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| Product | Description | |
|---|---|---|
| Cafestol | Cafestol is a natural bioactive substance isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans, it acts as a GST (glutathione S-transferase) inducer and exhibits chemoprotective activity. Dietary cafestol does increase total cholesterol and triglycerides in ApoE3Leiden mice, an effect which is associated with selective activation of farnesoid X receptors and pregnane X receptors. Group: Pharmaceutical. Alternative Names: Cafesterol; (3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol. CAS No. 469-83-0. Pack Sizes: 20 mg. Product ID: B1370-118807. Molecular formula: C20H28O3. Mole weight: 316.43. Custom synthesis is available. Send your inquiries for more information. |  London |
| Ezatiostat | Ezatiostat is a glutathione analog that acts as an inhibitor of glutathione S-transferase (GST) P1-1. TLK117, the active form of ezatiostat, inhibits GSTP1-1, resulting in phosphorylation of JNK, restoring JNK-mediated cellular proliferation and differentiation signaling pathways. Group: Pharmaceutical. Alternative Names: Telintra; Gamma-Glu-S-BzCys-PhGly diethyl ester; TLK-199; TLK 199. CAS No. 168682-53-9. Pack Sizes: 25 mg. Product ID: BAT-010079. Molecular formula: C27H35N3O6S. Mole weight: 529.652. Custom synthesis is available. Send your inquiries for more information. | London |
| RTA-408 | RTA-408 is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity. Upon administration, RTA 408 activates the cytoprotective transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH). Nrf2, a leucine zipper transcription factor, plays a key role in the maintenance of redox balance and cytoprotection against oxidative stress. Group: Pharmaceutical. Alternative Names: RTA408; RTA408; RTA-408. Omaveloxolone; Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-. CAS No. 1474034-05-3. Pack Sizes: 20 mg. Product ID: B0084-462776. Molecular formula: C33H44F2N2O3. Mole weight: 554.723. Custom synthesis is available. Send your inquiries for more information. | London |
| Sedanolide | Sedanolide is a natural phthalide compound originally isolated from seed oil of the Umbelliferae family, including celery. It is an inducer of glutathione S-transferase and inhibitor of chemically induced carcinogenesis. Group: Pharmaceutical. Alternative Names: 3-butyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one; trans-Sedanolide; 1(3H)-Isobenzofuranone, 3-butyl-3a,4,5,6-tetrahydro-. CAS No. 6415-59-4. Pack Sizes: 10 mg. Product ID: B1370-130717. Molecular formula: C12H18O2. Mole weight: 194.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Sulforaphane | Sulforaphaneis a naturally-occurring phytochemical belonging to the class of isothiocyanates. As the aglycone metabolite of glucosinolate glucoraphanin (sulforaphane glucosinolate), sulforaphane acts as an antioxidant and potent stimulator of endogenous detoxifying enzymes. This agent displays anticarcinogenic properties due to its ability to induce phase II detoxification enzymes, such as glutathione S-transferase and quinone reductase, thereby providing protection against certain carcinogens and toxic, reactive oxygen species. Broccoli sprouts contain large amounts of sulforaphane, which is also found in other cruciferous vegetables including cabbage and kale. Uses: Anti-inflammatory/antitumor. Group: Pharmaceutical. Alternative Names: 4-Methylsulfinylbutyl Isothiocyanate; Sulforaphan; DL-Sulforaphane; Butane, 1-isothiocyanato-4-(methylsulfinyl)-; (±)-sulforaphane; 4-Isothiocyanatobutyl methyl sulfoxide. CAS No. 4478-93-7. Pack Sizes: 1 g. Product ID: NP4355. Molecular formula: C6H11NOS2. Mole weight: 177.28. Custom synthesis is available. Send your inquiries for more information. | London |
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