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| Product | Description | |
|---|---|---|
| Abexinostat | Abexinostat, also known as PCI-24781 or CRA-024781, is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling. Group: Pharmaceutical. Alternative Names: CRA-024781; CRA 024781; CRA024781; PCI-24781; PCI24781; PCI 24781. CAS No. 783355-60-2. Pack Sizes: 100 mg. Product ID: B2693-286637. Molecular formula: C21H23N3O5. Mole weight: 397.431. Custom synthesis is available. Send your inquiries for more information. |  London |
| Belinostat | Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor. Belinostat targets HDAC enzymes to inhibit tumor cell proliferation and angiogenesis, induce apoptosis and promote cellular differentiation. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: Belinostat; PXD 101; Beleodaq; PDX101; PX 105684; PXD-101; PXD101; (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide. CAS No. 414864-00-9. Pack Sizes: 100 mg. Product ID: B0084-141764. Molecular formula: C15H14N2O4S. Mole weight: 318.347. Custom synthesis is available. Send your inquiries for more information. | London |
| CXD101 | CXD101 is a selective histone deacetylase (HDAC) inhibitor with IC50 of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. It exhibits antineoplastic activity. Group: Pharmaceutical. Alternative Names: HDAC-IN-4; CXD-101; CXD 101; N-(2-Aminophenyl)-4-(1-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)piperidin-4-yl)benzamide. CAS No. 934828-12-3. Pack Sizes: 10 mg. Product ID: B1370-379907. Molecular formula: C24H29N5O. Mole weight: 403.52. Custom synthesis is available. Send your inquiries for more information. | London |
| Entinostat | Entinostat is a histone deacetylase (HDAC) inhibitor displaying antiproliferative and antineoplastic effects. Entinostat induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), which slows cell growth, differentiation, and tumor development in vivo. Entinostat is potentially used as an antitumor drug in combination with other drugs like adriamycin, PARP inhibitors and Hsp90 inhibitors. Uses: Histone deacetylase inhibitors. Group: Pharmaceutical. Alternative Names: MS275; MS-275; MS 2275; SNDX275; SNDX-275; SNDX 275; Entinostat; pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate. CAS No. 209783-80-2. Pack Sizes: 500 mg. Product ID: B0084-062759. Molecular formula: C21H20N4O3. Mole weight: 376.416. Custom synthesis is available. Send your inquiries for more information. | London |
| M344 | M344 is a potent HDAC inhibitor, which can also induce expression of the pro-apoptotic genes, Puma and Bax, together with the morphological features of apoptosis, in MCF-7 cells. Group: Pharmaceutical. Alternative Names: M 344; M-344; Histone Deacetylase Inhibitor III. CAS No. 251456-60-7. Pack Sizes: 100 mg. Product ID: B1370-103604. Molecular formula: C16H25N3O3. Mole weight: 307.39. Custom synthesis is available. Send your inquiries for more information. | London |
| Panobinostat | Panobinostat is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: LBH589; LBH 589; LBH-589; NVP-LBH589; NVP-LBH 589; Panobinostat; trade name Farydak. CAS No. 404950-80-7. Pack Sizes: 500 mg. Product ID: B0084-141578. Molecular formula: C21H23N3O2. Mole weight: 349.434. Custom synthesis is available. Send your inquiries for more information. | London |
| Pracinostat | Pracinostat (SB939) is an orally bioavailable, small-molecule histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Pracinostat inhibits HDACs, which may result in the accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; the tumor suppressor protein-mediated inhibition of tumor cell division; and, finally, the induction of tumor cell apoptosis. This agent may possess improved metabolic, pharmacokinetic and pharmacological properties compared to other HDAC inhibitors. Group: Pharmaceutical. Alternative Names: SB939; SB 939; SB-939; SC-939; SC 939; SC939; Pracinostat. CAS No. 929016-96-6. Pack Sizes: 1 g. Product ID: B0084-286706. Molecular formula: C20H30N4O2. Mole weight: 358.486. Custom synthesis is available. Send your inquiries for more information. | London |
| Rocilinostat | Rocilinostat is an orally bioavailable histone deacetylase 6 (HDAC6) inhibitor with potential antineoplastic activity. It selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. Compared to non-selective HDAC inhibitor, Rocilinostat is able to reduce the toxic effects on normal, healthy cells. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: ACY-1215; ACY1215; ACY 1215; Rocilinostat; 2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide. CAS No. 1316214-52-4. Pack Sizes: 500 mg. Product ID: B0084-462644. Molecular formula: C24H27N5O3. Mole weight: 433.512. Custom synthesis is available. Send your inquiries for more information. | London |
| Tucidinostat | Tucidinostat is a novel inhibitor of HDAC1, 2, 3, and 10 with IC50 values of 95, 160, 67, 78 nM, respectively. It increases the acetylation levels of histone H3 and decreases histone deacetylase (HDAC) activity, inducing apoptosis of cancer cells. Group: Pharmaceutical. Alternative Names: HBI-8000; CS-055; Chidamide; Epidaza. CAS No. 1616493-44-7. Pack Sizes: 25 mg. Product ID: B2693-292408. Molecular formula: C22H19FN4O2. Mole weight: 390.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Vorinostat | Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM. Uses: Antineoplastic agents; histone deacetylase inhibitors. Group: Pharmaceutical. Alternative Names: MK-0683, MK 0683, MK0683, SAHA, M344, CCRIS 8456, HSDB 7930, Vorinostat, suberoylanilide hydroxamic acid, Zolinza. CAS No. 149647-78-9. Pack Sizes: 5 g. Product ID: B2693-059322. Molecular formula: C14H20N2O3. Mole weight: 264.3. Custom synthesis is available. Send your inquiries for more information. | London |
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