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| Product | Description | |
|---|---|---|
| Delamanid | 25mg Pack Size. Group: Antibiotics, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C25H25F3N4O5. CAS No. 681492-22-8. Prepack ID : 90026659-25mg. Molecular Weight : 534.48. |  |
| Delamanid | Delamanid is used for the treatment of multi-drug-resistant tuberculosis. It functions by blocking the synthesis of mycolic acids in Mycobacterium tuberculosis, the organism which causes tuberculosis, thus destabilising its cell wall. Uses: The treatment of multi-drug-resistant tuberculosis. Group: Pharmaceutical. Alternative Names: OPC-67683; OPC 67683; OPC67683; Deltyba; (2R)-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]phenoxy]methyl]-3H-imidazo[2,1-b][1,3]oxazole. CAS No. 681492-22-8. Pack Sizes: 100 mg. Product ID: B0084-459437. Molecular formula: C25H25F3N4O6. Mole weight: 534.492. Custom synthesis is available. Send your inquiries for more information. |  London |
| TBA-354 | TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates. TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy. TBA-354 has high bioavailability and a long elimination half-life. In vitro studies suggest a low risk of drug-drug interactions. Low-dose aerosol infection models of acute and chronic murine tuberculosis reveal time- and dose-dependent in vivo bactericidal activity that is at least as potent as that of delamanid and more potent than that of PA-824. Group: Pharmaceutical. Alternative Names: TBA-354, TBA 354, TBA354, SN31354, SN-31354, SN 31354. CAS No. 1257426-19-9. Pack Sizes: 100 mg. Product ID: B2693-463155. Molecular formula: C19H15F3N4O5. Mole weight: 436.34. Custom synthesis is available. Send your inquiries for more information. | London |
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