Find where to buy products from UK suppliers, including: distributors, industrial manufacturers, wholesalers, raw ingredients, bulk supplies and finished goods for sale.
Search for products or services, then visit the suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the USA.
| Product | Description | |
|---|---|---|
| Gabapentin Impurities | Gabapentin Impurities are critical for quality control and stability studies of the antiepileptic drug Gabapentin, primarily utilized in treating neuropathic pain and seizures. Evaluating these impurities ensures the drug's safety, efficacy, and compliance with pharmaceutical regulatory standards, maintaining therapeutic integrity throughout its shelf life. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Gabapentin Impurity 3 | Gabapentin Impurity 3 is a chemical with potential use for biochemical research, especially in the field of neurobiology. It is Gabapentin intermediate. Group: Pharmaceutical. CAS No. 1130-32-1. Pack Sizes: 100 g. Product ID: B2694-054846. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mirogabalin | This active molecular is an α2δ-1 ligand being developed for pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia which related to related to drugs such as gabapentin and pregabalin. Mirogabalin binds to the α2δ calcium channels (1 and 2) and was estimated to be much more potent than pregabalin. In Nov 2015, a Japanese company named Daiichi Sankyo plans a phase III trial for Postherpetic neuralgia and Neuropathic pain (in patients with diabetic peripheral neuropathy and renal impairment) in Japan. In May 2016, Pharmacokinetics and adverse data from a phase I trial in volunteers presented at the 35th Annual Scientific Meeting of the American Pain Society. Uses: Treatment of diabetic peripheral neuropathic pain. Group: Pharmaceutical. CAS No. 1138245-13-2. Pack Sizes: 25 mg. Product ID: B0084-475092. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Vigabatrin EP Impurity E | Vigabatrin EP Impurity E is a derivative of Vigabatrin. Vigabatrin is an inhibitor of the enzyme GABA transaminase (GABA-T) used as an antiepileptic drug. Group: Pharmaceutical. CAS No. 1378466-25-1. Pack Sizes: 1 g. Product ID: B1370-485133. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Vigabatrin Hydrochloride | A novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic. Group: Pharmaceutical. CAS No. 1391054-02-6. Pack Sizes: 50 mg. Product ID: B0084-463211. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Vigabatrin Impurities | Vigabatrin Impurities, identified during drug synthesis, are crucial for assessing the safety and efficacy of vigabatrin, an antiepileptic medication used to treat seizure disorders. Understanding these impurities aids in optimizing drug formulation and ensuring the quality control of vigabatrin, thus enhancing its therapeutic effectiveness for epilepsy management. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 16,17-Didehydro-19β-methyl-18-oxayohimban-16-carboxylic acid methyl ester | Mayumbine is a heteroyohimbine extracted from auwolfia vomitoria. Mayumbine was shown to suppress the in vitro binding of 3H-diazepam to the benzodiazepine sites within the rat GABAA receptor complex (IC50 = 76 ± 3.5 nM). Group: Pharmaceutical. CAS No. 25532-45-0. Pack Sizes: 5 mg. Product ID: NP0132. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 1-butylpyrrolidin-2-one | 1-Butylpyrrolidin-2-one is a pharmaceutical intermediate used in the synthesis of drugs such as gabapentin and levetiracetam, which are used to treat neuropathic pain and epilepsy. Group: Pharmaceutical. CAS No. 3470-98-2. Pack Sizes: 250 g. Product ID: B1370-397833. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2-{3-[5-(2-Hydroxypropan-2-yl)-1H-1,3-benzodiazol-1-yl]phenyl}benzamide | A GABAA receptor modulator that effects against anxiety. Group: Pharmaceutical. CAS No. 951654-29-8. Pack Sizes: 10 mg. Product ID: B0084-284807. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (2S,3S)-3-Hydroxypyrrolidine-2-carboxylic acid | (2S,3S)-3-Hydroxypyrrolidine-2-carboxylic acid, an essential substrate in the preparation of assorted biologically active molecules, is a formidable entity. This compound finds extensive utility as a chiral intermediate in the production of pharmacological agents with specific molecular arrangements. The synthetic derivatives of this intermediate exhibit GABA agonist and dopamine agonist activities with significant implications in managing pathologies related to Alzheimer's, Parkinson's and schizophrenia. Group: Pharmaceutical. CAS No. 4298-8-2. Pack Sizes: 100 mg. Product ID: B2699-117825. