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| Product | Description | |
|---|---|---|
| 25-Hydroxy-Cholesterol | 25-hydroxycholesterol is an inhibitor of human immunodeficiency virus replication in vitro. It induces apoptosis in human monocytic cell lines as well as in CEM cells associated with negative regulation of c-Myc. Group: Pharmaceutical. CAS No. 2140-46-7. Pack Sizes: 200 mg. Product ID: B2693-000027. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| SR3335 | The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM). It has no effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor &alpha. SR 3335 evokes RORα-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis. Group: Pharmaceutical. CAS No. 293753-05-6. Pack Sizes: 50 mg. Product ID: B2693-458981. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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