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| Product | Description | |
|---|---|---|
| 1,2,3,6-Tetragalloylglucose | 1,2,3,6-Tetragalloylglucose is a polyphenolic compound primarily used as a precursor of anti-HIV agents. Its galloyl groups inhibit HIV-1 integrase, a key enzyme in HIV replication. It also shows potential in treating neurodegenerative diseases due to its antioxidant properties. Group: Pharmaceutical. Alternative Names: 1,2,3,6-tetrakis(O-galloyl)-β-D-glucose. CAS No. 79886-50-3. Pack Sizes: 10 mg. Product ID: NP4337. Molecular formula: C34H28O22. Mole weight: 788.57. Custom synthesis is available. Send your inquiries for more information. |  London |
| 4-Defluoro Raltegravir | An impurity of Raltegravir. Raltegravir is an integrase inhibitor as an antiretroviral drug. It can be used for the treatment of HIV infection. Group: Pharmaceutical. Alternative Names: 1,6-Dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-N-(phenylmethyl)-4-pyrimidinecarboxamide. CAS No. 1193687-87-4. Pack Sizes: 2.5 mg. Product ID: B2694-483628. Molecular formula: C20H22N6O5. Mole weight: 426.44. Custom synthesis is available. Send your inquiries for more information. | London |
| Bictegravir | Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM for strand transfer activity. Bictegravir is a drug of the integrase inhibitor class that was copied from Dolutegravir by scientists at Gilead Sciences. Bictegravir also inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively) without exhibiting cytotoxicity (CC50s = 10.3, 3.7, 13, and 29.8 μM, respectively). In 2016, bictegravir was in a Phase 3 trial as part of a single tablet regimen in combination with tenofovir alafenamide (TAF) and emtricitabine (FTC) for the treatment of HIV-1 infection. Group: Pharmaceutical. Alternative Names: GS-9883; GS 9883; GS9883. CAS No. 1611493-60-7. Pack Sizes: 100 mg. Product ID: B2693-058383. Molecular formula: C21H18F3N3O5. Mole weight: 449.39. Custom synthesis is available. Send your inquiries for more information. | London |
| Cabotegravir (GSK744, GSK1265744) | Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with IC50 of 3.0 nM. Phase 2. Uses: Hiv integrase inhibitors. Group: Pharmaceutical. Alternative Names: S/GSK1265744; S/GSK 1265744; S/GSK-1265744; GSK744; GSK-744; GSK 744; Cabotegravir. CAS No. 1051375-10-0. Pack Sizes: 25 mg. Product ID: B0084-463362. Molecular formula: C19H17F2N3O5. Mole weight: 405.35. Custom synthesis is available. Send your inquiries for more information. | London |
| Dolutegravir | Dolutegravir is a two-metal-binding HIV-1 integrase inhibitor with IC50 of 2.7 nM, with modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. It blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). Group: Pharmaceutical. Alternative Names: GSK-1349572; GSK 1349572; GSK1349572; Tivicay. CAS No. 1051375-16-6. Pack Sizes: 25 mg. Product ID: B0084-438457. Molecular formula: C20H19F2N3O5. Mole weight: 419.38. Custom synthesis is available. Send your inquiries for more information. | London |
| Dolutegravir sodium | Dolutegravir sodium salt is a HIV integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. Uses: Hiv integrase inhibitors. Group: Pharmaceutical. Alternative Names: DTG; GSK1349572; GSK 1349572; GSK-1349572. CAS No. 1051375-19-9. Pack Sizes: 500 mg. Product ID: B2693-463509. Molecular formula: C20H18F2N3NaO5. Mole weight: 441.36. Custom synthesis is available. Send your inquiries for more information. | London |
| Elvitegravir | Elvitegravir is an HIV-1 integrase strand transfer inhibitor (INSTI) for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively. Uses: Anti-retroviral agents. Group: Pharmaceutical. Alternative Names: GS-9137; GS 9137; GS9137; JTK-303; JTK 303; JTK303; EVG; D06677; D 06677; D-06677. CAS No. 697761-98-1. Pack Sizes: 50 mg. Product ID: B0084-149112. Molecular formula: C23H23ClFNO5. Mole weight: 447.88. Custom synthesis is available. Send your inquiries for more information. | London |
| Methyl 5-Acetamido-7,8,9-tri-O-acetyl-5-N,4-O-carbonyl-3,5-dideoxy-2-S-phenyl-2-thio-D-glycero-b-D-galacto-2-nonulopyranosylonate | Methyl 5-Acetamido-7,8,9-tri-O-acetyl-5-N,4-O-carbonyl-3,5-dideoxy-2-S-phenyl-2-thio-D-glycero-b-D-galacto-2-nonulopyranosylonate, a chemical entity of paramount importance in pharmaceutical studies. This compound plays a key role in antiviral drug development, primarily focusing on HIV reverse transcriptase and integrase. Moreover, it exhibits inhibitory activity against an array of viruses, including Ebola and Zika, which presents a profound scope for therapeutic interventions. Group: Pharmaceutical. Alternative Names: Methyl (Phenyl 5-Acetamido-7,8,9-tri-O-acetyl-5-N,4-O-carbonyl-3,5-dideoxy-2-thio-D-glycero-b-D-galacto-2-nonulopyranosid)onate. CAS No. 934591-76-1. Pack Sizes: 250 mg. Product ID: B2705-001798. Molecular formula: C25H29NO12S. Mole weight: 567.56. Custom synthesis is available. Send your inquiries for more information. | London |
| Raltegravir Potassium Salt | Raltegravir is a potent, selective, and orally bioavailable inhibitor of HIV integrase (IC50 = 15 nM). It is metabolized primarily by uridine diphosphate glucuronosyltransferase 1A. Raltegravir has long-term efficacy and safety in managing HIV-1 infection in adults, children, and adolescents. Uses: Anti-hiv agents. Group: Pharmaceutical. Alternative Names: MK-0518; MK 0518; MK0518; Raltegravir. CAS No. 871038-72-1. Pack Sizes: 1 g. Product ID: B2692-078687. Molecular formula: C20H20FKN6O5. Mole weight: 482.514. Custom synthesis is available. Send your inquiries for more information. | London |
| Triethyl methanetricarboxylate | Triethyl methanetricarboxylate (CAS# 6279-86-3) is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors. Group: Pharmaceutical. Alternative Names: triethyl methanetricarboxylate. CAS No. 6279-86-3. Pack Sizes: 500 g. Product ID: B2699-323561. Molecular formula: C10H16O6. Mole weight: 232.23. Custom synthesis is available. Send your inquiries for more information. | London |
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