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 4-(2'-Bromoethyl)-3-chloro-1,3-dihydro-2-indoline-2-one | An intermediate of Ropinirole. Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1, and β-adrenoreceptors. Group: Pharmaceutical. CAS No. 120427-95-4. Pack Sizes: 100 mg. Product ID: B2694-055636. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acamprosate Calcium | Acamprosate calcium is a gamma-aminobutyric acid(GABA)agonist and modulator of glutamatergic systems. It has been used in alcohol dependence treatments and may be an effective augmentation therapy in patients with treatment-resistant anxiety. It has low bioavailability, but also has an excellent tolerability and safety profile. It is unique in that it is not metabolized by the liver and is also not impacted by alcohol use, so it can be administered to patients with hepatitis or liver disease and to patients who continue drinking alcohol. It was approved for use in the therapy of alcohol dependence and abuse in the United States in 2004. Uses: Alcohol deterrents. Group: Pharmaceutical. CAS No. 77337-73-6. Pack Sizes: 10 g. Product ID: B1370-076955. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acamprosate Calcium-[d12] | Acamprosate Calcium-[d12] is a labelled analogue of Acamprosate Calcium. Acamprosate calcium is a gamma-aminobutyric acid (GABA) agonist and modulator of glutamatergic systems. It has been used in alcohol-dependent treatments and may be an effective augmentation therapy in patients with treatment-resistant anxiety. It has low bioavailability, but also has an excellent tolerability and safety profile. It is unique in that it is not metabolized by the liver and is also not impacted by alcohol use, so it can be administered to patients with hepatitis or liver disease and to patients who continue drinking alcohol. It was approved for use in the therapy of alcohol dependence and abuse in the United States in 2004. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-003189. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-γ-aminobutyric acid | 4-Acetamidobutanoic acid is the main metabolite of GABA. 4-Acetamidobutanoic acid exhibits antioxidant and antibacterial activities. Group: Pharmaceutical. CAS No. 3025-96-5. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-007901. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Afobazole | Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety. Experiments of mice have showed antimutagenic and antiteratogenic properties. Group: Pharmaceutical. CAS No. 173352-21-1. Pack Sizes: 5 mg. Product ID: B0084-458641. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Afobazole hydrochloride | Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety. Experiments of mice have showed antimutagenic and antiteratogenic properties. Group: Pharmaceutical. CAS No. 173352-39-1. Pack Sizes: 100 mg. Product ID: B2693-463567. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AWD 131-138 | AWD 131-138 is a partial agonist of GABAA receptor with low affinity for the benzodiazepine binding site. AWD 131-138 exhibits potent anticonvulsant and anxiolytic properties in rodent models. It is used as an antiepileptic drug for the treatment of canine idiopathic epilepsy. Group: Pharmaceutical. CAS No. 188116-07-6. Pack Sizes: 10 mg. Product ID: B0084-244924. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Baclofen | Baclofen, an agonist of GABAB receptor, could be effective as a skeletal muscle relaxant and has been also found to have antispastic effect. Uses: Baclofen could be effective as a skeletal muscle relaxant and has been also found to have antispastic effect. Group: Pharmaceutical. CAS No. 1134-47-0. Pack Sizes: 25 g. Product ID: NP3355. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Baicalin | Baicalin is a flavone found in several species in the genus Scutellaria, including Scutellaria baicalensis and Scutellaria lateriflora. Baicalin is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABA receptor. Baicalin can also absorb ultraviolet rays, scavenge oxygen free radicals, and inhibit the production of melanin. Therefore, it can be used in medicine and cosmetics. It is a good functional cosmetic raw material. Group: Pharmaceutical. CAS No. 21967-41-9. Pack Sizes: 50 g. Product ID: BBF-03753. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Basmisanil | Basmisanil is a highly selective inverse agonist/negative allosteric modulator GABAAα5 receptors. It was developed by Roche to treat cognitive impairment associated with Down syndrome. In Apr 2016, Roche completed the phase II in Down syndrome (In adolescents, In adults) in USA, Argentina, Canada, France, Italy, Mexico, New Zealand, Singapore, Spain and the UK. In Sep 2016, Phase-II clinical trials in Neurological disorders (In adults, In the elderly) in Spain was on going. Uses: Down syndrome; neurological disorders. Group: Pharmaceutical. CAS No. 1159600-41-5. Pack Sizes: 100 mg. Product ID: B2693-475111. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CGP 35348 | CGP 35348 is a selective and brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes) with higher affinity for postsynaptic than presynaptic receptors. Group: Pharmaceutical. CAS No. 123690-79-9. Pack Sizes: 25 mg. Product ID: B1370-360418. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CGP 52432 | CGP52432 is a potent and selective GABAB receptor antagonist with IC50 value of 85 nM. Group: Pharmaceutical. CAS No. 139667-74-6. Pack Sizes: 20 mg. Product ID: B0084-211080. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Chamigrenal | Chamigrenal, a pharmacological treatment of anxiety disorders, intricately works towards ameliorating the perturbed functioning of the GABA receptors that ensue due to the hyperactivity of the brain. The convoluted mechanism of action mediates a stupor gently and minimizes the manifestation of anxiety symptoms. Additionally, it occasionally serves as an adjuvant in the management of insomnia. Group: Pharmaceutical. CAS No. 19912-84-6. Pack Sizes: 5 mg. Product ID: B0005-465632. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Escitalopram | Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase. Uses: Serotonin uptake inhibitors; antidepressive agents, second-generation. Group: Pharmaceutical. CAS No. 128196-01-0. Pack Sizes: 500 mg. Product ID: B2693-461840. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Fasoracetam | Fasoracetam is a GABA receptor modulator potentially for the treatment of attention deficit hyperactivity disorder. Group: Pharmaceutical. CAS No. 110958-19-5. Pack Sizes: 1 g. Product ID: B2693-083577. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Gaboxadol hydrochloride | THIP hydrochloride is a GABAA receptor agonist and GABAA-ρ receptor antagonist. THIP exhibits antinociceptive, anticonvulsant and sedative effects. It is used as a hypnotic agent for the treatment of patients with insomnia. Uses: Hypnotic. Group: Pharmaceutical. CAS No. 85118-33-8. Pack Sizes: 250 mg. Product ID: B2693-220946. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ginkgolide A | Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM. Group: Pharmaceutical. CAS No. 15291-75-5. Pack Sizes: 20 mg. Product ID: NP1492. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GOMISIN N | Gomisin N produced beneficial sedative and hypnotic bioactivity, which might be mediated by the modification of the serotonergic and GABAergic system. Uses: Anticancer, anti-hepatotoxic, anti-oxidative and anti-inflammatory. Group: Pharmaceutical. CAS No. 69176-52-9. Pack Sizes: 20 mg. Product ID: NP3918. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GRP (porcine) | GRP (porcine) is a mammalian bombesin-like peptide neurotransmitter that acts as an agonist for the gastrin-releasing peptide receptor (GRPR). It was shown to activate GABAergic interneurons in the amygdala resulting in an increase in GABA release and fear suppression in mice in vivo. Group: Pharmaceutical. CAS No. 74815-57-9. Pack Sizes: 10 mg. Product ID: B2693-032077. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Kushenol I | Kushenol I is a compound of the flavonoid class found in the Sophora flavescens Ait. Kushenol I is a GABAA receptor modulator and a Sodium-dependent glucose cotransporter 2(SGLT2) inhibitor. Group: Pharmaceutical. CAS No. 99119-69-4. Pack Sizes: 5 mg. Product ID: B0005-053514. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Lotilaner | Lotilaner is an insecticide and veterinary drug. It acts as a non-competitive antagonist of insects GABA receptors. Uses: An insecticide and veterinary drug. Group: Pharmaceutical. CAS No. 1369852-71-0. Pack Sizes: 5 mg. Product ID: B2693-475373. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-Despropyl Ropinirole HCl | An impurity of Ropinirole. Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1, and β-adrenoreceptors. Group: Pharmaceutical. CAS No. 173990-76-6. Pack Sizes: 10 mg. Product ID: B2694-479262. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Nefiracetam | Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Uses: Neuroprotective agents. Group: Pharmaceutical. CAS No. 77191-36-7. Pack Sizes: 1 g. Product ID: B0084-076916. