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| Product | Description | |
|---|---|---|
| Insulin aspart | Insulin aspart is an insulin analog that functions faster and lasts for a shorter time than regular insulin. Insulin aspart has been indicated for the treatment of type 1 and type 2 diabetes. Group: Pharmaceutical. CAS No. 116094-23-6. Pack Sizes: 25 mg. Product ID: BAT-016096. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Insulin Impurities | Insulin Impurities are by-products in insulin production, utilized in the biomedical field for quality control and safety assessment of insulin formulations. They play a crucial role in ensuring the therapeutic efficacy and minimizing adverse reactions in diabetes treatment. Studying these impurities aids in optimizing insulin manufacturing processes and improving diabetes management strategies. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2,2-dimethyldodecanoic Acid | 2,2-Dimethyldodecanoic acid, an intriguing biochemical, has emerged as a promising therapeutic candidate for the treatment of neurological disorders and diabetes. As a modulator of the mitochondrial membrane, this compound has garnered attention for its ability to enhance insulin sensitivity and glucose tolerance in experimental subjects, showcasing its therapeutic potential in metabolic disorders. Furthermore, preclinical investigations have yielded encouraging results, highlighting its potential to serve as a potent anxiolytic and antidepressant agent, rendering it a prime target for future research. Group: Pharmaceutical. CAS No. 2874-73-9. Pack Sizes: 10 g. Product ID: B1370-204330. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Aminophenyl a-D-mannopyranoside 6-phosphate | 4-Aminophenyl a-D-mannopyranoside 6-phosphate is a chemical compound used in the synthesis of phosphoinositide. This product is also used in the study of phosphatidylinositol (PI) signaling pathways, and has been shown to inhibit phospholipase C activity. Additionally, it has been found to be involved in the regulation of insulin secretion. Group: Pharmaceutical. CAS No. 74160-60-4. Pack Sizes: 100 mg. Product ID: B1370-000873. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Hydroxyisoleucine | 4-Hydroxyisoleucine, which comes from the seeds of Trigonella foenum-graecum L, could inhibit palmitate-induced, ROS-associated inflammation and restored insulin sensitivity through regulating IRS-1 function. It acts to improve insulin resistance by promoting mitochondrial biogenesis in high fructose diet fed STZ induced diabetic rats. Besides, 4-Hydroxyisoleucine could remarkably improve high glucose-induced IR in 3T3-L1 adipocytes. Meanwhile, 4-HIL could inhibit the secretion of TNF-alpha. Group: Pharmaceutical. CAS No. 781658-23-9. Pack Sizes: 100 mg. Product ID: B0005-347850. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5-[(2,4-Dichlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione | The esteemed 5-[(2,4-Dichlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione is a highly efficacious agent utilized in the management of type 2 diabetes mellitus. By enhancing insulin secretion and suppressing hepatic glucose output, it diligently lowers blood glucose concentrations, thereby promoting normoglycemia. Its demonstrated efficacy and mechanism of action render it an alluring therapeutic option for those with the aforementioned condition. Group: Pharmaceutical. CAS No. 51244-45-2. Pack Sizes: 50 mg. Product ID: B0001-284765. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5-[(2-Hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione | 5-[(2-Hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione, a chemical compound with potential therapeutic applications in diabetes and related metabolic disorders, exhibits insulin sensitizing properties that are aimed at lowering high-blood glucose levels and enhancing insulin sensitivity. Remarkably, this compound also has antioxidant and anti-inflammatory functions, which manifest its suitability in treating ailments associated with inflammation and oxidative stress. Therefore, it stands a good chance as a candidate for the treatment of various diseases with such pathological features. Group: Pharmaceutical. CAS No. 6325-94-6. Pack Sizes: 50 mg. Product ID: B0001-284762. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5-[(3,4-Dimethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione | 5-[(3,4-Dimethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione, a small molecule guanidine compound, exerts hypoglycemic effects in treating diabetes mellitus. The compound's hypoglycemic action is attributed to its capacity to augment insulin sensitivity as well as the uptake of glucose within cellular organelles. Group: Pharmaceutical. CAS No. 6325-95-7. Pack Sizes: 50 mg. Product ID: B0001-284770. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5-[(4-Hydroxy-3-methoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione | The compound 5-[(4-Hydroxy-3-methoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione finds applications in the biomedical domain as an antidiabetic medication. Its potential as an activator of the peroxisome proliferator-activated receptor gamma (PPARγ) has been acknowledged, presenting a promising approach towards the regulation of glucose metabolism and insulin sensitivity within the body. With demonstrated efficacy in the management of type 2 diabetes mellitus and associated complications, this synthetic compound presents a potential solution to this chronic condition. Group: Pharmaceutical. CAS No. 24044-50-6. Pack Sizes: 50 mg. Product ID: B0001-284767. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5-[Methylidene]thiazolidine-2,4-dione | 5-[Methylidene]thiazolidine-2,4-dione, a thiazolidinedione derivative, exhibits remarkable pharmaceutical potential in tackling diabetes via targeting the PPAR-γ protein responsible for maintaining glucose homeostasis. The efficacious drug candidate has demonstrated promising outcomes in ameliorating insulin resistance and alleviating hyperglycemia in diverse diabetes animal models, thus rendering it a potential therapeutic agent for diabetes management. Group: Pharmaceutical. CAS No. 36140-65-5. Pack Sizes: 50 mg. Product ID: B0001-284769. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ac-Octreotide | Ac-Octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Group: Pharmaceutical. CAS No. 83795-61-3. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-014620. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Amylin (human) | Amylin, islet Amyloid Polypeptide (IAPP), is a 37-residue peptide hormone secreted by pancreatic β-cells. It inhibits insulin-stimulated glucose uptake, delays gastric emptying and promotes satiety. It has glucose lowering effects in vivo. It is also used to study the mechanisms of amyloid deposition and its role in molecular misfolding processes expecially in conditions such as diabetes type II. Group: Pharmaceutical. CAS No. 122384-88-7. Pack Sizes: 1 mg. Product ID: BAT-006084. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Azoramide | Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It is a dual-function endoplasmic reticulum (ER) modulator in vitro. It improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones to protect cells against ER stress in multiple systems. It regulates ER folding and secretion capacity without inducing ER stress. It might have the protective effects of enhancing chaperone expression and reducing protein synthesis without inducing cytotoxicity and apoptosis. It showed potent antidiabetic activity in two independent mouse models of obesity by protecting pancreatic β cell function against ER stress and improving insulin sensitivity in vivo. It improves glucose homeostasis in mice with genetic obesity and diet-induced obesity. Group: Pharmaceutical. CAS No. 932986-18-0. Pack Sizes: 100 mg. Product ID: B1370-474920. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| β-Nicotinamide Mononucleotide | β-Nicotinamide mononucleotide, a major product of extracellular NAMPT reaction, could ameliorate glucose intolerance and also increase hepatic insulin sensitivity and sorts of gene expression involved in inflammatory response, oxidative stress and so on. Nutritional supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 1094-61-7. Pack Sizes: 5 g. Product ID: B0084-245647. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bi-linderone | Bi-linderone is a natural miscellaneou found in the roots of Lindera aggregata( Sims) Kosterm, it shows significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 microg/mL. Group: Pharmaceutical. CAS No. 1227375-09-8. Pack Sizes: 1 mg. Product ID: NP4323. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bruceine E | Bruceine E is extracted from the seeds of Brucea javanica (L.) Merr. It could reduce blood glucose concentration remarkably and may be used as an insulin secretagogue. Group: Pharmaceutical. CAS No. 21586-90-3. Pack Sizes: 1 mg. Product ID: NP1578. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Chrysin-7-O-glucuronide | Chrysin-7-O-glucuronide, a flavone compound derived from plants, has garnered attention for its therapeutic potential against cancer and diabetes. Prior investigations have demonstrated its ability to modulate the apoptotic pathways in cancer cells, leading to growth inhibition and reduced tumor progression. Furthermore, chrysin-7-O-glucuronide exhibits promising attributes as a glucose regulator, as evidenced by its capacity to enhance insulin sensitivity and support proper glucose metabolism. These findings collectively suggest chrysin-7-O-glucuronide as a worthy candidate for further exploration in the development of cancer and diabetes treatment. Group: Pharmaceutical. CAS No. 35775-49-6. Pack Sizes: 5 mg. Product ID: B2703-001241. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cosmosiin | Cosmosiin also called Apigenin 7-O-glucoside, is a natural flavonoid found in the flowers of Cosmos bipinnatus. Cosmosiin exhibits the activities of anti-HIV, anti-proliferative and antioxidant, the compound may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation. Uses: Anti-proliferative; antioxidant; anti-hiv. Group: Pharmaceutical. CAS No. 578-74-5. Pack Sizes: 20 mg. Product ID: NP1892. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CP-640186 | CP-640186 is a potent inhibitor of mammalian ACCs and can reduce body weight and improve insulin sensitivity in test animals. It has recently been shown to be a potent inhibitor of isoforms of mammalian ACCs. Most importantly, CP-640186 can reduce body fat mass and body weight, and improve insulin sensitivity, validating ACCs as targets for antiobesity and antidiabetes drugs. Group: Pharmaceutical. CAS No. 591778-68-6. Pack Sizes: 100 mg. Product ID: B2693-459321. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (Cys(S)²)-Octreotide trifluoroacetate salt | Trisulfide Octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B1370-449815. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| D-allo-Thr(6)-Octreotide trifluoroacetate salt | D-allo-Thr(6)-Octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B1370-449814. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| DCPIB | DCPIB is a potent and selective volume-sensitive anion channel (VSAC) blocker, swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells). It inhibits glucose-stimulated insulin in intact β-cells, and reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Group: Pharmaceutical. CAS No. 82749-70-0. Pack Sizes: 50 mg. Product ID: B2693-034500. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| D-Cys(2)-Octreotide trifluoroacetate salt | D-Cys(2)-Octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B1370-449817. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Degludec Impurities | Degludec Impurities are crucial in the biomedical industry for ensuring the purity and efficacy of insulin degludec formulations. By identifying and quantifying these impurities, researchers can refine pharmaceutical processes, ultimately aiding in the treatment of diabetes mellitus while maintaining drug safety and therapeutic effectiveness. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Diazoxide Impurities | Diazoxide Impurities are integral in the meticulous evaluation of antidiabetic and antihypertensive pharmaceuticals. These impurities are essential for determining the purity, safety, and efficacy of diazoxide formulations, crucial in hypoglycemia and hypertension management through modulation of smooth muscle relaxation and insulin secretion, thus ensuring pharmaceutical excellence. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Dihydroberberine | Dihydroberberine, isolated from the tubers of Corydalis decumbens (Thunb.) Pers, was identified that displayed improved in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents. It is also a potential therapeutic reagent for type 2 diabetes treatment. Uses: Anti-tumor. Group: Pharmaceutical. CAS No. 483-15-8. Pack Sizes: 10 mg. Product ID: B2703-465605. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| D-Thr(6)-Octreotide Acetate | D-Thr(6)-0ctreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Group: Pharmaceutical. CAS No. 87759-90-8. Pack Sizes: 10 mg. Product ID: B1370-449813. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ehp-inhibitor-1 | Ehp-inhibitor-1 is an Eph family tyrosine kinase inhibitor targeting Eph receptors. Study indicated that inhibition of Eph receptors results in an increase in glucose-stimulated insulin secretion from mouse and human pancreatic islets. Group: Pharmaceutical. CAS No. 861249-59-4. Pack Sizes: 50 mg. Product ID: B0084-284759. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ehp-inhibitor-2 | Ehp-inhibitor-2 is an Eph family tyrosine kinase inhibitor targeting Eph receptors. Study indicated that inhibition of Eph receptors results in an increase in glucose-stimulated insulin secretion from mouse and human pancreatic islets. Group: Pharmaceutical. CAS No. 861249-77-6. Pack Sizes: 50 mg. Product ID: B0084-284760. