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| Product | Description | |
|---|---|---|
| GDC-0152 | GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Smac, the endogenous IAP antagonist, relies on its N-terminal four amino-acid motif for binding to IAPs. Group: Pharmaceutical. Alternative Names: GDC-0152; GDC0152; GDC 0152. CAS No. 873652-48-3. Pack Sizes: 50 mg. Product ID: B2693-462525. Molecular formula: C25H34N6O3S. Mole weight: 498.646. Custom synthesis is available. Send your inquiries for more information. |  London |
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