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| Product | Description | |
|---|---|---|
| BIS(1-BUTYLPENTYL) DECANE-1,10-DIYL DIGLUTARATE | Abbreviated as Sec or U, in older publications also as Se-Cys, as a building block of selenoproteins, this 21st proteinogenic amino acid exists naturally in three domains of life, but not in every lineage. Uses: Used for the characterization of total sodium concentration in human blood plasma; also used for the preparation of nitrite-selective membrane electrode, used for the potentiometric determination of nad(p)h coenzymes. Group: Pharmaceutical. CAS No. 101342-76-1. Pack Sizes: 1 g. Product ID: B0001-236189. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Carmustine | Carmustine is antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. It is used in the treatment of brain tumors, multiple myeloma and some lymphomas. Group: Pharmaceutical. CAS No. 154-93-8. Pack Sizes: 5 g. Product ID: B2693-465289. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Dabigatran ethyl AcOH Salt | Dabigatran ethyl AcOH Salt, a remarkable pharmaceutical compound, plays a pivotal role in studying blood clots, encompassing deep vein thrombosand pulmonary embolism. It exerts its profound anticoagulant effects through targeted inhibition of thrombin, a pivotal enzyme in the intricate clotting cascade. Group: Pharmaceutical. CAS No. 1188263-64-0. Pack Sizes: 50 mg. Product ID: B0043-284782. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Dimethyl-l-arginine | Dimethyl-l-arginine is naturally found in blood plasma. It is produced from the continual protein modification processes in the cytoplasm of all human cells. Uses: Enzyme inhibitors. Group: Pharmaceutical. CAS No. 30315-93-6. Pack Sizes: 250 mg. Product ID: B0350-054018. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Enzastaurin | Enzastaurin is a protein kinase C beta inhibitor with 6- to 20-fold selectivity against PKCα, PKCγ and PKC&epsilon. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. Group: Pharmaceutical. CAS No. 170364-57-5. Pack Sizes: 200 mg. Product ID: B0084-085618. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Isopropyl 4-[4-[N,N-bis(2-hydroxyethyl)amino]phenyl]butyrate | Isopropyl 4-[4-[N,N-bis(2-hydroxyethyl)amino]phenyl]butyrate, a pharmaceutical intermediate, can be utilized in the production of drugs intended for the treatment of cardiovascular disease, such as hypertension. It functions as an angiotensin-converting enzyme (ACE) inhibitor, which reduces the likelihood of heart attack and stroke by regulating blood pressure levels. Consequently, it plays a valuable role in managing these serious medical conditions, thus improving overall health outcomes among patients. Group: Pharmaceutical. CAS No. 94086-78-9. Pack Sizes: 10 mg. Product ID: B2699-045702. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Lactosylsphingosine | Lactosylsphingosine, a sphingolipid, is a vital biomarker characterizing diverse lysosomal storage disorders such as Niemann-Pick disease and Gaucher disease due to its accumulation within the tissues and blood of affected people. Detection through blood examination or imaging studies makes identification possible. Therapy options include substrate reduction and enzyme replacement therapy. Furthermore, tracking variations in lactosylsphingosine may be employed to monitor therapy response and trace disease advancement, imparting substantial clinical value in disease management. Group: Pharmaceutical. CAS No. 109785-20-8. Pack Sizes: 1 mg. Product ID: B2705-003271. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| L-α-Aspartyl-D-phenylalanine methyl ester | L-α-Aspartyl-D-phenylalanine methyl ester, a dipeptide compound, bears promise in the biomedical sector for its potential inhibitory impact on angiotensin converting enzyme (ACE), thus potentially reducing blood pressure levels. It has also shown potential in the treatment of hypertensive, cardiac failure, and other cardiovascular conditions. The study of its properties continues to generate interest and attention from academia and the scientific community. Group: Pharmaceutical. CAS No. 22839-65-2. Pack Sizes: 50 mg. Product ID: B2699-116576. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Lanreotide | Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the 06 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits 06-alkyl-guanine transferase, an enzyme involved with DNA repair. Group: Pharmaceutical. CAS No. 108736-35-2. Pack Sizes: 25 mg. Product ID: BAT-010202. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Lisinopril Impurity F | Lisinopril Impurity F is an impurity of Lisinopril, a medication of the angiotensin-converting enzyme inhibitor class that is used to treat high blood pressure. Group: Pharmaceutical. CAS No. 1132650-67-9. Pack Sizes: 10 mg. Product ID: B2694-262437. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Lycopene | Lycopene, in the concentration used, is not toxic and also its health benefits in adipose tissue may play a role against obesity-related complications. Lycopene in tomato puree has decreased indicating an indirect effect on lycopene stability caused by high concentration of hydrogen peroxide and the activation of peroxidase enzymes leading to the reduction of ascorbic acid and its regenerative action towards lycopene. Besides, Lycopene protected β-carotene against isomerization during reactions with singlet oxygen and radicals. These findings can explain the pattern of carotenoid isomers analyzed in fruits and vegetables, where lycopene containing samples showed higher (all-E)/(9Z)-β-carotene ratios, and also in in vivo samples such as human blood plasma. Lycopene can be used as pigment in food processing, and is also used as raw material of antioxidant health food. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 502-65-8. Pack Sizes: 1 g. Product ID: B0005-464994. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Naringin | Naringin inhibits hepatic P-glycoprotein (P-gp) and some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions. Naringin can be used as an edible additive, mainly for gum, refreshing drinks, etc. It is a plant polyphenol that can inhibit tyrosinase, block melanin synthesis, reduce skin pigment intensity, absorb UV, prevent photoaging, reduce sun damage and age spot formation, and whiten and lighten spots. It also has the anti-glycation and antibacterial effect, can effectively improve skin tone and skin texture, prevent the generation of age spots, remove red bloodlines, and improve skin blood microcirculation. Uses: Antioxidant, anticancer, anti-atherogenic. Group: Pharmaceutical. CAS No. 10236-47-2. Pack Sizes: 250 g. Product ID: NP1904. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| OXi-4503 | OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated levels in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production. CA1 binds to tubulin at the same site as colchicine but with higher affinity. Group: Pharmaceutical. CAS No. 288847-35-8. Pack Sizes: 100 mg. Product ID: B0084-353235. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PF-1355 | PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MPO without disrupting a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. PF-1355 was used to test the hypothesis that MPO activity is a critical mediator of disease activity in immune complex vasculitis mouse models, and to support the confidence in rationale for this mechanism as a therapeutic approach to treat related human condition such as alleviating tissue injury caused by Goodpasture syndrome and pulmonary vasculitis induced by immune complexes. Group: Pharmaceutical. CAS No. 1435467-38-1. Pack Sizes: 50 mg. Product ID: B0084-474818. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Physostigmine salicylate | Physostigmine salicylate is a cholinesterase inhibitor that can cross blood-brain barrier. It forms slowly degrading carbamylated enzyme complex with acetylcholinesterase (AChE). It has been used to improve cognitive ability and treat glaucoma. Group: Pharmaceutical. CAS No. 57-64-7. Pack Sizes: 250 mg. Product ID: B0084-028331. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sacubitril | Sacubitril, also known as AHU377 or LCZ696, is an angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume. Group: Pharmaceutical. CAS No. 149709-62-6. Pack Sizes: 10 g. Product ID: B0084-458470. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| TC-S 7001 | TC-S 7001 is a potent and highly selective ROCK inhibitor. Its IC50 values are 0.6 and 1.1 nM for ROCK1 and ROCK2, respectively. It exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. It reduces blood pressure in normotensive and hypertensive rats. Group: Pharmaceutical. CAS No. 867017-68-3. Pack Sizes: 5 mg. Product ID: B2693-430574. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Trandolapril | Trandolapril is an angiotensin converting enzyme (ACE) inhibitor. It has a longer biological half-life and a high degree of lipophilicity than others. It is used to treat high blood pressure. It acts by competitive inhibition of ACE, which is a key enzyme in the renin-angiotensin system and plays an important role in regulating blood pressure. lt inhibits atherosclerosis1 and decreases the occurrence of atrial fibrillation2. It is marketed by Abbott Laboratories under the brand name Mavik. It has been listed. Uses: Trandolapril is used to treat high blood pressure. Group: Pharmaceutical. CAS No. 87679-37-6. Pack Sizes: 500 mg. Product ID: BAT-010063. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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