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Elafibranor | Elafibranor is a dual PPARα/δ agonist. Elafibranor increases plasma HDL and expression of Acox1, a PPARα target gene, and decreases plasma triglycerides and total cholesterol in the liver of ApoE2-KI wild-type mice. Elafibranor is identified as a drug candidate for the treatment of cardiometabolic diseases such as diabetes, insulin resistance, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD). Group: Pharmaceutical. CAS No. 923978-27-2. Pack Sizes: 250 mg. Product ID: B0084-074234. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Eriodictyol | Eriodictyol is a natural flavonoid found in the fruits of Citrus sinensis (L.) Osbeck. Eriodictyol exhibits activities of antidiabetic, anti-inflammatory and antioxidant. Eriodictyol can increases glucose uptake and improves insulin resistance. Group: Pharmaceutical. CAS No. 552-58-9. Pack Sizes: 10 mg. Product ID: NP2540. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Exenatide acetate | Exenatide acetate is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor with Ki value of 136 pM. It is a 39 amino acid peptide, which increases intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors. It was first isolated from the venom of H. horridum and consequently synthesized. It stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways via a GLP-1 receptor-dependent mechanism. It also stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells. It protects hippocampal neurons against glutamate-induced apoptosis, suggesting utility in neurodegenerative diseases. It also has anxiolytic and anti-depressant effects and induces satiety. It is an incretin mimetic approved for type 2 diabetes mellitus treatment. It also has neurotrophic/protective activity in cellular and animal models of stroke, Alzheimer's and Parkinson's diseases. Group: Pharmaceutical. CAS No. 914454-01-6. Pack Sizes: 100 mg. Product ID: BAT-010771. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Exendin 3 (9-39) | Exendin (9-39) is a specific and competitive glucagon-like peptide-1receptor antagonist (Kd = 1.7 nM at cloned human GLP-1 receptors). Exendin (9-39) inhibits insulin release and cAMP production caused by GLP-1 (7-36), exendin-3, and exendin-4. Group: Pharmaceutical. CAS No. 133514-43-9. Pack Sizes: 1 mg. Product ID: BAT-006203. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Genistein | Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. Genistein is developed to be an antitumor agent. Genistein has antioxidant effect, it can be used in cosmetics material. It is a plant polyphenol that can inhibit tyrosinase, block melanin synthesis, reduce skin pigment intensity, absorb UV, prevent photoaging, reduce sun damage and age spot formation, and whiten and lighten spots. It also has the anti-glycation and antibacterial effect, can effectively improve skin tone and skin texture, prevent the generation of age spots, remove red bloodlines, and improve skin blood microcirculation. Uses: Antitumor agent. Group: Pharmaceutical. CAS No. 446-72-0. Pack Sizes: 5 g. Product ID: BBF-01840. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GIP (human) | GIP (human) is a potent insulinotropic hormone synthesized by duodenal K-cells. It inhibits gastric acid secretion and stimulates pancreatic insulin release in response to glucose. Group: Pharmaceutical. CAS No. 100040-31-1. Pack Sizes: 1 mg. Product ID: BAT-006165. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Glimepiride | Glimepiride is a medium to long-acting sulfonylurea antidiabetic drug. It acts by stimulating the insulin release from pancreatic β-cells and decreases glucose output from the liver. Group: Pharmaceutical. CAS No. 93479-97-1. Pack Sizes: 10 g. Product ID: NP3448. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Glimepiride Impurities | Glimepiride Impurities play a crucial role in the pharmaceutical industry, primarily in the quality control and development of glimepiride-based medications. They are used to evaluate and ensure the purity and efficacy of glimepiride, a medication widely used in the treatment of type 2 diabetes by enhancing insulin secretion from pancreatic beta cells. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Glipizide Impurities | Glipizide Impurities are critical in the biomedical industry for analytical and quality control purposes in antidiabetic formulations. These impurities are employed to ensure the purity, efficacy, and safety of Glipizide, a well-known medication used in managing Type 2 diabetes by enhancing insulin secretion from pancreatic beta cells. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GLP-1(7-36) amide | GLP-1(7-36) amide is a glucose-dependent insulinotropic peptide displaying high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells (Kd = 204 pM). GLP-1 (7-36) amide exhibits antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration. Group: Pharmaceutical. CAS No. 107444-51-9. Pack Sizes: 1 mg. Product ID: BAT-006200. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GLP-1(7-37) | GLP-1 (7-37) is an insulinotropic peptide generated from the precursor peptide GLP-1 (1-37). It is a potent stimulator of insulin secretion at concentrations as low as 5 X 10(-11) M and has no effect on insulin secretion even at concentrations as high as 5 X 10(-7) M. It participates in the physiological regulation of insulin secretion. Uses: Glp-1 (7-37) acetate participates in the physiological regulation of insulin secretion. Group: Pharmaceutical. CAS No. 106612-94-6. Pack Sizes: 1 mg. Product ID: BAT-006116. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GLP-1 TFA | GLP-1 is a potent insulin secretagogue that has multiple synergetic effects on the glucose-dependent insulin secretion pathways of the beta-cell. Group: Pharmaceutical. Pack Sizes: 25 mg. Product ID: BAT-016125. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Glucagon-like peptide 1 (1-37), human | Glucagon-like peptide 1 (1-37) is a pancreatic hormone synthesized by post-translational processing of proglucagon. It decreases plasma glucose level in high-fat-fed mice when administered at 25 nmol/kg. Glucagon-like peptide 1 (1-37) exhibits no effect on food intake in rats and does not enhance pancreatic insulin secretion. However it induces insulin expression in intestinal epithelial cells, which can restore glucose homeostasis when implanted into diabetic mice. Group: Pharmaceutical. CAS No. 87805-34-3. Pack Sizes: 5 mg. Product ID: BAT-010492. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GW9508 | GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, and stimulates insulin secretion in a glucose-sensitive manner. GW9508 is commonly used in the treatment of type 2 diabetes. Group: Pharmaceutical. CAS No. 885101-89-3. Pack Sizes: 100 mg. Product ID: B0084-272136. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Homoplantaginin | Homoplantaginin is a flavonoid glycoside found in Scoparia dulcis. Homoplantaginin ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway, suggesting it may be used for the prevention and treatment of endothelial dysfunction associated with insulin resistance. Group: Pharmaceutical. CAS No. 17680-84-1. Pack Sizes: 25 mg. Product ID: B2703-465489. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| IGF-1 LR3 | IGF-1 LR3 is a lengthened analogue of human insulin-like growth factor 1 (IGF-1). Group: Pharmaceutical. CAS No. 946870-92-4. Pack Sizes: 5 mg. Product ID: BAT-006251. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| IXA4 | IXA4 is a highly selective and non-toxic IRE1/XBP1s activator, which activates the IRE1/XBP1s signaling, regardless of the global activation of the unfolded protein response (UPR) or other stress-responsive signaling pathways, such as heat shock response or oxidative stress response. IXA4 reduces APP secretion by activating IRE1. IXA4 therapy improves systemic glucose metabolism and hepatic insulin action through IRE1-dependent liver transcriptomic remodeling, thereby reducing glucose production and steatosis. IXA4-stimulated IRE1 activation also enhances pancreatic function. Group: Pharmaceutical. CAS No. 1185329-96-7. Pack Sizes: 100 mg. Product ID: B1370-382267. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| KIRA6 | KIRA6 allosterically inhibits IRE1α RNase kinase activity in vivo and promotes cell survival under ER stress. Systemically, KIRA6 preserves pancreatic β cells, increases insulin, and reduces hyperglycemia in Akita diabetic mice. Group: Pharmaceutical. CAS No. 1589527-65-0. Pack Sizes: 20 mg. Product ID: B0084-007192. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Linderaspirone A | Linderaspirone A, that is extracted from the roots of Lindera aggregata( Sims) Kosterm, showed significant activity against glucosamine-induced insulin resistance. Group: Pharmaceutical. CAS No. 1235126-46-1. Pack Sizes: 1 mg. Product ID: NP4320. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| L-Phe(1)-Octreotide trifluoroacetate salt | L-Phe(1)-Octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B1370-449818. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| L-Threoninol(Ac)-8-Octreotide trifluoroacetate salt | Threoninol(Ac)-8-Octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B1370-449816. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mazdutide acetate | Mazdutide acetate is a long-acting glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. Mazdutide acetate stimulates insulin secretion from mouse pancreatic islets, and can be used in studies of obesity and type 2 diabetes (T2D). Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B1370-449766. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MBX-2982 | MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion. Preclinical data indicate that MBX-2982 is a potent selective orally-active GPR119 agonist that functions through a unique dual mechanism of action. First, it acts directly on the beta cell to increase insulin secretion. In addition, MBX-2982 stimulates release of the incretin GLP-1 from the gut. This dual action is unique and may offer improved glucose homeostasis over existing diabetes therapies, with potential for weight loss and improved islet health. Group: Pharmaceutical. CAS No. 1037792-44-1. Pack Sizes: 20 mg. Product ID: B0084-456604. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MGF | Mechano growth factor (MGF) is a spliced variant of insulin-like growth factor 1 (IGF-1). IGF-1 is found in various tissues in the body including liver and muscle. Group: Pharmaceutical. Pack Sizes: 5 mg. Product ID: BAT-006153. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mitiglinide Impurities | Mitiglinide Impurities are critical in the pharmaceutical analysis of antidiabetic medications. They are essential for quality control and ensuring pharmacokinetic accuracy in mitiglinide formulations, which are primarily utilized for managing type 2 diabetes by enhancing insulin secretion. These impurities help in monitoring the drug's efficacy and safety during production. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mogroside V | Mogroside V is extracted from the fruit of Siraitia grosvenorii Swingle. It is 300 times sweeter than cane sugar and low in calories. It had a significant effect on insulin secretion and confirmed that the natural sweetener LHK could be beneficial for use by diabetic populations. Studies have found that mogrosides V have strong sweetness and functional effects. Group: Pharmaceutical. CAS No. 88901-36-4. Pack Sizes: 20 mg. Product ID: NP7008. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MSDC-0160 | MSDC-0160 reduces resistance in the insulin/IGF-1 signaling pathway and restores IGF-1-induced Akt and GSK-3 phosphorylation. Group: Pharmaceutical. CAS No. 146062-49-9. Pack Sizes: 25 mg. Product ID: B0084-311834. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MSDC-0602 | MSDC-0602 is an insulin sensitizer that has the potential to treat diabetes and other inflammatory diseases. It exhibits low affinity for binding and activation of PPAR&gamma. Group: Pharmaceutical. CAS No. 1133819-87-0. Pack Sizes: 50 mg. Product ID: B0084-284775. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Nateglinide Impurities | Nateglinide Impurities, intrinsic to rigorous evaluation and quality validation, play a crucial role in the realm of type 2 diabetes therapeutics, primarily through modulating insulin secretion. The stringent analysis and precise quantification of these impurities underpin drug safety and efficacy, fostering pharmaceutical advancements and upholding exacting regulatory frameworks. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Octreotide | Octreotide is an inhibitor of growth hormone, glucagon and insulin. It is also an agonist for sst2, sst3 and sst5 somatostatin receptors, hormone-secreting tumors. Uses: The treatment of hormone-secreting tumors, etc. Group: Pharmaceutical. CAS No. 83150-76-9. Pack Sizes: 5 mg. Product ID: BAT-010572. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PEG-MGF | PEG-MGF is a polyethylene glycol structure attached to a larger mechano growth factor molecule. It is a derived form of the IGF-1 (insulin-like growth factor-1), which stimulates myoblasts division and allows for muscle fibers to fuse and mature. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: BAT-006258. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Peptide YY (3-36) | Peptide YY (3-36) is a Y2/Y5 Neuropeptide Y receptor agonist (IC50= 0.11 nM for inhibition of 125I-PYY binding to Y2 receptor). Human peptide YY (PYY) has roles in energy homeostasis, food ingestion, gut motility and insulin secretion. Group: Pharmaceutical. CAS No. 126339-09-1. Pack Sizes: 5 mg. Product ID: BAT-006172. