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| Product | Description | |
|---|---|---|
| FMK | FMK is a potent, highly specific and irreversible ribosomal s6 kinase (RSK) inhibitor that covalently modifies the C-terminal kinase domain of RSK. Its IC50 value is 15 nM. It could prevent the activation of the N-terminal kinase domain of RSK by the C-terminal kinase domain, but does not affect the activity of the N-terminal domain. It binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. It induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells. It is used to determine the role of RSK as a direct regulator of NHE1 phosphorylation and sarcolemmal NHE activity in this cell type, in response to 1-adrenergic stimulation. Uses: Fmk could prevent the activation of the n-terminal kinase domain of rsk by the c-terminal kinase domain, but does not affect the activity of the n-terminal domain. it is used to determine the role of rsk as a direct regulator of nhe1 phosphorylation and sarcolemmal nhe activity in this cell type, in response to 1-adrenergic stimulation. Group: Pharmaceutical. Alternative Names: 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone;RSK2 kinase inhibitor. CAS No. 821794-92-7. Pack Sizes: 10 mg. Product ID: B0084-455721. Molecular formula: C18H19FN4O2. Mole weight: 342.37. Custom synthesis is available. Send your inquiries for more information. |  London |
| Boc-D-FMK | BOC-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα). It has been found to reduce the activation of nuclear factor kappa light chain enhancer of activated B cells (NF-kB), suppress the phosphorylation of subunit nuclear factor kappa light polypeptide gene enhancer in B cells inhibitor α (IkBα) and inhibit TNF-induced expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1). Moreover, it has also effectively attenuated the hepatocyte apoptosis in bile duct-ligated rats potentially improving the survival rates. Uses: Caspase inhibitors. Group: Pharmaceutical. Alternative Names: Boc-Asp(OMe)-fluoromethyl ketone; Caspase Inhibitor 3; N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone; BAF; Boc-D-Fluoromethyl Ketone; Boc-D(OMe)-FMK; 3S-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid, methyl ester; Caspase Inhibitor III. CAS No. 187389-53-3. Pack Sizes: 100 mg. Product ID: BAT-010386. Molecular formula: C11H18FNO5. Mole weight: 263.26. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-DEVD-FMK | Z-DEVD-FMK is a cell-permeant, irreversible caspase-3 inhibitor that can be used as an anaesthetic agent. It has been shown to suppress tumor cell apoptosis. Uses: Cysteine proteinase inhibitors. Group: Pharmaceutical. Alternative Names: Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK; Caspase-3 Inhibitor; Z-D(OMe)E(Ome)VD(OMe)-FMK; benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone; Caspase-3 Inhibitor II; Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone; Z-DEVD-fluoromethylketone. CAS No. 210344-95-9. Pack Sizes: 10 mg. Product ID: BAT-010236. Molecular formula: C30H41FN4O12. Mole weight: 668.67. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-IETD-FMK | Z-IETD-FMK is a selective and cell permeable caspase 8 inhibitor. Z-IETD-FMK inhibits T cell proliferation induced by PHA or anti-CD3 plus anti-CD28 without toxicity of resting T cells. Group: Pharmaceutical. Alternative Names: caspase-8 inhibitor; Z-IE(OMe)TD(OMe)-FMK; Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH2F; Z-Ile-Glu(OMe)-Thr-Asp(OMe) fluoromethylketone; N-benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone. CAS No. 210344-98-2. Pack Sizes: 50 mg. Product ID: BAT-010389. Molecular formula: C30H43FN4O11. Mole weight: 654.69. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-Phe-DL-Ala-FMK | Z-FA-FMK is an irreversible cysteine protease inhibitor, and it also inhibits caspases-2, -3, -6, and -7. Z-FA-FMK suppresses the degradation of fibrillar collagen by fibroblasts and osteoclasts, and reduces LPS-induced cytokine production via inhibition of NF-kappaB-dependent gene expression in macrophages. Uses: Cysteine proteinase inhibitors. Group: Pharmaceutical. Alternative Names: Z-Phe-DL-Ala-fluoromethylketone; Zfa-fmk; benzyloxycarbonyl-Phe-Ala-fluormethylketone; benzyloxycarbonylphenylalanyl-alanine fluoromethyl ketone; Carbamic acid, N-((1S)-2-((3-fluoro-1-methyl-2-oxopropyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-, phenylmethyl ester. CAS No. 197855-65-5. Pack Sizes: 50 mg. Product ID: B0084-209259. Molecular formula: C21H23FN2O4. Mole weight: 386.42. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-VAD-FMK | Z-VAD-FMK is a broad spectrum pan-caspase inhibitor that inhibits the intracellular activation of caspase-like proteases. Group: Pharmaceutical. Alternative Names: Z-VAD (OMe)-FMK; Caspase Inhibitor I. CAS No. 187389-52-2. Pack Sizes: 25 mg. Product ID: BAT-010214. Molecular formula: C22H30FN3O7. Mole weight: 467.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-VDVAD-FMK | Z-VDVAD-FMK is a cell-permeant and irreversible caspase-2 inhibitor and can inhibits apoptosis in various cell lines. Group: Pharmaceutical. Alternative Names: Z-VD(OMe)VAD(OMe)-FMK; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethyl ketone; benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone; L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-|A-aspartyl-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK. CAS No. 210344-92-6. Pack Sizes: 50 mg. Product ID: BAT-010375. Molecular formula: C32H46FN5O11. Mole weight: 695.74. Custom synthesis is available. Send your inquiries for more information. | London |
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