Product ID: 1448693-69-3. Molecular formula: C19H18N10O. Mole weight: 402.41. Custom synthesis is available. Send your inquiries for more information. | London |
| AAKIQASFRGHMARKK | AAKIQASFRGHMARKK. Group: Pharmaceutical. Alternative Names: RC3; PROTEIN KINASE SELECTIDE; PROTEIN KINASE C SELECTIDE(TM) SUBSTRATE; NEUROGRANIN (28-43); NEUROGRANIN FRAGMENT 28-43; NEUROGRANIN 28-43 [AAKIQASFRGHMARKK]. CAS No. 146554-17-8. Pack Sizes: 1mg;1g;10g. Product ID: 146554-17-8. Molecular formula: C78H134N28O19S. Mole weight: 1800.14. Custom synthesis is available. Send your inquiries for more information. | London |
| AAL-993 | AAL-993 is a VEGFR tyrosine kinase inhibitor that possesses dual inhibition of VEGFR signaling and HIF-1α expression through ERK inhibition without affecting Akt phosphorylation. Group: Pharmaceutical. Alternative Names: AAL 993; AAL993; 2-((4-pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide. CAS No. 269390-77-4. Pack Sizes: 1mg;1g;10g. Product ID: 269390-77-4. Molecular formula: C20H16F3N3O. Mole weight: 371.36. Custom synthesis is available. Send your inquiries for more information. | London |
| ABC-1183 | ABC-1183 is an inhibitor of glycogen synthase kinase 3 (GSK-3) alpha, glycogen synthase kinase 3 (GSK-3) beta and cyclin dependent kinase 9 (CDK-9). It can induce cell apoptosis and various signaling pathways. ABC-1183 shows toxicity to many cell lines in humans and mice. Group: Pharmaceutical. Alternative Names: ABC1183; ABC 1183; NSC797769; NSC-797769. CAS No. 1042735-18-1. Pack Sizes: 1mg;1g;10g. Product ID: 1042735-18-1. Molecular formula: C18H14N4OS. Mole weight: 334.39. Custom synthesis is available. Send your inquiries for more information. | London |
| ABC294640 | ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. Group: Pharmaceutical. Alternative Names: ABC-294640; ABC294640; ABC 294640; Opaganib; 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide. CAS No. 915385-81-8. Pack Sizes: 1mg;1g;10g. Product ID: 915385-81-8. Molecular formula: C23H25ClN2O. Mole weight: 380.9104. Custom synthesis is available. Send your inquiries for more information. | London |
| Abemaciclib | Abemaciclib is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. It is used for the treatment of advanced or metastatic breast cancers. Group: Pharmaceutical. Alternative Names: LY-2835219; LY 2835219; LY2835219; Verzenio; N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine. CAS No. 1231929-97-7. Pack Sizes: 100 mg. Product ID: B0084-462724. Molecular formula: C27H32F2N8. Mole weight: 506.61. Custom synthesis is available. Send your inquiries for more information. | London |
| Abn-CBD | Abn-CBD is a neurobehaviorally inactive cannabinoid and acts as a selective and potent agonist for GPR55 with EC50 value of 2.5 μM. It increases migration and phosphorylation of protein kinases in human umbilical vein endothelial cells. Group: Pharmaceutical. Alternative Names: 1,3-Benzenediol, 4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-; 1,3-Benzenediol, 4-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-, trans-(-)-; 4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol; Resorcinol, 4-p-mentha-1,8-dien-3-yl-5-pentyl-, trans-(-)-; Abnormal Cannabidiol; (1'R,2'R)-5'-methyl-6-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,4-diol; trans-(-)-4-p-Mentha-1,8-dien-3-yl-5-pentylresorcinol; trans-(-)-4-[3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol. CAS No. 22972-55-0. Pack Sizes: 1mg;1g;10g. Product ID: 22972-55-0. Molecular formula: C21H30O2. Mole weight: 314.47. Custom synthesis is available. Send your inquiries for more information. | London |
| ABT 702 | ABT 702 is a non-nucleoside adenosine kinase (ADK) inhibitor (IC50 = 2 nM and 50 nM in cytosolic and intact cell assays, respectively). Study conformed that ABT702 could reduce pain and inflammation in animal models, yet be clastogenic in an in vitro Chinese Hamster micronucleus assay. Group: Pharmaceutical. Alternative Names: ABT 702; ABT702; ABT-702; 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine. CAS No. 214697-26-4. Pack Sizes: 1mg;1g;10g. Product ID: 214697-26-4. Molecular formula: C22H19BrN6O. Mole weight: 463.33. Custom synthesis is available. Send your inquiries for more information. | London |
