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| Product | Description | |
|---|---|---|
| Gabapentin Impurity 3 | Gabapentin Impurity 3 is a chemical with potential use for biochemical research, especially in the field of neurobiology. It is Gabapentin intermediate. Group: Pharmaceutical. Alternative Names: 3,3-Pentamethyleneglutarimide; 1,1-Cyclohexane diacetimide; 3,3-Pentamethylene Glutarimide; 2,4-Dioxo-3-azaspiro[5.5]undecane; 1,1-Cyclohexanediacetimide; 3-Azaspiro[5.5]undecane-2,4-dione; NSC 400093. CAS No. 1130-32-1. Pack Sizes: 100 g. Product ID: B2694-054846. Molecular formula: C10H15NO2. Mole weight: 181.24. Custom synthesis is available. Send your inquiries for more information. |  London |
| Mirogabalin | This active molecular is an α2δ-1 ligand being developed for pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia which related to related to drugs such as gabapentin and pregabalin. Mirogabalin binds to the α2δ calcium channels (1 and 2) and was estimated to be much more potent than pregabalin. In Nov 2015, a Japanese company named Daiichi Sankyo plans a phase III trial for Postherpetic neuralgia and Neuropathic pain (in patients with diabetic peripheral neuropathy and renal impairment) in Japan. In May 2016, Pharmacokinetics and adverse data from a phase I trial in volunteers presented at the 35th Annual Scientific Meeting of the American Pain Society. Uses: Treatment of diabetic peripheral neuropathic pain. Group: Pharmaceutical. Alternative Names: 2-[(1R,5S,6S)-6-(aminomethyl)-3-ethyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid, DS-5565,CAS#1138245-21-2 ( Mirogabalin besylate). CAS No. 1138245-13-2. Pack Sizes: 25 mg. Product ID: B0084-475092. Molecular formula: C12H19NO2. Mole weight: 209.29. Custom synthesis is available. Send your inquiries for more information. | London |
| Vigabatrin EP Impurity E | Vigabatrin EP Impurity E is a derivative of Vigabatrin. Vigabatrin is an inhibitor of the enzyme GABA transaminase (GABA-T) used as an antiepileptic drug. Group: Pharmaceutical. Alternative Names: 2-(2-Aminobut-3-enyl)malonic Acid. CAS No. 1378466-25-1. Pack Sizes: 1 g. Product ID: B1370-485133. Molecular formula: C7H11NO4. Mole weight: 173.17. Custom synthesis is available. Send your inquiries for more information. | London |
| Vigabatrin Hydrochloride | A novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic. Group: Pharmaceutical. Alternative Names: γ-Vinyl-GABA hydrochloride; Sabril hydrochloride. CAS No. 1391054-02-6. Pack Sizes: 50 mg. Product ID: B0084-463211. Molecular formula: C6H12ClNO2. Mole weight: 165.62. Custom synthesis is available. Send your inquiries for more information. | London |
| 1-butylpyrrolidin-2-one | 1-Butylpyrrolidin-2-one is a pharmaceutical intermediate used in the synthesis of drugs such as gabapentin and levetiracetam, which are used to treat neuropathic pain and epilepsy. Group: Pharmaceutical. Alternative Names: 1-Butyl-2-pyrrolidinone; 1-Butyl-2-pyrrolidone. CAS No. 3470-98-2. Pack Sizes: 250 g. Product ID: B1370-397833. Molecular formula: C8H15NO. Mole weight: 141.21. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-{3-[5-(2-Hydroxypropan-2-yl)-1H-1,3-benzodiazol-1-yl]phenyl}benzamide | A GABAA receptor modulator that effects against anxiety. Group: Pharmaceutical. Alternative Names: 3'-(5-(2-Hydroxypropan-2-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-2-carboxamide; GABAA Modulator I; SCHEMBL1761811; MFCD30186081; AKOS027439948; ZINC117027649. CAS No. 951654-29-8. Pack Sizes: 10 mg. Product ID: B0084-284807. Molecular formula: C23H21N3O2. Mole weight: 371.44. Custom synthesis is available. Send your inquiries for more information. | London |