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Oxiracetam | Oxiracetam is a cyclic derivative of gamma-aminobutyric acid (GABA) that is used as a nootropic drug to improve memory and learning. Uses: Nootropic drug. Group: Pharmaceutical. CAS No. 62613-82-5. Pack Sizes: 5 g. Product ID: NP3414. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pagoclone | Pagoclone, an active (+)-enantiomer of the racemate RP 59037, is a ubtype selective partial agonist at GABAA receptor and used for the treatment of panic and anxiety disorders. Group: Pharmaceutical. CAS No. 133737-32-3. Pack Sizes: 500 mg. Product ID: B2693-057535. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pimpinellin | Pimpinellin, isolated from the fruits of Psoralea corylifolia L., is a GABA receptor antagonist. Uses: Phytoalexin. Group: Pharmaceutical. CAS No. 131-12-4. Pack Sizes: 10 mg. Product ID: NP1156. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Piperine | Piperine (1-Piperoylpiperidine) is an alkaloid isolated from black pepper, activating transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 μM) and modulates GABAA receptors (EC50s = 43-60 μM). It is used in some traditional medicines. Piperine is used as a spicy raw material in the food industry and has a sterilization effect. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 94-62-2. Pack Sizes: 250 g. Product ID: NP0605. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (R)-Baclofen | (R)-Baclofen is the R-enantiomer of Baclofen, which is a specific GABA-B receptor agonist and muscle relaxant (skeletal). It is primarily used to treat spasticity. Group: Pharmaceutical. CAS No. 69308-37-8. Pack Sizes: 5 g. Product ID: B0084-097120. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (R)-(-)-N-(3,5-Dinitrobenzoyl)-alpha-phenylglycine | (R)-(-)-N-(3,5-Dinitrobenzoyl)-alpha-phenylglycine, a vital compound, serves as an essential precursor in the pharmaceutical synthesis used to treat different maladies. This compound has demonstrated the property of improving the functioning of GABAergic neurotransmission, which makes it a promising therapeutic agent for combating anxiety and depression. Its potential in treating various mood disorders is a subject of ongoing scientific inquiry. Group: Pharmaceutical. CAS No. 74927-72-3. Pack Sizes: 100 g. Product ID: B2699-132507. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (S)-(-)-4-Amino-2-hydroxybutyric AcidAmikacin EP Impurity I | (S)-(-)-4-Amino-2-hydroxybutyric acid is an analogue of γ-aminobutyric acid (GABA) that exhibits potential inhibitory activity on GABA binding and uptake by brain. Group: Pharmaceutical. CAS No. 40371-51-5. Pack Sizes: 200 g. Product ID: B0084-091852. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (S)-homo-β-alanine | (S)-Homo-β-alanine, an amino acid occurring naturally, acts as an intermediary in thymine metabolism. Its potential to regulate oxidative stress and inflammation marks it as a prospective treatment for cardiovascular disease and hypertension. Also, research suggests its involvement in the synthesis of neurotransmitter gamma-aminobutyric acid (GABA) in the brain. Group: Pharmaceutical. CAS No. 3775-72-2. Pack Sizes: 10 g. Product ID: B2699-114069. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tetrahydrolavandulol | Tetrahydrolavandulol, a vital constituent in the realm of pharmacology, has been studied comprehensively due to its significant potential in treating anxiety and depression. Its functionality relies on positively modulating GABAA receptors, an allosteric mechanism that boosts the activity of GABA in the brain, thereby enabling a calming effect to prevail. Group: Pharmaceutical. CAS No. 2051-33-4. Pack Sizes: 1 g. Product ID: B2699-115002. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Thiocolchicoside | Thiocolchicoside is a semi-synthetic derivative of colchicine, an anti-inflammatory glycoside extracted from the flower seeds of superba gloriosa. Thiocolchicoside acts as a GABAA receptor antagonist exhibiting anti-inflammatory and analgesic activity. It is used as a muscle relaxant. Group: Pharmaceutical. CAS No. 602-41-5. Pack Sizes: 500 mg. Product ID: B0084-464811. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tiagabine hydrochloride | Tiagabine hydrochloride is an anticonvulsant and selective GABA reuptake inhibitor through inhibition of the synaptic GABA transporter GAT1. Tiagabine increases the synaptic GABA and enhances the neuronal inhibition. It is effective as adjunctive treatment of epilepsy and anxiety disorders. Group: Pharmaceutical. CAS No. 145821-59-6. Pack Sizes: 200 mg. Product ID: NP3227. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
Our database is helping our users find suppliers everyday.
