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| Product | Description | |
|---|---|---|
| α-epidermal growth factor, human | Recombinant human epidermal growth factor has the same structure as the human epidermal growth factor. EGF binds to epidermal growth factor receptor (EGFR) and stimulates cell growth and proliferation. Recombinant human epidermal growth factor is approved for the treatment of diabetic foot ulcers. Uses: The treatment of diabetic foot ulcers. Group: Pharmaceutical. Alternative Names: Human EGF; Nepidermin. CAS No. 62253-63-8. Pack Sizes: 1 mg. Product ID: BAT-010173. Molecular formula: C270H401N73O83S7. Mole weight: 6222. Custom synthesis is available. Send your inquiries for more information. |  London |
| Fibroblast Growth Factor-Basic | Fibroblast Growth Factor-Basic is a growth factor encoded by the FGF2 gene. It is found in basement membranes and sub-endothelial extracellular matrix. FGF2 specifically binds to fibroblast growth factor receptor (FGFR) proteins. Group: Pharmaceutical. Alternative Names: hBFGF; FGF-Basic; Basic fibroblast growth factor; bFGF. CAS No. 106096-93-9. Pack Sizes: 1 mg. Product ID: B0084-358404. Custom synthesis is available. Send your inquiries for more information. | London |
| Kerantinocyte Growth Factor | Recombinant Human KGF is an 18.9 kDa protein containing 163 amino residues. Group: Pharmaceutical. Alternative Names: Recombinant Human KGF; rhKGF; Fibroblastgrowth factor 7; KGF; hFGF-7;HBGF-7. CAS No. 148348-15-6. Pack Sizes: 50 mg. Product ID: B1370-167006. Mole weight: 18.9 kDa. Custom synthesis is available. Send your inquiries for more information. | London |
| 5,7-Dihydrox -4'-methoxyisoflavone | Biochanin A, an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM. Uses: Anti-tumorigenesis, anti-oxidation, and anti-inflammatory. Group: Pharmaceutical. Alternative Names: Biochanin; Pratensol; olmelin; 4'-methyl Genistein; 4-methylGenistein; 5,7-dihydroxy-4'-Methoxyisoflavone; NSC 123538; NSC-123538; NSC123538. CAS No. 491-80-5. Pack Sizes: 5 g. Product ID: NP1827. Molecular formula: C16H12O5. Mole weight: 284.26. Custom synthesis is available. Send your inquiries for more information. | London |
| A 484954 | A 484954 is a eukaryotic elongation factor-2 (eEF-2) kinase inhibitor (IC50 = 0.28 μM in enzymatic assay). A 484954 reduces eEF-2 phosphorylation with little effect on cancer cell growth. Group: Pharmaceutical. Alternative Names: A-484954; A 484954; A484954; 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide. CAS No. 142557-61-7. Pack Sizes: 1mg;1g;10g. Product ID: 142557-61-7. Molecular formula: C13H15N5O3. Mole weight: 289.29. Custom synthesis is available. Send your inquiries for more information. | London |
| ABT-510 | ABT-510 is a synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8). Group: Pharmaceutical. Alternative Names: ABT-510; ABT 510; ABT510. CAS No. 251579-55-2. Pack Sizes: 100 mg. Product ID: B2693-462640. Molecular formula: C46H83N13O11. Mole weight: 994.25. Custom synthesis is available. Send your inquiries for more information. | London |
| AC480 | AC480, also known as BMS-599626, is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. Group: Pharmaceutical. Alternative Names: BMS-599626; BMS 599626; BMS599626; AC 480; AC-480; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; (3S)-3-Morpholinylmethyl N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate; Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid, (3S)-3-morpholinylmethyl ester. CAS No. 714971-09-2. Pack Sizes: 1mg;1g;10g. Product ID: B0084-259278. Molecular formula: C27H27FN8O3. Mole weight: 530.55. Custom synthesis is available. Send your inquiries for more information. | London |
| AC710 | AC710 is a potent, selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity. AC710 is now a preclinical development candidate. Group: Pharmaceutical. Alternative Names: AC 710; AC-710. CAS No. 1351522-04-7. Pack Sizes: 1mg;1g;10g. Product ID: 1351522-04-7. Molecular formula: C31H42N6O4. Mole weight: 562.7. Custom synthesis is available. Send your inquiries for more information. | London |
| AEE-788 | AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. Group: Pharmaceutical. Alternative Names: AEE 788; AEE788; 6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine. CAS No. 497839-62-0. Pack Sizes: 10 mg. Product ID: B0084-258485. Molecular formula: C27H32N6. Mole weight: 440.595. Custom synthesis is available. Send your inquiries for more information. | London |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Group: Pharmaceutical. Alternative Names: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. CAS No. 118409-62-4. Pack Sizes: 100 mg. Product ID: B1370-195904. Molecular formula: C10H5N3O3. Mole weight: 215.16. Custom synthesis is available. Send your inquiries for more information. | London |