| (2S,3S)-3-Hydroxypyrrolidine-2-carboxylic acid | (2S,3S)-3-Hydroxypyrrolidine-2-carboxylic acid, an essential substrate in the preparation of assorted biologically active molecules, is a formidable entity. This compound finds extensive utility as a chiral intermediate in the production of pharmacological agents with specific molecular arrangements. The synthetic derivatives of this intermediate exhibit GABA agonist and dopamine agonist activities with significant implications in managing pathologies related to Alzheimer's, Parkinson's and schizophrenia. Group: Pharmaceutical. Alternative Names: trans-3-hydroxy-L-proline; (3S)-3-hydroxy-L-proline; L-Proline, 3-hydroxy-, (3S)-. CAS No. 4298-8-2. Pack Sizes: 100 mg. Product ID: B2699-117825. Molecular formula: C5H9NO3. Mole weight: 131.13. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-(2'-Bromoethyl)-3-chloro-1,3-dihydro-2-indoline-2-one | An intermediate of Ropinirole. Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1, and β-adrenoreceptors. Group: Pharmaceutical. Alternative Names: 4-(2-Bromoethyl)-3-chloro-1,3-dihydro-2H-indolin-2-one. CAS No. 120427-95-4. Pack Sizes: 100 mg. Product ID: B2694-055636. Molecular formula: C10H9BrClNO. Mole weight: 274.54. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Aminobutyric acid | Vigabatrin EP Impurity D (GABA) is an inhibitory neurotransmitter in mammalian central nervous system. It shows an effect of reducing neuronal excitability and regulating muscle tone. Nutritional supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: γ-Aminobutyric Acid; 4-Aminobutanoic Αcid; 3-Carboxypropylamine; 4-Aminobutyric Acid; Aminalon; GABA; Gaballon; Gamarex; Gammalon; Gammalone; Gammar; Gammasol; Mielogen; Mielomade; NSC 27418; NSC 32044; NSC 45460; NSC 51295; Oryza GABA Extract HC 90; Pharma-GABA 20S; Pharmagaba; Pharmagaba 20; Pharmagaba 20D; Piperidic acid; Piperidinic acid; γ-Aminobutanoic acid; ω-Aminobutyric Acid. CAS No. 56-12-2. Pack Sizes: 1mg;1g;10g. Product ID: BAT-008079. Molecular formula: C4H9NO2. Mole weight: 103.12. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Hydroxybenzaldehyde | 4-Hydroxybenzaldehyde comes from the herb of Gastrodia elata Blume, it shows an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant. Uses: Antiepileptic and anticonvulsive activity. Group: Pharmaceutical. Alternative Names: Bisoprolol Fumarate EP Impurity S; Bisoprolol EP Impurity S. CAS No. 123-08-0. Pack Sizes: 1mg;1g;10g. Product ID: NP5361. Molecular formula: C7H6O2. Mole weight: 122.12. Custom synthesis is available. Send your inquiries for more information. | London |
| A 784168 | A 784168 is a potent and selective TRPV1 antagonist (IC50 = 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin) exhibiting no activity against a range of receptors such as TRPA1, GABA, opioid, and purinergic receptors. Group: Pharmaceutical. Alternative Names: A 784168; A784168; A-784168; 3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide; 1-[3-(trifluoromethyl)pyridin-2-yl]-N-[4-(trifluoromethylsulfonyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamide. CAS No. 824982-41-4. Pack Sizes: 1mg;1g;10g. Product ID: 824982-41-4. Molecular formula: C19H15F6N3O3S. Mole weight: 479.4. Custom synthesis is available. Send your inquiries for more information. | London |
| AA 29504 | AA 29504 is a positive allosteric modulator of GABAA receptors with anxiolytic activity. It modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-containing receptors in Xenopus oocytes. AA 29504 is potentially used for the treatment of schizophrenia. Uses: Potential treatment of schizophrenia. Group: Pharmaceutical. Alternative Names: AA 29504; AA29504; AA-29504; N1-Ethoxycarbonyl-N4-[(2,4,6-trimethylpheny)lmethyl]-1,2,4-triaminobenzene; ethyl N-[2-amino-4-[(2,4,6-trimethylphenyl)methylamino]phenyl]carbamate. CAS No. 945828-50-2. Pack Sizes: 1mg;1g;10g. Product ID: 945828-50-2. Molecular formula: C19H25N3O2. Mole weight: 327.42. Custom synthesis is available. Send your inquiries for more information. | London |