| ABT 702 Dihydrochloride | ABT 702 Dihydrochloride is a potent and selective non-nucleoside adenosine kinase inhibitor with IC50 value of 1.7 nM. ABT 702 displays oral activity in animal models of pain and inflammation. In Mar 2005, ABT 702 was discontinued preclinical for Pain and Rheumatoid arthritis in USA. Uses: Anti-inflammation. Group: Pharmaceutical. Alternative Names: ABT702 Dihydrochloride; ABT-702 Dihydrochloride. CAS No. 1188890-28-9. Pack Sizes: 50 mg. Product ID: B2693-475131. Molecular formula: C22H21BrCl2N6O. Mole weight: 536.26. Custom synthesis is available. Send your inquiries for more information. | London |
| AC 220 dihydrochloride | AC 220 dihydrochloride is a potent and selective inhibitor of FMS-like tyrosine kinase-3 (FLT3) used for the treatment of AML. Uses: The treatment of aml. Group: Pharmaceutical. Alternative Names: AC 220 dihydrochloride; AC220 dihydrochloride; AC-220 dihydrochloride; Quizartinib dihydrochloride; 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea dihydrochloride. CAS No. 1132827-21-4. Pack Sizes: 1mg;1g;10g. Product ID: 1132827-21-4. Molecular formula: C29H32N6O4S.2HCl. Mole weight: 633.59. Custom synthesis is available. Send your inquiries for more information. | London |
| AC410 | AC410 is a Janus kinase 2 (JAK2) inhibitor with Kd of 0.18 nM. AC410 is selective for JAK2 and Kd is 2.5 nM for JAK1 and 5nM for JAK3. Phase I for the treatment of Autoimmune disorders and Inflammation is on-going. Uses: Autoimmune disorders; inflammation. Group: Pharmaceutical. Alternative Names: AC410; AC 410; AC-410; (S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol;1361415-86-2 (HCl). CAS No. 1361415-84-0. Pack Sizes: 1mg;1g;10g. Product ID: 1361415-84-0. Molecular formula: C19H16FN5O. Mole weight: 349.4. Custom synthesis is available. Send your inquiries for more information. | London |
| AC480 | AC480, also known as BMS-599626, is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. Group: Pharmaceutical. Alternative Names: BMS-599626; BMS 599626; BMS599626; AC 480; AC-480; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; (3S)-3-Morpholinylmethyl N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate; Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid, (3S)-3-morpholinylmethyl ester. CAS No. 714971-09-2. Pack Sizes: 1mg;1g;10g. Product ID: B0084-259278. Molecular formula: C27H27FN8O3. Mole weight: 530.55. Custom synthesis is available. Send your inquiries for more information. | London |
| AC710 | AC710 is a potent, selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity. AC710 is now a preclinical development candidate. Group: Pharmaceutical. Alternative Names: AC 710; AC-710. CAS No. 1351522-04-7. Pack Sizes: 1mg;1g;10g. Product ID: 1351522-04-7. Molecular formula: C31H42N6O4. Mole weight: 562.7. Custom synthesis is available. Send your inquiries for more information. | London |
| AC710 Mesylate | AC710 Mesylate is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFRα/PDGFRβ respectively. Group: Pharmaceutical. Alternative Names: AC710 Mesylate; AC 710 Mesylate; AC-710 Mesylate. CAS No. 1351522-05-8. Pack Sizes: 1mg;1g;10g. Product ID: 1351522-05-8. Molecular formula: C32H46N6O7S. Mole weight: 658.81. Custom synthesis is available. Send your inquiries for more information. | London |
| Acalabrutinib | Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Group: Pharmaceutical. Alternative Names: ACP-196; ACP196; ACP 196; Acalabrutinib; 4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide. CAS No. 1420477-60-6. Pack Sizes: 250 mg. Product ID: B0084-470855. Molecular formula: C26H23N7O2. Mole weight: 465.52. Custom synthesis is available. Send your inquiries for more information. | London |
| Acalabrutinib-[d4] | Acalabrutinib-[d4] is a labelled version of Acalabrutinib. Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Group: Pharmaceutical. Alternative Names: (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl-d4)benzamide; Acalabrutinib D4; Acalabrutinib-d4; 4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide-d4; ACP 196-d4; Calquence-d4. CAS No. 2699608-18-7. Pack Sizes: 5 mg. Product ID: BLP-003188. Molecular formula: C26H19D4N7O2. Mole weight: 469.53. Custom synthesis is available. Send your inquiries for more information. | London |
