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| Product | Description | |
|---|---|---|
| 2,9-Dibromo-1,10-Phenanthroline | 2,9-Dibromo-1,10-Phenanthroline, a heterocyclic aromatic compound comprising two fused six-membered rings, is an indispensable element in the field of biomedical research due to its unique properties. With its proficient nature, this compound provides a remarkable breakthrough in detecting and quantifying a wide range of metal ions. Its chelating activity along with its potential inhibitory effect towards metal-dependent enzymes makes it a valuable tool for a diverse range of laboratory applications. Further, with its exceptional medicinal properties, it plays a pivotal role in developing drugs to combat complex and multifactorial diseases such as cancer and Alzheimer's, highlighting the remarkable impact of this compound in the biomedical field. Group: Pharmaceutical. CAS No. 39069-02-8. Pack Sizes: 5 g. Product ID: B2699-179946. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 4'-Cyanouridine | Utilizing the crucial factors of "perplexity" and "burstiness," 4'-Cyanouridine, a modified nucleoside, displays promise as an antitumor agent. Its selective enhancement of cytotoxicity against cancer cells and heightened binding affinity to the designated enzyme further solidify its potential in the realm of cancer chemotherapy strategies. Group: Pharmaceutical. CAS No. 232589-05-8. Pack Sizes: 5 mg. Product ID: B2706-339130. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Enzastaurin | Enzastaurin is a protein kinase C beta inhibitor with 6- to 20-fold selectivity against PKCα, PKCγ and PKC&epsilon. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. Group: Pharmaceutical. CAS No. 170364-57-5. Pack Sizes: 200 mg. Product ID: B0084-085618. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ilomastat | Ilomastat is a broad-spectrum matrix metalloproteinase inhibitor, displaying potential anticancer activity. Ilomastat is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc. Ilomastat inhibits enzymes including thermolysin, peptide deformylase, and anthrax lethal factor endopeptidase (LF) produced by the bacterium Bacillus anthracis. Group: Pharmaceutical. CAS No. 142880-36-2. Pack Sizes: 25 mg. Product ID: B0084-302725. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Leucovorin Calcium | leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Group: Pharmaceutical. CAS No. 1492-18-8. Pack Sizes: 5 g. Product ID: B2693-301409. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Oclacitinib | Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 's) ranging from 10 to 99 nM and did not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nm). Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 's ranging from 36 to 249 nm. Oclacitinib had minimal effects on cytokines that did not activate the JAK1 enzyme in cells (erythropoietin, granulocyte/macrophage colony-stimulating factor, IL-12, IL-23; IC50 's > 1000 nm). These results demonstrate that oclacitinib is a targeted therapy that selectively inhibits JAK1-dependent cytokines involved in allergy, inflammation, and pruritus and suggests these are the mechanisms by which oclacitinib effectively controls clinical signs associated with allergic skin disease in dogs. Group: Pharmaceutical. CAS No. 1208319-26-9. Pack Sizes: 50 mg. Product ID: B0084-462291. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Panobinostat | Panobinostat is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 404950-80-7. Pack Sizes: 500 mg. Product ID: B0084-141578. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pyrroloquinoline quinone disodium salt | The disodium salt form of Pyrroloquinoline quinone which is a cofactor related to the enzyme-catalyzed redox reactions glucose and methanol dehydrogenase. Pyrroloquinoline quinone disodium salt is isolated from cultures of methylotropic bacteria and tissues of mammals. Nutritional supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 122628-50-6. Pack Sizes: 1 g. Product ID: BBF-05731. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Radotinib | Radotinib, also known as IY-5511, is an orally available, hydrochloride salt form of radotinib, a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome-positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. This agent has shown potent efficacy in CML cells that are resistant to the first-generation standard tyrosine kinase inhibitors, such as imatinib, nilotinib and dasatinib. PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. CAS No. 926037-48-1. Pack Sizes: 50 mg. Product ID: B0084-465339. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ulinastatin | Ulinastatin is an acid-resistant protease inhibitor derived from human urine, acting as a potent anti-inflammatory agent. It was shown to inhibit the activities of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin, lipase, hyaluronidase, factors IXa, Xa, XIa, and XlIa, and polymorphonuclear leukocyte elastase. Group: Pharmaceutical. CAS No. 80449-31-6. Pack Sizes: 1 g. Product ID: B2693-135299. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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