| AC 265347 | AC 265347 is a CaSR biased allosteric modulator (pEC50 = 7.8-8.1) that bias signaling towards the accumulation of PERK1/2 and IP1. AC 265347 stimulates CaSR signaling in cellular proliferation and phosphatidyl inositol (PI) hydrolysis assays. It significantly activates human GABAB or type I PTH receptors. Group: Pharmaceutical. Alternative Names: AC 265347; AC-265347; AC265347; α-(2,4-Dimethylphenyl)-α-methyl-2-benzothiazolemethanol; 1-(1,3-benzothiazol-2-yl)-1-(2,4-dimethylphenyl)ethanol. CAS No. 1253901-26-6. Pack Sizes: 1mg;1g;10g. Product ID: 1253901-26-6. Molecular formula: C17H17NOS. Mole weight: 283.39. Custom synthesis is available. Send your inquiries for more information. | London |
| Acamprosate Calcium | Acamprosate calcium is a gamma-aminobutyric acid(GABA)agonist and modulator of glutamatergic systems. It has been used in alcohol dependence treatments and may be an effective augmentation therapy in patients with treatment-resistant anxiety. It has low bioavailability, but also has an excellent tolerability and safety profile. It is unique in that it is not metabolized by the liver and is also not impacted by alcohol use, so it can be administered to patients with hepatitis or liver disease and to patients who continue drinking alcohol. It was approved for use in the therapy of alcohol dependence and abuse in the United States in 2004. Uses: Alcohol deterrents. Group: Pharmaceutical. Alternative Names: Calcium 3-acetamidopropane-1-sulfonate; Calcium 3-(acetylamino)propanesulphonate; 3-(Acetylamino)-1-propanesulfonic Acid Calcium Salt; Calcium Acetylhomotaurine; Alcomed; Sobriol; Aotal calcium; Calcium N-acetylhomotaurinate. CAS No. 77337-73-6. Pack Sizes: 10 g. Product ID: B1370-076955. Molecular formula: C10H20CaN2O8S2. Mole weight: 400.48. Custom synthesis is available. Send your inquiries for more information. | London |
| Afobazole | Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety. Experiments of mice have showed antimutagenic and antiteratogenic properties. Group: Pharmaceutical. Alternative Names: CM346; Afobazol; Fabomotizole; CM 346; CM-346. CAS No. 173352-21-1. Pack Sizes: 5 mg. Product ID: B0084-458641. Molecular formula: C15H21N3O2S. Mole weight: 307.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Afobazole hydrochloride | Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety. Experiments of mice have showed antimutagenic and antiteratogenic properties. Group: Pharmaceutical. Alternative Names: CM346 hydrochloride; Afobazol hydrochloride; Fabomotizole hydrochloride; CM 346 hydrochloride; CM-346 hydrochloride. CAS No. 173352-39-1. Pack Sizes: 100 mg. Product ID: B2693-463567. Molecular formula: C15H22ClN3O2S. Mole weight: 343.87. Custom synthesis is available. Send your inquiries for more information. | London |
| Avermectin B2a | Avermectin B2a is produced by the strain of Streptomyces avermitilis. It stimulates nerve cells to release Y-aminobutyric acid (GABA), which blocks the transmission of signals from the central nervous system to the motor nerve. It is not resistant to bacteria and fungi, but has strong activity to nematode parasites such as ancylostoma and Pteria, as well as insects such as flies. Abamectin B1a has the highest activity. Ivermectin obtained by catalytic hydrogenation contains 22 23- dihydroabamectin B1a (above 80%) and 22 23 dioxabamectin B1b (below 20%). Less active than B1a but less toxic. Used as repellent (subcutaneous or oral) for cattle, sheep and pigs, it is also effective against human filariasis. Group: Pharmaceutical. Alternative Names: Ivermectin EP Impurity C; (23S)-5-O-demethyl-23-hydroxy-22,23-dihydro-avermectin A1a. CAS No. 65195-57-5. Pack Sizes: 1mg;1g;10g. Product ID: BBF-00230. Molecular formula: C48H74O15. Mole weight: 891.09. Custom synthesis is available. Send your inquiries for more information. | London |
| AWD 131-138 | AWD 131-138 is a partial agonist of GABAA receptor with low affinity for the benzodiazepine binding site. AWD 131-138 exhibits potent anticonvulsant and anxiolytic properties in rodent models. It is used as an antiepileptic drug for the treatment of canine idiopathic epilepsy. Group: Pharmaceutical. Alternative Names: AWD 131-138; AWD-131-138; AWD131-138; AWD 131138; Imepitoin; 3-(4-chlorophenyl)-5-morpholin-4-yl-4H-imidazol-2-one. CAS No. 188116-07-6. Pack Sizes: 10 mg. Product ID: B0084-244924. Molecular formula: C13H14ClN3O2. Mole weight: 279.724. Custom synthesis is available. Send your inquiries for more information. | London |
