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| Product | Description | |
|---|---|---|
| 3'-Azido-3'-deoxyguanosine | 3'-Azido-3'-deoxyguanosine is an exceptionally robust antiviral compound meticulously formulated to intricately impede the microbial replication process by precisely directing its attention towards the viral DNA polymerase, disallowing its maleficent progression. Expertly synthesized, this quintessential nucleoside analogue incessantly finds application within the biomedical sector for its unprecedented multiplicity within research domains pertaining to antiviral pharmaceutical evolution and the efficacious research of viral ailments, most notably retroviruses and herpes viruses induced afflictions. Group: Pharmaceutical. CAS No. 98870-11-2. Pack Sizes: 50 mg. Product ID: B1370-064370. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 3'-Deoxythymidine | 3'-Deoxythymidine is a precursor of DNA polymerase β inhibitor. Group: Pharmaceutical. CAS No. 3416-5-5. Pack Sizes: 1 g. Product ID: B1370-090563. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5-Iodo-2'-deoxytubercidin | It is a derivative of 7-Iodo-7-deazadenine and is designed to be incorporated into DNA by using Vent(exo-) polymerase primers extension. Uses: Pharmaceutical intermediates. Group: Pharmaceutical. CAS No. 166247-63-8. Pack Sizes: 500 mg. Product ID: B0001-331316. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AOH1996 | AOH1996 is a small-molecule PCNA inhibitor that enhances the interaction between PCNA and the largest subunit of RNA polymerase II, RPB1, and dissociates PCNA from actively transcribed chromatin regions, while inducing DNA double-stranded breaks in a transcription-dependent manner. AOH1996 was identified as a selective chemotherapeutic. Group: Pharmaceutical. CAS No. 2089314-64-5. Pack Sizes: 100 mg. Product ID: B1370-426615. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ART558 | ART558 is a nanomolar potent, selective, allosteric DNA polymerase activity of Polθ inhibitor with IC50 of 7.9 nM. ART558 can be used in cancer research. Group: Pharmaceutical. CAS No. 2603528-97-6. Pack Sizes: 5 mg. Product ID: B1370-410227. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ART812 | ART812 is an orally active DNA polymerase Polθ inhibitor with IC 50 of 7.6 nM. ART812 also significantly inhibited PARP-resistant BRCA1 mutant tumor growth in rats. Group: Pharmaceutical. CAS No. 2607138-82-7. Pack Sizes: 50 mg. Product ID: B1370-410226. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bakuchiol | Bakuchiol is a phytoestrogen isolated from the seeds of Psoralea corylifolia L with anti-tumor, antioxidant, and antibacterial effects. Bakuchiol has a retinol-like effect on skin gene expression and properties. Bakuchiol inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 μM). Bakuchiol has hypoglycemic, hypolipidemic, anti-inflammatory, anti-wrinkle, soothing and liver protective, anticancer, antidepressant, and estrogen-like effects. Uses: Antioxidant. Group: Pharmaceutical. CAS No. 10309-37-2. Pack Sizes: 100 mg. Product ID: NP4619. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cidofovir dihydrate | Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is an acyclic nucleoside phosphonate, and is therefore independent of phosphorylation by viral enzymes, unlike acyclovir. Cidofovir was discovered at the Institute of Organic Chemistry and Biochemistry, Prague, and developed by Gilead Sciences and is marketed with the brand name Vistide by Gilead in the USA, and by Pfizer elsewhere. Maintenance therapy with cidofovir involves an infusion only once every two weeks, making it a convenient treatment option. Because dosing is relatively infrequent, a permanent catheter is not necessary for infusions. Uses: Antiviral agents. Group: Pharmaceutical. CAS No. 149394-66-1. Pack Sizes: 250 mg. Product ID: BBF-03991. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Letermovir | Letermovir is a novel anti-CMV compound which targets the pUL56 (amino acid 230-370) subunit of the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. It has a novel mode of action targets the enzyme UL56 terminase and keep active to other drug-resistant virus. It has been approved in prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT). Uses: Antiviral agents. Group: Pharmaceutical. CAS No. 917389-32-3. Pack Sizes: 5 mg. Product ID: B2693-460490. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N1-MethylpseudoUridine-5'-Triphosphate Sodium | It is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-methylpseudouridine can reduce the immunogenicity of the resulting mRNA. The product has passed the functionality test in transcription reaction. The solution is free of DNase and RNase contamination. Group: Pharmaceutical. Pack Sizes: 1 mL. Product ID: B2706-358101. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Olaparib | Olaparib, also known as AZD-2281 or KU-59436, is a small-molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks. Group: Pharmaceutical. CAS No. 763113-22-0. Pack Sizes: 1 g. Product ID: B0084-076683. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rucaparib | Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway. So, rucaparib has been also found to be most effective in cells deficient in DNA repair, where the cells deficient are caused by exposure to genotoxic agents, such as irradiation produces DNA damage and its toxicity is augmented when the DNA repair is impaired. Increased radiosensitivity in presence of rucaparib was associated with persistent DNA breaks as determined by gamma-H2AX and p53BP1 foci. Rucaparib radiosensitizes prostate cancer cells, most effectively those that are PTEN-deficient and are expressing ETS gene fusion proteins, which inhibits NHEJ DNA repair. Uses: Cancer therapy. Group: Pharmaceutical. CAS No. 283173-50-2. Pack Sizes: 250 mg. Product ID: B2693-104639. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rucaparib monocamsylate | Rucaparib camsylate is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, which work in DNA repair process. It was approved for the treatment of ovarian cancer, and Rubraca is proved to be a monotherapy for the patients deleterious BRCA mutation associated advanced ovarian cancer who were treated with two or more chemotherapies. Group: Pharmaceutical. CAS No. 1859053-21-6. Pack Sizes: 100 mg. Product ID: B0084-007117. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Talazoparib | Talazoparib, also known as BMN-673, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. Uses: For research used only. Group: Pharmaceutical. CAS No. 1207456-01-6. Pack Sizes: 100 mg. Product ID: B0084-462689. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Valganciclovir HCl | Valganciclovir hydrochloride hydrate is an antiviral used to treat cytomegalovirus infection. It is the prodrug of ganciclovir, a synthetic analog of 2'-deoxy-guanosine which is phosphorylated to a dGTP analog that competitively inhibits the incorporation of dGTP by viral DNA polymerase. Group: Pharmaceutical. CAS No. 175865-59-5. Pack Sizes: 2.5 g. Product ID: B0084-061144. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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