| AG-1557 | AG-1557 is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Group: Pharmaceutical. Alternative Names: AG-1557; AG 1557; AG1557; N-(3-Iodophenyl)-6,7-dimethoxyquinazolin-4-amine. CAS No. 189290-58-2. Pack Sizes: 50 mg. Product ID: B0084-284805. Molecular formula: C16H14IN3O2. Mole weight: 407.211. Custom synthesis is available. Send your inquiries for more information. | London |
| AG-879 | AG-879, a tyrphostin compound, is a dual EGFR/HER2 inhibitor that was administered together with androgen withdrawal therapy. It inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM). Group: Pharmaceutical. Alternative Names: α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide. CAS No. 148741-30-4. Pack Sizes: 20 mg. Product ID: B0084-195953. Molecular formula: C18H24N2OS. Mole weight: 316.5. Custom synthesis is available. Send your inquiries for more information. | London |
| All-trans Retinol | Vitamin A1 is a group of unsaturated nutritional organic compounds, which includes retinol, retinal, retinoic acid, several provitamin A carotenoids, and beta-carotene. Vitamin A1 is important for growth and development, the maintenance of the immune system, and good vision. Vitamin A1 is needed by the retina of the eye in the form of retinal, which combines with protein opsin to form rhodopsin, the light-absorbing molecule necessary for both low-light (scotopic vision) and color vision. Vitamin A1 also functions in a very different role as retinoic acid (an irreversibly oxidized form of retinol), which is an important hormone-like growth factor for epithelial and other cells. It has the functions of removing wrinkles, whitening and removing freckles, anti-aging, skin rejuvenation, acne removal, anti-oxidation, anti-ultraviolet, sunblock injury, anti-inflammatory and antibacterial, soothing and repairing, treating skin photoaging and rosacea. Uses: Vitamin a is indicated only for prevention or treatment of vitamin a deficiency states. Group: Pharmaceutical. Alternative Names: Vitamin A; Vitamin A1; 2,4,6,8-Nonatetraen-1-ol, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-; Retinol; Retinol, all-trans-; (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; A-Mulsal; A-Vitan; Acon; Afaxin; Agiolan; Agoncal; Alcovit A; all-trans-Retinol; all-trans-Retinyl alcohol; all-trans-Vitam | London |
| α-Tocotrienol | α-Tocotrienol is a form of vitamin E, a class of eight fat-soluble compounds. It was shown to induce apoptosis and inhibit proliferation, and down-regulate the fibroblast growth factor receptor-1 (FGFR1). Uses: Antioxidants. Group: Pharmaceutical. Alternative Names: (2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol. CAS No. 58864-81-6. Pack Sizes: 25 mg. Product ID: B0005-190073. Molecular formula: C29H44O2. Mole weight: 424.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Antagonist G | Antagonist G is a substance P analog, which is a broad spectrum neuropeptide growth factor antagonist and antiproliferative agent. It was developed for the treatment of small cell lung cancer. It could inhibit neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro. It also inhibits growth of SCLC xenografts in mice in vivo. It blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. It activates JNK and stimulates apoptosis. It is an anticancer agent and is resistant to degradation by peptidases. Group: Pharmaceutical. Alternative Names: [Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11). CAS No. 115150-59-9. Pack Sizes: 1 mg. Product ID: BAT-006104. Molecular formula: C49H66N12O6S. Mole weight: 951.2. Custom synthesis is available. Send your inquiries for more information. | London |
| Apatinib mesylate | Apatinib mesylate is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: YN968D1. CAS No. 1218779-75-9. Pack Sizes: 250 mg. Product ID: B2693-457664. Molecular formula: C25H27N5O4S. Mole weight: 493.58. Custom synthesis is available. Send your inquiries for more information. | London |
| ARQ-087 | ARQ-087, also known as Derazantinib, is an oral fibroblast growth factor receptor (FGFR) inhibitor with antitumor property. FGFR plays a role in the regulation of key cellular behaviors including proliferation, cell differentiation and so on. FGFR dysregulation is considered as a driver in multiple cancers. ARQ 087 binds to FGFR and effectively inhibits the activation of FGFR thus can suppress tumorigenesis and tumor growth. Group: Pharmaceutical. Alternative Names: ARQ 087; ARQ087; ARQ-087; Derazantinib; (6R)-6-(2-fluorophenyl)-N-[3-[2-(2-methoxyethylamino)ethyl]phenyl]-5,6-dihydrobenzo[h]quinazolin-2-amine. CAS No. 1234356-69-4. Pack Sizes: 5 mg. Product ID: B0084-008116. Molecular formula: C29H29FN4O. Mole weight: 468.576. Custom synthesis is available. Send your inquiries for more information. | London |
| AV-412 | AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Group: Pharmaceutical. Alternative Names: AV 412; AV412; N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide. CAS No. 451492-95-8. Pack Sizes: 20 mg. Product ID: B0084-324573. Molecular formula: C27H28ClFN6O. Mole weight: 507.01. Custom synthesis is available. Send your inquiries for more information. | London |