| Baicalin | Baicalin is a flavone found in several species in the genus Scutellaria, including Scutellaria baicalensis and Scutellaria lateriflora. Baicalin is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABA receptor. Baicalin can also absorb ultraviolet rays, scavenge oxygen free radicals, and inhibit the production of melanin. Therefore, it can be used in medicine and cosmetics. It is a good functional cosmetic raw material. Group: Pharmaceutical. Alternative Names: Baicalin;21967-41-9;Baicalein 7-O-glucuronide;7-D-Glucuronic acid-5,6-dihydroxyflavone;Baicalein 7-glucuronide;CHEBI:2981;MFCD00134418;347Q89U4M5;5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid;7-D-glucuronic acid-5,6-dihydroxy-flavone;CHEMBL485818;UNII-347Q89U4M5;5,6,7-trihydroxyflavone 7-O-beta-D-glucuronide;Baicalein 7-O-.beta.-D-glucuronide;beta-D-Glucopyranosidur. CAS No. 21967-41-9. Pack Sizes: 50 g. Product ID: BBF-03753. Molecular formula: C17H17ClN4. Mole weight: 320.8. Custom synthesis is available. Send your inquiries for more information. | London |
| Basmisanil | Basmisanil is a highly selective inverse agonist/negative allosteric modulator GABAAα5 receptors. It was developed by Roche to treat cognitive impairment associated with Down syndrome. In Apr 2016, Roche completed the phase II in Down syndrome (In adolescents, In adults) in USA, Argentina, Canada, France, Italy, Mexico, New Zealand, Singapore, Spain and the UK. In Sep 2016, Phase-II clinical trials in Neurological disorders (In adults, In the elderly) in Spain was on going. Uses: Down syndrome; neurological disorders. Group: Pharmaceutical. Alternative Names: (1,1-dioxidothiomorpholino)(6-((3-(4-fluorophenyl)-5-methylisoxazol-4-yl)methoxy)pyridin-3-yl)methanone; RG 1662; RG-1662; RG1662; RO5186582; RO-5186582; RO 5186582. CAS No. 1159600-41-5. Pack Sizes: 100 mg. Product ID: B2693-475111. Molecular formula: C21H20FN3O5S. Mole weight: 445.47. Custom synthesis is available. Send your inquiries for more information. | London |
| Broflanilide | Broflanilide, a GABA antagonist, is an insecticide that has high larvicidal activity against Spodoptera litura and is effective against pests with resistance to cyclodienes and fipronil. Group: Pharmaceutical. Alternative Names: N-[2-Bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl]-2-fluoro-3-(N-methylbenzamido)benzamide; 3-(Benzoylmethylamino)-N-[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-(trifluoromethyl)phenyl]-2-fluorobenzamide; 2-Fluoro-3-(N-methylbenzamido)-N-[2-bromo-4-(heptafluoroisopropyl)-6-(trifluoromethyl)phenyl]benzamide; 6'-Bromo-α,α,α,2-tetrafluoro-3-(N-methylbenzamido)-4'-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]benz-o-toluidide. CAS No. 1207727-04-5. Pack Sizes: 50 mg. Product ID: B1370-071090. Molecular formula: C25H14BrF11N2O2. Mole weight: 663.28. Custom synthesis is available. Send your inquiries for more information. | London |
| CGP 35348 | CGP 35348 is a selective and brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes) with higher affinity for postsynaptic than presynaptic receptors. Group: Pharmaceutical. Alternative Names: CGP35348; CGP-35348; (3-Aminopropyl)(diethoxymethyl)phosphinic acid. CAS No. 123690-79-9. Pack Sizes: 25 mg. Product ID: B1370-360418. Molecular formula: C8H20NO4P. Mole weight: 225.22. Custom synthesis is available. Send your inquiries for more information. | London |
