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| Product | Description | |
|---|---|---|
| Abituzumab | Abituzumab is a humanized anti-integrin αV monoclonal antibody developed for the treatment of prostate cancer metastatic. Abituzumab binds to αVβ3 and inhibits endothelial cell-cell interactions, endothelial cell-matrix interactions, and integrin-mediated tumor angiogenesis and metastasis in αVβ3-expressing tumor cells. Group: Pharmaceutical. Alternative Names: EMD 525797; DI17E6. CAS No. 1105038-73-0. Pack Sizes: 1mg;1g;10g. Product ID: 1105038-73-0. Custom synthesis is available. Send your inquiries for more information. |  London |
| Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Uses: Platelet aggregation inhibitors. Group: Pharmaceutical. Alternative Names: Arg Gly Asp Ser; RGDS peptide; Fibronectin Inhibitor. CAS No. 91037-65-9. Pack Sizes: 100 mg. Product ID: BAT-010205. Molecular formula: C15H27N7O8. Mole weight: 433.42. Custom synthesis is available. Send your inquiries for more information. | London |
| BIO 1211 | BIO 1211 is a selective and high affinity integrin α4β1 (Very Late Antigen 4; VLA-4) inhibitor with 200-fold selectivity for the activated form of α4β1 (KD = 70 pM; IC50 = 0.004 μM). Group: Pharmaceutical. Alternative Names: BIO-1211; BIO1211. CAS No. 187735-94-0. Pack Sizes: 50 mg. Product ID: BAT-010232. Molecular formula: C36H48N6O9. Mole weight: 708.8. Custom synthesis is available. Send your inquiries for more information. | London |
| BIO 5192 | BIO 5192 is a selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM) with selectivity for α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053,> 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively). BIO 5192 causes a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels. Group: Pharmaceutical. Alternative Names: BIO-5192; AMD-15057; BIO 5192; AMD 15057; BIO5192; AMD15057; (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid. CAS No. 327613-57-0. Pack Sizes: 10 mg. Product ID: B2693-119144. Molecular formula: C38H46Cl2N6O8S. Mole weight: 817.78. Custom synthesis is available. Send your inquiries for more information. | London |
| Cilengitide | Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(V)beta(3) and alpha(V)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. It is being studied for the treatment of glioblastoma. Group: Pharmaceutical. Alternative Names: 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid. CAS No. 188968-51-6. Pack Sizes: 100 mg. Product ID: BAT-010773. Molecular formula: C27H40N8O7. Mole weight: 588.65. Custom synthesis is available. Send your inquiries for more information. | London |
| c(phg-isoDGR-(NMe)k) | c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with IC50 of 2.9 nM. Group: Pharmaceutical. CAS No. 1844830-65-4. Pack Sizes: 1 mg. Product ID: BAT-006254. Molecular formula: C27H41N9O7. Mole weight: 603.67. Custom synthesis is available. Send your inquiries for more information. | London |
| c(RGDfK) | Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor. Group: Pharmaceutical. CAS No. 161552-03-0. Pack Sizes: 100 mg. Product ID: BAT-010763. Molecular formula: C27H41N9O7. Mole weight: 603.67. Custom synthesis is available. Send your inquiries for more information. | London |
| CWHM-12 | CWHM 12 demonstrated high potency against all of the five possible β subunit binding partners (αvβ1, αvβ3, αvβ5, αvβ6 and αvβ8) in in vitro ligand-binding assays, with somewhat less potency against αvβ5 than against the other αv integrins. Treated mice with CCl4 for 3 weeks to establish fibrotic disease and then treated with CWHM 12 or vehicle for the final 3 weeks of CCl4. CWHM12 significantly reduced liver fibrosis even after fibrotic disease had been established. Similar to our findings in the liver, administration of CWHM 12 significantly inhibited progression of pulmonary fibrosis. Group: Pharmaceutical. Alternative Names: CWHM12; CWHM 12; CWHM-12. CAS No. 1564286-55-0. Pack Sizes: 100 mg. Product ID: B0084-463546. Molecular formula: C26H32BrN5O6. Mole weight: 590.47. Custom synthesis is available. Send your inquiries for more information. | London |
| Cyclo(RGDyK) Trifluoroacetate | Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM. Group: Pharmaceutical. Alternative Names: Cyclo (RGDyK); Cyclo RGDyK; Cyclo(RGDyK) trifluoroacetate. CAS No. 250612-42-1. Pack Sizes: 100 mg. Product ID: BAT-010216. Molecular formula: C31H43F6N9O12. Mole weight: 847.71. Custom synthesis is available. Send your inquiries for more information. | London |
