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| Product | Description | |
|---|---|---|
| Flavopiridol | Flavopiridol. CAS No. 146426-40-6. Product ID: C-21743. |  CARBONE SCIENTIFIC UK |
| Flavopiridol Hydrochloride | Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Group: Pharmaceutical. Alternative Names: NSC 649890 HCl; NSC649890 HCl; NSC-649890 HCl. CAS No. 131740-09-5. Pack Sizes: 100 mg. Product ID: B0084-083124. Molecular formula: C21H20ClNO5.HCl. Mole weight: 438.3. Custom synthesis is available. Send your inquiries for more information. |  London |
| Dinaciclib | Dinaciclib, also known as SCH727965, is a potent CDK inhibitor with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC(50) values of 1, 1, 3, and 4 nmol/L, respectively. Compared with flavopiridol, Dinaciclib exhibits superior activity with an improved therapeutic index. Dinaciclib induced regression of established solid tumors in a range of mouse models following intermittent scheduling of doses below the maximally tolerated level. Group: Pharmaceutical. Alternative Names: SCH 727965; SCH727965; SCH-727965; PS095760; PS 095760; PS-095760; Dinaciclib. 2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol. CAS No. 779353-01-4. Pack Sizes: 25 mg. Product ID: B0084-454920. Molecular formula: C21H28N6O2. Mole weight: 396.49. Custom synthesis is available. Send your inquiries for more information. | London |
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