| Acalisib | Acalisib, also known as GS-9820, is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. p110beta/delta PI3K inhibitor GS-9820 inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells. Group: Pharmaceutical. Alternative Names: GS-9820; GS9820; GS 9820; CAL-120; CAL 120; CAL120; Acalisib; UNII-OVW60IDW1D. CAS No. 870281-34-8. Pack Sizes: 1mg;1g;10g. Product ID: 870281-34-8. Molecular formula: C21H16FN7O. Mole weight: 401.405. Custom synthesis is available. Send your inquiries for more information. | London |
| Acteoside | Verbascoside is a bioactive polyphenol from olive oil mill wastewater with known antioxidant activity, which is a protein kinase C inhibitor. Uses: Antineoplastic; antimetastatic;antimicrobial activity. Group: Pharmaceutical. Alternative Names: Verbascoside; Kusaginin; β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-, 4-[3-(3,4-dihydroxyphenyl)-2-propenoate]. (E)-; (3,4-Dihydroxyphenyl)ethyl O-α-rhamnopyranosyl(1→3)-4-O-caffeoyl-β-D glucopyranoside; Acteroside; Distinctive Active Powder SL Special; Distinctive Phytostem Lilac; NSC 603831; O'''-Desarabinosyllavandulifolioside A; Russetinol; Stereospermin; TJC 160; trans-Acteoside; trans-Verbascoside. CAS No. 61276-17-3. Pack Sizes: 100 mg. Product ID: NP5345. Molecular formula: C29H36O15. Mole weight: 624.59. Custom synthesis is available. Send your inquiries for more information. | London |
| AEE-788 | AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. Group: Pharmaceutical. Alternative Names: AEE 788; AEE788; 6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine. CAS No. 497839-62-0. Pack Sizes: 10 mg. Product ID: B0084-258485. Molecular formula: C27H32N6. Mole weight: 440.595. Custom synthesis is available. Send your inquiries for more information. | London |
| Afuresertib | Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Group: Pharmaceutical. Alternative Names: GSK-2110183; GSK 2110183; GSK2110183; GSK-2110183B; GSK 2110183B; GSK2110183B. CAS No. 1047644-62-1. Pack Sizes: 50 mg. Product ID: B1370-109132. Molecular formula: C18H17Cl2FN4OS. Mole weight: 427.32. Custom synthesis is available. Send your inquiries for more information. | London |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Group: Pharmaceutical. Alternative Names: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. CAS No. 118409-62-4. Pack Sizes: 100 mg. Product ID: B1370-195904. Molecular formula: C10H5N3O3. Mole weight: 215.16. Custom synthesis is available. Send your inquiries for more information. | London |
| AG-1557 | AG-1557 is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Group: Pharmaceutical. Alternative Names: AG-1557; AG 1557; AG1557; N-(3-Iodophenyl)-6,7-dimethoxyquinazolin-4-amine. CAS No. 189290-58-2. Pack Sizes: 50 mg. Product ID: B0084-284805. Molecular formula: C16H14IN3O2. Mole weight: 407.211. Custom synthesis is available. Send your inquiries for more information. | London |
| AG-879 | AG-879, a tyrphostin compound, is a dual EGFR/HER2 inhibitor that was administered together with androgen withdrawal therapy. It inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM). Group: Pharmaceutical. Alternative Names: α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide. CAS No. 148741-30-4. Pack Sizes: 20 mg. Product ID: B0084-195953. Molecular formula: C18H24N2OS. Mole weight: 316.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Alectinib | Alectinib, marketed as Alecensa, is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). Alectinib has a low potential for interactions. While it is metabolised by the liver enzyme CYP3A4, and blockers of this enzyme accordingly increase its concentrations in the body, they also decrease concentrations of the active metabolite M4, resulting in only a small overall effect. Conversely, CYP3A4 inducers decrease alectinib concentrations and increase M4 concentrations. Interactions via other CYP enzymes and transporter proteins cannot be excluded but are unlikely to be of clinical significance. Group: Pharmaceutical. Alternative Names: CH-5424802; CH5424802; CH 5424802; AF-802; RG-7853; RO5424802. CAS No. 1256580-46-7. Pack Sizes: 200 mg. Product ID: B0084-454466. Molecular formula: C30H34N4O2. Mole weight: 482.62. Custom synthesis is available. Send your inquiries for more information. | London |