| Defactinib | Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. The tyrosine kinase FAK is , a signal transducer for integrins that is upregulated in many tumor cell types and is involved in tumor cell invasion, migration and proliferation. Group: Pharmaceutical. Alternative Names: N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide; VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878. CAS No. 1073154-85-4. Pack Sizes: 200 mg. Product ID: B0084-462762. Molecular formula: C20H21F3N8O3S. Mole weight: 510.496. Custom synthesis is available. Send your inquiries for more information. | London |
| Firategrast | Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS). Group: Pharmaceutical. Alternative Names: SB-683699; SB 683699; SB683699; T-0047; T 0047; T0047; Firategrast. CAS No. 402567-16-2. Pack Sizes: 5 mg. Product ID: B0084-244915. Molecular formula: C27H27F2NO6. Mole weight: 499.5. Custom synthesis is available. Send your inquiries for more information. | London |
| GLPG-0187 | GLPG-0187 is a small molecule integrin receptor antagonist (IRA) with nanomolar affinity for the RGD-integrin receptors αvβ1, αvβ3, αvβ5, αvβ6 and α5β1 (IC50s = 1.2-3.7 nM). Integrin receptors are expressed on the surface of tumor vessel endothelial cells and some types of cancer cells, and play a crucial role in endothelial cell adhesion and migration. This compound shows an inhibitory activity of angiogenesis, bone-resorption and tumor, which is hopefully used as an anticancer drug. Uses: An integrin receptor antagonist (ira) can be used as an anticancer drug. Group: Pharmaceutical. Alternative Names: GLPG0187; GLPG 0187; GLPG-0187; UNII-43A5P87Z4T; 43A5P87Z4T; SCHEMBL2372722; CHEMBL3319236; (2S)-3-[[2,5-dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl]pyrimidin-4-yl]amino]-2-[(4-methoxyphenyl)sulfonylamino]propanoic acid. CAS No. 1320346-97-1. Pack Sizes: 10 mg. Product ID: B0084-484680. Molecular formula: C29H37N7O5S. Mole weight: 595.719. Custom synthesis is available. Send your inquiries for more information. | London |
| GRGDS | GRGDS is a synthetic integrin antagonist. Group: Pharmaceutical. Alternative Names: GRGDS; GRGDS 1/2ACOH 2H2O; GRGDS, FIBRONECTIN ATTACHMENT PEPTIDE; GLY-ARG-GLY-ASP-SER; GLY-ARG-GLY-ASP-SER 1/2ACOH 2H2O; H-GLY-ARG-GLY-ASP-SER-OH; glycyl-arginyl-glycyl-aspartyl-serine; GLY-ARG-GLY-ASP-SER ACETATE. CAS No. 96426-21-0. Pack Sizes: 50 mg. Product ID: BAT-010197. Molecular formula: C17H30N8O9. Mole weight: 490.5. Custom synthesis is available. Send your inquiries for more information. | London |
| GRGDSP | GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor which can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization. Group: Pharmaceutical. Alternative Names: H-Gly-Arg-Gly-Asp-D-Ser-Pro-OH; glycyl-L-arginyl-glycyl-L-alpha-aspartyl-D-seryl-L-proline. CAS No. 91037-75-1. Pack Sizes: 10 mg. Product ID: BAT-010499. Molecular formula: C22H37N9O10. Mole weight: 587.58. Custom synthesis is available. Send your inquiries for more information. | London |
| Obtustatin | Obtustatin is an integrin α1β1 inhibitor with IC50 value of 0.8 nM for α1β1 binding to type IV collagen. Some research shows that it has antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma. Group: Pharmaceutical. Alternative Names: H-Cys(1)-Thr-Thr-Gly-Pro-Cys(2)-Cys(3)-Arg-Gln-Cys(1)-Lys-Leu-Lys-Pro-Ala-Gly-Thr-Thr-Cys(4)-Trp-Lys-Thr-Ser-Leu-Thr-Ser-His-Tyr-Cys(2)-Thr-Gly-Lys-Ser-Cys(3)-Asp-Cys(4)-Pro-Leu-Tyr-Pro-Gly-OH; L-cysteinyl-L-threonyl-L-threonyl-glycyl-L-prolyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-glutaminyl-L-cysteinyl-L-lysyl-L-leucyl-L-lysyl-L-prolyl-L-alanyl-glycyl-L-threonyl-L-threonyl-L-cysteinyl-L-tryptophyl-L-lysyl-L-threonyl-L-seryl-L-leucyl-L-threonyl-L-seryl-L-histidyl-L-tyrosyl-L-cysteinyl-L-threonyl-glycyl-L-lysyl-L-seryl-L-cysteinyl-L-alpha-aspartyl-L-cysteinyl-L-prolyl-L-leucyl-L-tyrosyl-L-prolyl-glycine (1->10),(6->29),(7->34),(19->36)-tetrakis(disulfide). CAS No. 404882-00-4. Pack Sizes: 1 mg. Product ID: BAT-006085. Molecular formula: C184H284N52O57S8. Mole weight: 4393.07. Custom synthesis is available. Send your inquiries for more information. | London |
| RGD peptide | RGD peptide is an inhibitor of integrin-ligand interactions. Group: Pharmaceutical. Alternative Names: H-Gly-Arg-Gly-Asp-Asn-Pro-OH; RGD peptide (GRGDNP); glycyl-L-arginyl-glycyl-L-alpha-aspartyl-L-asparagyl-L-proline; (S)-1-((6S,12S,15S)-1-amino-15-(2-amino-2-oxoethyl)-6-(2-aminoacetamido)-12-(carboxymethyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecane)pyrrolidine-2-carboxylic acid. CAS No. 114681-65-1. Pack Sizes: 10 mg. Product ID: BAT-006171. Molecular formula: C23H38N10O10. Mole weight: 614.61. Custom synthesis is available. Send your inquiries for more information. | London |
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