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8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. It inhibits cell growth, decreases proliferation, increases differentiation and induces apoptosis. Group: Pharmaceutical. Alternative Names: 8-Br-3',5'-cyclo-adenosine monophosphate, sodium salt; 8-Br-3',5'-cyclo-AMP.Na; (8Br-cAMP) sodium salt; 8-Bromo-adenosine-3',5'-cyclic monophosphate, Sodium salt; 8-Br-cAMP sodium salt; 8-Bromoadenosine 3',5'-cyclic monophosphate sodium salt; Adenosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate), sodium salt (1:1). CAS No. 76939-46-3. Pack Sizes: 100 mg. Product ID: B1370-005325. Molecular formula: C10H10BrN5NaO6P. Mole weight: 430.08. Custom synthesis is available. Send your inquiries for more information.
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Givosiran sodium
Givosiran sodium is a small interfering RNA (siRNA) directed towards delta-aminolevulinate synthase 1 (ALAS1). Givosiran sodium has been indicated for the treatment of adults with acute hepatic porphyria (AHP). Group: Pharmaceutical. Alternative Names: ALN-AS1 sodium; ALN AS1 sodium; ALN-AS 1 sodium; WHO 10280 sodium; WHO-10280 sodium; WHO10280 sodium; Givlaari sodium; RNA, (Cm-sp-Am-sp-Gm-Am-Am-Am-(2'-deoxy-2'-fluoro)G-Am-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)C-Am-Um-Cm-Um-Um-Am), 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)G-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Gm-sp-Gm-sp-Um) (1:1) sodium salt. Pack Sizes: 10 mg. Product ID: B1370-212888. Molecular formula: C524H651F16N173Na43O316P43S6. Mole weight: 17,245.56 Da. Custom synthesis is available. Send your inquiries for more information.
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Inclisiran
Inclisiran is a medication approved for the treatment of people with atherosclerotic cardiovascular disease (ASCVD), ASCVD risk equivalents and heterozygous familial hypercholesterolemia (HeFH). It is a small interfering RNA (siRNA) that binds to PCSK9 messenger RNA, resulting in decreased concentrations of PCSK9 and plasma concentrations of LDL cholesterol. Group: Pharmaceutical. Alternative Names: ALN-PCSsc; ALN-60212; Leqvio; Inclisiran sodium; ALN-PCS; Leqvio; RNA, (Am-sp-(2'-deoxy-2'-fluoro)C-sp-Am-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-Am-Gm-sp-Am-sp-Am), complex with RNA (Cm-sp-Um-sp-Am-Gm-Am-Cm-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Um-dT-Um-Um-Gm-Cm-Um-Um-Um-Um-Gm-Um) 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate] (1:1). CAS No. 1639324-58-5. Pack Sizes: 5 mg. Product ID: B1370-057828. Molecular formula: C529H707F12N176O316P43S6. Mole weight: 16339.48. Custom synthesis is available. Send your inquiries for more information.
2'-O-Methyladenosine-5'-triphosphate, a pivotal compound within the realm of biomedicine, engenders cautious attention. Its versatility spans vast biomedical applications, including but not limited to the treatment of cancer, viral infections, and neurological disorders. This chemical entity's distinct molecular makeup renders it an auspicious instrument for refined therapeutic interventions. Consequently, the resolute exploration and multifarious prospects surrounding 2'-O-Methyladenosine-5'-triphosphate confer it profound significance within the dynamic milieu of the biomedical sector. Group: Pharmaceutical. Alternative Names: 2'-O-Me-ATP; [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-methoxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate; Adenosine 5'-(tetrahydrogen triphosphate), 2'-O-Methyl-; 2'-O-Methyladenosine 5'-(tetrahydrogen triphosphate); 2'-O-Methyl-ATP; 2'-OMe-ATP. CAS No. 30948-06-2. Pack Sizes: 1 mL. Product ID: B1370-340111. Molecular formula: C11H18N5O13P3. Mole weight: 521.21. Custom synthesis is available. Send your inquiries for more information.
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