| AZD3759 | AZD3759 is a n orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. Group: Pharmaceutical. Alternative Names: AZD3759; AZD-3759; AZD 3759. CAS No. 1626387-80-1. Pack Sizes: 1 g. Product ID: B0084-470884. Molecular formula: C22H23ClFN5O3. Mole weight: 459.91. Custom synthesis is available. Send your inquiries for more information. | London |
| AZD-4547 | AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. Group: Pharmaceutical. Alternative Names: AZD-4547; AZD 4547; AZD4547; N-{3-[2-(3,5-Dimethoxyphenyl)ethyl]-1h-Pyrazol-5-Yl}-4-[(3r,5s)-3,5-Dimethylpiperazin-1-Yl]benzamide. CAS No. 1035270-39-3. Pack Sizes: 100 mg. Product ID: B0084-456576. Molecular formula: C26H33N5O3. Mole weight: 463.582. Custom synthesis is available. Send your inquiries for more information. | London |
| AZD-9291 | AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). Uses: For research used only. Group: Pharmaceutical. Alternative Names: Mereletinib; AZD9291; AZD 9291; Osimertinib. CAS No. 1421373-65-0. Pack Sizes: 2.5 g. Product ID: B0084-462147. Molecular formula: C28H33N7O2. Mole weight: 499.61. Custom synthesis is available. Send your inquiries for more information. | London |
| Bardoxolone | Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events. Group: Pharmaceutical. Alternative Names: CDDO; RTA 401; RTA401; RTA-401. CAS No. 218600-44-3. Pack Sizes: 25 mg. Product ID: B0084-427947. Molecular formula: C31H41NO4. Mole weight: 491.66. Custom synthesis is available. Send your inquiries for more information. | London |
| BGJ-398 | BGJ398, also known as NVP-BGJ398, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Group: Pharmaceutical. Alternative Names: 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea; NVPBGJ398; NVPBGJ 398; NVPBGJ-398; BGJ398; BGJ-398; BG J398; Infigratinib. CAS No. 872511-34-7. Pack Sizes: 100 mg. Product ID: B2693-453477. Molecular formula: C26H31Cl2N7O3. Mole weight: 560.48. Custom synthesis is available. Send your inquiries for more information. | London |
| BI-3406 | BI-3406 is a potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS, and mutants of RAS are major oncogenes and occur in many human cancers. Inhibition of SOS1 in a mutant KRAS cell line can suppress tumor growth. Group: Pharmaceutical. Alternative Names: BI 3406; BI3406. CAS No. 2230836-55-0. Pack Sizes: 5 mg. Product ID: B2693-363125. Molecular formula: C23H25F3N4O3. Mole weight: 462.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Biotin | Biotin, also known as vitamin B7, is a water-soluble enzyme cofactor generated by intestinal bacteria or obtained from diet. Biotin is a growth factor present in minute amounts in every living cell. It is involved in metabolism of fats and carbohydrates, cell growth, as well as protein synthesis. Vitamin supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: D-biotin; Vitamin H; Coenzyme R; Vitamin B7; BIOTIN; 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, [3aS-(3aα,4β,6aα)]-; FACTOR S; BIOS H; Ritatin; biosii; BIOTINUM; D-Biotin; Bios-IIb; Meribin; cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; 1swk; Meribin; Factor S (vitamin); Injacom H; Lutavit H2; D-Biotin. CAS No. 58-85-5. Pack Sizes: 1mg;1g;10g. Product ID: BAT-008089. Molecular formula: C10H16N2O3S. Mole weight: 244.31. Custom synthesis is available. Send your inquiries for more information. | London |
| BLU-554 | BLU-554 is a potent and selective inhibitor of fibroblast growth factor receptor 4 (FGFR4) (IC50 = 5 nM), which is promisingly to be used for the treatment of hepatocellular carcinoma and cholangiocarcinoma. Group: Pharmaceutical. Alternative Names: BLU-554; BLU 554; BLU554, Fisogatinib; SCHEMBL16668287; EX-A841; MFCD30496704; N-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]oxan-4-yl]prop-2-enamide; BLU554. CAS No. 1707289-21-1. Pack Sizes: 10 mg. Product ID: B0084-008122. Molecular formula: C24H24Cl2N4O4. Mole weight: 503.38. Custom synthesis is available. Send your inquiries for more information. | London |
| BLZ945 | BLZ945 is an orally active, potent and selective CSF-1R inhibitor, which inhibits CSF-1R activity with an IC50 of 1nM and is more than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and Platelet-derived Growth Factor Receptor beta (PDGFRb). Group: Pharmaceutical. Alternative Names: sotuletinib; BLZ 945; BLZ-945. CAS No. 953769-46-5. Pack Sizes: 50 mg. Product ID: B0084-463485. Molecular formula: C20H22N4O3S. Mole weight: 398.48. Custom synthesis is available. Send your inquiries for more information. | London |
| BMS-536924 | BMS-536924 is a potent small molecule inhibitor of IGF-IR, which shows antitumor activity in multiple tumor models, including sarcoma. Group: Pharmaceutical. Alternative Names: BMS536924; BMS 536924; Insulin-like Growth Factor-1 Receptor Inhibitor; (S)-4-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one. CAS No. 468740-43-4. Pack Sizes: 50 mg. Product ID: B1370-142616. Molecular formula: C25H26ClN5O3. Mole weight: 479.96. Custom synthesis is available. Send your inquiries for more information. | London |
