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| Product | Description | |
|---|---|---|
| 2',3'-cGAMP | 2',3'-cGAMP was considered to be the metazoan second messenger which is produced by cGAMP synthase (cGAS), the mammalian intrinsic immune DNA sensor. It can activate innate immunity by directly binding the endoplasmic reticulum-resident receptor STING (stimulator of interferon genes). Group: Pharmaceutical. Alternative Names: Cyclic [G(2',5')pA(3',5')p]; 2'-Guanylic acid, adenylyl-(3'→5')-, cyclic nucleotide; 2',3'-Cyclic guanosine adenosine monophosphate; 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate; 2'-3'-cyclic GMP-AMP; cGAMP(2'→5'); c[G(2',5')pA(3',5')p]; Cyclic Gp(2'→5')Ap(3'→5'). CAS No. 1441190-66-4. Pack Sizes: 1 mg. Product ID: B1370-006099. Molecular formula: C20H24N10O13P2. Mole weight: 674.41. Custom synthesis is available. Send your inquiries for more information. |  London |
| 2'3'-cGAMP photo affinity probe | 2'3'-cyclic GMP-AMP (2'3'-cGAMP), generated by cyclic GMP-AMP synthase (cGAS) under activation by cytosolic DNA, has a vital role in innate immune response via its receptor protein stimulator of interferon genes (STING) to fight viral infections and tumors. 2'3'-cGAMP-based photoaffinity probes can capture and isolate 2'3'-cGAMP-binding proteins. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B1370-099265. Custom synthesis is available. Send your inquiries for more information. | London |
| AC 264613 | AC 264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). AC 264613 inhibits interferon regulatory factor 5 and decreases interleukin-12p40 production via lipopolysaccharide-stimulated macrophages. PI hydrolysis, Ca2+ mobilization and cellular proliferation are activated by AC 264613 in vitro (pEC50 = 6.9, 7.0 and 7.5, respectively). Group: Pharmaceutical. Alternative Names: AC-264613; AC 264613; AC264613; (±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide. CAS No. 1051487-82-1. Pack Sizes: 1mg;1g;10g. Product ID: 1051487-82-1. Molecular formula: C19H18BrN3O2. Mole weight: 400.27. Custom synthesis is available. Send your inquiries for more information. | London |
| Aloe emodin | Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71. Aloe-emodin has anti-tumor activity, antibacterial activity, immunosuppressive effect, and purgative effect. It is now widely used as a raw material for medicines and cosmetics. Uses: Antineuroectodermal tumor. Group: Pharmaceutical. Alternative Names: Aloe-emodin;Aloe emodin;481-72-1;Aloeemodin;Aloe-emodine;Rhabarberone;1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione;3-Hydroxymethylchrysazine;3-Hydroxymethylchrysazin;EMODINE;1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone;1,8-Dihydroxy-3-hydroxymethylanthraquinone;9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-;1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione;NSC 38628;CCRIS 3526;U. CAS No. 481-72-1. Pack Sizes: 5 g. Product ID: BBF-05794. Molecular formula: C15H10O5. Mole weight: 270.24. Custom synthesis is available. Send your inquiries for more information. | London |
| (D)-(+)-Neopterin | Neopterin, a pyrazino-pyrimidine compound derived from GTP, n is a precursor of tetrahydrobiopterin and can be used as a biochemical marker indicative of cell proliferation. Neopterin is synthesized in response to interferon-γ stimulation, and used as a marker of T helper cell-induced immune activation. Neopterin is also an indicator of oxidative stress, and modulates the effects of reactive oxygen species (ROS). Group: Pharmaceutical. Alternative Names: 2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone; Neopterin; 2-Amino-4-hydroxy-6-(1,2,3-trihydroxypropyl)pteridine; 2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)-4(8H)-pteridone; 6-D-erythro-Neopterin; D-(+)-Neopterin; D-erythro-Neopterin. CAS No. 2009-64-5. Pack Sizes: 100 mg. Product ID: B2693-070923. Molecular formula: C9H11N5O4. Mole weight: 253.21. Custom synthesis is available. Send your inquiries for more information. | London |
| Golotimod | Golotimod is an orally bioactive synthetic peptide containing the amino acids D-glutamine and L-tryptophan connected by a gamma-glutamyl linkage with potential immunostimulating, antimicrobial and antineoplastic activities. Golotimod has been shown to inhibit the expression of STAT-3, reversing immunosuppression and stimulating an anti-tumor immune response. It may stimulate the production of T-lymphocytes (in particular the helper T [Th1] cells), activate macrophages, and increase levels of interleukin 2 and interferon gamma. Group: Pharmaceutical. Alternative Names: SCV-07; Gamma-D-Glu-L-trp; SCV07; SCV 07; Gamma-D-Glutamyl-L-tryptophan; (2R)-2-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid. CAS No. 229305-39-9. Pack Sizes: 50 mg. Product ID: BAT-010153. Molecular formula: C16H19N3O5. Mole weight: 333.34. Custom synthesis is available. Send your inquiries for more information. | London |
| SR-717 lithium | SR-717 is an agonist of stimulator of interferon genes (STING) for treating cancer. Group: Pharmaceutical. Alternative Names: SR 717 lithium; SR717 lithium. CAS No. 2375421-09-1. Pack Sizes: 100 mg. Product ID: B1370-342009. Molecular formula: C15H8F2LiN5O3. Mole weight: 351.2. Custom synthesis is available. Send your inquiries for more information. | London |
| Tilorone dihydrochloride | Tilorone dihydrochloride, as a broad-spectrum, orally active antiviral agent, is an orally active interferon inducer. Group: Pharmaceutical. Alternative Names: 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one;dihydrochloride. CAS No. 27591-69-1. Pack Sizes: 100 mg. Product ID: B0046-064904. Molecular formula: C25H34N2O3 · 2HCl. Mole weight: 483.47. Custom synthesis is available. Send your inquiries for more information. | London |
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