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| Product | Description | |
|---|---|---|
| BQU57 | BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. Group: Pharmaceutical. CAS No. 1637739-82-2. Pack Sizes: 50 mg. Product ID: B0084-463448. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| CASIN | CASIN is a selective GTPase Cdc42 inhibitor (IC50=2 uM), reducing active levels of Cdc42 in aged hematopoietic stem cells. Uses: Cdc42 gtpase inhibitor. Group: Pharmaceutical. CAS No. 425399-05-9. Pack Sizes: 100 mg. Product ID: B1370-286220. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GGTI-2418 | GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. GGTase I catalyzes the lipid posttranslational modification which is required for the function of Rho GTPases (frequently found aberrantly activated in human cancer). GGTase I inhibitors block Rho function in cancer cells and induce a G1 phase cell cycle arrest by a mechanism involving induction of the CDK inhibitors p21waf and p27kip, CDK2 and CDK4 inhibition and hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation of PI3K/Akt. Group: Pharmaceutical. CAS No. 501010-06-6. Pack Sizes: 2.5 mg. Product ID: B0084-462530. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| NSC 23766 trihydrochloride | NSC 23766 is a Rac GTPase inhibitor that suppresses Rac GTPase activation by the Rac-specific GEFs. It shows an inhibitory activity in the influenza virus, as well as the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells. Group: Pharmaceutical. CAS No. 1177865-17-6. Pack Sizes: 25 mg. Product ID: B0084-007260. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pluripotin | SC1 (Pluripotin) was identified in a cell-based chemical library screen for small molecules that regulate mouse embryonic stem (ES) cell self-renewal. SC1 is sufficient to sustain long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of extracellular signal-regulated kinase 1 (ERK1) and Ras GTPase-activating protein (Ras-GAP). Mouse ES cells maintained in the presence of SC1 retain their ability to differentiate into cells representing all three germ layers in vitro, form chimeric mouse, and contribute to germ line in vivo. Uses: Self-renewal. Group: Pharmaceutical. CAS No. 839707-37-8. Pack Sizes: 100 mg. Product ID: B2693-462953. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| RBC8 | RBC8 is a novel small molecule inhibitor of Ral GTPase; has IC50 of 3.5 μM in H2122 cell and 3.4 μM in H358 cell. Group: Pharmaceutical. CAS No. 361185-42-4. Pack Sizes: 50 mg. Product ID: B0084-463350. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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