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| Product | Description | |
|---|---|---|
| Everolimus | Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cytokine-mediated lymphocyte proliferation. Everolimus can be used as an immunosuppressant in the treatment of renal cell cancer and other cancers. Uses: Immunosuppressant. Group: Pharmaceutical. Alternative Names: RAD-001; RAD001; RAD 001; Afinitor; Certican; Zortress; RAD001; SDZ-RAD. CAS No. 159351-69-6. Pack Sizes: 100 mg. Product ID: BAT-010106. Molecular formula: C53H83NO14. Mole weight: 958.24. Custom synthesis is available. Send your inquiries for more information. |  London |
| Everolimus, Cyclosporine and Tacrolimus Mix Standard | Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Cyclosporine is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Tacrolimus is also an immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Group: Pharmaceutical. Pack Sizes: 1mg;1g;10g. Molecular formula: C53H83NO14/C62H111N11O12/C44H69N. Mole weight: 958.22/1202.61/612.02. Custom synthesis is available. Send your inquiries for more information. | London |
| (19Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin Sodium Salt | (19Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin Sodium Salt. Uses: Metabolite of the immunosuppressant macrolide sdz rad (also known as everolimus e945400) which is an analog of the parent drug rapamycin (r124000). Group: Pharmaceutical. Alternative Names: (2S)-1-[2-oxo-2-[(2R,3R,6S)-tetrahydro-2-hydroxy-6-[(2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19Z,21R)-14-hydroxy-22-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxo-3,5,7,15,19-docosapentaen-1-yl]-3-methyl-2H-pyran-2-yl]acetyl]-2-piperidinecarboxylic Acid Sodium Salt; seco Everolimus Sodium Salt. CAS No. 220127-31-1. Pack Sizes: 1mg;1g;10g. Product ID: 220127-31-1. Molecular formula: C53H82NNaO14. Mole weight: 980.21. Custom synthesis is available. Send your inquiries for more information. | London |
| 42-O-[2-[[Hydroxy[2-(trimethylammonio)ethoxy]phosphinyl]oxy]ethyl] Rapamycin Inner Salt | 42-O-[2-[[Hydroxy[2-(trimethylammonio)ethoxy]phosphinyl]oxy]ethyl] Rapamycin Inner Salt. Uses: A phosphocholine ester metabolite of the immunosuppressant macrolide sdz rad (also known as everolimus e945400) which is an analog of the parent drug rapamycin (r124000). Group: Pharmaceutical. Alternative Names: ATG 181. CAS No. 1062645-51-5. Pack Sizes: 1mg;1g;10g. Product ID: 1062645-51-5. Molecular formula: C58H95N2O17P. Mole weight: 1123.35. Custom synthesis is available. Send your inquiries for more information. | London |
| Rapamycin | Rapamycin is an mTOR inhibitor immunosuppressant and kinase inhibitor with both antifungal and antineoplastic properties. It selectively inhibits the transcriptional activation of cytokines. Uses: Antifungal and antineoplastic agent. Group: Pharmaceutical. Alternative Names: Sirolimus; (-)-Rapamycin; AY 22989; AY-22989; I-2190A; NSC 226080; RAPA; RAP; RPM; SLM; WY-090217; Everolimus EP Impurity A. CAS No. 53123-88-9. Pack Sizes: 500 mg. Product ID: BBF-02627. Molecular formula: C51H79NO13. Mole weight: 914.19. Custom synthesis is available. Send your inquiries for more information. | London |
| SAR-405 | SAR-405 is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM, Kd=1.5 nM) without disrupting other PI3K isoforms and mTOR (IC50 > 10,000 nM). Concomitant inhibition of Vps34 and mTOR, with SAR405 and mTOR inhibitor everolimus, results in synergistic antiproliferative activity in renal tumor cell lines. Group: Pharmaceutical. Alternative Names: SAR 405; SAR405; 4H-Pyrimido[1,?2-a]?pyrimidin-4-one, 9-[(5-chloro-3-pyridinyl)?methyl]?-6,?7,?8,?9-tetrahydro-2-[(3R)?-3-methyl-4-morpholinyl]?-8-(trifluoromethyl)?-, (8S)?-; (8S)-9-[(5-Chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one. CAS No. 1523406-39-4. Pack Sizes: 10 mg. Product ID: B2693-482215. Molecular formula: C19H21ClF3N5O2. Mole weight: 443.85. Custom synthesis is available. Send your inquiries for more information. | London |
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