| Alisertib | MLN8237 is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Aurora kinase inhibitor MLN8237 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Group: Pharmaceutical. Alternative Names: MLN8237; MLN-8237; MLN 8237; alisertib. Benzoic acid, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-. CAS No. 1028486-01-2. Pack Sizes: 100 mg. Product ID: B2693-336876. Molecular formula: C27H20ClFN4O4. Mole weight: 518.9. Custom synthesis is available. Send your inquiries for more information. | London |
| ALK5 Inhibitor II hydrochloride | ALK5 inhibitor II was identified as a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (ALK5 autophosphorylation, IC50s = 4 nM, TGF-β cellular assay, IC50s = 18 nM, ALK5 binding in HepG2 cells, IC50s = 23 nM). This compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription. This product is a hydrochloride form. Group: Pharmaceutical. Alternative Names: E 616452; RepSox; SJN 2511. CAS No. 446859-33-2. Pack Sizes: 50 mg. Product ID: B0084-068993. Molecular formula: C17H13N5·HCl. Mole weight: 323.8. Custom synthesis is available. Send your inquiries for more information. | London |
| Alpelisib | Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Group: Pharmaceutical. Alternative Names: BYL-719; BYL719; BYL 719; Alpelisib. CAS No. 1217486-61-7. Pack Sizes: 100 mg. Product ID: B0084-457654. Molecular formula: C19H22F3N5O2S. Mole weight: 441.473. Custom synthesis is available. Send your inquiries for more information. | London |
| α-Amyloid Precursor Protein Modulator | α-Amyloid Precursor Protein Modulator is a cell-permeable protein kinase C (PKC) activator. It was shown to induce differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. Group: Pharmaceutical. Alternative Names: TPPB; alpha-APP Modulator; (2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide. CAS No. 497259-23-1. Pack Sizes: 2.5 mg. Product ID: B0084-314011. Molecular formula: C27H30F3N3O3. Mole weight: 501.55. Custom synthesis is available. Send your inquiries for more information. | London |
| α-Amyrin | α-Amyrin is a triterpenoid that has been found in B. copallifera and has diverse biological activities. It activates the ERK and GSK-3β signaling pathways. α-Amyrin is a potential protein kinase A inhibitor. Group: Pharmaceutical. Alternative Names: Viminalol; alpha-Amyrenol; Urs-12-en-3beta-ol; (3β)-urs-12-en-3-ol. CAS No. 638-95-9. Pack Sizes: 10 mg. Product ID: B1370-147265. Molecular formula: C30H50O. Mole weight: 426.73. Custom synthesis is available. Send your inquiries for more information. | London |
| α-Viniferin | α-Viniferin isolated from the herb of Carex humilis Leyss. It inhibits AChE activity is specific, reversible and noncompetitive,down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages. Uses: Anti-inflammatory activity; antifungal; inhibits protein kinase c; inhibits prostaglandin h2 synthase carex humilis. Group: Pharmaceutical. Alternative Names: (+)-α-viniferin. CAS No. 62218-13-7. Pack Sizes: 1 mg. Product ID: NP4646. Molecular formula: C42H30O9. Mole weight: 678.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Alsterpaullone | Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Group: Pharmaceutical. Alternative Names: 9-Nitropaullone; NSC 705701; 7,12-Dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one. CAS No. 237430-03-4. Pack Sizes: 50 mg. Product ID: B2693-103248. Molecular formula: C16H11N3O3. Mole weight: 293.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Altiratinib | Altiratinib, also known as DCC-270, DP-5164, is an oral, selective and highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases with potential anticancer activity. DCC-2701 effectively reduces tumor burden in vivo and blocks c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Importantly, DCC-2701's anti-proliferative activity was dependent on c-MET activation induced by stromal human fibroblasts and to a lesser extent exogenous HGF. DCC-2701 may be superior to HGF antagonists that are in clinical trials and that pTyr(1349) levels might be a good indicator of c-MET activation and likely response to targeted therapy as a result of signals from the microenvironment. Group: Pharmaceutical. Alternative Names: DCC2701; DCC 2701; DCC-2701; DP 5164; DP5164; DP-5164; Altiratinib. CAS No. 1345847-93-9. Pack Sizes: 50 mg. Product ID: B2693-463181. Molecular formula: C26H21F3N4O4. Mole weight: 510.46. Custom synthesis is available. Send your inquiries for more information. | London |
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