| Brivanib | Brivanib is the hydrolyzed form of Brivanib alaninate, which is a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. Alternative Names: BMS540215; BMS-540215; BMS 540215. CAS No. 649735-46-6. Pack Sizes: 20 mg. Product ID: B0084-146707. Molecular formula: C19H19FN4O3. Mole weight: 370.37756. Custom synthesis is available. Send your inquiries for more information. | London |
| Brivanib alaninate | Brivanib alaninate is the alaninate ester of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. Alternative Names: BMS-582664; BMS582664; BMS 582664. CAS No. 649735-63-7. Pack Sizes: 10 mg. Product ID: B2693-146708. Molecular formula: C22H24FN5O4. Mole weight: 441.45. Custom synthesis is available. Send your inquiries for more information. | London |
| Cediranib dihydrochloride | Cediranib (AZD-2171; tentative trade name Recentin) is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.The drug is being developed by AstraZeneca as a possible anti-cancer chemotherapeutic agent for oral administration. Group: Pharmaceutical. Alternative Names: US brand name: Recentin. Foreign brand name: Recentin. Code name: AZD2171.AZD 2171; AZD-2171. CAS No. 288383-20-0. Pack Sizes: 50 mg. Product ID: B2693-065171. Molecular formula: C25H27FN4O3. Mole weight: 450.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Chrysoeriol | Chrysoeriol is a natural compound isolated from the herbs of Medicago sativa. Chrysoeriol can potently inhibit the induction of nitric oxide synthase by blocking activator protein 1 (AP-1) activation and its anti-inflammatory effects. Chrysoeriol can induce nod genes in rhizobium meliloti. Chrysoeriol can inhibit the downstream signal transduction pathways of platelet-derived growth factor (PDGF)-Rbeta, including ERK1/2, p38, and Akt phosphorylation, which suggests that chrysoeriol may be used for the prevention and treatment of vascular diseases during restenosis after coronary angioplasty. Group: Pharmaceutical. Alternative Names: 5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one; 4',5,7-Trihydroxy-3'-methoxyflavone; 3'-Methoxy-4',5,7-trihydroxyflavone; 3'-Methoxyapigenin; 3'-O-Methylluteolin; 5,7,4'-Trihydroxy-3'-methoxyflavone; Chrysoriol; Luteolin 3'-Methyl Ether; Scoparol; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-. CAS No. 491-71-4. Pack Sizes: 25 mg. Product ID: NP2023. Molecular formula: C16H12O6. Mole weight: 300.27. Custom synthesis is available. Send your inquiries for more information. | London |
| Coronarin A | Coronarin A, a natural diterpenoid isolated from the rhizomes of Hedychium coronarium, exhibits good growth inhibition activities on HUVEC proliferation. At the concentration of 10 micro g/mL, coronarin A and epi-coronarin A especially suppressed the growth factor induced tube formation of HUVEC. Uses: Inhibit growth of huvec. Group: Pharmaceutical. Alternative Names: (2S,4R,4aS,8aS)-4-[(E)-2-(3-Furyl)vinyl]-4a,8,8-trimethyl-3-methy lenedecahydro-2-naphthalenol. CAS No. 119188-33-9. Pack Sizes: 1 mg. Product ID: NP1285. Molecular formula: C20H28O2. Mole weight: 300.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Dacomitinib | Dacomitinib, aslo known as PF-299 and PF-00299804; or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types. Group: Pharmaceutical. Alternative Names: dacomitinib; PF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804; PF-299; PF 299; PF299. CAS No. 1110813-31-4. Pack Sizes: 250 mg. Product ID: B0084-452473. Molecular formula: C24H25ClFN5O2. Mole weight: 469.945. Custom synthesis is available. Send your inquiries for more information. | London |
| Desmethyl Erlotinib | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Group: Pharmaceutical. Alternative Names: 2-[[4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]ethanol. CAS No. 183321-86-0. Pack Sizes: 5 mg. Product ID: B2694-263407. Molecular formula: C21H21N3O4. Mole weight: 379.42. Custom synthesis is available. Send your inquiries for more information. | London |
| D-γ-Tocotrienol | γ-Tocotrienol is a form of vitamin E, a class of eight fat-soluble compounds. It was shown to induce apoptosis and inhibit proliferation, and down-regulate the fibroblast growth factor receptor-1 (FGFR1). Group: Pharmaceutical. Alternative Names: [R-(E,E)]-3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol; (2R)-3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol; 2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-6-chromanol; (2R)-3,4-Dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl]-2H-1-benzopyran-6-ol; (R)-γ-Tocotrienol; 7,8-Dimethyltocotrienol; Plastochromanol 3; γ-Tocotrienol. CAS No. 14101-61-2. Pack Sizes: 50 mg. Product ID: B0005-078430. Molecular formula: C28H42O2. Mole weight: 410.63. Custom synthesis is available. Send your inquiries for more information. | London |
| Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))(3Z,3'E)-bis(2-oxoindoline-6-carboxylate) | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Group: Pharmaceutical. Alternative Names: Nintedanib Impurity 50. CAS No. 2410284-90-9. Pack Sizes: 1 mg. Product ID: B2694-478193. Molecular formula: C56H52N8O8. Mole weight: 965.08. Custom synthesis is available. Send your inquiries for more information. | London |
| Enzastaurin | Enzastaurin is a protein kinase C beta inhibitor with 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. Group: Pharmaceutical. Alternative Names: 3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione; LY-317615. CAS No. 170364-57-5. Pack Sizes: 200 mg. Product ID: B0084-085618. Molecular formula: C32H29N5O2. Mole weight: 515.617. Custom synthesis is available. Send your inquiries for more information. | London |
| Erdafitinib | Erdafitinib, also known as JNJ-42756493, is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Group: Pharmaceutical. Alternative Names: JNJ-42756493; JNJ 42756493; JNJ42756493; Erdafitinib. CAS No. 1346242-81-6. Pack Sizes: 250 mg. Product ID: B0084-470835. Molecular formula: C25H30N6O2. Mole weight: 446.55. Custom synthesis is available. Send your inquiries for more information. | London |
| Erlotinib-3-vinyl Hydrochloride | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Group: Pharmaceutical. Alternative Names: 6,7-Bis(2-methoxyethoxy)-N-(3-vinylphenyl)quinazolin-4-amine hydrochloride; 4-Quinazolinamine, N-(3-ethenylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1). CAS No. 1624294-38-7. Pack Sizes: 25 mg. Product ID: B1370-173396. Molecular formula: C22H26ClN3O4. Mole weight: 431.91. Custom synthesis is available. Send your inquiries for more information. | London |
| Erlotinib-[d6] Hydrochloride | Erlotinib-[d6] Hydrochloride is the labelled analogue of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Erlotinib is a medication used to treat non-small cell lung cancer and pancreatic cancer. Group: Pharmaceutical. Alternative Names: N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy-d3)-4-quinazolinamine Hydrochloride; 6,7-Bis(2-methoxyethoxy-d3)-4-(3-ethynylanilino)quinazoline Hydrochloride; [6,7-Bis(2-methoxyethoxy-d3)quinazolin-4-yl]-(3-ethynylphenyl)amine Hydrochloride; Erlotinib D6 Hydrochloride. CAS No. 1189953-78-3. Pack Sizes: 5 mg. Product ID: BLP-006076. Molecular formula: C22H18D6ClN3O4. Mole weight: 435.93. Custom synthesis is available. Send your inquiries for more information. | London |
| Erlotinib Impurity 8 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Group: Pharmaceutical. Alternative Names: N-(3-Desethynylphenyl)-N-(3-bromophenyl) Erlotinib; N-(3-bromophenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine. CAS No. 328528-74-1. Pack Sizes: 25 mg. Product ID: B2694-471125. Molecular formula: C20H22BrN3O4. Mole weight: 448.32. Custom synthesis is available. Send your inquiries for more information. | London |
| Fenretinide | Fenretinide is an orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. Uses: Anticarcinogenic agents. Group: Pharmaceutical. Alternative Names: 4-HPR; McNR-1967; McNR1967; McNR 1967; HPR; Fenretinide. N-(4-Hydroxyphenyl)retinamide; 4-HPR; 4-hydroxyphenylretinamide; 4-Hydroxyphenyl retinamide. CAS No. 65646-68-6. Pack Sizes: 250 mg. Product ID: B0084-074597. Molecular formula: C26H33NO2. Mole weight: 391.54572. Custom synthesis is available. Send your inquiries for more information. | London |
| FGF-401 | FGF-401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4) (IC50 = 1.9 nM) developed for the treatment of solid tumor. Group: Pharmaceutical. Alternative Names: FGF401; FGF-401; FGF 401; roblitinib; N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide. CAS No. 1708971-55-4. Pack Sizes: 10 mg. Product ID: B0084-007362. Molecular formula: C25H30N8O4. Mole weight: 506.56. Custom synthesis is available. Send your inquiries for more information. | London |
| Fruquintinib | Fruquintinib, also known as HMPL-013, is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities. Group: Pharmaceutical. Alternative Names: Fruquintinib; HMPL013; HMPL 013; HMPL-013. CAS No. 1194506-26-7. Pack Sizes: 50 mg. Product ID: B2693-470819. Molecular formula: C21H19N3O5. Mole weight: 393.39. Custom synthesis is available. Send your inquiries for more information. | London |
| Futibatinib | Futibatinib is an orally bioavailable, selective and irreversible inhibitor of fibroblast growth factor receptors (FGFRs), displaying antineoplastic activity. It inhibits FGFR-mediated signal transduction and tumor cell proliferation. Group: Pharmaceutical. Alternative Names: 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1-pyrazolo[3,4-d]pyrimidinyl]-1-pyrrolidinyl]-2-propen-1-one; 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]pyrazolo[3,4-d]pyrimidin-1-yl]pyrrolidin-1-yl]prop-2-en-1-one. CAS No. 1448169-71-8. Pack Sizes: 250 mg. Product ID: B2693-292398. Molecular formula: C22H22N6O3. Mole weight: 418.45. Custom synthesis is available. Send your inquiries for more information. | London |
