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| Product | Description | |
|---|---|---|
| Imidazo[1,2-b]pyridazine | Imidazo[1,2-b] pyridazine, a heterocyclic compound, plays a crucial role in the research and development of novel anti-neoplastic agents. Its mechanism of action involves selective enzyme inhibition, highlighting its potential as a therapeutic candidate for a wide spectrum of malignancies. Group: Pharmaceutical. CAS No. 766-55-2. Pack Sizes: 1mg;1g;10g. Product ID: NP3189. Molecular formula: C6H5N3. Mole weight: 119.12. Custom synthesis is available. Send your inquiries for more information. |  London |
| Imidazo[1,2-b]pyridazine | Imidazo[1,2-b]pyridazine. Uses: Pharmaceuticals, Personal Care, Industrial. Grades: Pharma, Cosmetic, Food, Feed, Technical. CAS No. 766-55-2. Pack Sizes: Bulk. Cenik is your partner of choice for Hard-to-find chemicals. We don't just provide products, we supply solutions to your technical and regulatory specifications. |  Cenik Chemicals |
| GNE-8525 | This active molecular is a selective pan-TRK inhibitor. GNE-8525 shows potent antiproliferation activity (IC50 = 0.003 μM) and it shows in vivo antitumor efficacy in tumor xenograft model derived from the KM12 cell line. TRKA are believed to be the key oncogenic driver in many tumors including glioblastoma, melanoma and so on. Uses: Antitumor. Group: Pharmaceutical. Alternative Names: GNF-8625; GNF 8625; GNF8625. (R)-1-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-[2,4'-bipyridin]-2'-yl)piperidin-4-ol. CAS No. 1196546-33-4. Pack Sizes: 50 mg. Product ID: B0084-475140. Molecular formula: C31H30FN7O. Mole weight: 535.63. Custom synthesis is available. Send your inquiries for more information. | London |
| LY2784544 | LY2784544 is a potent and selective JAK2 inhibitor (IC50 = 3 nM), and exhibits less potency against JAK3 (IC50 =48 nM). LY2784544 effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC50 = 20 and 55 nM, respectively). It reduces JAK2V617F tumor cell burden with no effect on erythroid progenitor cells. Group: Pharmaceutical. Alternative Names: Gandotinib; LY-2784544; 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine. CAS No. 1229236-86-5. Pack Sizes: 25 mg. Product ID: B0084-286443. Molecular formula: C23H25ClFN7O. Mole weight: 469.949. Custom synthesis is available. Send your inquiries for more information. | London |
| Ponatinib | Ponatinib is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively. Group: Pharmaceutical. Alternative Names: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide; AP24534; AP-24534; AP 24534; Ponatinib Brand name: Iclusig. CAS No. 943319-70-8. Pack Sizes: 300 mg. Product ID: B0084-272000. Molecular formula: C29H27F3N6O. Mole weight: 532.56. Custom synthesis is available. Send your inquiries for more information. | London |
| Ponatinib hydrochloride | Ponatinib hydrochloride is an oral drug for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). It is a multi-targeted tyrosine-kinase inhibitor. It has potential antiangiogenic and antineoplastic activities. It inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. It inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3). It was developed by Ariad Pharm and has been listed. Uses: Ponatinib hydrochloride is an oral drug for the treatment of chronic myeloid leukemia (cml) and philadelphia chromosome-positive (ph+) acute lymphoblastic leukemia (all). it has potential antiangiogenic and antineoplastic activities. Group: Pharmaceutical. Alternative Names: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride; AP24534; AP-24534; AP 24534; Ponatinib HCl; Ponatinib hydrochloride trade name Iclusig. CAS No. 1114544-31-8. Pack Sizes: 300 mg. Product ID: B0084-475072. Molecular formula: C29H28ClF3N6O. Mole weight: 569.03. Custom synthesis is available. Send your inquiries for more information. | London |
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