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| Product | Description | |
|---|---|---|
| ETP-46321 | ETP-46321 is a potent and orally bioavailable PI3K α, δ inhibitor with potent biochemical and cellular activity and good pharmacokinetic properties (PK) after oral dosing. ETP-46321 PK/PD studies showed time dependent downregulation of AKT(Ser473) phosphorylation, which correlates with compound levels in tumor tissue and demonstrating to be efficacious in a GEMM mouse tumor model driven by a K-Ras(G12V) oncogenic mutation. Treatment with ETP-46321 resulted in significant tumor growth inhibition. Group: Pharmaceutical. Alternative Names: ETP46321; ETP-46321; ETP 46321; 5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine. CAS No. 1252594-99-2. Pack Sizes: 300 mg. Product ID: B0084-462342. Molecular formula: C20H27N9O3S. Mole weight: 473.556. Custom synthesis is available. Send your inquiries for more information. |  London |
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