| Galunisertib | Galunisertib is a potent and selective inhibitor of transforming growth factor beta receptor (TGF-βR) kinase. It was shown to inhibit self-renewal of cancer stem cells. Group: Pharmaceutical. Alternative Names: LY 2157299; LY-2157299; 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide. CAS No. 700874-72-2. Pack Sizes: 100 mg. Product ID: B0084-307752. Molecular formula: C22H19N5O. Mole weight: 369.428. Custom synthesis is available. Send your inquiries for more information. | London |
| Gly-His-Lys | Gly-His-Lys is a tripeptide that can form a complex with copper ions. It is used for hair growth and skin care in cosmetics. It is a liver cell growth factor and stimulates hepatic erythropoietic factor production. It plays an important role in the care process of skin natural aging, such as cell proliferation, inflammation, angiogenesis, pigment formation and protein synthesis and regulation. Peptides are used in cosmetics to promote collagen production, anti-free radical oxidation, anti-inflammatory repair, anti-edema, whitening, breast enhancement and weight loss. It plays an important role in the care process of skin natural aging, such as cell proliferation, inflammation, angiogenesis, pigment formation and protein synthesis and regulation. Peptides are used in cosmetics to promote collagen production, anti-free radical oxidation, anti-inflammatory repair, anti-edema, whitening, breast enhancement and weight loss. Group: Pharmaceutical. Alternative Names: L-Lysine, glycyl-L-histidyl-; L-Lysine, N2-(N-glycyl-L-histidyl)-; Glycyl-L-histidyl-L-lysine; GHK; GHK Tripeptide; Growth-modulating peptide; Growth-modulating peptide (human); Kollaren; Kollaren BG; Liver cell growth factor; Liver growth factor; NSC 379527; Prezatide; Tripeptide 1. CAS No. 49557-75-7. Pack Sizes: 5 g. Product ID: BAT-010755. Molecular formula: C14H24N6O4. Mole weight: 340.38. Custom synthesis is available. Send your inquiries for more information. | London |
| Golvatinib | golvatinib (also known as E7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of various tumor cell types and play important roles in tumor cell growth, migration and angiogenesis. Group: Pharmaceutical. Alternative Names: E7050; E-7050; E 7050; Golvatinib. CAS No. 928037-13-2. Pack Sizes: 50 mg. Product ID: B2693-460626. Molecular formula: C33H37F2N7O4. Mole weight: 633.701. Custom synthesis is available. Send your inquiries for more information. | London |
| Hericenone C | Hericenone C is an aromatic monoterpenoid isolated from the mushroom Hericium erinaceum. Hericenone C could promote nerve growth factor (NGF) synthesis. Group: Pharmaceutical. Alternative Names: Hexadecanoic acid, [4-[(2E)-3,7-dimethyl-5-oxo-2,6-octadien-1-yl]-2-formyl-3-hydroxy-5-methoxyphenyl]methyl ester. CAS No. 137592-03-1. Pack Sizes: 5 mg. Product ID: B1370-452012. Molecular formula: C35H54O6. Mole weight: 570.8. Custom synthesis is available. Send your inquiries for more information. | London |
| Icotinib | Icotinib Hydrochloride (BPI-2009H), or Icotinib, is a highly selective, first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Group: Pharmaceutical. Alternative Names: BPI-2009H. CAS No. 610798-31-7. Pack Sizes: 300 mg. Product ID: B0084-459334. Molecular formula: C22H21N3O4. Mole weight: 391.42. Custom synthesis is available. Send your inquiries for more information. | London |
| Icotinib hydrochloride | Icotinib Hydrochloride is a quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), which is upregulated in a variety of cancer cell types. Icotinib supresses the cancer cell proliferation via EGFR tyrosine kinase inhibition. Group: Pharmaceutical. Alternative Names: Icotinib HCl; BPI-2009; BPI 2009; BPI2009. CAS No. 1204313-51-8. Pack Sizes: 300 mg. Product ID: BBF-04036. Molecular formula: C22H22ClN3O4. Mole weight: 427.88. Custom synthesis is available. Send your inquiries for more information. | London |
| IGF-1 LR3 | IGF-1 LR3 is a lengthened analogue of human insulin-like growth factor 1 (IGF-1). Group: Pharmaceutical. Alternative Names: Long R3-IGF-1; IGF-1 Long R3; Long arginine 3-IGF-1. CAS No. 946870-92-4. Pack Sizes: 5 mg. Product ID: BAT-006251. Molecular formula: C400H625N111O115S9. Mole weight: 9117.6. Custom synthesis is available. Send your inquiries for more information. | London |
