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| Product | Description | |
|---|---|---|
| Indole-3-acetic acid | 100g Pack Size. Group: Building Blocks, Indoles, Organics. Formula: C H NO . CAS No. 87-51-4. Prepack ID : 14179886-100g. Molecular Weight : 175.19. |  |
| Corynoxeine | Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and a useful and prospective compound in the prevention and treatment for vascular diseases. Uses: Antihypertension. Group: Pharmaceutical. Alternative Names: corynoxeine; (7R,16E,20α)-16,17,18,19-Tetradehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester; (alphaE,1'R,6'R,7'S,8'aS)-6'-Ethenyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid methyl ester; 16,17,18,19-Tetradehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester; Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-aceticacid, 6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-a-(methoxymethylene)-2-oxo-, methyl ester, (aE,1'R,6'R,7'S,8'aS)-. CAS No. 630-94-4. Pack Sizes: 10 mg. Product ID: B2703-450788. Molecular formula: C22H26N2O4. Mole weight: 382.45. Custom synthesis is available. Send your inquiries for more information. |  London |
| Hypaphorine | Hypaphorine is an indole-3-acetic acid antagonist which specifically competes with indole-3-acetic acid in binding to the indole-3-acetic acid-binding site in plant peroxidases. Group: Pharmaceutical. Alternative Names: Lenticin; Tryptophan betaine; Glyyunnanenine. CAS No. 487-58-1. Pack Sizes: 10 mg. Product ID: B2703-465879. Molecular formula: C14H18N2O2. Mole weight: 246.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Isocorynoxeine | Isocorynoxeine, one of the major alkaloids from Uncaria Hook, shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. Group: Pharmaceutical. Alternative Names: Isocorynoxeine; (16E,20α)-16,17,18,19-Tetradehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester; (alphaE,1'S,6'R,7'S,8'aS)-6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid methyl ester. CAS No. 51014-29-0. Pack Sizes: 10 mg. Product ID: NP0559. Molecular formula: C22H26N2O4. Mole weight: 382.45. Custom synthesis is available. Send your inquiries for more information. | London |
| Isorhynchophylline | Rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and anticonvulsant activity of the Uncaira species plant extracts. Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, the present results suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia. Group: Pharmaceutical. Alternative Names: methyl (E)-2-((3S,6'R,7'S,8a'S)-6'-ethyl-2-oxo-2',3',6',7',8',8a'-hexahydro-5'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate; Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'R,7'S,8'aS)-; 7-Isorhyncophylline; Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E,20α)-; (+)-Isorhynchophylline; Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, [1'S-[1'α,6'α,7'β(E),8'aα]]-. CAS No. 6859-1-4. Pack Sizes: 50 mg. Product ID: NP0065. Molecular formula: C22H28N2O4. Mole weight: 384.47. Custom synthesis is available. Send your inquiries for more information | London |
| Laropiprant | a drug used in combination with niacin to reduce blood cholesterol (LDL and VLDL) that is no longer sold. Uses: A potent, selective dp1 receptor antagonist. Group: Pharmaceutical. Alternative Names: (3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-cyclopent[b]indole-3-acetic acid. CAS No. 571170-77-9. Pack Sizes: 50 mg. Product ID: B0084-474242. Molecular formula: C21H19ClFNO4S. Mole weight: 435.91. Custom synthesis is available. Send your inquiries for more information. | London |
| Setipiprant | Setipiprant is a potent, orally available and selective CRTH2 antagonist, which is a G protein-coupled receptor for PGD2. It may be a promising target for the treatment of allergic disorders. It was well tolerated and reduced both the allergen-induced LAR and the associated AHR in allergic asthmatics at multiple oral doses. It is a drug originally developed by Actelion, but it failed to show sufficient advantages and was discontinued from further development in this application. Later it was developed as a novel treatment for baldness by Kythera. Uses: Setipiprant may be a promising target for the treatment of allergic disorders. Group: Pharmaceutical. Alternative Names: ACT-129968; ACT 129968; ACT129968; 2-(2-(1-naphthoyl)-8-fluoro-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)acetic acid;ACT129968;2-[8-fluoro-2-(naphthalene-1-carbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid;8-Fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-5H-pyrido[4,3-b]indole-5-acetic acid; KYTH-105; KYTH105; KYTH 105. CAS No. 866460-33-5. Pack Sizes: 25 mg. Product ID: B0084-474875. Molecular formula: C24H19FN2O3. Mole weight: 402.42. Custom synthesis is available. Send your inquiries for more information. | London |