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PF-5190457 | PF-5190457 is a selective Growth hormone secretagogue receptor inverse agonist and it can increase insulin secretion in glucose-stimulated human islets. No recent reports of development were reported for phase-I development in Type-2-diabetes-mellitus. Uses: Type 2 diabetes mellitus. Group: Pharmaceutical. CAS No. 1334782-79-4. Pack Sizes: 500 mg. Product ID: B2693-475313. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rebaudioside A | Rebaudioside A is extracted from the leaves of Stevia rebaudiana Bertoni. It is a glucosylated steviol glycoside studied and used as a non-glycemic food sweetener. It is approximately 250 to 300 times sweeter than sucrose. It does not contribute calories or carbohydrates to the diet and do not affect blood glucose or insulin response. It is safe for human consumption under its intended conditions of use as a general purpose sweetener. Group: Pharmaceutical. CAS No. 58543-16-1. Pack Sizes: 50 g. Product ID: NP1551. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rebaudioside I | Rebaudioside I, a plant-derived non-caloric sweetener extracted from Stevia rebaudiana leaves, has been widely adopted in food and beverage industries as a sugar supplement. Beyond its sweetness, this compound demonstrates tremendous potential for managing type 2 diabetes, by enhancing insulin secretion and improving glucose tolerance. Evidence also suggests that rebaudioside I may possess both anti-inflammatory and anti-tumor properties, making it a promising candidate for therapeutic applications. Group: Pharmaceutical. CAS No. 1220616-34-1. Pack Sizes: 1 mg. Product ID: B1999-003557. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rebaudioside M | Rebaudioside M is a natural sweetener extracted from the stevia plant. It is commonly used as a substitute for sugar in various food and beverage products due to its high sweetness and low calorie content. Additionally, studies have shown that rebaudioside M may have potential applications in the treatment of diabetes and obesity due to its ability to regulate blood sugar levels and improve insulin sensitivity. Group: Pharmaceutical. CAS No. 1220616-44-3. Pack Sizes: 10 mg. Product ID: B2705-003561. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Repaglinide | Repaglinide is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used for the treatment of type II diabetes. Group: Pharmaceutical. CAS No. 135062-02-1. Pack Sizes: 1 g. Product ID: NP3248. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Repaglinide Impurities | Repaglinide Impurities are crucial in the biomedical industry for quality control and the development of antidiabetic medications. These impurities are analyzed to ensure the purity and efficacy of Repaglinide, a drug used to manage type 2 diabetes by stimulating insulin release from the pancreas. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rhoifolin | Rhoifolin is a natural flavonoid isolated from the leaves of Turpinia arguya Seem. It may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation. Rhoifolin inhibits the activity of anti-inflmmatory and increases the total antioxidant capacity in a reverse dose order, which can cause a time and reverse dose dependent reduction of carrageenin-induced rat paw oedema, significantly abrogate prostaglandin E2 level, significantly diminish the TNF-a release in the inflammatory exudates. The compound could also be used as an ideal anticancer agent, and it discriminates between cancerous and non cancerous cell as it kills only the former one, so the side effects which may appear during chemotherapy could be overcome. Uses: Anti-inflammatory; anti-cancer. Group: Pharmaceutical. CAS No. 17306-46-6. Pack Sizes: 25 mg. Product ID: NP1948. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Roseoside | Roseoside comes from the herbs of Catharanthus roseus. Roseoside has insulinotropic activity, enhances insulin release from the β-cell line INS-1. And it has Inhibitory activity on leukotriene release from mouse bone marrow-derived cultured mast cells (BMCMC). Uses: Insulinotropic activity. Group: Pharmaceutical. CAS No. 54835-70-0. Pack Sizes: 1 mg. Product ID: NP5607. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Salcaprozate sodium | Salcaprozate sodium (SNAC) is used as an excipient in drug formulation as a chemical permeation enhancer (PE) to aid the oral absorption of macromolecules, peptides and proteins such as insulin (diabetes), heparin (heart attacks and angina) and cyanocobalamin (vitamin B12 deficiency and anaemia) which would otherwise have poor bioavailability. SNAC is considered to be safe for human consumption (GRAS) by the FDA. Group: Pharmaceutical. CAS No. 203787-91-1. Pack Sizes: 5 g. Product ID: BAT-010174. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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