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| Product | Description | |
|---|---|---|
| 3-Methylquinoxaline-2-carboxylic Acid-[d4] | 3-Methylquinoxaline-2-carboxylic Acid-[d4] is the labelled analogue of 3-Methylquinoxaline-2-carboxylic Acid. 3-Methylquinoxaline-2-carboxylic acid (MQCA) is a major metabolite of olaquindox, an antibiotic and swine growth regulator. Group: Pharmaceutical. CAS No. 2244217-93-2. Pack Sizes: 10 mg. Product ID: BLP-003037. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Chrysin-7-O-glucuronide | Chrysin-7-O-glucuronide, a flavone compound derived from plants, has garnered attention for its therapeutic potential against cancer and diabetes. Prior investigations have demonstrated its ability to modulate the apoptotic pathways in cancer cells, leading to growth inhibition and reduced tumor progression. Furthermore, chrysin-7-O-glucuronide exhibits promising attributes as a glucose regulator, as evidenced by its capacity to enhance insulin sensitivity and support proper glucose metabolism. These findings collectively suggest chrysin-7-O-glucuronide as a worthy candidate for further exploration in the development of cancer and diabetes treatment. Group: Pharmaceutical. CAS No. 35775-49-6. Pack Sizes: 5 mg. Product ID: B2703-001241. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Epacadostat | Epacadostat, also known as INCB024360 or INCB24360, is a potent and selective IDO1 inhibitor with IC50 of 71.8 nM±17.5 nM, with potential immunomodulating and antineoplastic activities. It has been shown to promote T and natural killer-cell growth, to increase IFN-γ production, and to reduce conversion to regulatory T (Treg)-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells. Group: Pharmaceutical. CAS No. 1204669-58-8. Pack Sizes: 100 mg. Product ID: B0084-465275. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Fulvestrant Beta-Isomer | Fulvestrant Beta-Isomer, a drug utilized in the management of metastatic breast cancer associated with hormone receptor positivity, acts as a selective estrogen receptor down-regulator that impedes breast cancer cell growth by binding to and disintegrating estrogen receptors. Its modus operandi is to lower the expression of estrogen receptors. Group: Pharmaceutical. CAS No. 407577-53-1. Pack Sizes: 2.5 mg. Product ID: B1370-471901. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GSK525762 | GSK525762A, also known as I-BET-762 and GSK525762, is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor GSK525762 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomain at the N-terminus, BET proteins, comprising of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth. Group: Pharmaceutical. CAS No. 1260907-17-2. Pack Sizes: 25 mg. Product ID: B2693-457801. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Icaritin | Icaritin is unable to promote proliferation, migration and tube-like structure formation by human umbilical vein endothelial cells (HUVECs) in vitro. Icaritin potently inhibited proliferation of K562 cells (IC50 was 8 μM) and primary CML cells (IC50 was 13.4 μM for CML-CP and 18 μM for CML-BC), induced CML cells apoptosis and promoted the erythroid differentiation of K562 cells with time-dependent manner. Furthermore, Icaritin was able to suppress the growth of primary CD34+ leukemia cells (CML) and Imatinib-resistant cells, and to induce apoptosis. Icaritin strongly inhibited the growth of breast cancer MDA-MB-453 and MCF7 cells. At concentrations of 2-3 μM, icaritin induced cell cycle arrest at the G(2)/M phase accompanied by a down-regulation of the expression levels of the G(2)/M regulatory proteins such as cyclinB, cdc2 and cdc25C. Icaritin at concentrations of 4-5 μM, however, induced apoptotic cell death characterized by the accumulation of the annexin V- and propidium iodide-positive cells, cleavage of poly ADP-ribose polymerase (PARP) and down-regulation of the Bcl-2 expression. In mouse leukemia model, Icaritin could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells as effective as Imatinib without suppression of bone marrow. Icaritin could up-regulate phospho-JNK or phospho-C-Jun and down-regulate phospho-ERK, phospho-P-38, Jak-2, phospho-Stat3 and phospho-Akt expression with dose- or ti | London |
| Methoprene Impurities | Methoprene Impurities are used in the biomedical industry primarily for the analysis and quality assurance of methoprene formulations, an insect growth regulator. These impurities help in evaluating the efficacy of methoprene, which is applied in controlling mosquito populations and mitigating vector-borne diseases like malaria and dengue. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| m-Methoxytopolin riboside | It can be used in biological study in influence of plant growth regulators on shoot proliferation and secondary metabolite production in micropropagated Huernia hystrix. Group: Pharmaceutical. CAS No. 101565-95-1. Pack Sizes: 1 g. Product ID: B2706-291769. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N6-isopentenyladenosine | It is a cytokinin growth regulator that can be produced endogenously by plants to guide the differentiation of callus cells. In the research of anticancer drugs, it can induce cell cycle contraction and apoptosis. Uses: Plant growth regulators. Group: Pharmaceutical. CAS No. 7724-76-7. Pack Sizes: 5 g. Product ID: BBF-04042. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Neratinib | Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells. Group: Pharmaceutical. CAS No. 698387-09-6. Pack Sizes: 500 mg. Product ID: B0084-347125. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| OTX015 | OTX015 is a potent BET bromodomian inhibitor, which targets the BET bromodomain proteins 2, 3, and 4 (BRD). BRDs 2, 3, and 4 are considered potential cancer targets because of their pivotal role in regulating the transcription of growth-promoting genes and cell cycle regulators. Group: Pharmaceutical. CAS No. 202590-98-5. Pack Sizes: 50 mg. Product ID: B0084-462751. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tabimorelin Impurities | Tabimorelin Impurities hold significant value in biomedical research as they elucidate the pharmacokinetic profiles and metabolic pathways of the growth hormone secretagogue tabimorelin, under investigation for growth hormone deficiency treatment. They contribute to assessing drug purity, stability, and safety, aspects vital for therapeutic development and regulatory adherence. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Zilpaterol Impurities | Zilpaterol Impurities are critical in the biomedical industry for ensuring the safety and efficacy of zilpaterol, a beta-agonist used to enhance growth in livestock. Studying these impurities supports the development of analytical methods and ensures compliance with regulatory standards, contributing to public health by monitoring drug quality and safety. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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