| Compstatin | Compstatinis, a 13-residue cyclic peptide, is a potent inhibitor of the complement system (IC50= 12 μM) and binds to complement component C3. Group: Pharmaceutical. Alternative Names: H-Ile-Cys(1)-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys(1)-Thr-NH2; L-isoleucyl-L-cysteinyl-L-valyl-L-valyl-L-glutaminyl-L-alpha-aspartyl-L-tryptophyl-glycyl-L-histidyl-L-histidyl-L-arginyl-L-cysteinyl-L-threoninamide (2->12)-disulfide; 2-[(4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-4-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]carbamoyl]-34-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-25-(3-amino-3-oxopropyl)-7-[3-(diaminomethylideneamino)propyl]-10,13-bis(1H-imidazol-5-ylmethyl)-19-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33-decaoxo-28,31-di(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decazacyclopentatriacont-22-yl]acetic acid. CAS No. 206645-99-0. Pack Sizes: 5 mg. Product ID: BAT-006096. Molecular formula: C66H99N23O17S2. Mole weight: 1550.77. Custom synthesis is available. Send your inquiries for more information. | London |
| INDOL-3-YL-ACETIC ACID UN | INDOL-3-YL-ACETIC ACID UN, UK suppliers of laboratory chemicals and apparatus needed |  |
| Methyl 1-Acetyl-2-oxoindoline-6-carboxylate | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Group: Pharmaceutical. Alternative Names: 1-acetyl-2-oxo-3H-indole-6-carboxylic acid methyl ester; methyl 1-acetyl-2-oxo-3H-indole-6-carboxylate. CAS No. 676326-36-6. Pack Sizes: 100 mg. Product ID: B1421-184191. Molecular formula: C12H11NO4. Mole weight: 233.22. Custom synthesis is available. Send your inquiries for more information. | London |
| Nintedanib Impurity 6 (Intedanib Impurity 6) | BIBF 1202 is the major in-vivo metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR. It is a related compound of Intedanib, which is an indolinone derivative that inhibits angiokinase and an antitumor agent. It is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (VEGF) signaling pathway thus inhibition of tumor angiogenesis. Uses: Bibf 1202 is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (vegf) signaling pathway thus inhibition of tumor angiogenesis. Group: Pharmaceutical. Alternative Names: BIBF-1202; BIBF 1202; BIBF1202. (3Z)-2,3-Dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid;(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1 -yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic acid;Nintedanib Impurity 5. CAS No. 894783-71-2. Pack Sizes: 50 mg. Product ID: B0084-474893. Molecular formula: C30H31N5O4. Mole weight: 525.6. Custom synthesis is available. Send your inquiries for more information. | London |
| Physostigmine salicylate | Physostigmine salicylate is a cholinesterase inhibitor that can cross blood-brain barrier. It forms slowly degrading carbamylated enzyme complex with acetylcholinesterase (AChE). It has been used to improve cognitive ability and treat glaucoma. Group: Pharmaceutical. Alternative Names: [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate (2-hydroxybenzoic acid) salt. CAS No. 57-64-7. Pack Sizes: 250 mg. Product ID: B0084-028331. Molecular formula: C22H27N3O5. Mole weight: 413.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Timapiprant | Timapiprant is a potent and selective D prostanoid receptor 2 (DP2; CRTH2) antagonist. It effectively improves lung function and symptoms in patients with atopic eosinophilic asthma. It was shown to reduce both nasal and eye symptoms in allergic subjects exposed to grass pollen. Group: Pharmaceutical. Alternative Names: OC-000459; OC 000459; OC000459; 2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-indol-1-yl)acetic acid. CAS No. 851723-84-7. Pack Sizes: 25 mg. Product ID: B2693-459861. Molecular formula: C21H17FN2O2. Mole weight: 348.37. Custom synthesis is available. Send your inquiries for more information. | London |
| Vinorelbine Ditartrate | Vinorelbine ditartrate, whose base is Vinorelbine, is a selective mitotic microtubule antagonist. It inhibits proliferation of Hela cells (IC50= 1.25 nM) and suppress microtubule dynamics (IC50 = 3.8 nM). Uses: Antitumor. Group: Pharmaceutical. Alternative Names: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester; 125317-39-7; Navelbine; KW-2307; Ambap125317-39-7; MFCD03613607; AB15572; NVB; Q-100110; (2B,3B,4B,5A,12R,19A)-4-(ACETYLOXY)-6,7-DIDEHYDRO-15-[(2R,6R,8S)-4-ETHYL-1,3,6,7,8,9-HEXAHYDRO-8-(METHOXYCARBONYL)-2,6-METHANO-2H-AZECINO[4,3-B]INDOL-8-YL]-3-HYDROXY-16-METHOXY-1-METHYLASPIDOSPERMIDINE-3-CARBOXYLIC ACID; 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt]; 3',4'-DIDEHYDRO-4'-DEOXY-C'-NORVINCALEUKOBLASTINE [R-(R*,R*)-2-3-DIHYDROXYBUTANEDIOATE (1:2)SALT], 5'-NORANHYDRO; 3',4'-DIDEHYDRO-4'-DEOXY-C'-NORVINCALEUKOBLASTINE R-(R*,R*)-2-3-DIHYDROXYBUTANEDIOATE (1:2) SALT; 3',4'-DIDEHYDRO-4'-DEOXY-C'-NORVINCALEUKOBLASTINE R-(R*,R*)-2-3-DIHYDROXYBUTANEDIOATE SALT. CAS No. 125317-39-7. Pack Sizes: 1 g. Product ID: B2692-311522. Molecular formula: C45H54N4O8.2C4H6O6. Mole weight: 1079.1. Custom synthesis is available. Send your inquiries for more information. | London |
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