| CGP 52432 | CGP52432 is a potent and selective GABAB receptor antagonist with IC50 value of 85 nM. Group: Pharmaceutical. Alternative Names: Cgp 52432; Cgp52432; Cgp52432; 3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid. CAS No. 139667-74-6. Pack Sizes: 20 mg. Product ID: B0084-211080. Molecular formula: C15H24Cl2NO4P. Mole weight: 384.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Chamigrenal | Chamigrenal, a pharmacological treatment of anxiety disorders, intricately works towards ameliorating the perturbed functioning of the GABA receptors that ensue due to the hyperactivity of the brain. The convoluted mechanism of action mediates a stupor gently and minimizes the manifestation of anxiety symptoms. Additionally, it occasionally serves as an adjuvant in the management of insomnia. Group: Pharmaceutical. Alternative Names: Spiro[5.5]?undec-2-ene-3-carboxaldehyde, 7,?7-dimethyl-11-methylene-, (-)?-. CAS No. 19912-84-6. Pack Sizes: 5 mg. Product ID: B0005-465632. Molecular formula: C15 H22 O. Mole weight: 218.33. Custom synthesis is available. Send your inquiries for more information. | London |
| Escitalopram | Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase. Uses: Serotonin uptake inhibitors; antidepressive agents, second-generation. Group: Pharmaceutical. Alternative Names: (S)-Citalopram; S-(+)-Citalopram; Seroplex. CAS No. 128196-01-0. Pack Sizes: 500 mg. Product ID: B2693-461840. Molecular formula: C20H21FN2O. Mole weight: 324.39. Custom synthesis is available. Send your inquiries for more information. | London |
| Etaqualone | Etaqualone is an analog of methaqualone, a non-barbiturate sedative also known as Quaalude. It exhibits agonist activity for GABAA receptor, resulting in sedative, hypnotic, muscle relaxant and central nervous system depressant properties. It is marketed in some European countries as insomnia therapy. Group: Pharmaceutical. Alternative Names: Athinazone; Ethinazone; Aolan; 3-(2-ethylphenyl)-2-methylquinazolin-4-one. CAS No. 7432-25-9. Pack Sizes: 1mg;1g;10g. Product ID: 7432-25-9. Molecular formula: C17H16N2O. Mole weight: 264.328. Custom synthesis is available. Send your inquiries for more information. | London |
| Fasoracetam | Fasoracetam is a GABA receptor modulator potentially for the treatment of attention deficit hyperactivity disorder. Group: Pharmaceutical. Alternative Names: (5R)-5-(piperidine-1-carbonyl)-2-pyrrolidone; (5R)-5-piperidin-1-ylcarbonylpyrrolidin-2-one. CAS No. 110958-19-5. Pack Sizes: 1 g. Product ID: B2693-083577. Molecular formula: C10H16N2O2. Mole weight: 196.248. Custom synthesis is available. Send your inquiries for more information. | London |
| Fipronil | Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gated chloride channels and glutamate-gated chloride channels, resulting in central nervous system toxicity. Fipronil can be used to kill parasites such as fleas and lice on cats and dogs. Group: Pharmaceutical. Alternative Names: Fluocyanobenpyrazole; (RS)-5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)pyrazole-3-carbonitrile; 5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile; (+/-)-Fipronil; 1-(2,6-Dichloro-4-trifluoromethylphenyl)-3-cyano-5-amino-4-(trifluoromethylsulfinyl)pyrazole; Frontline Spot-on; Frontline Spray; Frontline Top Spot; Goliath gel; Granedo MC; Grenade MC; Maxforce FC; Maxforce FC Select Roach Killer Bait Gel; Over'n Out; Regent; Regent TS; Termidor; Termidor 80WG; TopChoice; RM 1601; NSC-758960. CAS No. 120068-37-3. Pack Sizes: 1mg;1g;10g. Product ID: BBF-05824. Molecular formula: C12H4Cl2F6N4OS. Mole weight: 437.15. Custom synthesis is available. Send your inquiries for more information. | London |
| Fipronil-[pyrazole-13C3,cyano-13C] | Labelled Fipronil. Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gated chloride channels and glutamate-gated chloride channels, resulting in central nervous system toxicity. Group: Pharmaceutical. Alternative Names: 5-Amino-3-cyano-13C-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]pyrazole-13C3. CAS No. 2140327-54-2. Pack Sizes: 10 mg. Product ID: BLP-008734. Molecular formula: C8[13C]4H4Cl2F6N4OS. Mole weight: 441.12. Custom synthesis is available. Send your inquiries for more information. | London |
