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| Product | Description | |
|---|---|---|
| α-epidermal growth factor, human | Recombinant human epidermal growth factor has the same structure as the human epidermal growth factor. EGF binds to epidermal growth factor receptor (EGFR) and stimulates cell growth and proliferation. Recombinant human epidermal growth factor is approved for the treatment of diabetic foot ulcers. Uses: The treatment of diabetic foot ulcers. Group: Pharmaceutical. CAS No. 62253-63-8. Pack Sizes: 1 mg. Product ID: BAT-010173. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| AEE-788 | AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. Group: Pharmaceutical. CAS No. 497839-62-0. Pack Sizes: 10 mg. Product ID: B0084-258485. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AV-412 | AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Group: Pharmaceutical. CAS No. 451492-95-8. Pack Sizes: 20 mg. Product ID: B0084-324573. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BGJ-398 | BGJ398, also known as NVP-BGJ398, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Group: Pharmaceutical. CAS No. 872511-34-7. Pack Sizes: 100 mg. Product ID: B2693-453477. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BI-3406 | BI-3406 is a potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS, and mutants of RAS are major oncogenes and occur in many human cancers. Inhibition of SOS1 in a mutant KRAS cell line can suppress tumor growth. Group: Pharmaceutical. CAS No. 2230836-55-0. Pack Sizes: 5 mg. Product ID: B2693-363125. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bonducellin | Bonducellin is isolated from the herbs of Caesalpinia spinosa. Bonducellin shows weak antiproliferative against A2780 human ovarian cancer cell line with the IC50 value of 10.6 uM. Bonducellin has anti-inflammatory activities that can significantly and dose-dependently inhibit the inflammatory mediators: nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. Bonducellin shows modulation in the MIC of EtBr by eight fold at a concentration of 62.5 mg/L and also shows significant efflux pump inhibitory activity. Group: Pharmaceutical. CAS No. 83162-84-9. Pack Sizes: 2 mg. Product ID: NP2129. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CC-885 | CC-885 is a cereblon (CRBN) modulator with an anti-tumour activity mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. CC-885 potently suppresses the proliferation of human acute myeloid leukaemia (AML) tumour cell lines. Uses: Antitumor agent. Group: Pharmaceutical. CAS No. 1010100-07-8. Pack Sizes: 100 mg. Product ID: B2693-054699. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Dacomitinib | Dacomitinib, aslo known as PF-299 and PF-00299804; or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types. Group: Pharmaceutical. CAS No. 1110813-31-4. Pack Sizes: 250 mg. Product ID: B0084-452473. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| FGF-401 | FGF-401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4) (IC50 = 1.9 nM) developed for the treatment of solid tumor. Group: Pharmaceutical. CAS No. 1708971-55-4. Pack Sizes: 10 mg. Product ID: B0084-007362. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| IGF-1 LR3 | IGF-1 LR3 is a lengthened analogue of human insulin-like growth factor 1 (IGF-1). Group: Pharmaceutical. CAS No. 946870-92-4. Pack Sizes: 5 mg. Product ID: BAT-006251. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Irbinitinib | Irbinitinib,also known as ARRY-380 and ONT-380, is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 937263-43-9. Pack Sizes: 100 mg. Product ID: B0084-462666. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Lapatinib Ditosylate | Lapatinib is a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 388082-77-7. Pack Sizes: 1 g. Product ID: B0084-067756. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Minocycline hydrochloride | Minocycline (INN) is a semi-synthetic broad-spectrum tetracycline antibiotic. Minocycline hydrochloride is the most lipid-soluble form, which binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis. In combination with CHIR 99021, (S)-(+)-Dimethindene maleate and human leukemia inhibitory factor, it induces the formation of extended pluripotent stem (EPS) cells. Group: Pharmaceutical. CAS No. 13614-98-7. Pack Sizes: 5 g. Product ID: BBF-03822. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Plitidepsin | Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin shows potent anticancer activity against a large variety of cultured human cancer cells, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth. Group: Pharmaceutical. CAS No. 137219-37-5. Pack Sizes: 1 mg. Product ID: BAT-010093. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PX-478 dihydrochloride | PX-478 is an HIF-1alpha inhibitor and an orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be fully elucidated, HIF1-alpha inhibitor PX-478 appears to inhibit hypoxia-inducible factor 1-alpha (HIF1A) expression, which may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation, and the induction of tumor cell apoptosis. The inhibitory effect of this agent is independent of the tumor suppressor genes VHL and p53 and may be related to derangements in glucose uptake and metabolism due to inhibition of glucose transporter-1 (Glut-1). PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity. It is rapidly absorbed following oral and i.p. administration and gives excellent Cmax and AUC via these routes. Group: Pharmaceutical. CAS No. 685898-44-6. Pack Sizes: 100 mg. Product ID: B2693-459441. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Recombinant IGF-I (human) | Recombinant IGF-I (human) is a monoclonal antibody that binds to the epidermal growth factor receptor (EGFR) and inhibits its activity. Group: Pharmaceutical. CAS No. 67763-96-6. Pack Sizes: 1 mg. Product ID: BAT-010854. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rogaratinib | Rogaratinib is a pan inhibitor of human fibroblast growth factor receptors (FGFRs). It reduced proliferation in FGFR-addicted cancer cell lines of various cancer types including lung, breast, colon and bladder cancer. Group: Pharmaceutical. CAS No. 1443530-05-9. Pack Sizes: 25 mg. Product ID: B2693-004563. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ruscogenin | Ruscogenin is a saponin found in the root of Ophiopogon japonicus. It inhibits the expressions of TF, iNOS, and NF-kappaB p65 and is therefore a potential target for acute lung injury or sepsis. It remarkably inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner. Group: Pharmaceutical. CAS No. 472-11-7. Pack Sizes: 10 mg. Product ID: B2703-464341. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Saikosaponin D | Saikosaponin D is extracted from the root of Bupleurum chinense DC. It protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. It possesses potent cytotoxicity against human hepatocellular carcinoma cells. It inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase. It was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release. Uses: Anti-inflammatory agents, non-steroidal. Group: Pharmaceutical. CAS No. 20874-52-6. Pack Sizes: 20 mg. Product ID: NP7004. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SB239063 | SB239063 is a potent p38MAPK inhibitor. SB 239063 had an IC(50) of 44 nM for inhibition of recombinant purified human p38alpha. In lipopolysaccharide-stimulated human peripheral blood monocytes, SB 239063 inhibited interleukin-1 and tumor necrosis factor-alpha production. SB 239063 may be useful for the treatment of asthma and other inflammatory disorders. Uses: Protein kinase inhibitors. Group: Pharmaceutical. CAS No. 193551-21-2. Pack Sizes: 100 mg. Product ID: B2693-196670. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Solamargine | Solamargine, a steroidal alkaloid glycoside, is isolated from the fruits of a traditional Chinese medicinal herb called Solanum incanum L., triggered gene expression of human tumor necrosis factor receptor (TNFR) I which might lead to cell apoptosis. Uses: Anti-trypanosomal. Group: Pharmaceutical. CAS No. 20311-51-7. Pack Sizes: 25 mg. Product ID: NP0028. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| T-5224 | T-5224 is a selective inhibitor of c-Fos/activator protein-1. T-5224 ameliorates liver injury and improves survival through decreasing production of proinflammatory cytokines and chemokines in endotoxemic mice. T-5224 has been investigated in phase II human clinical trials. T-5224 may be a promising new treatment for septic kidney injury. Activator protein 1 (AP-1) is a pivotal transcription factor that regulates a wide range of cellular processes including proliferation, apoptosis, differentiation, survival, cell migration, and transformation. Accumulating evidence supports that AP-1 plays an important role in several severe disorders including cancer, fibrosis, and organ injury, as well as inflammatory disorders such as asthma, psoriasis, and rheumatoid arthritis. Group: Pharmaceutical. CAS No. 530141-72-1. Pack Sizes: 100 mg. Product ID: B1370-462792. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tectorigenin | Tectorigenin induced differentiation of human promyelocytic leukemia HL-60 cells to granulocytes and monocytes/macrophages, and caused apoptotic changes of DNA in the cells, as did genistein. Tectorigenin also inhibited autophosphorylation of epidermal growth factor (EGF) receptor by EGF and decreased the expression of Bcl-2 protein, with less activity than genistein. From these results, tectorigenin may be a possible therapeutic agent for leukemia. Uses: Antioxidant. Group: Pharmaceutical. CAS No. 548-77-6. Pack Sizes: 100 mg. Product ID: NP2537. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| TNF-α (46-65), human | TNF-α (46-65), human is a compound accomplishing its efficacy by specifically targeting a fragment of Tumor Necrosis Factor-alpha (TNF-α), finding purpose in the studyof diverse conditions, encompassing rheumatoid arthritis, psoriasis, Crohn's disease and ulcerative colitis. Group: Pharmaceutical. CAS No. 144796-72-5. Pack Sizes: 5 mg. Product ID: BAT-006197. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ulinastatin | Ulinastatin is an acid-resistant protease inhibitor derived from human urine, acting as a potent anti-inflammatory agent. It was shown to inhibit the activities of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin, lipase, hyaluronidase, factors IXa, Xa, XIa, and XlIa, and polymorphonuclear leukocyte elastase. Group: Pharmaceutical. CAS No. 80449-31-6. Pack Sizes: 1 g. Product ID: B2693-135299. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Vosoritide | Vosoritide is a medicine used to treat achondroplasia. Vosoritide works by binding to a receptor (target) called natriuretic peptide receptor type B (NPR-B), which reduces the activity of fibroblast growth factor receptor 3 (FGFR3). Uses: vosoritide, a synthetic analog of the human growth hormone receptor antagonist bmp-7, has emerged as a promising candidate in drug development, particularly in the area of ??rare genetic diseases characterized by impaired skeletal growth and development. achondroplasia is the most common form of disproportionate dwarfism and is characterized by abnormal skeletal growth and development, especial. Group: Pharmaceutical. CAS No. 1480724-61-5. Pack Sizes: 50 mg. Product ID: BAT-009108. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| YKL-06-061 | YKL-06-061 is a small molecule serine/threonine-protein kinase SIK1 inhibitor (Ki = 6.56 nM) that is hopefully developed to be a dermatologic drug impacting UV protection and skin cancer risk. It causes a dose-dependent increase in microphthalmia-associated transcription factor (MITF) mRNA expression during 3-hour function in normal human melanocytes, UACC62 human melanoma cells, and UACC257 human melanoma cells. Uses: A potential dermatologic drug. Group: Pharmaceutical. CAS No. 2172617-15-9. Pack Sizes: 50 mg. Product ID: B0084-112344. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Kerantinocyte Growth Factor | Recombinant Human KGF is an 18.9 kDa protein containing 163 amino residues. Group: Pharmaceutical. CAS No. 148348-15-6. Pack Sizes: 50 mg. Product ID: B1370-167006. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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