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| Product | Description | |
|---|---|---|
| A 1070722 | A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β) with 50-fold selectivity over other protein kinases such as CDK. It decreases phosphorylation of microtubule-associated protein Tau in vitro. A 1070722 exhibits neuroprotective activity thus is identified as a therapeutic drug candidate for neurodegenerative and psychiatric disorders. Uses: Potential treatment of neurodegenerative disorders. Group: Pharmaceutical. Alternative Names: A 1070722; A1070722; A-1070722; 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea. CAS No. 1384424-80-9. Pack Sizes: 1mg;1g;10g. Product ID: 1384424-80-9. Molecular formula: C17H13F3N4O2. Mole weight: 362.31. Custom synthesis is available. Send your inquiries for more information. |  London |
| ABC-1183 | ABC-1183 is an inhibitor of glycogen synthase kinase 3 (GSK-3) alpha, glycogen synthase kinase 3 (GSK-3) beta and cyclin dependent kinase 9 (CDK-9). It can induce cell apoptosis and various signaling pathways. ABC-1183 shows toxicity to many cell lines in humans and mice. Group: Pharmaceutical. Alternative Names: ABC1183; ABC 1183; NSC797769; NSC-797769. CAS No. 1042735-18-1. Pack Sizes: 1mg;1g;10g. Product ID: 1042735-18-1. Molecular formula: C18H14N4OS. Mole weight: 334.39. Custom synthesis is available. Send your inquiries for more information. | London |
| α-Amyrin | α-Amyrin is a triterpenoid that has been found in B. copallifera and has diverse biological activities. It activates the ERK and GSK-3β signaling pathways. α-Amyrin is a potential protein kinase A inhibitor. Group: Pharmaceutical. Alternative Names: Viminalol; alpha-Amyrenol; Urs-12-en-3beta-ol; (3β)-urs-12-en-3-ol. CAS No. 638-95-9. Pack Sizes: 10 mg. Product ID: B1370-147265. Molecular formula: C30H50O. Mole weight: 426.73. Custom synthesis is available. Send your inquiries for more information. | London |
| AR-A014418 | AR-A014418 is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β), a serine/threonine protein kinase involved in multiple diseases including Alzheimer's disease and type 2 diabetes. Group: Pharmaceutical. Alternative Names: SN 4521; SN4521; SN-4521; AR-A 014418; AR-A014418; AR-A-014418; AR-AO-14418; GSK-3beta Inhibitor VIII; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea. CAS No. 487021-52-3. Pack Sizes: 25 mg. Product ID: B0084-258809. Molecular formula: C12H12N4O4S. Mole weight: 308.312. Custom synthesis is available. Send your inquiries for more information. | London |
| AR-AO 14418-[d3] | AR-AO 14418-[d3] is a labelled analogue of AR-AO 14418, a Glycogen Synthase Kinase 3β (GSK-3β) inhibitor. Group: Pharmaceutical. Alternative Names: AR-AO 14418-d3; AR-A014418-d3. CAS No. 1216908-63-2. Pack Sizes: 5 mg. Product ID: BLP-014119. Molecular formula: C12H9D3N4O4S. Mole weight: 311.33. Custom synthesis is available. Send your inquiries for more information. | London |
| BIO | BIO is a potent and reversible inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β. BIO enhances reprogramming of mouse fibroblasts, neural stem cells, and thymocytes to induced pluripotent stem (iPS) cells. It also promotes differentiation of cardiomyocytes from human ES and iPS cells. Group: Pharmaceutical. Alternative Names: GSK-3 Inhibitor IX; 6-bromoindirubin-3-oxime; 6-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol. CAS No. 667463-62-9. Pack Sizes: 25 mg. Product ID: B2693-286135. Molecular formula: C16H10BrN3O2. Mole weight: 356.17. Custom synthesis is available. Send your inquiries for more information. | London |
| CP21R7 | CP21R7 is a potent and selective GSK3β inhibitor. It acts as an activator of stem cells prior to the induction of differentiation of stem cells to endothelial and smooth muscle cells. Uses: Cp21r7 is a selective gsk-3β inhibitor which could probably influence luciferase activity at some extent. Group: Pharmaceutical. Alternative Names: 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione. CAS No. 125314-13-8. Pack Sizes: 300 mg. Product ID: B0084-474432. Molecular formula: C19H15N3O2. Mole weight: 317.34. Custom synthesis is available. Send your inquiries for more information. | London |
| GSK3326595 | GSK3326595, also called as EPZ015938, is an orally available and specific inhibitor of protein arginine methyltransferase 5 (PRMT5) that potently inhibits tumor growth in vitro and in vivo in animal models and has entered clinical trials for the treatment of solid tumors and non-Hodgkin's lymphoma. Group: Pharmaceutical. Alternative Names: GSK-3326595; GSK 3326595; GSK3326595; EPZ015938; EPZ 015938; EPZ-015938; 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide. CAS No. 1616392-22-3. Pack Sizes: 100 mg. Product ID: B2693-007330. Molecular formula: C24H32N6O3. Mole weight: 452.55. Custom synthesis is available. Send your inquiries for more information. | London |
| Indirubin | Indirubin is an inhibitor of GSK-3β and cyclin-dependent kinases (CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p35). Also, Indirubin is a specific Aryl Hydrocarbon receptor (AHR) ligand. Uses: Antibiotics, antineoplastic. Group: Pharmaceutical. Alternative Names: Indirubin; C.I. 73200, Couroupitine B, Indigo red, Indigopurpurin, NSC 105327; NSC-105327; NSC105327; Indigopurpurin; Couroupitine B; [2,3'-Biindolinylidene]-2',3-dione; 3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one. CAS No. 479-41-4. Pack Sizes: 200 mg. Product ID: NP0564. Molecular formula: C16H10N2O2. Mole weight: 262.268. Custom synthesis is available. Send your inquiries for more information. | London |
| Indirubin-3'-monoxime | Indirubin-3'-monoxime, a chemical derivative of indirubin, is an inhibitor of GSK-3β with dual affinity for CDK1/5 receptor. It significantly inhibited the proliferation and induced apoptosis in all of the RCC cell lines. Group: Pharmaceutical. Alternative Names: indirubin-3'-oxime; 3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one. CAS No. 160807-49-8. Pack Sizes: 100 mg. Product ID: B1370-352635. Molecular formula: C16H11N3O2. Mole weight: 277.28. Custom synthesis is available. Send your inquiries for more information. | London |
| RGB-286638 Free base | RGB-286638 is a novel CDK inhibitor. It inhibited several tyrosine and serine/threonine non-CDK enzymes, i.e. GSK-3β, TAK1, AMPK, Jak2, MEK1. It demonstrated equimolar (50nM) activity in freshly isolated tumor cells from MM patients, while manifesting less cytotoxicity in healthy donor PBMCs. It reduced the phosphorylation of Rb at S807/811 in MM.1S and MM.1R cells, but had no effects on p-Rb S780. Group: Pharmaceutical. Alternative Names: 1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea; RGB 286638; RGB286638. CAS No. 784210-88-4. Pack Sizes: 100 mg. Product ID: B0084-463330. Molecular formula: C29H35N7O4. Mole weight: 545.63. Custom synthesis is available. Send your inquiries for more information. | London |
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