| Fluxametamide | Fluxametamide, a broad-spectrum insecticide, is an antagonist of GABA- and glutamate-gated chloride channels, with IC50s of 1.95 and 225 nM for M. domestica GABACls and GluCls. Group: Pharmaceutical. Alternative Names: 4-(5-(3,5-Dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl)-N-((methoxyimino)methyl)-2-methylbenzamide; Benzamide, 4-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl)-N-((methoxyamino)methylene)-2-methyl-; 4-[5-(3,5-Dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[(methoxyimino)methyl]-o-toluamide. CAS No. 928783-29-3. Pack Sizes: 500 mg. Product ID: B1370-381842. Molecular formula: C20H16Cl2F3N3O3. Mole weight: 474.26. Custom synthesis is available. Send your inquiries for more information. | London |
| Gaboxadol hydrochloride | THIP hydrochloride is a GABAA receptor agonist and GABAA-ρ receptor antagonist. THIP exhibits antinociceptive, anticonvulsant and sedative effects. It is used as a hypnotic agent for the treatment of patients with insomnia. Uses: Hypnotic. Group: Pharmaceutical. Alternative Names: THIP hydrochloride; Gaboxadol HCl. CAS No. 85118-33-8. Pack Sizes: 250 mg. Product ID: B2693-220946. Molecular formula: C6H8N2O2 · HCl. Mole weight: 176.6. Custom synthesis is available. Send your inquiries for more information. | London |
| Ginkgolide A | Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM. Group: Pharmaceutical. Alternative Names: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione; 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11aS*)]-; [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11aS*)]-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione; Bilobalide A; BN 52020. CAS No. 15291-75-5. Pack Sizes: 20 mg. Product ID: NP1492. Molecular formula: C20H24O9. Mole weight: 408.4. Custom synthesis is available. Send your inquiries for more information. | London |
| GOMISIN N | Gomisin N produced beneficial sedative and hypnotic bioactivity, which might be mediated by the modification of the serotonergic and GABAergic system. Uses: Anticancer, anti-hepatotoxic, anti-oxidative and anti-inflammatory. Group: Pharmaceutical. Alternative Names: GOMISIN N; Benzo(3,4)cycloocta(1,2-F)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13as)-. CAS No. 69176-52-9. Pack Sizes: 20 mg. Product ID: NP3918. Molecular formula: C23H28O6. Mole weight: 400.46. Custom synthesis is available. Send your inquiries for more information. | London |
| GRP (porcine) | GRP (porcine) is a mammalian bombesin-like peptide neurotransmitter that acts as an agonist for the gastrin-releasing peptide receptor (GRPR). It was shown to activate GABAergic interneurons in the amygdala resulting in an increase in GABA release and fear suppression in mice in vivo. Group: Pharmaceutical. Alternative Names: Gastrin Releasing Peptide porcine. CAS No. 74815-57-9. Pack Sizes: 10 mg. Product ID: B2693-032077. Molecular formula: C126H198N38O31S2. Mole weight: 2805.31. Custom synthesis is available. Send your inquiries for more information. | London |
| Homocarnosine acetate | L-Homocarnosine is a human metabolite and a brain-specific dipeptide of γ-aminobutyric acid (GABA) and histidine. Group: Pharmaceutical. Alternative Names: L-Homocarnosine acetate. Pack Sizes: 10 mg. Product ID: BAT-017111. Molecular formula: C12H20N4O5. Mole weight: 300.31. Custom synthesis is available. Send your inquiries for more information. | London |
