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Givosiran sodium Givosiran sodium is a small interfering RNA (siRNA) directed towards delta-aminolevulinate synthase 1 (ALAS1). Givosiran sodium has been indicated for the treatment of adults with acute hepatic porphyria (AHP). Group: Pharmaceutical. Alternative Names: ALN-AS1 sodium; ALN AS1 sodium; ALN-AS 1 sodium; WHO 10280 sodium; WHO-10280 sodium; WHO10280 sodium; Givlaari sodium; RNA, (Cm-sp-Am-sp-Gm-Am-Am-Am-(2'-deoxy-2'-fluoro)G-Am-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)C-Am-Um-Cm-Um-Um-Am), 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)G-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Gm-sp-Gm-sp-Um) (1:1) sodium salt. Pack Sizes: 10 mg. Product ID: B1370-212888. Molecular formula: C524H651F16N173Na43O316P43S6. Mole weight: 17,245.56 Da. Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London

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