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| Product | Description | |
|---|---|---|
| Disodium (R)-2-Hydroxyglutarate | Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM. In U-87MG cells, (R)-2-Hydroxyglutarate acts as a weak antagonist of α-KG to inhibit α-KG-dependent histone demethylases and increase dimethylation on both H3K9 and H3K79. Group: Pharmaceutical. CAS No. 103404-90-6. Pack Sizes: 100 mg. Product ID: BAT-008968. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| NLG-919 | NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Group: Pharmaceutical. CAS No. 1402836-58-1. Pack Sizes: 50 mg. Product ID: B0084-462741. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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