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| Product | Description | |
|---|---|---|
| Gemcitabine | Gemcitabine is a nucleoside analogue used in chemotherapy. It treats cancers including testicular cancer, breast cancer, ovarian cancer, non-small cell lung cancer, pancreatic cancer and bladder cancer. Group: Pharmaceutical. Alternative Names: 2'-Deoxy-2',2'-difluorocytidine; 2'-Deoxy-2',2'-difluoro-D-cytidine; 2',2'-Difluoro-2'-deoxycytidine; 4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 2',2'-Difluorodeoxycytidine; DDFC; DFdC; Folfugem; GemLip; Gemcel; NSC 613327; Gemzar. CAS No. 95058-81-4. Pack Sizes: 25 g. Product ID: NP3544. Molecular formula: C9H11F2N3O4. Mole weight: 263.2. Custom synthesis is available. Send your inquiries for more information. |  London |
| Gemcitabine (alpha-Isomer) Hydrochloride | Gemcitabine (alpha-Isomer) Hydrochloride is an α-Anomer of Gemcitabine. Gemcitabine is a nucleoside analogue used in chemotherapy. It treats cancers including testicular cancer, breast cancer, ovarian cancer, non-small cell lung cancer, pancreatic cancer and bladder cancer. Group: Pharmaceutical. Alternative Names: 2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl)-, hydrochloride (1:1); Gemcitabine EP Impurity B hydrochloride; 4-Amino-1-(2-deoxy-2,2-difluoro-α-D-erythropentofuranosyl)pyrimidin-2(1H)-one hydrochloride; Gemcitabine α-anomer hydrochloride; Gemcitabine Impurity B hydrochloride; 1'-Epi Gemcitabine hydrochloride; 1-(2,2-Difluoro-2-deoxy-α-D-ribofuranosyl)cytosine hydrochloride; α-Gemcitabine hydrochloride. CAS No. 122111-05-1. Pack Sizes: 25 mg. Product ID: B2694-261177. Molecular formula: C9H12F2N3O4Cl. Mole weight: 299.65. Custom synthesis is available. Send your inquiries for more information. | London |
| Gemcitabine elaidate | Gemcitabine elaidate (also known as CO-101; CP-4126) is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Due to its lipophilicity, gemcitabine 5'-elaidic acid ester exhibits an increased cellular uptake and accumulation, resulting in an increased conversion to active metabolites, compared to gemcitabine. In addition, this formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase. Group: Pharmaceutical. Alternative Names: CO-101; CO101; CO 101; CP-4126; CP4126; CP 4126. CAS No. 210829-30-4. Pack Sizes: 25 mg. Product ID: B2706-225221. Molecular formula: C27H43F2N3O5. Mole weight: 527.654. Custom synthesis is available. Send your inquiries for more information. | London |
| Gemcitabine hydrochloride | 5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C9H11F2N3O4 ยท HCl. CAS No. 122111-03-9. Prepack ID : 56199790-5g. Molecular Weight : 299.66. |  |
| Gemcitabine hydrochloride | Gemcitabine induced NF-κB activity in BxPC-3, PANC-1, and MIA PaCa-2 cells and decreased the level of the NF-κB inhibitor IκBα in BxPC-3 and PANC-1 cells. Uses: Antimetabolites, antineoplastic. Group: Pharmaceutical. Alternative Names: Gemzar; Gemcitabine HCl; LY188011 hydrochloride. CAS No. 122111-03-9. Pack Sizes: 5 g. Product ID: B0046-464018. Molecular formula: C9H11F2N3O4.HCI. Mole weight: 299.66. Custom synthesis is available. Send your inquiries for more information. | London |
| Gemcitabine Monophosphate | A monophosphorylated derivative of Gemcitabine and has been found to exhibit potent activities as a cytotoxic agent and induce apoptosis. Group: Pharmaceutical. Alternative Names: 2',2'-difluorodeoxycytidine Monophosphate; Gemcitabine 5'-phosphate. CAS No. 116371-67-6. Pack Sizes: 25 mg. Product ID: B1370-007036. Molecular formula: C9H12F2N3O7P. Mole weight: 343.18. Custom synthesis is available. Send your inquiries for more information. | London |
| Gemcitabine Triphosphate (triethylammonium salt form) | An impurity of Gemcitabine. Gemcitabine is an antineoplastic chemotherapy medication of the antimetabolites class. It halts cell division through damaging RNA or DNA which control the process. It can be used to treat multiple cancers. Group: Pharmaceutical. Alternative Names: Cytidine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2',2'-difluoro-, compd. with N,N-diethylethanamine (1:3); 2'-Deoxy-2',2'-difluorocytidine 5'-(Tetrahydrogen Triphosphate) triethylammonium; Gemcitabine Triphosphate Tri(triethylamine) Salt. CAS No. 1035495-84-1. Pack Sizes: 5 mg. Product ID: B1002-007250. Molecular formula: C9H14F2N3O13P3.3C6H15N. Mole weight: 806.71. Custom synthesis is available. Send your inquiries for more information. | London |
| Acelarin | Acelarin is a DNA synthesis inhibitor with EC50 of 0.2 nM. Acelarin is a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine. It is converted into the active metabolites dFdCDP and dFdCTP. dFdCDP can inhibit ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA replication; dFdCTP can be incorporated into DNA, resulting in premature termination of DNA replication and eventually induction of apoptosis. Phase III clinical trials for the treatment of Pancreatic cancer are on-going. Uses: Pancreatic cancer. Group: Pharmaceutical. Alternative Names: NUC-1031; NUC 1031; NUC1031; GTPL7389; GTPL 7389; GTPL-7389; SCHEMBL17171316; Benzyl (2S)-2-[({[(2R,3S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy}(phenoxy)phosphoryl)amino]propanoate. CAS No. 840506-29-8. Pack Sizes: 50 mg. Product ID: B2693-476645. Molecular formula: C25H27F2N4O8P. Mole weight: 580.48. Custom synthesis is available. Send your inquiries for more information. | London |
| LY2109761 | LY2109761 is a novel inhibitor of TGF-β receptor type I/type II kinases (IC50 = 69 nM), displaying antitumor activity. In vivo study demonstrated that LY2109761, in combination with gemcitabine, significantly reduced the tumor burden, prolonged survival, and reduced spontaneous abdominal metastases. Group: Pharmaceutical. Alternative Names: LY-2109761; 4-(2-((4-(2-(Pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)oxy)ethyl)morpholine. CAS No. 700874-71-1. Pack Sizes: 100 mg. Product ID: B2693-286403. Molecular formula: C26H27N5O2. Mole weight: 441.52. Custom synthesis is available. Send your inquiries for more information. | London |
| N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite | N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite is an indispensable compound within the biomedical domain with widespread application as a phosphoramidite constituent during oligonucleotide synthesis, primarily in the research of antisense therapy and gene silencing. Group: Pharmaceutical. Alternative Names: N4-Bz-DMT-2',2'-difluoro-dC-CE-Phosphoramidite; DMTr-2',2'-difluoro-dC(Bz)-3'-CED-phosphoramidite; Gemcitabine amidite; Gemcitabine 3'-CE phosporamidite; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine 3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; 5'-O-DMT-N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine 3'-CE phosphoramidite; 5'-DMT-N4-Bz-2',2'-difluoro-dC 3'-CE phosphoramidite. CAS No. 142808-44-4. Pack Sizes: 100 mg. Product ID: B2706-337702. Molecular formula: C46H50F2N5O8P. Mole weight: 869.89. Custom synthesis is available. Send your inquiries for more information. | London |
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