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| Product | Description | |
|---|---|---|
| GGTI-2418 | GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. GGTase I catalyzes the lipid posttranslational modification which is required for the function of Rho GTPases (frequently found aberrantly activated in human cancer). GGTase I inhibitors block Rho function in cancer cells and induce a G1 phase cell cycle arrest by a mechanism involving induction of the CDK inhibitors p21waf and p27kip, CDK2 and CDK4 inhibition and hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation of PI3K/Akt. Group: Pharmaceutical. Alternative Names: GGTI 2418; GGTI-2418; GGTI 2418. CAS No. 501010-06-6. Pack Sizes: 2.5 mg. Product ID: B0084-462530. Molecular formula: C23H31N5O4. Mole weight: 441.532. Custom synthesis is available. Send your inquiries for more information. |  London |
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