| Kushenol I | Kushenol I is a compound of the flavonoid class found in the Sophora flavescens Ait. Kushenol I is a GABAA receptor modulator and a Sodium-dependent glucose cotransporter 2(SGLT2) inhibitor. Group: Pharmaceutical. Alternative Names: NSC 668937. CAS No. 99119-69-4. Pack Sizes: 5 mg. Product ID: B0005-053514. Molecular formula: C26H30O7. Mole weight: 454.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Lotilaner | Lotilaner is an insecticide and veterinary drug. It acts as a non-competitive antagonist of insects GABA receptors. Uses: An insecticide and veterinary drug. Group: Pharmaceutical. Alternative Names: (S)-3-methyl-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxamide. CAS No. 1369852-71-0. Pack Sizes: 5 mg. Product ID: B2693-475373. Molecular formula: C20H14Cl3F6N3O3S. Mole weight: 569.75. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Despropyl Ropinirole HCl | An impurity of Ropinirole. Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1, and β-adrenoreceptors. Group: Pharmaceutical. Alternative Names: 4-(2-(propylamino)ethyl)indolin-2-one hydrochloride. CAS No. 173990-76-6. Pack Sizes: 10 mg. Product ID: B2694-479262. Molecular formula: C13H18N2O.HCl. Mole weight: 254.76. Custom synthesis is available. Send your inquiries for more information. | London |
| Nefiracetam | Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Uses: Neuroprotective agents. Group: Pharmaceutical. Alternative Names: Nefiracetam; 77191-36-7; N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide; Translon; DM 9384. CAS No. 77191-36-7. Pack Sizes: 1 g. Product ID: B0084-076916. Molecular formula: C14H18N2O2. Mole weight: 246.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Oxiracetam | Oxiracetam is a cyclic derivative of gamma-aminobutyric acid (GABA) that is used as a nootropic drug to improve memory and learning. Uses: Nootropic drug. Group: Pharmaceutical. Alternative Names: 4-Hydroxy-2-oxopyrrolidine-N-acetamide; Hydroxypiracetam; Neuromet; ISF 2522; (+-)-Oxiracetam. CAS No. 62613-82-5. Pack Sizes: 5 g. Product ID: NP3414. Molecular formula: C6H10N2O3. Mole weight: 158.16. Custom synthesis is available. Send your inquiries for more information. | London |
| Pimpinellin | Pimpinellin, isolated from the fruits of Psoralea corylifolia L., is a GABA receptor antagonist. Uses: Phytoalexin. Group: Pharmaceutical. Alternative Names: 5,6-Dimethoxy-2H-furo[2,3-h]chromen-2-one. CAS No. 131-12-4. Pack Sizes: 10 mg. Product ID: NP1156. Molecular formula: C13H10O5. Mole weight: 246.2. Custom synthesis is available. Send your inquiries for more information. | London |
| Piperine | Piperine (1-Piperoylpiperidine) is an alkaloid isolated from black pepper, activating transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 μM) and modulates GABAA receptors (EC50s = 43-60 μM). It is used in some traditional medicines. Piperine is used as a spicy raw material in the food industry and has a sterilization effect. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one. CAS No. 94-62-2. Pack Sizes: 250 g. Product ID: NP0605. Molecular formula: C17H19NO3. Mole weight: 285.34. Custom synthesis is available. Send your inquiries for more information. | London |
| (R)-(-)-N-(3,5-Dinitrobenzoyl)-alpha-phenylglycine | (R)-(-)-N-(3,5-Dinitrobenzoyl)-alpha-phenylglycine, a vital compound, serves as an essential precursor in the pharmaceutical synthesis used to treat different maladies. This compound has demonstrated the property of improving the functioning of GABAergic neurotransmission, which makes it a promising therapeutic agent for combating anxiety and depression. Its potential in treating various mood disorders is a subject of ongoing scientific inquiry. Group: Pharmaceutical. Alternative Names: N-(3,5-Dinitrobenzoyl)phenylglycine; DNBPG. CAS No. 74927-72-3. Pack Sizes: 100 g. Product ID: B2699-132507. Molecular formula: C15H11N3O7. Mole weight: 345.26. Custom synthesis is available. Send your inquiries for more information. | London |
| (S)-(-)-4-Amino-2-hydroxybutyric AcidAmikacin EP Impurity I | (S)-(-)-4-Amino-2-hydroxybutyric acid is an analogue of γ-aminobutyric acid (GABA) that exhibits potential inhibitory activity on GABA binding and uptake by brain. Group: Pharmaceutical. Alternative Names: (2S)-4-Amino-2-hydroxybutanoic Acid; (S)-4-Amino-2-hydroxybutanoic Acid; (S)-4-Amino-2-hydroxybutyric Acid; 4-Amino-(2S)-hydroxybutyric Acid; L-(-)-4-Amino-2-hydroxybutyric Acid; L-(-)-γ-Amino-α-hydroxybutyric Acid; L-4-Amino-2-hydroxybutyric Acid; L-γ-Amino-α-hydroxybutyric Acid; (S)-(-)-4-Amino-2-hydroxybutyric Acid. CAS No. 40371-51-5. Pack Sizes: 200 g. Product ID: B0084-091852. Molecular formula: C4H9NO3. Mole weight: 119.12. Custom synthesis is available. Send your inquiries for more information. | London |
