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| Product | Description | |
|---|---|---|
| Dasatinib | Dasatinib, also known as BMS-354825, is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. Group: Pharmaceutical. CAS No. 302962-49-8. Pack Sizes: 25 g. Product ID: NP3264. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Dasatinib Impurities | Dasatinib Impurities are critical for evaluating the purity and efficacy of dasatinib, a tyrosine kinase inhibitor utilized in treating chronic myeloid leukemia and acute lymphoblastic leukemia. Analyzing these impurities ensures the safety and effectiveness of dasatinib in clinical applications, supporting its continued use in cancer therapy. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Dasatinib N-Oxide | Dasatinib N-Oxide is an oxidative metabolite of Dasatinib (M5 metabolite). Group: Pharmaceutical. CAS No. 910297-52-8. Pack Sizes: 5 mg. Product ID: B0708-469805. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-Deshydroxyethyl Dasatinib | N-Deshydroxyethyl Dasatinib is a metabolite of Dasatinib. Group: Pharmaceutical. CAS No. 910297-51-7. Pack Sizes: 2 mg. Product ID: B0708-469807. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Radotinib | Radotinib, also known as IY-5511, is an orally available, hydrochloride salt form of radotinib, a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome-positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. This agent has shown potent efficacy in CML cells that are resistant to the first-generation standard tyrosine kinase inhibitors, such as imatinib, nilotinib and dasatinib. PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. CAS No. 926037-48-1. Pack Sizes: 50 mg. Product ID: B0084-465339. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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