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| Product | Description | |
|---|---|---|
| Irinotecan | Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. It is used for the treatment of colon and rectum cancers. It binds to topoisomerase I-DNA complex, preventing religation of the DNA strand and leading to double-strand DNA breakage and cell death. Uses: Anticancer drug. Group: Pharmaceutical. Alternative Names: Irinophore C; Irinotecan lactone; Irinotecan mylan; Onivyde; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.; (S)-[1,4'-Bipiperidine]-1'-carboxylic Acid 4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl Ester; Camptosar; Irinotecanum; CPT-11; CPT 11; CPT11; (+)-Irinotecan. CAS No. 97682-44-5. Pack Sizes: 1mg;1g;10g. Product ID: BBF-05861. Molecular formula: C33H38N4O6. Mole weight: 586.68. Custom synthesis is available. Send your inquiries for more information. |  London |
| Irinotecan-[d10] Hydrochloride | Irinotecan-[d10] Hydrochloride is the labelled analogue of Irinotecan, which is a DNA topoisomerase inhibitor. Group: Pharmaceutical. Alternative Names: Irinotecan D10 Hydrochloride. CAS No. 718612-62-5. Pack Sizes: 10 mg. Product ID: BLP-012397. Molecular formula: C33H29D10ClN4O6. Mole weight: 633.2. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan EP Impurity A | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Group: Pharmaceutical. Alternative Names: (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-9-yl (1,4'-bipiperidine)-1'-carboxylate; 11-Desethyl Irinotecan. CAS No. 103816-16-6. Pack Sizes: 5 mg. Product ID: B1370-473338. Molecular formula: C31H34N4O6. Mole weight: 558.64. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan EP Impurity B | 10-Hydroxycamptothecin inhibits the growth of BT-20 and MDA-231 cell with IC50 of 34.3 nM and 7.27 nM, respectively, more potently than camptothecin (CPT) with IC50 of >500 nM. 10-Hydroxycamptothecin is also an impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Uses: Anti-cancer. Group: Pharmaceutical. Alternative Names: 10-Hydroxycamptothecin; Irinotecan Related Compound A; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-; (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (S)-; Camptothecine, 10-hydroxy-; (+)-10-Hydroxycamptothecin; (S)-10-Hydroxycamptothecin; 10-HCPT; 10-Hydroxycamptothecin; 10-Hydroxycamptothecine; Hydroxycamptothecin; NSC 107124; USP Irinotecan Related Compound A; Irinotecan USP Related Compound A. CAS No. 19685-09-7. Pack Sizes: 5 g. Product ID: B2703-086753. Molecular formula: C20H16N2O5. Mole weight: 364.35. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan EP Impurity C | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Group: Pharmaceutical. Alternative Names: 8-ethyl irinotecan; (S)-4,8,11-Triethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-9-yl (1,4'-bipiperidine)-1'-carboxylate. CAS No. 947687-02-7. Pack Sizes: 10 mg. Product ID: B1370-186673. Molecular formula: C35H42N4O6. Mole weight: 614.75. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan EP Impurity E (SN-38) | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. It inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. Uses: The treatment of colorectal cancer. Group: Pharmaceutical. Alternative Names: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione; 10-Hydroxy-7-ethylcamptothecin; SN 38 Lactone; Irinotecan EP Impurity E; SN-38; USP Irinotecan Related Compound B; Irinotecan Related Compound B; Irinotecan EP Impurity E; NSC-673596. CAS No. 86639-52-3. Pack Sizes: 1 g. Product ID: BADC-01393. Molecular formula: C22H20N2O5. Mole weight: 392.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan EP Impurity G | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Group: Pharmaceutical. Alternative Names: (4S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 7,11-Diethyl-10-hydroxycamptothecin. CAS No. 947687-01-6. Pack Sizes: 2.5 mg. Product ID: B2694-468001. Molecular formula: C24H24N2O5. Mole weight: 420.47. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan hydrochloride | Irinotecan Hcl(CPT-11 Hcl) prevents DNA from unwinding by inhibition of topoisomerase 1. Uses: Topoisomerase i inhibitors. Group: Pharmaceutical. Alternative Names: CPT-11 hydrochloride; CPT 11 hydrochloride; CPT11 hydrochloride; Camptothecin 11 hydrochloride. CAS No. 100286-90-6. Pack Sizes: 1mg;1g;10g. Product ID: NP3346. Molecular formula: C33H39ClN4O6. Mole weight: 623.14. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan Hydrochloride Trihydrate | The hydrochloride salt of Irinotecan. Irinotecan is a prodrug that can be activated to 7-ethyl-10-hydroxy-camptothecin (SN-38) by the carboxylesterase-converting enzyme. SN-38 inhibits topoisomerase I to suppress DNA replication and promote cell death. Group: Pharmaceutical. Alternative Names: CPT-11 HCl Trihydrate; CPT 11 HCl Trihydrate; CPT11 HCl Trihydrate; Irinotecan Hcl Trihydrate; UNII-042LAQ1IIS. CAS No. 136572-09-3. Pack Sizes: 1 g. Product ID: B0084-057943. Molecular formula: C33H38N4O6.HCl.3H2O. Mole weight: 677.18. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan Hydroxyl Acid Disodium Salt | The active metabolite of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Group: Pharmaceutical. Alternative Names: SN-38 Hydroxy Acid Disodium Salt; SN-38 Carboxylate Disodium Salt; (S)-2-(12-ethyl-2-hydroxy-8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoic acid, sodium salt (1:2). Pack Sizes: 10 mg. Product ID: B1370-186667. Molecular formula: C22H20N2Na2O6. Mole weight: 454.38. Custom synthesis is available. Send your inquiries for more information. | London |
| 7-Ethyl Camptothecin | The main reasons for the superior antitumor activity of 7-Ethylcamptothecin compared with CPT are as follows: (a) 7-Ethylcamptothecin had a stronger growth-inhibiting activity against tumor cells, and (b) 7-Ethylcamptothecin remained in the intestinal tract for a longer time and in higher amounts when administered in vivo. 7-Ethyl Camptothecin is a natural compound found in the barks of Camptotheca acuminata Decne, it can be used as a cosmetics material. Group: Pharmaceutical. Alternative Names: (S)-4,11-Diethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; 7-ethylcamptothecin; (4S)-4,11-diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Irinotecan EP Impurity F. CAS No. 78287-27-1. Pack Sizes: 10 g. Product ID: B2703-464837. Molecular formula: C22H20N2O4. Mole weight: 376.42. Custom synthesis is available. Send your inquiries for more information. | London |
| (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione | (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione is a key intermediate for the synthesis of irinotecan and camptothecin analogues. It is also an ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Group: Pharmaceutical. Alternative Names: 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (4S)-; (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione; Irinotecan Intermediates (94-5); 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (S)-; (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)trione. CAS No. 110351-94-5. Pack Sizes: 10 g. Product ID: BBF-05888. Molecular formula: C13H13NO5. Mole weight: 263.25. Custom synthesis is available. Send your inquiries for more information. | London |
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