| Sevoflurane | Sevoflurane is an ether inhalation anaesthetic agent primarily used for the induction and maintenance of general anesthesia. It has been shown to enhance inhibitory postsynaptic channel activity (GABA and glycine), and inhibit excitatory synaptic channel activity (NMDA, nicotinic acetylcholine, serotonin, and glutamate) in the central nervous system. Group: Pharmaceutical. Alternative Names: Sevofluran; Ultane; 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane; Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl ester; Fluoromethyl 1,1,1,3,3,3-Hexafluoro-2-propyl ester. CAS No. 28523-86-6. Pack Sizes: 1mg;1g;10g. Product ID: 28523-86-6. Molecular formula: C4H3F7O. Mole weight: 200.1. Custom synthesis is available. Send your inquiries for more information. | London |
| (S)-homo-β-alanine | (S)-Homo-β-alanine, an amino acid occurring naturally, acts as an intermediary in thymine metabolism. Its potential to regulate oxidative stress and inflammation marks it as a prospective treatment for cardiovascular disease and hypertension. Also, research suggests its involvement in the synthesis of neurotransmitter gamma-aminobutyric acid (GABA) in the brain. Group: Pharmaceutical. Alternative Names: (S)-beta-homoalanine. CAS No. 3775-72-2. Pack Sizes: 10 g. Product ID: B2699-114069. Molecular formula: C4H9NO2. Mole weight: 103.11. Custom synthesis is available. Send your inquiries for more information. | London |
| Tetrahydrolavandulol | Tetrahydrolavandulol, a vital constituent in the realm of pharmacology, has been studied comprehensively due to its significant potential in treating anxiety and depression. Its functionality relies on positively modulating GABAA receptors, an allosteric mechanism that boosts the activity of GABA in the brain, thereby enabling a calming effect to prevail. Group: Pharmaceutical. Alternative Names: 2-Isopropyl-5-methylhexan-1-ol. CAS No. 2051-33-4. Pack Sizes: 1 g. Product ID: B2699-115002. Molecular formula: C10H22O. Mole weight: 158.28. Custom synthesis is available. Send your inquiries for more information. | London |
| Thiocolchicoside | Thiocolchicoside is a semi-synthetic derivative of colchicine, an anti-inflammatory glycoside extracted from the flower seeds of superba gloriosa. Thiocolchicoside acts as a GABAA receptor antagonist exhibiting anti-inflammatory and analgesic activity. It is used as a muscle relaxant. Group: Pharmaceutical. Alternative Names: N-[(7S)-3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide; (S)-N-[3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide; Coltramyl; Coltrax; Miorel; Miotens; Muscoril; Colchicoside, 10-thio-; 2-Demethoxy-2-glucosidoxythiocolchicine; Etoshine MR; NSC 147755; R 271; Thiocholshikoside. CAS No. 602-41-5. Pack Sizes: 500 mg. Product ID: B0084-464811. Molecular formula: C27H33NO10S. Mole weight: 563.62. Custom synthesis is available. Send your inquiries for more information. | London |
| Tiagabine hydrochloride | Tiagabine hydrochloride is an anticonvulsant and selective GABA reuptake inhibitor through inhibition of the synaptic GABA transporter GAT1. Tiagabine increases the synaptic GABA and enhances the neuronal inhibition. It is effective as adjunctive treatment of epilepsy and anxiety disorders. Group: Pharmaceutical. Alternative Names: Gabitril hydrochloride; NO050328 hydrochloride; NO328 hydrochloride; NO-050328 hydrochloride; NO 328 hydrochloride; NO O050328 hydrochloride; NO 328 hydrochloride; TGB hydrochloride. CAS No. 145821-59-6. Pack Sizes: 200 mg. Product ID: NP3227. Molecular formula: C20H26ClNO2S2. Mole weight: 412.01. Custom synthesis is available. Send your inquiries for more information. | London |
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