| iMDK | iMDK is an inhibitor of midkine (MDK) expression, a growth factor commonly expressed in malignant tumors. iMDK dose-dependently inhibits MDK expression to attenuate certain tumor cell growth. It inhibits PI3K/Akt pathway thus induces apoptosis in MDK-expressing H441 lung adenocarcinoma cells. Uses: Antitumor agent. Group: Pharmaceutical. Alternative Names: 3-[2-(4-fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl]-2H-chromen-2-one. CAS No. 881970-80-5. Pack Sizes: 25 mg. Product ID: B1370-055117. Molecular formula: C21H13FN2O2S. Mole weight: 376.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Irbinitinib | Irbinitinib,also known as ARRY-380 and ONT-380, is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: ARRY-380; ARRY 380; ARRY380; ONT-380; ONT-380; ONT-380. CAS No. 937263-43-9. Pack Sizes: 100 mg. Product ID: B0084-462666. Molecular formula: C26H24N8O2. Mole weight: 480.532. Custom synthesis is available. Send your inquiries for more information. | London |
| Isoliensinine | Isoliensinine, a natural phenolic bisbenzyltetrahydroisoquinoline alkaloid, has received considerable attention for its potential biological effects such as antioxidant and anti-HIV activities. It possesses an anti-proliferative effect, which is related to the decrease of the overexpression of growth factors PDGF-beta, bFGF, proto-oncogene c-fos, c-myc and hsp70. Group: Pharmaceutical. Alternative Names: (+)-Isoliensinin; (1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol. CAS No. 6817-41-0. Pack Sizes: 5 mg. Product ID: B2703-464368. Molecular formula: C37H42N2O6. Mole weight: 610.7. Custom synthesis is available. Send your inquiries for more information. | London |
| JNJ-26483327 | JNJ-26483327 is an orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB). Group: Pharmaceutical. Alternative Names: JNJ-26483327; JNJ 26483327; JNJ26483327. CAS No. 807640-87-5. Pack Sizes: 10 mg. Product ID: B0084-462547. Molecular formula: C22H25BrN4O2. Mole weight: 457.372. Custom synthesis is available. Send your inquiries for more information. | London |
| Lapatinib Ditosylate | Lapatinib is a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: GW-572016; GW 572016; GW572016. CAS No. 388082-77-7. Pack Sizes: 1 g. Product ID: B0084-067756. Molecular formula: C29H26ClFN4O4S.2C7H8O3S. Mole weight: 925.46. Custom synthesis is available. Send your inquiries for more information. | London |
| Lavendustin A | Lavendustin A is an epidermal growth factor receptor inhibitor tyrosine kinase with IC50 value of 11 nM. Group: Pharmaceutical. Alternative Names: Lavendustin A; RG 14355; RG-14355; RG14355; 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid. CAS No. 125697-92-9. Pack Sizes: 10 mg. Product ID: B0084-047820. Molecular formula: C21H19NO6. Mole weight: 381.38. Custom synthesis is available. Send your inquiries for more information. | London |
| Linifanib | Description of Linifanib: Linifanib is an orally bioavailable, small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Linifanib inhibits members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families; it exhibits much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. This agent does not have a general antiproliferative effect due to its high dose requirement. However, linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as fms-related tyrosine kinase receptor-3 (FLT3). Group: Pharmaceutical. Alternative Names: ABT869; ABT 869; ABT-869; Linifanib. CAS No. 796967-16-3. Pack Sizes: 200 mg. Product ID: B0084-151820. Molecular formula: C21H18FN5O. Mole weight: 375.407. Custom synthesis is available. Send your inquiries for more information. | London |
| Melatonin | Melatonin is a hormone produced in the brain by the pineal gland from the amino acid tryptophan. It can be used as an antioxidant. Melatonin is involved in many biological functions such as circadian rhythm, sleep, the stress response, aging, and immunity. Melatonin's antioxidant defense system can interrupt free radical chain reactions, remove free radicals, and play an anti-aging and anti-wrinkle role. It can inhibit the production of a variety of inflammatory factors, and has the effect of eliminating inflammation and whitening spots. In addition, it can promote hair growth and care for hair. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]-; 3-(2-Acetamidoethyl)-5-methoxyindole; 5-Methoxy-N-acetyltryptamine; Circadin; Melatol; Melatonine; Melaxen; Melovine; N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide; N-Acetyl-5-methoxytryptamine; NSC 113928; NSC 56423; Regulin; Slenyto; ML-236B; ML 236B; ML236B. CAS No. 73-31-4. Pack Sizes: 20 g. Product ID: NP0519. Molecular formula: C13H16N2O2. Mole weight: 232.28. Custom synthesis is available. Send your inquiries for more information. | London |
| Methyl 1-Acetyl-2-oxoindoline-6-carboxylate | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Group: Pharmaceutical. Alternative Names: 1-acetyl-2-oxo-3H-indole-6-carboxylic acid methyl ester; methyl 1-acetyl-2-oxo-3H-indole-6-carboxylate. CAS No. 676326-36-6. Pack Sizes: 100 mg. Product ID: B1421-184191. Molecular formula: C12H11NO4. Mole weight: 233.22. Custom synthesis is available. Send your inquiries for more information. | London |
