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| Product | Description | |
|---|---|---|
| Elacridar hydrochloride | Elacridar is an orally bioavailable inhibitor of P-glycoprotein (P-gp) and ABCG2. Group: Pharmaceutical. Alternative Names: Elacridar HCl; N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide hydrochloride. CAS No. 143851-98-3. Pack Sizes: 50 mg. Product ID: B0084-458012. Molecular formula: C34H33N3O5.HCl. Mole weight: 600.1. Custom synthesis is available. Send your inquiries for more information. |  London |
| Elacridar | Elacridar hydrochloride (GF120918A) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects. Group: Pharmaceutical. Alternative Names: GF120918; GF-120918; GF 120918; GF-120918A; GF120918A; GF 120918A; GG 918; D03968. Elacridar hydrochloride. CAS No. 143664-11-3. Pack Sizes: 100 mg. Product ID: B0084-311800. Molecular formula: C34H33N3O5. Mole weight: 563.654. Custom synthesis is available. Send your inquiries for more information. | London |
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