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| Product | Description | |
|---|---|---|
| 9-Aminocamptothecin | 9-Aminocamptothecin is a water-insoluble camptothecin derivative and an inhibitor of the nuclear enzyme topoisomerase I, disrupting the repair of single-strand DNA breakages. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 91421-43-1. Pack Sizes: 100 mg. Product ID: NP0052. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Aclarubicin A | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. It intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. It is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. It has potent antineoplastic activity. It is used in the treatment of cancer. It can induce histone eviction from chromatin upon intercalation. It has been listed. Uses: Aclarubicin has potent antineoplastic activity. it is used in the treatment of cancer. it can induce histone eviction from chromatin upon intercalation. Group: Pharmaceutical. CAS No. 57576-44-0. Pack Sizes: 1mg; 1g; 10g. Product ID: BBF-00542. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Aclarubicin hydrochloride | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting replication and repair of DNA and RNA, and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin. Uses: Antibiotics, antineoplastic. Group: Pharmaceutical. CAS No. 75443-99-1. Pack Sizes: 5 mg. Product ID: BBF-04081. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ametantrone | Ametantrone (AM) is a topoisomerase II inhibitor leading to covalent cross-links in DNA of tumor cells. It is a synthetic 9,10-anthracenedione containing two (hydroxyethylamino)ethylamino residues at positions 1 and 4. Along with other anthraquinones and anthracyclines, it shares a polycyclic intercalating moiety and charged side chains that stabilize DNA binding. Group: Pharmaceutical. CAS No. 64862-96-0. Pack Sizes: 5 mg. Product ID: B0084-146674. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Amonafide | Amonafide is an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 69408-81-7. Pack Sizes: 50 mg. Product ID: B0084-097145. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Carminomycin I | It is produced by the strain of Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair, and RNA and protein synthesis. Group: Pharmaceutical. CAS No. 50935-04-1. Pack Sizes: 10 mg. Product ID: BBF-00703. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CKD 602 | CKD-602 is a topoisomerase I inhibitor. It is a synthetic and water-soluble camptothecin derivative which forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. CKD-602 has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group. Group: Pharmaceutical. CAS No. 213819-48-8. Pack Sizes: 20 mg. Product ID: B0084-087456. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CL2A-SN 38 | CL2A-SN 38 is a drug-linker conjugate for ADC by using SN 38 (a DNA Topoisomerase I inhibitor), linked via CL2A. Group: Pharmaceutical. CAS No. 1279680-68-0. Pack Sizes: 5 mg. Product ID: BADC-00742. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Clinafloxacin | Clinafloxacin is a fluoroquinolone antibiotic with a broad-range of antibacterial activity. It inhibits both DNA gyrase and topoisomerase IV. Group: Pharmaceutical. CAS No. 105956-97-6. Pack Sizes: 100 mg. Product ID: B0084-053762. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Doxorubicin hydrochloride | Doxorubicin is an anthracycline antibiotic with antineoplastic activity produced by the bacterium Streptomyces peucetius var. Doxorubicin is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. Uses: Adcs cytotoxin. Group: Pharmaceutical. CAS No. 25316-40-9. Pack Sizes: 1 g. Product ID: BBF-03859. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| DXD | DXD, an Exatecan derivative for ADC, is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 μM. It can be used as a payload for antibody-conjugated drug ADCs targeting HER2. Group: Pharmaceutical. CAS No. 1599440-33-1. Pack Sizes: 25 mg. Product ID: BADC-01394. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Enrofloxacin | Enrofloxacin is a fluoroquinolone antibiotic that prevents DNA superhelix and DNA synthesis by inhibiting bacterial DNA gyrase (a type II topoisomerase). It can be used for bacterial diseases caused by sensitive bacteria in livestock and small animals. Group: Pharmaceutical. CAS No. 93106-60-6. Pack Sizes: 100 g. Product ID: BBF-04643. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Etoposide | Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. Group: Pharmaceutical. CAS No. 33419-42-0. Pack Sizes: 25 g. Product ID: NP4193. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Exatecan Mesylate | Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting the religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogs. Group: Pharmaceutical. CAS No. 169869-90-3. Pack Sizes: 500 mg. Product ID: BBF-04655. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Guajadial F | Guajadial F is a sesquiterpenoid-based meroterpenoid isolated from the leaves of Psidium guajava. Guajadial F has potential anticancer effects. Biochemical topoisomerase I (Top1) assay revealed that guajadial F acted as a Top1 catalytic inhibitor and delayed Top1 poison-mediated DNA damage. Group: Pharmaceutical. CAS No. 1529775-08-3. Pack Sizes: 1 mg. Product ID: NP5861. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan-[d10] Hydrochloride | Irinotecan-[d10] Hydrochloride is the labelled analogue of Irinotecan, which is a DNA topoisomerase inhibitor. Group: Pharmaceutical. CAS No. 718612-62-5. Pack Sizes: 10 mg. Product ID: BLP-012397. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan EP Impurity E (SN-38) | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. It inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. Uses: The treatment of colorectal cancer. Group: Pharmaceutical. CAS No. 86639-52-3. Pack Sizes: 1 g. Product ID: BADC-01393. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan Hydrochloride Trihydrate | The hydrochloride salt of Irinotecan. Irinotecan is a prodrug that can be activated to 7-ethyl-10-hydroxy-camptothecin (SN-38) by the carboxylesterase-converting enzyme. SN-38 inhibits topoisomerase I to suppress DNA replication and promote cell death. Group: Pharmaceutical. CAS No. 136572-09-3. Pack Sizes: 1 g. Product ID: B0084-057943. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Moxifloxacin-[d3] | Moxifloxacin-[d3] is a labelled form of Moxifloxacin. Moxifloxacin exerts its effects by trapping a DNA drug enzyme complex and specfically inhibiting ATP-dependent enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. Group: Pharmaceutical. CAS No. 1092356-42-7. Pack Sizes: 10 mg. Product ID: BLP-013398. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Moxifloxacin Hydrochloride | Moxifloxacin exerts its effects by trapping a DNA drug enzyme complex and specifically inhibiting ATP-dependent enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. It is a fluoroquinolone antibiotic with broad-spectrum bactericidal activity against gram-positive and gram-negative strains. Group: Pharmaceutical. CAS No. 186826-86-8. Pack Sizes: 100 g. Product ID: BBF-04614. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pirarubicin | Pirarubicin is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into DNA and interacts with topoisomerase II, used as an antineoplastic agent. Group: Pharmaceutical. CAS No. 72496-41-4. Pack Sizes: 25 mg. Product ID: BBF-03937. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PNU-159682 | PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes. It is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity, and shows >3,000-fold cytotoxic than its parent compound (MMDX and doxorubicin). It is a more potent and well tolerated ADC cytotoxin than doxorubicin. Uses: Adcs cytotoxin. Group: Pharmaceutical. CAS No. 202350-68-3. Pack Sizes: 5 mg. Product ID: BBF-05916. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PNU159682-EDA | PNU159682-EDA is a drug-linker conjugate for ADC by using PNU159682 (a potent DNA topoisomerase II inhibitor), linked via EDA. Group: Pharmaceutical. CAS No. 2255344-14-8. Pack Sizes: 5 mg. Product ID: BADC-01404. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rubitecan | Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells. This agent also prevents repair of reversible single-strand DNA breaks. Group: Pharmaceutical. CAS No. 91421-42-0. Pack Sizes: 100 mg. Product ID: B2692-079493. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tirapazamine | Tirapazamine is a benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. CAS No. 27314-97-2. Pack Sizes: 1 g. Product ID: B2693-350792. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Topotecan hydrochloride | Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Uses: Topoisomerase i inhibitors. Group: Pharmaceutical. CAS No. 119413-54-6. Pack Sizes: 1 g. Product ID: NP0530. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Zoliflodacin | Zoliflodacin, an oxazolidinone derivative, has been found to be a DNA gyrase inhibitor that could be used as an antibacterial agent. It is still under Phase II trial in Gonorrhea. Uses: Topoisomerase ii inhibitors. Group: Pharmaceutical. CAS No. 1620458-09-4. Pack Sizes: 1 mg. Product ID: B0084-475910. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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