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| Product | Description | |
|---|---|---|
| A-740003 | A-740003 is potent, selective and competitive P2X7 receptor antagonist. Its IC50 values are 18 and 40 nM for rat and human receptors respectively measured by agonist-stimulated changes in intracellular calcium concentrations. It displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. It reduces nociception in animal models of persistent neuropathic and inflammatory pain. It showed weak or no activity (IC(50) > 10 muM) at other P2 receptors and an array of other neurotransmitter and peptide receptors, ion channels, reuptake sites, and enzymes. It potently blocked agonist-evoked IL-1beta release (IC(50) = 156 nM) and pore formation (IC(50) = 92 nM) in differentiated human THP-1 cells. It produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Uses: A-740003 produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Group: Pharmaceutical. Alternative Names: A-740003; A 740003; A740003; N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide. CAS No. 861393-28-4. Pack Sizes: 1mg;1g;10g. Product ID: 861393-28-4. Molecular formula: C26H30N6O3. Mole weight: 474.55. Custom synthesis is available. Send your inquiries for more information. |  London |
| (+/-)-Amorolfine | (+/-)-Amorolfine is a highly powerful antifungal compound exhibiting its efficacy in studying diverse fungal infections, encompassing dermatophytes and yeasts, that frequently afflict toenails and fingernails. Group: Pharmaceutical. Alternative Names: Ro 14-4767-002; 2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine; 2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine; Morpholine, 4-(3-(4-(1,1-dimethylpropyl)phenyl)-2-methylpropyl)-2,6-dimethyl-. CAS No. 67467-83-8. Pack Sizes: 1mg;1g;10g. Product ID: NP3519. Molecular formula: C21H35NO. Mole weight: 317.517. Custom synthesis is available. Send your inquiries for more information. | London |
| Ibrexafungerp | Ibrexafungerp, an intravenous and orally bioavailable semisynthetic derivative of enfumafungin, is a triterpene antifungal agent indicated for the treatment of adult and postmenarchal pediatric females with vulvovaginal candidiasis (VVC). It is a glucan synthase inhibitor. Group: Pharmaceutical. Alternative Names: Brexafemme; SCY-078; MK3118; 4H-1,4a-Propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid, 15-[(2R)-2-amino-2,3,3-trimethylbutoxy]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-, (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-. CAS No. 1207753-03-4. Pack Sizes: 10 mg. Product ID: BBF-05813. Molecular formula: C44H67N5O4. Mole weight: 730.03. Custom synthesis is available. Send your inquiries for more information. | London |
| Ibrexafungerp Citrate | Ibrexafungerp Citrate, an intravenous and orally bioavailable semisynthetic derivative of enfumafungin, is a triterpene antifungal agent indicated for the treatment of adult and postmenarchal pediatric females with vulvovaginal candidiasis (VVC). It is a glucan synthase inhibitor. Group: Pharmaceutical. Alternative Names: Brexafemme Citrate; SCY-078 Citrate; MK-3118 Citrate; 4H-1,4a-Propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid, 15-[(2R)-2-amino-2,3,3-trimethylbutoxy]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-, (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt). CAS No. 1965291-08-0. Pack Sizes: 10 mg. Product ID: BBF-05812. Molecular formula: C50H75N5O11. Mole weight: 922.17. Custom synthesis is available. Send your inquiries for more information. | London |
| Losmapimod | Losmapimod is a promising new agent against cardiovascular diseases. This drug works by inhibiting p38 MAP kinases, which play an important role in the development of atherosclerosis and heart failure caused by ischemic conditions. Losmapimod did not cause an improvement in exercise tolerance or lung function, despite being well-tolerated in this COPD population. The p38 MAPK inhibitor losmapimod (GW856553) attenuates the pro-inflammatory response in humans by reducing PIC production. Group: Pharmaceutical. Alternative Names: Losmapimod; GW856553; GW-856553; GW 856553 GSK-AHAB; GW856553X; 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide. CAS No. 585543-15-3. Pack Sizes: 25 mg. Product ID: B0084-094991. Molecular formula: C22H26FN3O2. Mole weight: 383.467. Custom synthesis is available. Send your inquiries for more information. | London |
| LY2228820 dimesylate | LY2228820 dimesylate is the salt form of LY2228820, a tri-substituted imidazole derivative and p38α and β MAPK inhibitor. LY2228820 inhibits tumor growth in various cancer models. Group: Pharmaceutical. Alternative Names: Ralimetinib Mesylate; Ralimetinib dimesylate; 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine mesylate. CAS No. 862507-23-1. Pack Sizes: 10 mg. Product ID: B0084-286454. Molecular formula: C26H37FN6O6S2. Mole weight: 612.74. Custom synthesis is available. Send your inquiries for more information. | London |
| Omadacycline hydrochloride | Omadacycline hydrochloride is the hydrochloride salt of Omadacycline which is the first intravenous and oral 9-aminomethylcycline in clinical development for multiple infectious disease indications. Group: Pharmaceutical. Alternative Names: (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-9-[(2,2-dimethylpropylamino)methyl]-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride; Omadacycline (hydrochloride). CAS No. 1196800-39-1. Pack Sizes: 50 mg. Product ID: B0046-007288. Molecular formula: C29H40N4O7.HCl. Mole weight: 593.11. Custom synthesis is available. Send your inquiries for more information. | London |
| Rosuvastatin EP Impurity A Calcium Salt | Rosuvastatin EP Impurity A Calcium Salt is an impurity of Rosuvastatin, which is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. Group: Pharmaceutical. Alternative Names: 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-2-[[(2-hydroxy-2-methylpropyl)sulfonyl]methylamino]-6-(1-methylethyl)-5-pyrimidinyl]-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)-; (3R,5S,E)-7-(4-(4-Fluorophenyl)-2-((2-hydroxy-N,2-dimethylpropyl)sulfonamido)-6-isopropylpyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate Calcium Salt; S-Desmethyl-S-(2-hydroxy-2-methylpropyl) Rosuvastatin Calcium Salt; (3R,5S,6E)-7-[2-(2,N-Dimethyl-2-hydroxypropane-1-sulfonamido)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid calcium salt; Calcium (3R,5S,E)-7-{4-(4-fluorophenyl)-2-[(2-hydroxy-N,2-dimethylpropyl)sulfonamide]-6-isopropylpyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate salt (1:2); USP Rosuvastatin Related Compound A; Rosuvastatin Related Compound A; Rosuvastatin USP Related Compound A. CAS No. 1714147-47-3. Pack Sizes: 5 mg. Product ID: B2694-010332. Molecular formula: C25H33FN3O7S.1/2Ca. Mole weight: 558.65. Custom synthesis is available. Send your inquiries for more information. | London |
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