| Methyl 2,5-dihydroxycinnamate | Methyl 2,5-dihydroxycinnamate, a stable analog of erbstatin, is a stable, potent inhibitor of EGFR kinase activity. It is described to be four-times more stable than erbstatin in calf serum2. It was shown to delay the S-phase induction by epidermal growth factor in quiescent normal rat kidney cells, without affecting the total amount of DNA synthesis. Group: Pharmaceutical. Alternative Names: Methyl 2,5-dihydoxycinnamate; 3-(2,5-dihydroxyphenyl)-2-propenoic acid, methyl ester; Erbstatin Analog. CAS No. 63177-57-1. Pack Sizes: 100 mg. Product ID: B0084-012976. Molecular formula: C10H10O4. Mole weight: 194.19. Custom synthesis is available. Send your inquiries for more information. | London |
| MGF | Mechano growth factor (MGF) is a spliced variant of insulin-like growth factor 1 (IGF-1). IGF-1 is found in various tissues in the body including liver and muscle. Group: Pharmaceutical. Alternative Names: MGF E-domain; IGF-1 EC; Mechano Growth Factor. Pack Sizes: 5 mg. Product ID: BAT-006153. Molecular formula: C121H199N40O40. Mole weight: 2868.19. Custom synthesis is available. Send your inquiries for more information. | London |
| Motesanib | Motesanib is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors. It also potently inhibits angiogenesis and induces regression in tumor xenografts. Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4- ylmethyl)amino]pyridine-3-carboxamide; AMG 706; AMG706; AMG706; motesanib. CAS No. 453562-69-1. Pack Sizes: 100 mg. Product ID: B0084-069090. Molecular formula: C22H23N5O. Mole weight: 373.45. Custom synthesis is available. Send your inquiries for more information. | London |
| Naquotinib | Naquotinib is an irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity with IC50 of 8-33 nM toward EGFR mutants. Group: Pharmaceutical. Alternative Names: ASP 8273; ASP8273; ASP-8273; (R)-5-((1-acryloylpyrrolidin-3-yl)oxy)-6-ethyl-3-((4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazine-2-carboxamide. CAS No. 1448232-80-1. Pack Sizes: 5 mg. Product ID: B0084-475727. Molecular formula: C30H42N8O3. Mole weight: 562.719. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Desmethyl Vandetanib | N-Desmethyl Vandetanib is a metabolite of Vandetanib. Vandetanib is an antitumor drug used for the treatment of medullary thyroid cancer. Vandetanib effects through inhibiting vascular endothelial growth factor receptor-2 (VEGFR), epidermal growth factor receptor (EGFR) and the RET-tyrosine kinase activity. Group: Pharmaceutical. Alternative Names: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(4-piperidinylmethoxy)-4-quinazolinamine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(piperidin-4-yl)methoxy]quinazoline. CAS No. 338992-12-4. Pack Sizes: 5 mg. Product ID: B1926-260255. Molecular formula: C21H22BrFN4O2. Mole weight: 461.34. Custom synthesis is available. Send your inquiries for more information. | London |
| Neratinib | Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells. Group: Pharmaceutical. Alternative Names: 2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-; (2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide; (E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide; (E)-N-[4-[[3-Chloro-4-((pyridin-2-yl)meth. CAS No. 698387-09-6. Pack Sizes: 500 mg. Product ID: B0084-347125. Molecular formula: C30H29ClN6O3. Mole weight: 557.04. Custom synthesis is available. Send your inquiries for more information. | London |
| Nilotinib monohydrochloride monohydrate | Nilotinib monohydrochloride monohydrate is an orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. It binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells. It also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor (PDGF-R) and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors (GISTs). Uses: Tyrosine kinase inhibitors. Group: Pharmaceutical. Alternative Names: AMN-107; AMN 107; AMN107; Tasigna. CAS No. 923288-90-8. Pack Sizes: 100 mg. Product ID: B0084-182383. Molecular formula: C28H25ClF3N7O2. Mole weight: 583.99. Custom synthesis is available. Send your inquiries for more information. | London |
| Nintedanib Impurity 6 (Intedanib Impurity 6) | BIBF 1202 is the major in-vivo metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR. It is a related compound of Intedanib, which is an indolinone derivative that inhibits angiokinase and an antitumor agent. It is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (VEGF) signaling pathway thus inhibition of tumor angiogenesis. Uses: Bibf 1202 is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (vegf) signaling pathway thus inhibition of tumor angiogenesis. Group: Pharmaceutical. Alternative Names: BIBF-1202; BIBF 1202; BIBF1202. (3Z)-2,3-Dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid;(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1 -yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic acid;Nintedanib Impurity 5. CAS No. 894783-71-2. Pack Sizes: 50 mg. Product ID: B0084-474893. Molecular formula: C30H31N5O4. Mole weight: 525.6. Custom synthesis is available. Send your inquiries for more information. | London |
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